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Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms. Am J Physiol Regul Integr Comp Physiol. 2011;301(4):R873\u201384. https:\/\/doi.org\/10.1152\/ajpregu.00001.2011This review how mitochondrial dysfunction can be a cause for dyspnea.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"879_CR56","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1378\/chest.107.2.317","volume":"107","author":"RG Hooper","year":"1995","unstructured":"Hooper RG, Thomas AR, Kearl RA. Mitochondrial enzyme deficiency causing exercise limitation in normal-appearing adults. 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Chest. 2017;152(3):618\u201326. https:\/\/doi.org\/10.1016\/j.chest.2017.03.020This paper discusses primary and secondary mitochondrial dysfunction in patients with airway dysfunction.","journal-title":"Chest"},{"issue":"1","key":"879_CR59","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","volume":"36","author":"GJW van der Windt","year":"2012","unstructured":"van der Windt GJW, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8(+) T cell memory development. Immunity. 2012;36(1):68\u201378. https:\/\/doi.org\/10.1016\/j.immuni.2011.12.007This paper discusses the improtance fo mitochondrial metabolism in CD8 T cell memory.","journal-title":"Immunity"},{"issue":"5","key":"879_CR60","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1042\/CS20150024","volume":"129","author":"MR Edwards","year":"2015","unstructured":"\u2022 Edwards MR, Sultan P, del Arroyo AG, Whittle J, Karmali SN, Moonesinghe SR, et al. Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Clin Sci (Lond). 2015;129(5):423\u201337. https:\/\/doi.org\/10.1042\/CS20150024This paper discusses how post-surgical mitochondrial dysfunction contributes to morbidity.","journal-title":"Clin Sci (Lond)"},{"issue":"12","key":"879_CR61","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1002\/art.40223","volume":"69","author":"A Perl","year":"2017","unstructured":"Perl A. Metabolic control of immune system activation in rheumatic diseases. Arthritis & Rheumatology. 2017;69(12):2259\u201370. https:\/\/doi.org\/10.1002\/art.40223This is an excellent review discussing how metabolic changes influence immune function.","journal-title":"Arthritis & Rheumatology"},{"issue":"1","key":"879_CR62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41556-018-0217-x","volume":"21","author":"J Jung","year":"2019","unstructured":"Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity. Nat Cell Biol. 2019;21(1):85\u201393. https:\/\/doi.org\/10.1038\/s41556-018-0217-xThis is an excellent review discussing how metabolic changes influence immune function.","journal-title":"Nat Cell Biol"},{"issue":"5","key":"879_CR63","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ni.3704","volume":"18","author":"EL Mills","year":"2017","unstructured":"\u2022 Mills EL, Kelly B, O'Neill LAJ. Mitochondria are the powerhouses of immunity. Nat Immunol. 2017;18(5):488\u201398. https:\/\/doi.org\/10.1038\/ni.3704This is an excellent review discussing how metabolic changes influence immune function.","journal-title":"Nat Immunol"},{"issue":"4","key":"879_CR64","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","volume":"38","author":"EL Pearce","year":"2013","unstructured":"\u2022 Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. 2013;38(4):633\u201343. https:\/\/doi.org\/10.1016\/j.immuni.2013.04.005This is an excellent review discussing how metabolic changes influence immune function.","journal-title":"Immunity"},{"key":"879_CR65","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mito.2017.10.006","volume":"41","author":"G Desdin-Mico","year":"2018","unstructured":"\u2022 Desdin-Mico G, Soto-Heredero G, Mittelbrunn M. Mitochondrial activity in T cells. Mitochondrion. 2018;41:51\u20137. https:\/\/doi.org\/10.1016\/j.mito.2017.10.006This review discusses various forms of mitochondrial metabolism in different subpopulations of T cells.","journal-title":"Mitochondrion"},{"issue":"9","key":"879_CR66","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41590-019-0442-x","volume":"20","author":"LM Charbonnier","year":"2019","unstructured":"Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of Foxp3. 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Novel insights into systemic autoimmune rheumatic diseases using shared molecular signatures and an integrative analysis. Epigenetics. 2017;12(6):433\u201340. https:\/\/doi.org\/10.1080\/15592294.2017.1303581This paper discusses various genetic disorders, including those affecting metabolism in autoimmune diseases.","journal-title":"Epigenetics"},{"issue":"3","key":"879_CR69","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.autrev.2008.07.041","volume":"8","author":"D Fernandez","year":"2009","unstructured":"Fernandez D, Perl A. Metabolic control of T cell activation and death in SLE. Autoimmun Rev. 2009;8(3):184\u20139. https:\/\/doi.org\/10.1016\/j.autrev.2008.07.041This is one of the first papers to look at metabolic control of T cell function in SLE.","journal-title":"Autoimmun Rev"},{"issue":"4","key":"879_CR70","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1177\/0961203308097477","volume":"18","author":"A Jonsen","year":"2009","unstructured":"Jonsen A, Yu X, Truedsson L, Nived O, Sturfelt G, Ibrahim S, et al. Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus. Lupus. 2009;18(4):309\u201312. https:\/\/doi.org\/10.1177\/0961203308097477This paper discusses how mitochondrial mutations might contribute to SLE.","journal-title":"Lupus"},{"issue":"5","key":"879_CR71","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/bor.0000000000000413","volume":"29","author":"YL Lightfoot","year":"2017","unstructured":"Lightfoot YL, Blanco LP, Kaplan MJ. Metabolic abnormalities and oxidative stress in lupus. Curr Opin Rheumatol. 2017;29(5):442\u20139. https:\/\/doi.org\/10.1097\/bor.0000000000000413This is a nice review of metabolic disorders in SLE.","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"879_CR72","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000098211","volume":"73","author":"K Ryo","year":"2006","unstructured":"\u2022 Ryo K, Yamada H, Nakagawa Y, Tai Y, Obara K, Inoue H, et al. Possible involvement of oxidative stress in salivary gland of patients with Sjogren's syndrome. Pathobiology. 2006;73(5):252\u201360 This paper reviews evidence that there is mitochondrial dysfunction in the salivary glands of pateints with Sjogren's syndrome.","journal-title":"Pathobiology"},{"issue":"4","key":"879_CR73","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/08916930410001708715","volume":"37","author":"FC Soliotis","year":"2004","unstructured":"Soliotis FC, Moutsopoulos HM. Sjogren's syndrome. Autoimmunity. 2004;37(4):305\u20137 This is a nice review of Sjogren's syndrome.","journal-title":"Autoimmunity"},{"key":"879_CR74","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clim.2019.04.009","volume":"203","author":"FB Vivino","year":"2019","unstructured":"\u2022 Vivino FB, Bunya VY, Massaro-Giordano G, Johr CR, Giattino SL, Schorpion A, et al. Sjogren's syndrome: an update on disease pathogenesis, clinical manifestations and treatment. Clin Immunol. 2019;203:81\u2013121. https:\/\/doi.org\/10.1016\/j.clim.2019.04.009This is an up to date review of clincial and basic aspects of Sjogren's syndrome.","journal-title":"Clin Immunol"},{"issue":"3","key":"879_CR75","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s12016-007-8004-7","volume":"32","author":"A Triantafyllopoulou","year":"2007","unstructured":"\u2022 Triantafyllopoulou A, Moutsopoulos H. Persistent viral infection in primary Sjogren's syndrome: review and perspectives. Clin Rev Allergy Immunol. 2007;32(3):210\u20134 This paper discusses the possible role of chronic viral infection in Sjogren's syndrome.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"879_CR76","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1365-2249.2009.03966.x","volume":"157","author":"P Szodoray","year":"2009","unstructured":"\u2022 Szodoray P, Papp G, Horvath IF, Barath S, Sipka S, Nakken B, et al. Cells with regulatory function of the innate and adaptive immune system in primary Sjogren's syndrome. 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Immunometabolism of regulatory T cells. Nat Immunol. 2016;17(6):618\u201325. https:\/\/doi.org\/10.1038\/ni.3466This paper discusses how metabolism influences regulatory T cell function.","journal-title":"Nat Immunol"},{"key":"879_CR79","doi-asserted-by":"publisher","unstructured":"\u2022 Fardoun MM, Nassif J, Issa K, Baydoun E, Eid AH. Raynaud's phenomenon: a brief review of the underlying mechanisms. Front Pharmacol. 2016;7. https:\/\/doi.org\/10.3389\/fphar.2016.00438 This is a nice review of Raynaud's syndrome.","DOI":"10.3389\/fphar.2016.00438"},{"issue":"1","key":"879_CR80","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.berh.2016.04.001","volume":"30","author":"M Hughes","year":"2016","unstructured":"\u2022 Hughes M, Herrick AL. Raynaud's phenomenon. 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Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation. J Neurol Sci. 2009;278(1\u20132):35\u201340. https:\/\/doi.org\/10.1016\/j.jns.2008.11.016This paper dscribes vascular abnormalities associated with a mitochndrial mutation.","journal-title":"J Neurol Sci"},{"issue":"18","key":"879_CR83","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/eurheartj\/ehu047","volume":"35","author":"CF Wenceslau","year":"2014","unstructured":"\u2022 Wenceslau CF, McCarthy CG, Szasz T, Spitler K, Goulopoulou S, Webb RC, et al. Mitochondrial damage-associated molecular patterns and vascular function. 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Clin Rheumatol. 