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Biochem Biophys Res Commun. 2016;478(3):1074\u20139. \n                      https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.066\n                      \n                    .","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"724_CR96","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","volume":"146","author":"H Yin","year":"2014","unstructured":"Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, et al. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology. 2014;146(3):801\u201311. \n                      https:\/\/doi.org\/10.1053\/j.gastro.2013.11.008\n                      \n                    .","journal-title":"Gastroenterology"},{"key":"724_CR97","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1096\/fj.201700612R","volume":"32","author":"M Li","year":"2017","unstructured":"Li M, Hong W, Hao C, Li L, Wu D, Shen A, et al. SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice. FASEB J. 2017;32:500\u201311. \n                      https:\/\/doi.org\/10.1096\/fj.201700612R\n                      \n                    .","journal-title":"FASEB J"},{"issue":"4","key":"724_CR98","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.bbrc.2017.03.155","volume":"486","author":"Z Zeng","year":"2017","unstructured":"Zeng Z, Cheng S, Chen H, Li Q, Hu Y, Wang Q, et al. Activation and overexpression of Sirt1 attenuates lung fibrosis via P300. Biochem Biophys Res Commun. 2017;486(4):1021\u20136. \n                      https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.155\n                      \n                    .","journal-title":"Biochem Biophys Res Commun"},{"key":"724_CR99","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1165\/rcmb.2016-0192OC","volume":"58","author":"H Chu","year":"2017","unstructured":"Chu H, Jiang S, Liu Q, Ma Y, Zhu X, Liang M, et al. SIRT1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing pro-inflammatory and pro-fibrotic processes. Am J Respir Cell Mol Biol. 2017;58:28\u201339. \n                      https:\/\/doi.org\/10.1165\/rcmb.2016-0192OC\n                      \n                    .","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"724_CR100","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1002\/art.39061","volume":"67","author":"J Wei","year":"2015","unstructured":"\u2022\u2022 Wei J, Ghosh AK, Chu H, Fang F, Hinchcliff ME, Wang J, et al. The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor beta signaling. Arthritis Rheumatol. 2015;67(5):1323\u201334. \n                      https:\/\/doi.org\/10.1002\/art.39061\n                      \n                    . One of the first papers to demonstrate that SIRT1 plays an antifibrotic role in SSc-associated dermal fibrosis by inhibiting TGF-\u03b2 signaling.","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"724_CR101","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jdermsci.2017.04.013","volume":"87","author":"X Zhu","year":"2017","unstructured":"\u2022 Zhu X, Chu H, Jiang S, Liu Q, Liu L, Xue Y, et al. Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway. J Dermatol Sci. 2017;87(2):149\u201358. \n                      https:\/\/doi.org\/10.1016\/j.jdermsci.2017.04.013\n                      \n                    . This study identifies downregulation of mTOR signaling as a mechanism for the antifibrotic effects of SIRT1 in SSc-associated dermal fibrosis.","journal-title":"J Dermatol Sci"},{"issue":"10","key":"724_CR102","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1111\/bph.13460","volume":"173","author":"XZ Bai","year":"2016","unstructured":"Bai XZ, Liu JQ, Yang LL, Fan L, He T, Su LL, et al. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. Br J Pharmacol. 2016;173(10):1589\u2013601. \n                      https:\/\/doi.org\/10.1111\/bph.13460\n                      \n                    .","journal-title":"Br J Pharmacol"},{"key":"724_CR103","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","volume":"136","author":"X Tang","year":"2017","unstructured":"Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, et al. SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy. 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Am J Physiol Heart Circ Physiol. 2015;308(5):H424\u201334. \n                      https:\/\/doi.org\/10.1152\/ajpheart.00454.2014\n                      \n                    .","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"724_CR105","doi-asserted-by":"publisher","first-page":"914","DOI":"10.18632\/aging.100252","volume":"2","author":"AV Hafner","year":"2010","unstructured":"Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, et al. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010;2(12):914\u201323. \n                      https:\/\/doi.org\/10.18632\/aging.100252\n                      \n                    .","journal-title":"Aging (Albany NY)"},{"issue":"8","key":"724_CR106","doi-asserted-by":"publisher","first-page":"e006114","DOI":"10.1161\/JAHA.117.006114","volume":"6","author":"T Wei","year":"2017","unstructured":"Wei T, Huang G, Gao J, Huang C, Sun M, Wu J, et al. Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis. J Am Heart Assoc. 2017;6(8):e006114. \n                      https:\/\/doi.org\/10.1161\/JAHA.117.006114\n                      \n                    .","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"724_CR107","first-page":"3258","volume":"9","author":"X Guo","year":"2017","unstructured":"Guo X, Yan F, Li J, Zhang C, Bu P. SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway. Am J Transl Res. 2017;9(7):3258\u201369.","journal-title":"Am J Transl Res"},{"key":"724_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2017.04.027","volume":"460","author":"P He","year":"2017","unstructured":"He P, Li Z, Yue Z, Gao H, Feng G, Wang P, et al. SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction. Mol Cell Endocrinol. 2017;460:1\u201313. \n                      https:\/\/doi.org\/10.1016\/j.mce.2017.04.027\n                      \n                    .","journal-title":"Mol Cell Endocrinol"},{"issue":"24","key":"724_CR109","doi-asserted-by":"publisher","first-page":"39592","DOI":"10.18632\/oncotarget.17165","volume":"8","author":"N Li","year":"2017","unstructured":"Li N, Zhang J, Yan X, Zhang C, Liu H, Shan X, et al. SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension. Oncotarget. 2017;8(24):39592\u2013604. \n                      https:\/\/doi.org\/10.18632\/oncotarget.17165\n                      \n                    .","journal-title":"Oncotarget"},{"issue":"43","key":"724_CR110","doi-asserted-by":"publisher","first-page":"69321","DOI":"10.18632\/oncotarget.12504","volume":"7","author":"K Akamata","year":"2016","unstructured":"\u2022\u2022 Akamata K, Wei J, Bhattacharyya M, Cheresh P, Bonner MY, Arbiser JL, et al. SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis. Oncotarget. 2016;7(43):69321\u201336. \n                      https:\/\/doi.org\/10.18632\/oncotarget.12504\n                      \n                    . One of the first studies to implicate SIRT3 in regulating SSc-associated fibrosis. This study investigates the role of the new compound hexafluoro in promoting the antifibrotic effects of SIRT3 in SSc-associated skin and lung fibrosis.","journal-title":"Oncotarget"},{"issue":"5","key":"724_CR111","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/gerona\/glw151","volume":"72","author":"ML Sosulski","year":"2017","unstructured":"\u2022\u2022 Sosulski ML, Gongora R, Feghali-Bostwick C, Lasky JA, Sanchez CG. Sirtuin 3 deregulation promotes pulmonary fibrosis. J Gerontol A Biol Sci Med Sci. 2017;72(5):595\u2013602. \n                      https:\/\/doi.org\/10.1093\/gerona\/glw151\n                      \n                    . This study identifies deacetylation by SIRT3 of major oxidative stress response regulators as a mechanism for the antifibrotic effects of SIRT3 in pulmonary fibrosis.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"724_CR112","doi-asserted-by":"publisher","first-page":"L68","DOI":"10.1152\/ajplung.00188.2016","volume":"312","author":"S Bindu","year":"2017","unstructured":"\u2022\u2022 Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, et al. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017;312(1):L68\u201378. \n                      https:\/\/doi.org\/10.1152\/ajplung.00188.2016\n                      \n                    . This study identifies the role of SIRT3 in stabilizing the mitochondrial DNA repair enzyme OGG1 as a mechanism for its antifibrotic effects in pulmonary fibrosis.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"724_CR113","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1096\/fj.201601077R","volume":"31","author":"RP Jablonski","year":"2017","unstructured":"\u2022 Jablonski RP, Kim SJ, Cheresh P, Williams DB, Morales-Nebreda L, Cheng Y, et al. SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis. FASEB J. 2017;31(6):2520\u201332. \n                      https:\/\/doi.org\/10.1096\/fj.201601077R\n                      \n                    . This study identifies the loss of SIRT3 protection against oxidant-induced mitochondrial DNA damage and apoptosis in type 2 alveolar epithelial cells as a mechanism for lung fibrosis.","journal-title":"FASEB J"},{"issue":"3","key":"724_CR114","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.trsl.2014.08.008","volume":"165","author":"K Tian","year":"2015","unstructured":"Tian K, Liu Z, Wang J, Xu S, You T, Liu P. Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappaB signaling. Transl Res. 2015;165(3):374\u201386. \n                      https:\/\/doi.org\/10.1016\/j.trsl.2014.08.008\n                      \n                    .","journal-title":"Transl Res"},{"issue":"3","key":"724_CR115","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.18632\/aging.101214","volume":"9","author":"W Huang","year":"2017","unstructured":"Huang W, Liu H, Zhu S, Woodson M, Liu R, Tilton RG, et al. Sirt6 deficiency results in progression of glomerular injury in the kidney. Aging (Albany NY). 2017;9(3):1069\u201383. \n                      https:\/\/doi.org\/10.18632\/aging.101214\n                      \n                    .","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"724_CR116","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1096\/fj.201700098RR","volume":"31","author":"SO Ka","year":"2017","unstructured":"Ka SO, Bang IH, Bae EJ, Park BH. Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor. FASEB J. 2017;31(9):3999\u20134010. \n                      https:\/\/doi.org\/10.1096\/fj.201700098RR\n                      \n                    .","journal-title":"FASEB J"},{"issue":"3","key":"724_CR117","doi-asserted-by":"publisher","first-page":"L391","DOI":"10.1152\/ajplung.00097.2010","volume":"300","author":"S Minagawa","year":"2011","unstructured":"\u2022\u2022 Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300(3):L391\u2013401. \n                      https:\/\/doi.org\/10.1152\/ajplung.00097.2010\n                      \n                    . This study identifies the antifibrotic role of SIRT6 in modulating the crosstalk between senescent epithelium and fibroblasts in pulmonary fibrosis.","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"issue":"37","key":"724_CR118","doi-asserted-by":"publisher","first-page":"61011","DOI":"10.18632\/oncotarget.17723","volume":"8","author":"K Tian","year":"2017","unstructured":"\u2022 Tian K, Chen P, Liu Z, Si S, Zhang Q, Mou Y, et al. Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-beta1\/Smad3 signaling. Oncotarget. 2017;8(37):61011\u201324. \n                      https:\/\/doi.org\/10.18632\/oncotarget.17723\n                      \n                    . This report identifies the role of SIRT6 in attenuating TGF-\u03b2-induced EMT in pulmonary fibrosis.","journal-title":"Oncotarget"},{"issue":"6","key":"724_CR119","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","volume":"102","author":"O Vakhrusheva","year":"2008","unstructured":"Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, et al. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008;102(6):703\u201310. \n                      https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.164558\n                      \n                    .","journal-title":"Circ Res"},{"issue":"6","key":"724_CR120","doi-asserted-by":"publisher","first-page":"L945","DOI":"10.1152\/ajplung.00473.2016","volume":"312","author":"AE Wyman","year":"2017","unstructured":"\u2022 Wyman AE, Noor Z, Fishelevich R, Lockatell V, Shah NG, Todd NW, et al. Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2017;312(6):L945\u2013L58. \n                      https:\/\/doi.org\/10.1152\/ajplung.00473.2016\n                      \n                    . This study evaluates the expression of all seven SIRTs in lung tissues and fibroblasts from patients with SSc and IPF and identifies SIRT7 as a novel regulator of lung fibrosis.","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"724_CR121","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3389\/fphys.2017.00394","volume":"8","author":"Y Li","year":"2017","unstructured":"Li Y, Meng X, Wang W, Liu F, Hao Z, Yang Y, et al. Cardioprotective effects of SIRT6 in a mouse model of transverse aortic constriction-induced heart failure. Front Physiol. 2017;8:394. \n                      https:\/\/doi.org\/10.3389\/fphys.2017.00394\n                      \n                    .","journal-title":"Front Physiol"},{"issue":"1","key":"724_CR122","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/annrheumdis-2014-205740","volume":"75","author":"P Zerr","year":"2016","unstructured":"\u2022\u2022 Zerr P, Palumbo-Zerr K, Huang J, Tomcik M, Sumova B, Distler O, et al. Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis. Ann Rheum Dis. 2016;75(1):226\u201333. \n                      https:\/\/doi.org\/10.1136\/annrheumdis-2014-205740\n                      \n                    . This is an important early study that demonstrates reduced SIRT1 expression in skin tissues from patients with SSc.