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This in vitro study showed that the Hdac inhibitor, vorinostat, represses matrix degrading enzymes and the overproduction of nitric oxide by inhibiting MAPK signaling and nuclear translocation and transcriptional activity of NF-kappaB in human chondrocytes.","journal-title":"Int Immunopharmacol"},{"key":"602_CR101","doi-asserted-by":"publisher","first-page":"A156","DOI":"10.1016\/j.joca.2015.02.911","volume":"23","author":"MS Makki","year":"2015","unstructured":"Makki MS, Haqqi TM. HDAC inhibitor SAHA induces MCPIP1 expression and suppresses Il-6 expression in human OA chondrocytes. Osteoarthr Cartil. 2015;23:A156. doi: 10.1016\/j.joca.2015.02.911 . This in vitro study showed that SAHA (vorinostat) induces the expression of a negative regulator of Il-6 in human OA chondrocytes, which suppressed Il-6 and reduced matrix degradation.","journal-title":"Osteoarthr Cartil"},{"key":"602_CR102","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s13075-015-0774-3","volume":"17","author":"D Cai","year":"2015","unstructured":"Cai D, Yin S, Yang J, Jiang Q, Cao W. Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. Arthritis Res Ther. 2015;17:269. doi: 10.1186\/s13075-015-0774-3 . This report showed that Nrf2 regulates expression of antioxidant enzymes and is necessary for chrondroprotection by HDIs in an OA model.","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"602_CR103","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/j.joca.2013.09.008","volume":"21","author":"JH Wang","year":"2013","unstructured":"Wang JH, Shih KS, Wu YW, Wang AW, Yang CR. Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1beta signaling in osteoarthritis fibroblast-like synoviocytes. Osteoarthr Cartil. 2013;21(12):1987\u201396. doi: 10.1016\/j.joca.2013.09.008 . This paper showed that Hdac inhibitors indirectly modulates cytokine signaling through microRNAs that block cytokine-induced signaling in OA synoviocytes.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"602_CR104","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/j.1365-2184.2009.00633.x","volume":"42","author":"S Lee","year":"2009","unstructured":"Lee S, Park JR, Seo MS, Roh KH, Park SB, Hwang JW, et al. Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells. 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