{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:43:48Z","timestamp":1778571828157,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s11926-016-0619-3","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T05:38:10Z","timestamp":1478151490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Predictors of Poor Outcome in ANCA-Associated Vasculitis (AAV)"],"prefix":"10.1007","volume":"18","author":[{"given":"Luis E.","family":"Vega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis R.","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"619_CR1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrrheum.2014.104","volume":"10","author":"CG Kallenberg","year":"2014","unstructured":"Kallenberg CG. Key advances in the clinical approach to ANCA-associated vasculitis. Nat Rev Rheumatol. 2014;10:489\u201393.","journal-title":"Nat Rev Rheumatol"},{"key":"619_CR2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJMoa1108735","volume":"367","author":"P Lyons","year":"2012","unstructured":"\u2022 Lyons P, Rayner T, Trivedi S, et al. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med. 2012;367:214\u201323. This genome wide association study in AAV patients shows that there are significant genetic contribution to pathogenesis of disease and distinct genetic associations with GPA and MPA.","journal-title":"N Engl J Med"},{"issue":"7","key":"619_CR3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11926-014-0428-5","volume":"16","author":"MF Ugarte-Gil","year":"2014","unstructured":"Ugarte-Gil MF, Espinoza LR. Genetic of ANCA-associated vasculitides. Curr Rheumatol Rep. 2014;16(7):428.","journal-title":"Curr Rheumatol Rep"},{"key":"619_CR4","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.2215\/CJN.13071211","volume":"7","author":"DY Chang","year":"2012","unstructured":"Chang DY, Luo H, Zhou XJ, et al. Association of HLA genes with clinical outcomes of ANCA-associated vasculitis. Clin J Am Soc Nephrol. 2012;7:1293\u20139.","journal-title":"Clin J Am Soc Nephrol"},{"key":"619_CR5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000355744","volume":"37","author":"U Persson","year":"2013","unstructured":"Persson U, Gullstrand B, Pettersson A, et al. A candidate gene approach to ANCA-associated vasculitis reveals links to the C3 and CTLA-4 genes but not to the IL1-Ra and Fc\u03b3-RIIa genes. Kidney Blood Press Res. 2013;37:641\u20138.","journal-title":"Kidney Blood Press Res"},{"issue":"2","key":"619_CR6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3899\/jrheum.131430","volume":"42","author":"Y Cao","year":"2015","unstructured":"\u2022\u2022 Cao Y, Liu K, Tian Z, et al. PTPN22 R620W polymorphism and ANCA disease risk in white populations: a meta-analysis. J Rheum. 2015;42(2):292\u20139. A meta-analysis of four studies of the PTPN22 620W allele confers susceptibility to the occurrence and development of ANCA disease in whites, with specific evidence among subsets with GPA, MPA, and PR3 ANCA.","journal-title":"J Rheum"},{"issue":"7","key":"619_CR7","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/art.39153","volume":"67","author":"PC Graysson","year":"2015","unstructured":"\u2022\u2022 Graysson PC, Carmona-Rivera C, Xu L, et al. Neutrophil-related gene expression and low-density granulocytes associated with disease activity and response to treatment in ANCA-associated vasculitis. Arthritis and Rheum. 2015;67(7):1922\u201332. Recently published study using serum from the RAVE study, which investigated biomarkers involved in the pathophysiology of ANCA-associated vasculitis and sought to determine if LDG contribute to gene expression signatures in AAV. Granulocyte-related gene expression was associated with disease activity and relatively poor response to treatment in AAV.","journal-title":"Arthritis and Rheum"},{"issue":"4","key":"619_CR8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.lpm.2013.01.020","volume":"42","author":"C Rahmattulla","year":"2013","unstructured":"Rahmattulla C, Berden A, Bajema I. Kidneys in ANCA-associated vasculitis: what to learn from biopsies? Press Med. 2013;42(4):563\u20135.","journal-title":"Press Med"},{"key":"619_CR9","first-page":"1628.1636","volume":"21","author":"A Berden","year":"2010","unstructured":"Berden A, Ferrario F, Hagen EC, et al. Histopathological classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol. 2010;21:1628.1636.","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"619_CR10","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/ndt\/gfr643","volume":"27","author":"DY Chang","year":"2012","unstructured":"Chang DY, Wu LH, Liu G, et al. Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center. Nephrol Dial Transplant. 2012;27(6):2343\u20139.","journal-title":"Nephrol Dial Transplant"},{"key":"619_CR11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10157-012-0755-7","volume":"17","author":"E Muso","year":"2013","unstructured":"Muso E, Endo T, Itabashi M, et al. Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts. Clin Exp Nephrol. 2013;17:659\u201362.","journal-title":"Clin Exp Nephrol."},{"key":"619_CR12","first-page":"711A","volume":"23","author":"CL Ellis","year":"2012","unstructured":"Ellis CL, Manno R, Racusen LC, et al. New histopathologic classification of anti-neutrophil cytoplasmic antibody associated pauci-immune glomerulonephritis: correlation with renal outcome (Abstract). J Am Soc Nephrol. 2012;23:711A.","journal-title":"J Am Soc Nephrol"},{"key":"619_CR13","first-page":"711A","volume":"23","author":"S Ford","year":"2012","unstructured":"Ford S, Polkinghorne K, Longano A, et al. Renal function and sclerotic glomerular injury predict poor prognosis in patients presenting with anti-neutrophil cytoplasmic antibody associated vasculitis (Abstract). J Am Soc Nephrol. 2012;23:711A.","journal-title":"J Am Soc Nephrol"},{"key":"619_CR14","doi-asserted-by":"crossref","unstructured":"Shah S, Havill J, Rahman MH, Geetha D. A historical study of American patients with anti-neutrophil cytoplasmic antibody negative pauci-immune glomerulonephritis. Clin Rheumatol 2016;35(4):953\u2013960.","DOI":"10.1007\/s10067-015-3086-8"},{"key":"619_CR15","doi-asserted-by":"crossref","unstructured":"Hanaoka H, Ota Y, Takeuchi T, Kuwana M. Poor renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and normal renal function at diagnosis Clin Rheumatol 2016;35(2):495\u2013500.","DOI":"10.1007\/s10067-015-3162-0"},{"key":"619_CR16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/ndt\/gfu237","volume":"30","author":"A Tanna","year":"2015","unstructured":"Tanna A, Guarino L, Tam FWK, et al. Long-term outcome of anti-neutrophil cytoplasm antibody-associated glomerulonephritis: evaluation of the international histological classification and other prognostic factors. Nephrol Dial Transplant. 2015;30:1185\u201392.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"619_CR17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.ajkd.2013.08.025","volume":"63","author":"GSL Ford","year":"2014","unstructured":"Ford GSL, Polkinghorne KR, Longano A, et al. Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis. Am J Kidney Dis. 2014;63(2):227\u201335.","journal-title":"Am J Kidney Dis"},{"issue":"Supp 89","key":"619_CR18","first-page":"S56","volume":"33","author":"G Moroni","year":"2015","unstructured":"Moroni G, Binda V, Leoni A, et al. Predictors of renal survival in ANCA-associated vasculitis. Validation of a histopathological classification schema and review of the literature. Clin Exp Rheumatol. 2015;33(Supp 89):S56\u201363.","journal-title":"Clin Exp Rheumatol"},{"key":"619_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MD.0b013e318205a4c6","volume":"90","author":"L Guillevin","year":"2011","unstructured":"Guillevin L, Pagnoux C, Seror R, et al. The Five Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitides Study Group (FVSG) cohort. Medicine. 