{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:05:51Z","timestamp":1791907551765,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,7,15]],"date-time":"2012-07-15T00:00:00Z","timestamp":1342310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s11926-012-0279-x","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T10:09:54Z","timestamp":1342260594000},"page":"549-556","source":"Crossref","is-referenced-by-count":211,"title":["Mechanisms of Chronic Pain in Osteoarthritis"],"prefix":"10.1007","volume":"14","author":[{"given":"Hans-Georg","family":"Schaible","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,15]]},"reference":[{"key":"279_CR1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","volume":"10","author":"H Breivik","year":"2006","unstructured":"Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10:287\u2013333.","journal-title":"Eur J Pain"},{"key":"279_CR2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/ar2531","volume":"11","author":"DT Felson","year":"2009","unstructured":"Felson DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther. 2009;11:203.","journal-title":"Arthritis Res Ther"},{"key":"279_CR3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/art.33451","volume":"64","author":"YT Konttinen","year":"2012","unstructured":"Konttinen YT, Sillat T, Barreto G, et al. Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses. Arthritis Rheum. 2012;64:613\u20136.","journal-title":"Arthritis Rheum"},{"key":"279_CR4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","volume":"23","author":"MB Goldring","year":"2011","unstructured":"Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23:471\u20138.","journal-title":"Curr Opin Rheumatol"},{"key":"279_CR5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.27290","volume":"62","author":"J Bondeson","year":"2010","unstructured":"Bondeson J, Blom AB, Wainwright S. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum. 2010;62:647\u201357.","journal-title":"Arthritis Rheum"},{"key":"279_CR6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/art.30148","volume":"63","author":"Y Zhang","year":"2011","unstructured":"\u2022 Zhang Y, Nevitt M, Niu J, et al. Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum. 2011;63:691\u20139. This paper reports important data on the sources of pain in patients with knee OA.","journal-title":"Arthritis Rheum"},{"key":"279_CR7","first-page":"199","volume-title":"Pain in osteoarthritis","author":"G Ordeberg","year":"2009","unstructured":"Ordeberg G. Evidence of sensitization to pain in human osteoarthritis. In: Felson DT, Schaible H-G, editors. Pain in osteoarthritis. Hoboken: Wiley Blackwell; 2009. p. 199\u2013209."},{"key":"279_CR8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.joca.2011.03.007","volume":"19","author":"JR Hochman","year":"2011","unstructured":"Hochman JR, Gagliese L, Davis AM, Hawker GA. Neuropathic pain symptoms in a community knee OA cohort. Osteoarthritis Cartilage. 2011;19:647\u201354.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/art.30414","volume":"63","author":"F Eckstein","year":"2011","unstructured":"Eckstein F, Cotofana S, Wirth W, et al. Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage. Arthritis Rheum. 2011;63:2257\u201367.","journal-title":"Arthritis Rheum"},{"key":"279_CR10","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/art.33502","volume":"64","author":"R Wittoek","year":"2012","unstructured":"Wittoek R, Cruyssen BV, Verbruggen G. Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints. Arthritis Rheum. 2012;64:1430\u20136.","journal-title":"Arthritis Rheum"},{"key":"279_CR11","volume-title":"Wall and Melzack\u00b4s textbook of pain","author":"H-G Schaible","year":"2012","unstructured":"Schaible H-G. Joint pain \u2013 Basic mechanisms. In: McMahon SB, Koltzenburg M, editors. Wall and Melzack\u00b4s textbook of pain. 6th ed. Oxford: Elsevier; 2012. in press.","edition":"6"},{"key":"279_CR12","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1002\/art.27608","volume":"62","author":"H-J Im","year":"2010","unstructured":"Im H-J, Kim J-S, Li X, et al. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum. 2010;62:2995\u20133005.","journal-title":"Arthritis Rheum"},{"key":"279_CR13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","volume":"128","author":"SP Ivanavicius","year":"2007","unstructured":"Ivanavicius SP, Ball AD, Heapy CG, et al. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. Pain. 2007;128:272\u201382.","journal-title":"Pain"},{"key":"279_CR14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2474-12-134","volume":"12","author":"S Orita","year":"2011","unstructured":"Orita S, Ishikawa T, Miyagi M, et al. Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain. BMC Musculoskelet Disord. 2011;12:134.","journal-title":"BMC Musculoskelet Disord"},{"key":"279_CR15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2011.01.027","volume":"493","author":"P Liu","year":"2011","unstructured":"Liu P, Okun A, Guo R-C, et al. Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett. 2011;493:72\u20135.","journal-title":"Neurosci Lett"},{"key":"279_CR16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pbb.2010.11.003","volume":"97","author":"CE Ferland","year":"2011","unstructured":"Ferland CE, Levrty S, Beaudry F, Vachon P. Gait analysis and pain response of two rodent models of osteoarthritis. Pharmacol Biochem Behav. 2011;97:603\u201310.","journal-title":"Pharmacol Biochem Behav"},{"key":"279_CR17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","volume":"18","author":"AM Malfait","year":"2010","unstructured":"Malfait AM, Ritchie J, Gil AS, et al. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010;18:572\u201380.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00221-009-1782-9","volume":"196","author":"H-G Schaible","year":"2009","unstructured":"Schaible H-G, Richter F, Ebersberger A, et al. Joint pain. Exp Brain Res. 2009;196:153\u201362.","journal-title":"Exp Brain Res"},{"key":"279_CR19","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2009.08.063","volume":"465","author":"N Schuelert","year":"2009","unstructured":"Schuelert N, McDougall JJ. Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociception in the knee joint of the rat. Neurosci Lett. 2009;465:184\u20138.","journal-title":"Neurosci Lett"},{"key":"279_CR20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.pain.2008.10.013","volume":"141","author":"JJ McDougall","year":"2009","unstructured":"McDougall JJ, Andruski B, Schuelert N, et al. Unravelling the relationship between age, nociception and joint destruction in naturally occurring osteoarthritis of Dunkin Hartley guinea pigs. Pain. 2009;141:222\u201332.","journal-title":"Pain"},{"key":"279_CR21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3305","volume":"13","author":"H-G Schaible","year":"2011","unstructured":"Schaible H-G, Ebersberger A, Natura G. Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines. Arthritis Res Ther. 2011;13:210.","journal-title":"Arthritis Res Ther"},{"key":"279_CR22","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","volume":"363","author":"NE Lane","year":"2010","unstructured":"\u2022\u2022 Lane NE, Schnitzer TJ, Birbara CA, et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med. 2010;363:1521\u201331. This study shows for the first time the use of a monoclonal antibody to NGF in pain treatment in patients with moderate to severe OA pain.","journal-title":"N Engl J Med"},{"key":"279_CR23","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.joca.2011.09.006","volume":"19","author":"H Nagashima","year":"2011","unstructured":"Nagashima H, Suzuki M, Araki S, et al. Preliminary assessment of the safety and efficacy of tenazumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study. Osteoarthritis Cartilage. 2011;19:1405\u201312.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.joca.2011.01.009","volume":"19","author":"TJ Schnitzer","year":"2011","unstructured":"Schnitzer TJ, Lane NE, Birbara C, et al. Long-term open-label study of tanezumab for moderate to severe osteoarthritis. Osteoarthritis Cartilage. 2011;19:639\u201346.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR25","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1007\/978-3-540-29805-2_2721","volume-title":"Encyclopedia of pain, volume 2","author":"D Bennett","year":"2007","unstructured":"Bennett D. NGF, sensitization of nociceptors. In: Schmidt RF, Willis WD, editors. Encyclopedia of pain, volume 2. Berlin, Heidelberg New York, Tokyo: Springer; 2007. p. 1338\u201342."