{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:58:06Z","timestamp":1762459086153},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s11926-013-0325-3","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T05:02:00Z","timestamp":1364274120000},"source":"Crossref","is-referenced-by-count":30,"title":["Anti-oxidation Treatment of Ultra High Molecular Weight Polyethylene Components to Decrease Periprosthetic Osteolysis: Evaluation of Osteolytic and Osteogenic Properties of Wear Debris Particles in a Murine Calvaria Model"],"prefix":"10.1007","volume":"15","author":[{"given":"Justin M.","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim J.","family":"Hallab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Shuo","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"325_CR1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1874325000903010115","volume":"3","author":"E Gomez-Barrena","year":"2009","unstructured":"Gomez-Barrena E, Medel F, Puertolas JA. Polyethylene oxidation in total hip arthroplasty: evolution and new advances. Open Orthop J. 2009;3:115\u201320.","journal-title":"Open Orthop J"},{"issue":"Suppl 3","key":"325_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2106\/JBJS.K.01220","volume":"93","author":"SE Graves","year":"2012","unstructured":"\u2022\u2022 Graves SE, et al. A multinational assessment of metal-on-metal bearings in hip replacement. J Bone Joint Surg Am. 2012;93 Suppl 3:43\u20137. Highly cited reference describing early failure problems with metal-on-metal implants.","journal-title":"J Bone Joint Surg Am"},{"key":"325_CR3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0883-5403(96)80176-8","volume":"11","author":"E Garcia-Cimbrelo","year":"1996","unstructured":"Garcia-Cimbrelo E, et al. Mittelmeier ceramic-ceramic prosthesis after 10\u00a0years. J Arthroplasty. 1996;11:773\u201381.","journal-title":"J Arthroplasty"},{"key":"325_CR4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0969-806X(01)00431-5","volume":"62","author":"M Jahan","year":"2001","unstructured":"Jahan M, et al. A study of long-lived free radicals in gamma-irradiated medical grade polyethlene. Radiat Phys Chem. 2001;62:141\u20134.","journal-title":"Radiat Phys Chem"},{"key":"325_CR5","unstructured":"Currier BH, et al. Shelf life and in vivo duration. Impacts on performance of tibial bearings. Clin Orthop Relat Res. 1997;342:111\u201322."},{"key":"325_CR6","unstructured":"Gomez-Barrena E, et al. Role of polyethylene oxidation and consolidation defects in cup performance. Clin Orthop Relat Res. 1998;352:105\u201317."},{"key":"325_CR7","first-page":"182","volume":"67","author":"NJ Hallab","year":"2009","unstructured":"Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009;67:182\u20138.","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"325_CR8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jmbbm.2011.03.012","volume":"4","author":"SA Atwood","year":"2011","unstructured":"\u2022\u2022 Atwood SA, et al. Tradeoffs amongst fatigue, wear, and oxidation resistance of cross-linked ultra-high molecular weight polyethylene. J Mech Behav Biomed Mater. 2011;4:1033\u201345. This is the first study to simultaneously evaluate fatigue crack propagation, wear, oxidation, and microstructure in a wide variety of clinically-relevant ultra-high molecular weight polyethylene. The trade-off we have shown in fatigue, wear, and oxidation performance is critical to the material's long-term success in total joint replacements.","journal-title":"J Mech Behav Biomed Mater"},{"key":"325_CR9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.arth.2009.04.022","volume":"25","author":"SM Kurtz","year":"2009","unstructured":"\u2022 Kurtz SM, et al. Mechanical properties, oxidation, and clinical performance of retrieved highly cross-linked Crossfire liners after intermediate-term implantation. J Arthroplasty. 2009;25:614\u201323. e611-612. Highly cited reference on the properties and clinical performance of UHMWPE bearings.","journal-title":"J Arthroplasty"},{"key":"325_CR10","unstructured":"Lidgren L, et al. The invention relates to a method for the preparation in a reactor of a UHMWPE material doped with an antioxidant, preferably vitamin E. US patent# 6448315. 2002."},{"key":"325_CR11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00264-010-1161-y","volume":"35","author":"E Oral","year":"2010","unstructured":"\u2022 Oral E, Muratoglu OK. Vitamin E diffused, highly crosslinked UHMWPE: a review. Int Orthop. 2010;35:215\u201323. Highly cited reference on the incorporation of vitamin E into UHMWPE bearings.","journal-title":"Int Orthop"},{"key":"325_CR12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1243\/0954411001535219","volume":"214","author":"E Ingham","year":"2000","unstructured":"Ingham E, Fisher J. Biological reactions to wear debris in total joint replacement. Proc Inst Mech Eng H. 2000;214:21\u201337.","journal-title":"Proc Inst Mech Eng H"},{"key":"325_CR13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.biomaterials.2004.04.035","volume":"26","author":"E Ingham","year":"2005","unstructured":"Ingham E, Fisher J. The role of macrophages in osteolysis of total joint replacement. Biomaterials. 2005;26:1271\u201386.","journal-title":"Biomaterials"},{"key":"325_CR14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11420-006-9003-6","volume":"2","author":"PE Purdue","year":"2006","unstructured":"Purdue PE, et al. The central role of wear debris in periprosthetic osteolysis. HSS J. 2006;2:102\u201313.","journal-title":"HSS J"},{"key":"325_CR15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","volume":"154","author":"KD Merkel","year":"1999","unstructured":"Merkel KD, et al. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol. 1999;154:203\u201310.","journal-title":"Am J Pathol"},{"key":"325_CR16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/jor.1100180602","volume":"18","author":"EM Schwarz","year":"2000","unstructured":"Schwarz EM, et al. Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res. 2000;18:849\u201355.","journal-title":"J Orthop Res"},{"key":"325_CR17","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.biomaterials.2004.06.010","volume":"26","author":"M Knoch von","year":"2005","unstructured":"von Knoch M, et al. The decrease of particle-induced osteolysis after a single dose of bisphosphonate. Biomaterials. 2005;26:1803\u20138.","journal-title":"Biomaterials"},{"key":"325_CR18","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jor.20620","volume":"26","author":"R Tsutsumi","year":"2008","unstructured":"Tsutsumi R, et al. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. J Orthop Res. 2008;26:1340\u20136.","journal-title":"J Orthop Res"},{"key":"325_CR19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0736-0266(01)00083-3","volume":"20","author":"JJ Goater","year":"2002","unstructured":"Goater JJ, et al. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002;20:169\u201373.","journal-title":"J Orthop Res"},{"key":"325_CR20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1359\/jbmr.2001.16.4.660","volume":"16","author":"X Zhang","year":"2001","unstructured":"Zhang X, et al. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001;16:660\u201370.","journal-title":"J Bone Miner Res"},{"key":"325_CR21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1359\/jbmr.2001.16.2.338","volume":"16","author":"LM Childs","year":"2001","unstructured":"Childs LM, et al. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res. 2001;16:338\u201347.","journal-title":"J Bone Miner Res"},{"key":"325_CR22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1359\/jbmr.2002.17.2.192","volume":"17","author":"LM Childs","year":"2002","unstructured":"Childs LM, et al. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002;17:192\u20139.","journal-title":"J Bone Miner Res"},{"key":"325_CR23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0736-0266(03)00156-6","volume":"22","author":"JC Clohisy","year":"2004","unstructured":"Clohisy JC, et al. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J Orthop Res. 2004;22:13\u201320.","journal-title":"J Orthop Res"},{"key":"325_CR24","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/jor.20184","volume":"24","author":"JC Clohisy","year":"2006","unstructured":"Clohisy JC, et al. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res. 2006;24:1358\u201365.","journal-title":"J Orthop Res"},{"key":"325_CR25","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/jor.20199","volume":"24","author":"Y Yamanaka","year":"2006","unstructured":"Yamanaka Y, et al. Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. J Orthop Res. 2006;24:1349\u201357.","journal-title":"J Orthop Res"},{"key":"325_CR26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jor.22190","volume":"31","author":"L Burton","year":"2012","unstructured":"Burton L, et al. Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation. J Orthop Res. 2012;31:73\u201380.","journal-title":"J Orthop Res"},{"key":"325_CR27","doi-asserted-by":"crossref","first-page":"135ra165","DOI":"10.1126\/scitranslmed.3003393","volume":"4","author":"A Mediero","year":"2012","unstructured":"\u2022\u2022 Mediero A, et al. Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med. 2012;4:135ra165. Novel therapeutic approach to prevent wear debris-induced osteolysis.","journal-title":"Sci Transl Med"},{"key":"325_CR28","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.orthres.2004.08.023","volume":"23","author":"N Taki","year":"2005","unstructured":"Taki N, et al. Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. J Orthop Res. 2005;23:376\u201383.","journal-title":"J Orthop Res"},{"key":"325_CR29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0736-0266(00)00033-4","volume":"19","author":"SG Kaar","year":"2001","unstructured":"Kaar SG, et al. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice. J Orthop Res. 2001;19:171\u20138.","journal-title":"J Orthop Res"},{"key":"325_CR30","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2106\/00004623-199711000-00004","volume":"79","author":"JM Martell","year":"1997","unstructured":"Martell JM, Berdia S. Determination of polyethylene wear in total hip replacements with use of digital radiographs. J Bone Joint Surg Am. 1997;79:1635\u201341.","journal-title":"J Bone Joint Surg Am"},{"key":"325_CR31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/ar384","volume":"4","author":"RJ Looney","year":"2002","unstructured":"Looney RJ, et al. Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Res. 2002;4:59\u201363.","journal-title":"Arthritis Res"},{"key":"325_CR32","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2106\/JBJS.E.01305","volume":"89","author":"DW Howie","year":"2007","unstructured":"Howie DW, et al. Progression of acetabular periprosthetic osteolytic lesions measured with computed tomography. J Bone Joint Surg Am. 2007;89:1818\u201325.","journal-title":"J Bone Joint Surg Am"},{"key":"325_CR33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0736-0266(03)00093-7","volume":"21","author":"EM Schwarz","year":"2003","unstructured":"Schwarz EM, et al. Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo. J Orthop Res. 2003;21:1049\u201355.","journal-title":"J Orthop Res"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-013-0325-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-013-0325-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-013-0325-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:16:04Z","timestamp":1553642164000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-013-0325-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["325"],"URL":"https:\/\/doi.org\/10.1007\/s11926-013-0325-3","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]},"article-number":"325"}}