{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:32:43Z","timestamp":1761561163507},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Treat Options Gastro"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1007\/s11938-002-0047-5","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T06:35:25Z","timestamp":1181198125000},"page":"251-258","source":"Crossref","is-referenced-by-count":9,"title":["Functional heartburn"],"prefix":"10.1007","volume":"5","author":[{"given":"Jan","family":"Tack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"47_CR1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.44.2008.S1","volume":"44","author":"J Dent","year":"1999","unstructured":"Dent J, Brun J, Fendrick AM, et al.: An evidence-based appraisal of reflux disease management\u2014the Genval workshop report. Gut 1999, 44:S1\u201316.","journal-title":"Gut"},{"issue":"Suppl 2","key":"47_CR2","first-page":"II","volume":"45","author":"RE Clouse","year":"1999","unstructured":"Clouse RE, Richter JE, Heading RC, et al.: Functional esophageal disorders. Gut 1999, 45(Suppl 2):II 31\u201336.","journal-title":"Gut"},{"key":"47_CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1572-0241.2001.03511.x","volume":"96","author":"R Fass","year":"2001","unstructured":"Fass R, Fennerty MB, Vakil N: Nonerosive reflux disease\u2014current concepts and dilemmas. Am J Gastroenterol 2001, 96:303\u2013314. Good, up-to-date overview of problems in the treatment of reflux disease.","journal-title":"Am J Gastroenterol"},{"key":"47_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0002-9343(92)80051-Z","volume":"92","author":"RB Lynn","year":"1992","unstructured":"Lynn RB: Mechanisms of esophageal pain. Am J Med 1992, 92:11\u201319.","journal-title":"Am J Med"},{"key":"47_CR5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/BF02233842","volume":"11","author":"P Hookman","year":"1966","unstructured":"Hookman P, Siegel CI, Hendrix TR: Failure of oxethazine to alter acid induced esophageal pain. Am J Dig Dis 1966, 11:811.","journal-title":"Am J Dig Dis"},{"key":"47_CR6","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1053\/gast.1996.v111.pm8898633","volume":"111","author":"NA Tobey","year":"1996","unstructured":"Tobey NA, Carson JL, Alkiek RA, et al.: Dilated intercelluar spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996, 111:1200\u20131205.","journal-title":"Gastroenterology"},{"key":"47_CR7","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1053\/gast.1996.1101982","volume":"110","author":"PJ Kahrilas","year":"1996","unstructured":"Kahrilas PJ, Quigley EMM: Clinical esophageal pH recording: a technical review for practice guideline development. Gastroenterology 1996, 110:1982\u20131996.","journal-title":"Gastroenterology"},{"key":"47_CR8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/07853899509031939","volume":"27","author":"J Isolauri","year":"1995","unstructured":"Isolauri J, Laippala P: Prevalence of symptoms suggestive of gastroesophageal reflux disease in an adult population. Ann Med 1995, 27:67\u201370.","journal-title":"Ann Med"},{"issue":"Suppl 1","key":"47_CR9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000200911","volume":"51","author":"SJ Spechler","year":"1992","unstructured":"Spechler SJ: Epidemiology and natural history of gastroesophageal reflux disease. Digestion 1992, 51(Suppl 1):24\u201329.","journal-title":"Digestion"},{"key":"47_CR10","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1046\/j.1365-2036.1997.00185.x","volume":"11","author":"JP Galmiche","year":"1997","unstructured":"Galmiche JP, Barthelemy P, Hamelin B: Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride. Aliment Pharmacol Ther 1997, 11:765\u2013773.","journal-title":"Aliment Pharmacol Ther"},{"key":"47_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/00042737-199802000-00004","volume":"10","author":"R Carlsson","year":"1998","unstructured":"Carlsson R, Dent J, Watts R, et al.: Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol 1998, 10:119\u2013124.