2011;90:19\u201327.","journal-title":"Medicine"},{"issue":"(4) part 2","key":"619_CR20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.lpm.2013.02.037","volume":"42","author":"C Maldini","year":"2013","unstructured":"Maldini C, Resche-Rigon M, et al. A risk score for predicting short-term incidence of death or relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis. Press Med. 2013;42((4) part 2):666.","journal-title":"Press Med"},{"key":"619_CR21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s11926-012-0291-1","volume":"14","author":"K Bhamra","year":"2012","unstructured":"Bhamra K, Luqmani R. Damage assessment in ANCA-associated vasculitis. Curr Rheumatol Rep. 2012;14:494\u2013500.","journal-title":"Curr Rheumatol Rep"},{"issue":"sup.85","key":"619_CR22","first-page":"S118","volume":"32","author":"C Ponte","year":"2014","unstructured":"Ponte C, Sznajd J, ONeill L, Luqmani RA. Optimization of vasculitis disease assessment in clinical trials, clinical care and long-term databases. Clin Exp Rheumatol. 2014;32(sup.85):S118\u201325.","journal-title":"Clin Exp Rheumatol"},{"key":"619_CR23","unstructured":"\u2022 Kronbichler A, Kerschbaum J, Grundingler G, et al. Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis. Nephrol Dial Transplant 2015. A systematic literature review was performed, which identified 161 marker molecules. They identified promising biomarkers and proposed a biomarker panel comprising CRP and urinary MCP-1 in patients with AAV and renal involvement."},{"issue":"8","key":"619_CR24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/rheumatology\/keu427","volume":"54","author":"PC Grayson","year":"2015","unstructured":"Grayson PC, Monach PA, Pagnoux C, et al. Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis. Rheumatology (Oxford). 2015;54(8):1351\u20139.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"619_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0121737","volume":"10","author":"C Dejaco","year":"2015","unstructured":"Dejaco C, Oppl B, Monach P, et al. Serum biomarkers in patients with relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss). PLoS One. 2015;10(3):1\u20138.","journal-title":"PLoS One"},{"issue":"9","key":"619_CR26","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1681\/ASN.2014040407","volume":"6","author":"S Brix","year":"2015","unstructured":"Brix S, Stege G, Disteldorf E, et al. CC chemokine ligand 18 in ANCA-associated crescentic glomerulonephritis. J Am Soc Nephrol. 2015;6(9):2105\u201317.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"619_CR27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/cei.12422","volume":"178","author":"A Souza de","year":"2014","unstructured":"de Souza A, Abdulahad WH, Sosicka P, et al. Are urinary levels of high mobility group box 1 marker of active nephritis in anti-neutrophil cytoplasmic antibody-associated vasculitis? Clin and Exp Immunol. 2014;178(2):270\u20138.","journal-title":"Clin and Exp Immunol"},{"key":"619_CR28","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1186\/ar4344","volume":"15","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Shi W, Tang S, et al. The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis. Arthritis Res Ther. 2013;15:R161.","journal-title":"Arthritis Res Ther"},{"key":"619_CR29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/03009742.2015.1006247","volume":"44","author":"P Willeke","year":"2015","unstructured":"Willeke P, Kumpers P, Schluter B, et al. Platelet counts as a biomarker in ANCA-associated vasculitis. Scand J Rheumatol. 2015;44:302\u20138.","journal-title":"Scand J Rheumatol"},{"key":"619_CR30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/art.38916","volume":"67","author":"S Unizony","year":"2015","unstructured":"Unizony S, Lim N, Phippard DJ, et al. Peripheral CD5+ B cells in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol. 2015;67:535\u201344.","journal-title":"Arthritis Rheumatol"},{"key":"619_CR31","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1136\/annrheumdis-2014-206496","volume":"74","author":"MY Md Yusof","year":"2015","unstructured":"Md Yusof MY, Vital EM, Das S, et al. Repeat cycles of rituximab on clinical relapse in ANCA-associated vasculitis: identifying B cell biomarkers for relapse to guide retreatment decisions. Ann Rheum Dis. 2015;74:1734\u20138.","journal-title":"Ann Rheum Dis"},{"key":"619_CR32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000357154","volume":"126","author":"Y Molad","year":"2014","unstructured":"Molad Y, Tovar A, Ofer-Shiber S. Association of low serum complement 3 with reduced patient and renal survival in anti-myeloperoxidase-associated small-vessel vasculitis. Nephron Clin Pract. 