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Outside the submitted work, Kadota H, Shirai Y, and Okazaki Y have nothing to disclose. Gono T, Takeno M, and Kuwana M have relevant financial activities outside the submitted work as follows: Gono T, personal fees from Astellas Pharma, personal fees from Chugai Pharmaceutical, personal fees from Daiichi sankyo, personal fees from Janssen Pharmaceutical, personal fees from Mitsubishi Tanabe Pharma, personal fees from Ono Pharmaceutical; Takeno M, personal fees from Celgene, personal fees from Tanabe-Mitsubishi, Co, personal fees from Eizai, Abbbie, grants from Novortis; Kuwana M, grants and personal fees from Chugai Pharmaceutical, grants and personal fees from Mitsubishi Tanabe Pharma, grants and personal fees from Ono Pharmaceutical, grants and personal fees from Pfizer, personal fees from Janssen Pharmaceutical, grants and personal fees from Astellas Pharma, grants and personal fees from Esai, personal fees from Boehringer Ingelheim, personal fees from Bayer, personal fees from Corbus, personal fees from Reata.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was approved by the ethics committee of Nippon Medical School Hospital (approval number 28-12-680) and was conducted in accordance with the Declaration of Helsinki. Our patient provided informed consent to participate in this study and consent for the use of the data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}],"article-number":"10"}}