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"47_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3109\/00365529709011211","volume":"32","author":"TL Venables","year":"1997","unstructured":"Venables TL, Newland RD, Pate AC, et al.: Omeprazole 10 mg once daily, omeprazole 20 mg once daily or ranitidine 150 mg twice daily evaluated as initial therapy for the relief of symptoms of gastroesophageal reflux in general practice. Scand J Gastroenterol 1997, 32:965\u2013973.","journal-title":"Scand J Gastroenterol"},{"key":"47_CR13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/gut.37.4.457","volume":"37","author":"G Shi","year":"1995","unstructured":"Shi G, Bruley des Varannes S, Scarpignato C, et al.: Reflux-related symptoms in patients with normal oesophageal exposure to acid. The acid hypersensitive oesophagus. Gut 1995, 37:457\u2013464.","journal-title":"Gut"},{"key":"47_CR14","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.29.7.886","volume":"29","author":"F Johnsson","year":"1988","unstructured":"Johnsson F, Joelsson B: Reproducibility of ambulatory esophageal pH monitoring. Gut 1988, 29:886\u2013889.","journal-title":"Gut"},{"key":"47_CR15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0016-5085(58)80023-2","volume":"34","author":"LM Bernstein","year":"1958","unstructured":"Bernstein LM, Baker LA: A clinical test for esophagitis. Gastroenterology 1958, 34:760\u2013781.","journal-title":"Gastroenterology"},{"key":"47_CR16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0016-5085(89)90890-1","volume":"96","author":"JL Smith","year":"1989","unstructured":"Smith JL, Opekum AR, Larakai R, Graham DY: Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease. Gastroenterology 1989, 96:683\u2013689.","journal-title":"Gastroenterology"},{"key":"47_CR17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1172\/JCI104760","volume":"42","author":"CI Siegel","year":"1963","unstructured":"Siegel CI, Hendrix TR: Esophageal motor abnormalities induced by acid perfusion in patients with heartburn. J Clin Invest 1963, 42:686\u2013695.","journal-title":"J Clin Invest"},{"key":"47_CR18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1445-2197.1978.tb07294.x","volume":"49","author":"KJ Breen","year":"1978","unstructured":"Breen KJ, Whelan G: The diagnosis of reflux esophagitis: an evaluation of five investigative procedures. Aust N Z J Surg 1978, 49:156\u2013161.","journal-title":"Aust N Z J Surg"},{"key":"47_CR19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/00000658-197305000-00008","volume":"177","author":"WS Battle","year":"1973","unstructured":"Battle WS, Nyhus LM, Bombeck GT: Gastro-esophageal reflux. Diagnosis and treatment. Ann Surg 1973, 177:560\u2013565.","journal-title":"Ann Surg"},{"key":"47_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0016-5085(76)80088-1","volume":"71","author":"J Behar","year":"1976","unstructured":"Behar J, Biancani P, Sheahan DG: Evaluation of esophageal tests in the diagnosis of reflux esophagitis. Gastroenterology 1976, 71:9\u201315.","journal-title":"Gastroenterology"},{"key":"47_CR21","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/S0140-6736(66)90472-7","volume":"ii","author":"JR Bennett","year":"1966","unstructured":"Bennett JR, Atkinson M: Oesophageal acid perfusion in the diagnosis of precordial pain. Lancet 1966, ii:1150\u20131152.","journal-title":"Lancet"},{"key":"47_CR22","first-page":"1","volume":"61","author":"LJ Bentz","year":"1972","unstructured":"Bentz LJ, Hootkin LA, Marguiles S, et al.: A comparison of clinical measurements of gastroesophageal reflux. Gastroenterology 1972, 61:1\u20135.","journal-title":"Gastroenterology"},{"key":"47_CR23","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/BF01535789","volume":"33","author":"GJ Wiener","year":"1988","unstructured":"Wiener GJ, Richter JE, Copper JB, et al.: Ambulatory 24-hour esophageal pH monitoring: reproducibility and variability of the pH parameters. Dig Dis Sci 1988, 33:1127\u20131133.","journal-title":"Dig Dis Sci"},{"key":"47_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1046\/j.1365-2362.1996.104249.x","volume":"26","author":"BLAM Weusten","year":"1996","unstructured":"Weusten BLAM, Roelofs JMM, Akkermans LMA, et al.: Objective determination of pH thresholds in the analysis of 24 hour ambulatory esophageal pH monitoring. Eur J Clin Invest 1996, 26:151\u2013158.","journal-title":"Eur J Clin Invest"},{"key":"47_CR25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/BF02090215","volume":"39","author":"HGT Lam","year":"1994","unstructured":"Lam HGT, Breumelhof R, Roelofs JMM, et al.: What is the optimal time window in symptom analysis of 24-hour esophageal pressure and pH data?