},{"key":"279_CR26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2010.03.002","volume":"149","author":"KE McNamee","year":"2010","unstructured":"McNamee KE, Burleigh A, Gompels LL, et al. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 2010;149:386\u201392.","journal-title":"Pain"},{"key":"279_CR27","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1002\/art.27715","volume":"62","author":"F Richter","year":"2010","unstructured":"Richter F, Natura G, Loeser S, et al. Tumor necrosis factor-\u03b1 (TNF-\u03b1) causes persistent sensitization of joint nociceptors for mechanical stimuli. Arthritis Rheum. 2010;62:3806\u201314.","journal-title":"Arthritis Rheum"},{"key":"279_CR28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.2009.05301.x","volume":"1193","author":"H-G Schaible","year":"2010","unstructured":"Schaible H-G, Segond von Banchet G, Boettger MK, et al. The role of proinflammatory cytokines in the generation and maintenance of joint pain. Ann N Y Acad Sci. 2010;1193:60\u20139.","journal-title":"Ann N Y Acad Sci"},{"key":"279_CR29","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar3079","volume":"12","author":"MK Boettger","year":"2010","unstructured":"Boettger MK, Leuchtweis J, K\u00fcmmel D, et al. Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. Arthritis Res Ther. 2010;12:R140.","journal-title":"Arthritis Res Ther"},{"key":"279_CR30","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/art.30360","volume":"63","author":"M Attur","year":"2011","unstructured":"Attur M, Belitskaya-L\u00e9vy I, Oh C, et al. Increased interleukin-1\u00df gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum. 2011;63:1908\u201317.","journal-title":"Arthritis Rheum"},{"key":"279_CR31","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar3553","volume":"14","author":"N Schuelert","year":"2012","unstructured":"Schuelert N, McDougall JJ. Involvement of Nav1.8 sodium channels in the transduction of mechanical pain in a rodent model of osteoarthritis. Arthritis Res Ther. 2012;14:R5.","journal-title":"Arthritis Res Ther"},{"key":"279_CR32","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joca.2010.09.005","volume":"18","author":"N Schuelert","year":"2010","unstructured":"Schuelert N, Zhang C, Mogg AJ, et al. Paradoxical effects of the cannabinoid CB(2) receptor agonist GW405833 on rat osteoarthritic knee joint pain. Osteoarthritis Cartilage. 2010;18:1536\u201343.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR33","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/ard.2008.092015","volume":"67","author":"W Zhang","year":"2008","unstructured":"Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008;67:1716\u201323.","journal-title":"Ann Rheum Dis"},{"key":"279_CR34","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/ar3394","volume":"13","author":"MK Boettger","year":"2011","unstructured":"Boettger MK, K\u00fcmmel D, Harrison A, Schaible H-G. Evaluation of long-term antinociceptive properties of of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain. Arthritis Res Ther. 2011;13:R110.","journal-title":"Arthritis Res Ther"},{"key":"279_CR35","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1136\/ard.2009.118042","volume":"69","author":"A Jorgensen","year":"2010","unstructured":"Jorgensen A, Stengaard-Pedersen K, Simonsen O, et al. Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double blind study of 337 patients followed for 1\u00a0year. Ann Rheum Dis. 2010;69:1097\u2013102.","journal-title":"Ann Rheum Dis"},{"key":"279_CR36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/ard.2008.094623","volume":"69","author":"X Chevalier","year":"2010","unstructured":"Chevalier X, Jerosch J, Goupille P, et al. Single, intraarticular treatment with 6\u00a0ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis. 2010;69:113\u20139.","journal-title":"Ann Rheum Dis"},{"key":"279_CR37","doi-asserted-by":"crossref","unstructured":"Berenbaum F, Grifka J, Cazzaniga J, et al. A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis. Ann Rheum Dis. doi: 10.1136\/annrheumdis-2011-200972 .","DOI":"10.1136\/annrheumdis-2011-200972"},{"key":"279_CR38","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.joca.2008.11.013","volume":"17","author":"A Gomis","year":"2009","unstructured":"Gomis A, Miralles A, Schmidt RF, Belmonte C. Intra-articular injections of hyaluronan solutions of different elastoviscosity reduce nociceptive nerve activity in a model of osteoarthritic knee joint of the guinea pig. Osteoarthritis Cartilage. 