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There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11926-021-01042-6","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:30:44Z","timestamp":1635550244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-1286","authenticated-orcid":false,"given":"Ali","family":"Mobasheri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-6375","authenticated-orcid":false,"given":"Armaghan","family":"Mahmoudian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-9382","authenticated-orcid":false,"given":"Ursule","family":"Kalvaityte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-9163","authenticated-orcid":false,"given":"Ilona","family":"Uzieliene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-4462","authenticated-orcid":false,"given":"Christina E.","family":"Larder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-8148","authenticated-orcid":false,"given":"Mich\u00e8le M.","family":"Iskandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-9880","authenticated-orcid":false,"given":"Stan","family":"Kubow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-9321","authenticated-orcid":false,"given":"Paulo Cesar","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-9632","authenticated-orcid":false,"suffix":"Jr","given":"Cyro Scala","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-0496","authenticated-orcid":false,"given":"Lacey J.","family":"Favazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6768-9231","authenticated-orcid":false,"given":"Luc J.C.","family":"van Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-5525","authenticated-orcid":false,"given":"Pieter J.","family":"Emans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-7545","authenticated-orcid":false,"given":"P\u00e9rola G.","family":"Plapler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-8708","authenticated-orcid":false,"given":"Michael J.","family":"Zuscik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"1042_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.joca.2020.01.002","volume":"28","author":"M Kloppenburg","year":"2020","unstructured":"Kloppenburg M, Berenbaum F. 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He has consulted for Genacol and Sterifarma, companies that produce and market collagen supplements. Ali Mobasheri has also consulted for Sanofi (Brazil), Pfizer Consumer Health, GSK Consumer Health, and Ach\u00e9 (Ach\u00e9 Laborat\u00f3rios Farmac\u00eauticos), companies that have ongoing R&D activities in joint health supplements. Stan Kubow has received funding from Genacol for research in his laboratory at McGill University. Luc J.C. van Loon has received research grants, consulting fees, speaking honoraria, or a combination of these for research on the impact of exercise and nutrition on muscle metabolism, which include funding from companies that produce collagen such as Gelita and PB Leiner. A full overview on research funding is provided at:\n                      \n                      Michael J. Zuscik has received support from Rousselot Nutrition and Health, a company that has developed collagen peptide-based supplements and DOD Grant # W81XWH1910808.The other authors declare that they have no competing interests. This paper was written by the authors within the scope of their academic and research positions. None of the other authors have any relationships that could be construed as biased or inappropriate. The public funding bodies that support our work were not involved in the data collection, analysis, and interpretation. The decision to submit the paper for publication was not influenced by any of the public funding bodies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"78"}}