{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T14:30:35Z","timestamp":1747751435685,"version":"3.33.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Treat Options Gastro"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1007\/s11938-000-0038-3","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T17:44:12Z","timestamp":1180892652000},"page":"487-499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The porphyrias"],"prefix":"10.1007","volume":"3","author":[{"given":"Herbert L.","family":"Bonkovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham F.","family":"Barnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"38_CR1","first-page":"1050","volume":"86","author":"HL Bonkovsky","year":"1991","unstructured":"Bonkovsky HL, Healey JF, Lourie AN, Gerron GG: Intravenous heme-albumin in acute intermittent porphyria. Evidence for repletion of hepatic hemoproteins and regulatory heme pools. Am J Gastroenterol 1991, 86:1050\u20131056. A paper with details of how to prepare heme-albumin solutions, showing effectiveness of IV heme-albumin in acute porphyrias and effects in normal subjects.","journal-title":"Am J Gastroenterol"},{"key":"38_CR2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0016-5085(93)90739-Y","volume":"105","author":"HL Bonkovsky","year":"1993","unstructured":"Bonkovsky HL: Advances in understanding and treating \u201cthe little imitator\u201d, acute porphyria. Gastroenterology 1993, 105:590\u2013594.","journal-title":"Gastroenterology"},{"key":"38_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1055\/s-2007-1007141","volume":"18","author":"HL Bonkovsky","year":"1998","unstructured":"Bonkovsky HL, Barnard GF: Diagnosis of porphyric syndromes: a practical approach in the era of molecular biology. Semin Liver Dis 1998, 18:57\u201365. Provides a cost-effective approach to diagnosis and differential diagnosis of the porphyrias, including charts of algorithms to follow.","journal-title":"Semin Liver Dis"},{"key":"38_CR4","first-page":"75","volume":"4","author":"HL Bonkovsky","year":"1998","unstructured":"Bonkovsky HL: Porphyria cutanea tarda and hepatitis C. Viral Hepatitis Review 4 1998:75\u201395. A recent, comprehensive review.","journal-title":"Viral Hepatitis Review"},{"key":"38_CR5","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1002\/hep.510270627","volume":"27","author":"HL Bonkovsky","year":"1998","unstructured":"Bonkovsky HL, Poh-Fitzpatrick M, Pimstone N, et al.: Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. Hepatology 1998, 27:1661\u20131669. Paper stressing the importance of risk factors (HCV infection, HFE mutations, alcohol, estrogens) in pathogenesis of clinically manifest PCT.","journal-title":"Hepatology"},{"key":"38_CR6","first-page":"447","volume-title":"Conn\u2019s Current Therapy","author":"HL Bonkovsky","year":"2000","unstructured":"Bonkovsky HL, Barnard GF: The porphyrias. In Conn\u2019s Current Therapy, edn 52. Edited by Rakel RE. Philadelphia: WB Saunders; 2000:447\u2013453. An up-to-date review of pathogenesis and management.","edition":"edn 52"},{"key":"38_CR7","doi-asserted-by":"crossref","unstructured":"Cable EE, Pepe JA, Karamitsios NC, et al.: Differential effects of metalloporphyrins on mRNA levels of delta-aminolevulinate synthase and heme oxygenase: studies in cultured chick embryo liver cells. J Clin Invest 1994, 649\u2013654. Paper establishing the principle of synergism of metalloporphyrins to down regulate ALA synthase.","DOI":"10.1172\/JCI117381"},{"key":"38_CR8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0016-5085(93)90726-S","volume":"105","author":"SB Dover","year":"1993","unstructured":"Dover SB, Moore MB, Fitzsimmons EJ, et al.: Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria. Gastroenterology 1993, 105:500\u2013506. First application in humans to the combination of heme plus an inhibitor of HO to prolong the therapeutic efficacy of heme in acute porphyria.","journal-title":"Gastroenterology"},{"key":"38_CR9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1056\/NEJM199404143301519","volume":"330","author":"L Guarini","year":"1994","unstructured":"Guarini L, Piomelli S, Poh-Fitzpatrick MB, et al.: Hydroxyurea in congenital erythropoietic porphyria. N Engl J Med 1994, 330:1092\u20131093.","journal-title":"N Engl J Med"},{"key":"38_CR10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1212\/WNL.49.1.97","volume":"49","author":"M Hahn","year":"1997","unstructured":"Hahn M, Gildemeister OS, Krauss GL, et al.: Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells\u2014potential implications for patients with acute porphyria. Neurology 1997, 49:97\u2013106. Demonstration of safety of gabapentin and vigabatrin, but not felbamate, lamotrigine, or tiagabine, among newer anticonvulsants.","journal-title":"Neurology"},{"key":"38_CR11","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0022-3565(24)35221-8","volume":"29","author":"RW Lambrecht","year":"1999","unstructured":"Lambrecht RW, Gildemeister OS, Pepe JA, et al.: Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells. J Pharmacol Exp Ther 1999a, 29:1150\u20131155. Paper that defines which of the newer antidepressants and anxiolytic agents are safer for use in acute porphyria.","journal-title":"J Pharmacol Exp Ther"},{"key":"38_CR12","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0006-2952(99)00154-9","volume":"58","author":"RW Lambrecht","year":"1999","unstructured":"Lambrecht RW, Gildemeister OS, Williams A, et al.: Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation. Biochem Pharmacol 1999b, 58:887\u2013896. Paper that defines which of the newer antihypertensive and analgesics are safer for use in acute porphyria.","journal-title":"Biochem Pharmacol"},{"key":"38_CR13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1159\/000029891","volume":"12","author":"A Monastrili","year":"1999","unstructured":"Monastrili A, Georgiou S, Bolsen K, et al.: Treatment of porphyria cutanea tarda with oral thalidomide. Skin Pharmacol 1999, 12:305\u2013311. Recent interesting report; needs confirmation.","journal-title":"Skin Pharmacol"},{"key":"38_CR14","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/00007890-199903270-00023","volume":"67","author":"JH Reichheld","year":"1999","unstructured":"Reichheld JH, Katz E, Banner BF, et al.: The value of intravenous heme-albumin and plasmapheresis in reducing post-operative complications of orthotopic liver transplantation for erythropoietic protoporphyria. Transplantation 1999, 67:922\u2013928. Paper describing the usefulness of IV heme-albumin and plasmapheresis in managing EPP patients around the time of liver transplantation.","journal-title":"Transplantation"}],"container-title":["Current Treatment Options in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-000-0038-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11938-000-0038-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-000-0038-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-000-0038-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T22:01:37Z","timestamp":1737064897000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11938-000-0038-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["38"],"URL":"https:\/\/doi.org\/10.1007\/s11938-000-0038-3","relation":{},"ISSN":["1092-8472","1534-309X"],"issn-type":[{"type":"print","value":"1092-8472"},{"type":"electronic","value":"1534-309X"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}