2014;126:67\u201374.","journal-title":"Nephron Clin Pract"},{"key":"619_CR33","first-page":"S-64","volume":"33","author":"C Skoglund","year":"2015","unstructured":"Skoglund C, Carlsen AL, Weiner M, et al. Circulating microRNA expression pattern separates patients with anti-neutrophil cytoplasmic antibody associated vasculitis from healthy controls. Clin Exp Rheumatol. 2015;33:S-64\u201371.","journal-title":"Clin Exp Rheumatol"},{"issue":"18","key":"619_CR34","doi-asserted-by":"crossref","first-page":"e843","DOI":"10.1097\/MD.0000000000000843","volume":"94","author":"YY Shi","year":"2015","unstructured":"Shi YY, Li ZY, Zhao MH, Chen M. The CD4 lymphocyte count is a better predictor of overall infection than the total lymphocyte count in ANCA-associated vasculitis under corticosteroid and cyclophosphamide regimen: a retrospective cohort. Medicine. 2015;94(18):e843\u201310.1097.","journal-title":"Medicine"},{"issue":"1","key":"619_CR35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/cei.12625","volume":"181","author":"RM Tarzi","year":"2015","unstructured":"Tarzi RM, Liu J, Schneiter S, et al. CD14 expression is increased on monocytes in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and correlates with the expression of ANCA autoantigens. Clin Exp Immunol. 2015;181(1):65\u201375.","journal-title":"Clin Exp Immunol"},{"key":"619_CR36","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3899\/jrheum.130758","volume":"41","author":"Y Cao","year":"2014","unstructured":"Cao Y, Tian Z, Li W, et al. Predictors of treatment resistance and relapses in Chinese patients with antineutrophil cytoplasmic antibody-associated disease. J Rheumatol. 2014;41:916\u201322.","journal-title":"J Rheumatol"},{"key":"619_CR37","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/art.38044","volume":"65","author":"EM Miloslavsky","year":"2013","unstructured":"Miloslavsky EM, Specks U, Merkel PA, et al. Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol. 2013;65:2441\u20139.","journal-title":"Arthritis Rheumatol"},{"key":"619_CR38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2172-15-20","volume":"15","author":"TM Hassan","year":"2014","unstructured":"Hassan TM, Hassan AS, Igoe A, et al. Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow-up in ANCA-associated vasculitis. BMC Immunol. 2014;15:20.","journal-title":"BMC Immunol"},{"key":"619_CR39","doi-asserted-by":"crossref","unstructured":"Grau RG. Drug-induced vasculitis. New insights and a changing lineup of suspects. Curr Rheumatol Rep 2015","DOI":"10.1007\/s11926-015-0545-9"},{"key":"619_CR40","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1681\/ASN.2013060606","volume":"25","author":"D Nakazawa","year":"2014","unstructured":"Nakazawa D, Shida H, Tomaru U, Yoshida M, Nishio S, Atsumi T, et al. Enhanced formation and disordered regulation of NETs in myeloperidase-ANCA-associated microscopic polyangiitis. J Am Soc Nephrol. 2014;25:990\u20137.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"619_CR41","doi-asserted-by":"crossref","first-page":"e0148197","DOI":"10.1371\/journal.pone.0148197","volume":"11","author":"H Wang","year":"2016","unstructured":"Wang H, Sha L-L, Ma T-T, Zhang L-X, Chan M, Zhao M-H. Circulating levels of neutrophil extracellular traps is not a useful biomarker for assessing disease activity in antineutrophil cytoplasmic antibody-associated vasculitis. PLoS One. 2016;11(2):e0148197.","journal-title":"PLoS One"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-016-0619-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-016-0619-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-016-0619-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T02:40:52Z","timestamp":1498358452000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-016-0619-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["619"],"URL":"https:\/\/doi.org\/10.1007\/s11926-016-0619-3","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]},"article-number":"70"}}