\n                           Dig Dis Sci 1994, 39:402\u2013409.","journal-title":"Dig Dis Sci"},{"key":"47_CR26","first-page":"358","volume":"83","author":"GJ Wiener","year":"1988","unstructured":"Wiener GJ, Richter JE, Cooper JB, et al.: The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 1988, 83:358\u2013361.","journal-title":"Am J Gastroenterol"},{"key":"47_CR27","first-page":"1664","volume":"86","author":"R Breumelhof","year":"1991","unstructured":"Breumelhof R, Smout AJPM: The symptom sensitivity index: a valuable additional parameter in 24 hour esophageal pH recording. Am J Gastroenterol 1991, 86:1664.","journal-title":"Am J Gastroenterol"},{"key":"47_CR28","first-page":"140","volume":"2","author":"C Emde","year":"1990","unstructured":"Emde C, Armstrong D, Blum AL: Chest pain due to gastroesophageal reflux: presentation of a mathematical procedure to assess its significance. J Gastrointest Motil 1990, 2:140.","journal-title":"J Gastrointest Motil"},{"key":"47_CR29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/gut.31.7.738","volume":"31","author":"G Ghillebert","year":"1990","unstructured":"Ghillebert G, Janssens J, Vantrappen G, et al.: Ambulatory 24 hour intraoesophageal pH and pressure recordings vs provocation tests in the diagnosis of chest pain of oesophageal origin. Gut 1990, 31:738\u2013744.","journal-title":"Gut"},{"key":"47_CR30","first-page":"A90","volume":"103","author":"J Janssens","year":"1992","unstructured":"Janssens J, Vantrappen G, Vos R, Ghillebert G: The acid burden over an extended period preceding a reflux episode is a major determinant in the development of heartburn [Abstract]. Gastroenterology 1992, 103:A90.","journal-title":"Gastroenterology"},{"key":"47_CR31","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/0016-5085(94)90815-X","volume":"107","author":"BLAM Weusten","year":"1994","unstructured":"Weusten BLAM, Roelofs JMM, Akkermans LMA, et al.: The symptom association probability: an improved method for symptom analysis of 24 h esophageal pH data. Gastroenterology 1994, 107:1741\u20131745.","journal-title":"Gastroenterology"},{"key":"47_CR32","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1007\/BF01536707","volume":"34","author":"F Baldi","year":"1989","unstructured":"Baldi F, Ferrarini F, Longanes A, et al.: Acid gastroesophageal reflux and symptom occurrence: analysis of some factors influencing their association. Dig Dis Sci 1989, 34:1890\u20131893.","journal-title":"Dig Dis Sci"},{"key":"47_CR33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/gut.32.2.128","volume":"32","author":"PJ Howard","year":"1991","unstructured":"Howard PJ, Maher L, Pryde A, Heading RC: Symptomatic gastro-esophageal reflux, abnormal oesophageal acid exposure, and mucosal acid sensitivity are three separate, though related, aspects of gastro-esophageal reflux disease. Gut 1991, 32:128\u2013132.","journal-title":"Gut"},{"key":"47_CR34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1136\/gut.40.6.775","volume":"40","author":"RE Marshall","year":"1997","unstructured":"Marshall RE, Anggiansah A, Owen WA, Owe WJ: The relationship between acid and bile reflux and symptoms in gastro-esophageal reflux disease. Gut 1997, 40:182\u2013187.","journal-title":"Gut"},{"key":"47_CR35","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1111\/j.1572-0241.2001.03863.x","volume":"96","author":"G Koek","year":"2001","unstructured":"Koek G, Tack J, Sifrim D, Lerut T, Janssens J: The role of acid- and duodeno-gastro-esophageal reflux in symptomatic gastro-esophageal reflux disease. Am J Gastroenterol, 2001, 96:2033\u20132040.","journal-title":"Am J Gastroenterol"},{"key":"47_CR36","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1053\/gast.2001.24840","volume":"120","author":"MF Vela","year":"2001","unstructured":"Vela MF, Camacho-Lobato L, Srinivasan R, et al.: Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology 2001, 120:1599\u20131606. A good article focusing on 2-hour drug studies of 12 patients taking omeprazole to relieve gastrointestinal reflux.","journal-title":"Gastroenterology"},{"key":"47_CR37","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/0016-5085(88)90542-2","volume":"94","author":"L Peters","year":"1988","unstructured":"Peters L, Maas L, Petty D, et al.: Spontaneous noncardiac chest pain. Evaluation by 24-hour ambulatory esophageal motility and pH monitoring. Gastroenterology 1988, 94:878\u2013886.","journal-title":"Gastroenterology"},{"key":"47_CR38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/BF01300762","volume":"36","author":"F Nevens","year":"1991","unstructured":"Nevens F, Janssens J, Piessens J, et al.: Prospective study on the prevalence of esophageal chest pain in patients referred on an elective basis to a cardiac unit for suspected myocardial ischemia. Dig Dis Sci 1991, 36:228\u2013235.","journal-title":"Dig Dis Sci"},{"key":"47_CR39","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1001\/jama.253.13.1914","volume":"253","author":"JE Richter","year":"1985","unstructured":"Richter JE, Johns DN, Wu WC, Castell DO: Are esophageal motility abnormalities produced during the intra-esophageal acid perfusion test?