2014;33(12):1829\u201333. https:\/\/doi.org\/10.1007\/s10067-013-2434-9This paper discusses the use of Nimodipne in the treatment of headache due to CNS vasospasm.","journal-title":"Clin Rheumatol"},{"issue":"1\u20132","key":"879_CR89","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12016-007-8070-x","volume":"35","author":"P Cacoub","year":"2008","unstructured":"\u2022 Cacoub P, Saadoun D. Hepatitis C virus infection induced vasculitis. Clin Rev Allergy Immunol. 2008;35(1\u20132):30\u20139. https:\/\/doi.org\/10.1007\/s12016-007-8070-xThis paper discusses vasculitis associated with hepatitis C infection.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"879_CR90","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.rdc.2009.03.006","volume":"35","author":"P Cacoub","year":"2009","unstructured":"\u2022 Cacoub P, Terrier B. Hepatitis B-related autoimmune manifestations. 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Chronic parvovirus B19 infection and systemic necrotising vasculitis: opportunistic infection or aetiological agent? Lancet. 1994;343(8908):1255\u20138 This is a report of vasculitides associated with parvovirus infection.","journal-title":"Lancet"},{"issue":"1","key":"879_CR93","first-page":"35","volume":"4","author":"R Mader","year":"1992","unstructured":"\u2022 Mader R, Keystone E. Infections that cause vasculitis. CurrOpRheumatol. 1992;4(1):35\u20138 This is a review of infections causing vasculitis.","journal-title":"CurrOpRheumatol."},{"issue":"2","key":"879_CR94","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/MPG.0b013e3182514805","volume":"55","author":"J Bhardwaj","year":"2012","unstructured":"\u2022 Bhardwaj J, Wan DQ, Koenig MK, Liu Y, Hashmi SS, Rhoads JM. Impaired gastric emptying and small bowel transit in children with mitochondrial disorders. J Pediatr Gastroenterol Nutr. 2012;55(2):194\u20139. https:\/\/doi.org\/10.1097\/MPG.0b013e3182514805This is a nice review of GI dysmotility in patients with mitochondrial disorders.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"879_CR95","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1017\/S0022215110001477","volume":"124","author":"N Hiraki","year":"2010","unstructured":"\u2022 Hiraki N, Udaka T, Yamamoto H, Kadokawa Y, Ohkubo J, Suzuki H. Mitochondrial neurogastrointestinal encephalomyopathy associated with progressive hearing loss. J Laryngol Otol. 2010;124(9):1007\u20139. https:\/\/doi.org\/10.1017\/S0022215110001477This is a case report of a patient with MINGE syndrome.","journal-title":"J Laryngol Otol"},{"issue":"588","key":"879_CR96","doi-asserted-by":"publisher","first-page":"eaaw3159","DOI":"10.1126\/scisignal.aaw3159","volume":"12","author":"Tal Yardeni","year":"2019","unstructured":"\u2022 Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, et al. Host mitochondria influence gut microbiome diversity: a role for ROS. Sci Signal. 2019;12(588). https:\/\/doi.org\/10.1126\/scisignal.aaw3159This interesting paper discusses how host mitochondrial function influences the microbiome.","journal-title":"Science Signaling"},{"issue":"9","key":"879_CR97","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1074\/jbc.RA117.000809","volume":"293","author":"F Lopes","year":"2018","unstructured":"\u2022 Lopes F, Keita AV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, et al. ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction. J Biol Chem. 2018;293(9):3073\u201387. https:\/\/doi.org\/10.1074\/jbc.RA117.000809 This paper discusses how mitochondrial dysfunction can cause epithelial barrier dysfunction.","journal-title":"J Biol Chem"},{"key":"879_CR98","doi-asserted-by":"publisher","first-page":"619","DOI":"10.2741\/4231","volume":"19","author":"J Garrido-Maraver","year":"2014","unstructured":"\u2022 Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, et al. Clinical applications of coenzyme Q10. Frontiers in Bioscience-Landmark. 2014;19:619\u201333. https:\/\/doi.org\/10.2741\/4231This is a nice review of current uses of CoQ10.","journal-title":"Frontiers in Bioscience-Landmark"},{"issue":"3","key":"879_CR99","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1530\/joe-18-0578","volume":"240","author":"J Sun","year":"2019","unstructured":"\u2022 Sun J, Zhu HP, Wang XR, Gao QQ, Li ZY, Huang HY. CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy. J Endocrinol. 2019;240(3):445\u201365. https:\/\/doi.org\/10.1530\/joe-18-0578This paper discusses use of CoQ10 in diabetic nephropathy.","journal-title":"J Endocrinol"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-020-0879-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-020-0879-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-020-0879-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:42:00Z","timestamp":1613263320000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-020-0879-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,14]]},"references-count":99,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["879"],"URL":"https:\/\/doi.org\/10.1007\/s11926-020-0879-9","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,14]]},"assertion":[{"value":"14 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"8"}}