2009;17:798\u2013804.","journal-title":"Osteoarthritis Cartilage"},{"key":"279_CR39","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1002\/art.30422","volume":"63","author":"S Ashraf","year":"2011","unstructured":"Ashraf S, Mapp PI, Walsh DA. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum. 2011;63:2700\u201310.","journal-title":"Arthritis Rheum"},{"key":"279_CR40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","volume":"149","author":"L Arendt-Nielsen","year":"2010","unstructured":"Arendt-Nielsen L, Nie H, Laursen MB, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010;149:573\u201381.","journal-title":"Pain"},{"key":"279_CR41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1744-8069-5-45","volume":"5","author":"W Rahman","year":"2009","unstructured":"Rahman W, Bauer CS, Bannister K, et al. Descending serotoninergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthitic pain. Mol Pain. 2009;5:45.","journal-title":"Mol Pain"},{"key":"279_CR42","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1002\/art.27698","volume":"62","author":"DR Sagar","year":"2010","unstructured":"Sagar DR, Staniaszek LE, Okine BN, et al. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis Rheum. 2010;62:3666\u201376.","journal-title":"Arthritis Rheum"},{"key":"279_CR43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pain.2009.08.013","volume":"148","author":"A Telleria-Diaz","year":"2010","unstructured":"Telleria-Diaz A, Schmidt M, Kreusch S, et al. Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: involvement of prostaglandins and endocannabinoids. Pain. 2010;148:26\u201335.","journal-title":"Pain"},{"key":"279_CR44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3959(00)00310-9","volume":"88","author":"E Kosek","year":"2000","unstructured":"Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following surgical pain relief. Pain. 2000;88:69\u201378.","journal-title":"Pain"},{"key":"279_CR45","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/art.24837","volume":"61","author":"SE Gwilym","year":"2009","unstructured":"Gwilym SE, Keltner JR, Warnaby CE, et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 2009;61:1226\u201334.","journal-title":"Arthritis Rheum"},{"key":"279_CR46","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/art.22460","volume":"56","author":"B Kulkarni","year":"2007","unstructured":"Kulkarni B, Bentley DE, Elliott R, et al. Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum. 2007;56:1345\u201354.","journal-title":"Arthritis Rheum"},{"key":"279_CR47","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1002\/art.27585","volume":"62","author":"SE Gwilym","year":"2010","unstructured":"Gwilym SE, Filippini N, Douaud G, et al. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty. Arthritis Rheum. 2010;62:2930\u201340.","journal-title":"Arthritis Rheum"},{"key":"279_CR48","doi-asserted-by":"crossref","first-page":"13746","DOI":"10.1523\/JNEUROSCI.3687-09.2009","volume":"29","author":"R Rodriguez-Raecke","year":"2009","unstructured":"Rodriguez-Raecke R, Niemeier A, Ihle K, et al. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci. 2009;29:13746\u201350.","journal-title":"J Neurosci"},{"key":"279_CR49","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1073\/pnas.1011774108","volume":"108","author":"A Hess","year":"2011","unstructured":"Hess A, Axmann R, Rech J, et al. Blockade of TNF-\u03b1 rapidly inhibits pain responses in the central nervous system. PNAS. 2011;108:3731\u201336.","journal-title":"PNAS"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-012-0279-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-012-0279-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-012-0279-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:49:59Z","timestamp":1559436599000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-012-0279-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,15]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["279"],"URL":"https:\/\/doi.org\/10.1007\/s11926-012-0279-x","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,15]]}}}