\n                           JAMA 1985, 253:1914.","journal-title":"JAMA"},{"key":"47_CR40","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/BF01540039","volume":"24","author":"EE Soffer","year":"1989","unstructured":"Soffer EE, Scalabrini P, Wingate D: Spontaneous noncardiac chest pain: value of ambulatory esophageal pH and motility monitoring. Dig Dis Sci 1989, 24:1651\u20131655.","journal-title":"Dig Dis Sci"},{"key":"47_CR41","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/0016-5085(86)90270-2","volume":"90","author":"J Janssens","year":"1986","unstructured":"Janssens J, Vantrappen G, Ghillebert G: 24-hour recording of esophageal pressure and pH in patients with non-cardiac chest pain. Gastroenterology 1986, 90:1978\u20131984.","journal-title":"Gastroenterology"},{"key":"47_CR42","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/BF01537406","volume":"35","author":"EG Hewson","year":"1990","unstructured":"Hewson EG, Dalton CB, Richter JE: Comparison of esophageal manometry, provocative testing and ambulatory monitoring in patients with unexplained chest pain. Dig Dis Sci 1990, 35:302\u2013309.","journal-title":"Dig Dis Sci"},{"key":"47_CR43","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0016-5085(90)91147-X","volume":"99","author":"R Breumelhof","year":"1990","unstructured":"Breumelhof R, Nadorp JHSM, Akkermans LMA, Smout AJPM: Analysis of 24-hour esophageal pH and pressure data in unselected patients with non-cardiac chest pain. Gastroenterology 1990, 99:1257\u20131264.","journal-title":"Gastroenterology"},{"key":"47_CR44","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0016-5085(98)70014-9","volume":"115","author":"R Fass","year":"1998","unstructured":"Fass R, Naliboff B, Higa L, et al.: Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998, 115:1363\u20131373.","journal-title":"Gastroenterology"},{"key":"47_CR45","first-page":"G743","volume":"281","author":"N Pehlivanov","year":"2001","unstructured":"Pehlivanov N, Liu J, Mittal RK: Sustained esophageal contraction: a motor correlate of heartburn symptom. Am J Physiol 2001, 281:G743\u2013751.","journal-title":"Am J Physiol"},{"key":"47_CR46","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0016-5085(99)70225-8","volume":"116","author":"D Balaban","year":"1999","unstructured":"Balaban D, Yamamoto Y, Liu J, et al.: Sustained esophaegal contraction: a marker of esophaeal chest pain identified by intraluminal ultrasonography. Gastroetnerology 1999, 116:29\u201337.","journal-title":"Gastroetnerology"},{"key":"47_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365529509093228","volume":"30","author":"BT Johnston","year":"1995","unstructured":"Johnston BT, Lewis SA, Collins JSA, et al.: Acid perception in gastro-oesopahgeal reflux disease is dependent on psychological factors. Scand J Gastroenterol 1995, 30:1\u20135.","journal-title":"Scand J Gastroenterol"},{"key":"47_CR48","first-page":"11","volume":"88","author":"LA Bradley","year":"1993","unstructured":"Bradley LA, Richter JE, Pulliam TJ: The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 1993, 88:11\u201319.","journal-title":"Am J Gastroenterol"},{"key":"47_CR49","first-page":"1797","volume":"90","author":"LH Baker","year":"1995","unstructured":"Baker LH, Lieberman D, Oehlke M: Psychological distress in patients with gastroesophageal reflux disease. Am J Gastroetnerol 1995, 90:1797\u20131803.","journal-title":"Am J Gastroetnerol"},{"key":"47_CR50","first-page":"1997","volume":"92","author":"BE Schenk","year":"1997","unstructured":"Schenk BE, Kuipers EJ, Klinkenberg-Knol EC, et al.: Omeprazole as a diagnostic toool in gstroesophageal reflux disease. Am J Gastroenterol 1997, 92:1997\u20132000.","journal-title":"Am J Gastroenterol"},{"key":"47_CR51","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0016-5085(98)70363-4","volume":"115","author":"R Fass","year":"1998","unstructured":"Fass R, Fennerty MB, Ofman JJ, et al.: The clinical and economic value of a short course of omeprazole in patients with non-cardiac chest pain. Gastroenterology 1998, 115:42\u201349.","journal-title":"Gastroenterology"},{"key":"47_CR52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0016-5085(79)80210-3","volume":"76","author":"G Vantrappen","year":"1979","unstructured":"Vantrappen G, Janssens J, Hellemans J, Coremans G: Achalasia, diffuse esophageal spasm, and related motility disorders. Gastroenterology 1979, 76:450.","journal-title":"Gastroenterology"},{"key":"47_CR53","unstructured":"Tack J, Koek G, Demedts I, et al.: Gastro-esophageal reflux disease poorly responsive to proton pump inhibitors: acid reflux, bile reflux, or both? 2002, In Press."