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"724_CR123","doi-asserted-by":"publisher","first-page":"e41394","DOI":"10.1371\/journal.pone.0041394","volume":"7","author":"AS Patel","year":"2012","unstructured":"Patel AS, Lin L, Geyer A, Haspel JA, An CH, Cao J, et al. Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012;7(7):e41394. \n                      https:\/\/doi.org\/10.1371\/journal.pone.0041394\n                      \n                    .","journal-title":"PLoS One"},{"key":"724_CR124","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/acel.12514","volume":"15","author":"Y Romero","year":"2016","unstructured":"Romero Y, Bueno M, Ramirez R, Alvarez D, Sembrat JC, Goncharova EA, et al. mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. Aging Cell. 2016;15:1103\u201312. \n                      https:\/\/doi.org\/10.1111\/acel.12514\n                      \n                    .","journal-title":"Aging Cell"},{"issue":"4","key":"724_CR125","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2016.10.016","volume":"167","author":"W Yang","year":"2016","unstructured":"\u2022 Yang W, Nagasawa K, Munch C, Xu Y, Satterstrom K, Jeong S, et al. Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization. Cell. 2016;167(4):985\u20131000 e21. \n                      https:\/\/doi.org\/10.1016\/j.cell.2016.10.016\n                      \n                    . This proteomic analysis, which identifies numerous mitochondrial protein targets for SIRT3, provides a basis for future studies investigating new molecular targets for the antifibrotic effects of SIRT3.","journal-title":"Cell"},{"issue":"1","key":"724_CR126","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1755-1536-5-11","volume":"5","author":"NW Todd","year":"2012","unstructured":"Todd NW, Luzina IG, Atamas SP. Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair. 2012;5(1):11. \n                      https:\/\/doi.org\/10.1186\/1755-1536-5-11\n                      \n                    .","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"9","key":"724_CR127","doi-asserted-by":"publisher","first-page":"664","DOI":"10.18632\/aging.100807","volume":"7","author":"H Yanai","year":"2015","unstructured":"Yanai H, Shteinberg A, Porat Z, Budovsky A, Braiman A, Ziesche R, et al. Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients. Aging (Albany NY). 2015;7(9):664\u201372. \n                      https:\/\/doi.org\/10.18632\/aging.100807\n                      \n                    .","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"724_CR128","doi-asserted-by":"publisher","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","volume":"313","author":"D Alvarez","year":"2017","unstructured":"Alvarez D, Cardenes N, Sellares J, Bueno M, Corey C, Hanumanthu VS, et al. IPF lung fibroblasts have a senescent phenotype. Am J Physiol Lung Cell Mol Physiol. 2017;313(6):L1164\u2013L73. \n                      https:\/\/doi.org\/10.1152\/ajplung.00220.2017\n                      \n                    .","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"724_CR129","doi-asserted-by":"publisher","first-page":"14532","DOI":"10.1038\/ncomms14532","volume":"8","author":"MJ Schafer","year":"2017","unstructured":"\u2022 Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, et al. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017;8:14532. \n                      https:\/\/doi.org\/10.1038\/ncomms14532\n                      \n                    . This study highlights the emerging view of pulmonary fibrosis as a disease resulting from the accumulation of senescent fibroblasts and role for senolytic therapies in ameliorating fibrosis.","journal-title":"Nat Commun"},{"issue":"2","key":"724_CR130","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","volume":"23","author":"CD Wiley","year":"2016","unstructured":"Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab. 2016;23(2):303\u201314. \n                      https:\/\/doi.org\/10.1016\/j.cmet.2015.11.011\n                      \n                    .","journal-title":"Cell Metab"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-018-0724-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-018-0724-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-018-0724-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T17:58:59Z","timestamp":1589738339000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-018-0724-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,17]]},"references-count":130,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["724"],"URL":"https:\/\/doi.org\/10.1007\/s11926-018-0724-6","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,17]]},"assertion":[{"value":"17 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"16"}}