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J Immunol. 2014;193(5):2168\u201377. \n                      https:\/\/doi.org\/10.4049\/jimmunol.1400977\n                      \n                    .","journal-title":"J Immunol"},{"issue":"7","key":"714_CR48","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1136\/annrheumdis-2015-207776","volume":"75","author":"C Spee-Mayer von","year":"2016","unstructured":"\u2022 von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, et al. Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis. 2016;75(7):1407\u201315. This study showed that treatment of a small number of SLE patients with a low-dose IL-2 regimen expanded functional Tregs in vivo\n                              . \n                      https:\/\/doi.org\/10.1136\/annrheumdis-2015-207776\n                      \n                    .","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"714_CR49","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nm.4148","volume":"22","author":"J He","year":"2016","unstructured":"\u2022 He J, Zhang X, Wei Y, Sun X, Chen Y, Deng J, et al. Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus. Nat Med. 2016;22(9):991\u20133. This study showed that treatment of 38 lupus patients with low-dose IL-2 resulted in the reductions of disease activity in all patients. The findings associated with increased Tregs frequency and reduced Tfh and Th17 cell responses. 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Arthritis Rheum. 2012;64(9):2937\u201346. \n                      https:\/\/doi.org\/10.1002\/art.34502\n                      \n                    .","journal-title":"Arthritis Rheum"},{"issue":"9","key":"714_CR51","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.4049\/jimmunol.1301859","volume":"192","author":"H Kato","year":"2014","unstructured":"Kato H, Perl A. Mechanistic target of rapamycin complex 1 expands Th17 and CD4\u2212CD8\u2212 double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus. J Immunol. 2014;192(9):4134\u201344. \n                      https:\/\/doi.org\/10.4049\/jimmunol.1301859\n                      \n                    .","journal-title":"J Immunol"},{"issue":"5","key":"714_CR52","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.4049\/jimmunol.1301005","volume":"191","author":"ZW Lai","year":"2013","unstructured":"Lai ZW, Borsuk R, Shadakshari A, Yu J, Dawood M, Garcia R, et al. Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus. J Immunol. 2013;191(5):2236\u201346. \n                      https:\/\/doi.org\/10.4049\/jimmunol.1301005\n                      \n                    .","journal-title":"J Immunol"},{"issue":"12","key":"714_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143689","volume":"10","author":"A Mathian","year":"2015","unstructured":"Mathian A, Jouenne R, Chader D, Cohen-Aubart F, Haroche J, Fadlallah J, et al. Regulatory T cell responses to high-dose methylprednisolone in active systemic lupus erythematosus. PLoS One. 2015;10(12):e0143689. \n                      https:\/\/doi.org\/10.1371\/journal.pone.0143689\n                      \n                    .","journal-title":"PLoS One"},{"issue":"1","key":"714_CR54","doi-asserted-by":"publisher","first-page":"R35","DOI":"10.1186\/ar4188","volume":"15","author":"O Weigert","year":"2013","unstructured":"Weigert O, von Spee C, Undeutsch R, Kloke L, Humrich JY, Riemekasten G. CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZB x NZW)F1 lupus mice. Arthritis Res Ther. 2013;15(1):R35. \n                      https:\/\/doi.org\/10.1186\/ar4188\n                      \n                    .","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"714_CR55","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.clim.2015.01.006","volume":"157","author":"G Qiao","year":"2015","unstructured":"Qiao G, Yang L, Li Z, Williams JW, Zhang J. A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells. Clin Immunol. 2015;157(2):166\u201374. \n                      https:\/\/doi.org\/10.1016\/j.clim.2015.01.006\n                      \n                    .","journal-title":"Clin Immunol"},{"issue":"7","key":"714_CR56","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3109\/08916934.2014.915954","volume":"47","author":"T Koga","year":"2014","unstructured":"Koga T, Mizui M, Yoshida N, Otomo K, Lieberman LA, Crisp\u00edn JC, et al. KN-93, an inhibitor of calcium\/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+ regulatory T cells in MRL\/lpr mice. Autoimmunity. 2014;47(7):445\u201350. \n                      https:\/\/doi.org\/10.3109\/08916934.2014.915954\n                      \n                    .","journal-title":"Autoimmunity"},{"issue":"3","key":"714_CR57","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.clim.2013.08.008","volume":"149","author":"L Zhang","year":"2013","unstructured":"Zhang L, Bertucci AM, Ramsey-Goldman R, Harsha-Strong ER, Burt RK, Datta SK. Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity. Clin Immunol. 2013;149(3):365\u201378. \n                      https:\/\/doi.org\/10.1016\/j.clim.2013.08.008\n                      \n                    .","journal-title":"Clin Immunol"},{"issue":"3","key":"714_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060394","volume":"8","author":"Z Sthoeger","year":"2013","unstructured":"Sthoeger Z, Zinger H, Sharabi A, Asher I, Mozes E. The tolerogenic peptide, hCDR1, down-regulates the expression of interferon-\u03b1 in murine and human systemic lupus erythematosus. PLoS One. 2013;8(3):e60394. \n                      https:\/\/doi.org\/10.1371\/journal.pone.0060394\n                      \n                    .","journal-title":"PLoS One"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-018-0714-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-018-0714-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-018-0714-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T19:08:35Z","timestamp":1550689715000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-018-0714-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1007\/s11926-018-0714-8","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"21 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"6"}}