},{"key":"47_CR54","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/BF02064206","volume":"40","author":"KC Trimble","year":"1995","unstructured":"Trimble KC, Douglas S, Pryde A, Heading RC: Clinical characteristics and natural history of symptomatic but not excess gastroesophageal reflux. Dig Dis Sci 1995, 40:1098\u20131104.","journal-title":"Dig Dis Sci"},{"key":"47_CR55","first-page":"911","volume":"24","author":"S Sacher-Huvelin","year":"2000","unstructured":"Sacher-Huvelin S, Gournay J, Amouretti M, et al.: Natural histroy and quality of life of patients with acid hypersensitivie esophagus syndrome. Comparison with classical gastro-esohageal reflux disease. Gastroenterol Clin Biol 2000, 24:911\u2013916.","journal-title":"Gastroenterol Clin Biol"},{"key":"47_CR56","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1001\/archinte.160.12.1803","volume":"160","author":"JE Richter","year":"2000","unstructured":"Richter JE, Campbel DR, Kahrilas PJ, et al.: Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch Intern Med 2000, 160:1803\u20131809.","journal-title":"Arch Intern Med"},{"key":"47_CR57","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1001\/archinte.160.12.1810","volume":"160","author":"J Richter","year":"2000","unstructured":"Richter J, Peura D, Benjamin SB, et al.: Efficacy of omeprazole for the treatment of symptomatic acid reflux disease without esophagitis. Arch Intern Med 2000, 160:1810\u20131816.","journal-title":"Arch Intern Med"},{"key":"47_CR58","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1097\/00004836-199409000-00003","volume":"19","author":"R Fass","year":"1994","unstructured":"Fass R, Macke C, Sampliner RE: 24-hour pH monitoring in symptomatic patients without erosive esophagitis who did not respond to antireflux treatment. J Clin Gastroenterol 1994, 19:970\u2013999.","journal-title":"J Clin Gastroenterol"},{"key":"47_CR59","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/gut.40.5.587","volume":"40","author":"RGP Watson","year":"1997","unstructured":"Watson RGP, Tham TCK, Johnston BT, et al.: Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux, the \u201csensitive esophagus.\u201d\n                           Gut 1997, 40:587\u2013590.","journal-title":"Gut"},{"key":"47_CR60","first-page":"581","volume-title":"The Esophagus","author":"J Tack","year":"1998","unstructured":"Tack J, Janssens J: The esophagus and noncardiac chest pain. In The Esophagus. Edited by Castell DO, Richter JM. Philadelphia: Lippincott-Raven; 1998:581\u2013594."},{"key":"47_CR61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0016-5085(94)90061-2","volume":"107","author":"J McDonald-Haile","year":"1994","unstructured":"McDonald-Haile J, Bradley LA, Bailey MA, et al.: Relaxation training reduces symptom reports and acid exposure in patients with gastro-esophageal reflux disease. Gastroenterology 1994, 107:61\u201369.","journal-title":"Gastroenterology"},{"key":"47_CR62","unstructured":"Broekaert D, Fischle B, Sifrim D, et al.: Influence of citalopram, a selective serotonin reuptake inhibitor on oesophageal sensitivity in healthy volunteers: a double blind, placebo-controlled study. 2002, In Press."}],"container-title":["Current Treatment Options in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-002-0047-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11938-002-0047-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-002-0047-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-002-0047-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T11:16:19Z","timestamp":1652613379000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11938-002-0047-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["47"],"URL":"https:\/\/doi.org\/10.1007\/s11938-002-0047-5","relation":{},"ISSN":["1092-8472","1534-309X"],"issn-type":[{"value":"1092-8472","type":"print"},{"value":"1534-309X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}