{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T22:23:39Z","timestamp":1697322219644},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Treat Options Gastro"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1007\/s11938-005-0021-0","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T17:48:40Z","timestamp":1180892920000},"page":"285-291","source":"Crossref","is-referenced-by-count":12,"title":["Functional heartburn"],"prefix":"10.1007","volume":"8","author":[{"given":"Ram","family":"Dickman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Fass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"21_CR1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/gut.51.6.885","volume":"51","author":"R Fass","year":"2002","unstructured":"Fass R, Tougas G: Functional heartburn: the stimulus, the pain, and the brain. Gut 2002, 51: 885\u2013892. A very important paper that summarizes in detail the pathophysiology, clinical presentation and treatment of functional heartburn.","journal-title":"Gut"},{"key":"21_CR2","first-page":"75","volume-title":"The Esophagus","author":"EC Klinkenberg-Knol","year":"1999","unstructured":"Klinkenberg-Knol EC, Castell DO: Clinical spectrum and diagnosis of gastroesophageal reflux disease. In The Esophagus. 3rd ed. Castell DO, Richter JE, editors. Philadelphia: Lippincott Williams and Wilkins 1999, 75\u2013380."},{"key":"21_CR3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3109\/00365529709011212","volume":"32","author":"T Lind","year":"1997","unstructured":"Lind T, Havelund T, Carlsson R: Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997, 32: 974\u2013979. An important paper that describes the symptom response rate of functional heartburn patients to PPI therapy as compared to NERD patients with abnormal pH values.","journal-title":"Scand J Gastroenterol"},{"key":"21_CR4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/13814789509161628","volume":"1","author":"RH Jones","year":"1995","unstructured":"Jones RH, Hungin ADS, Phillips J: Gastroesophageal reflux disease in primary care in Europe: clinical presentation and endoscopic findings. Eur J Gen Pract 1995, 1: 14\u2013154.","journal-title":"Eur J Gen Pract"},{"key":"21_CR5","first-page":"1997","volume":"92","author":"BE Schenk","year":"1997","unstructured":"Schenk BE, Kuipers EJ, Klinkenberg-Knol EC: Omeprazole as a diagnostic tool in gastroesophageal reflux disease. Am J Gastroenterol 1997, 92: 1997\u20132000.","journal-title":"Am J Gastroenterol"},{"key":"21_CR6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/00365529850166149","volume":"33","author":"F Johnsson","year":"1998","unstructured":"Johnsson F, Weywadt L, Solhaug JH, et al.: One-week omeprazole treatment in the diagnosis of gastro-oesophageal reflux disease. Scand J Gastroenterol 1998, 33: 15\u201320.","journal-title":"Scand J Gastroenterol"},{"key":"21_CR7","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/archinte.159.18.2161","volume":"159","author":"R Fass","year":"1999","unstructured":"Fass R, Ofman JJ, Gralnek IM, Johnson C, et al.: Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease. Arch Intern Med 1999, 159: 2161\u20132168.","journal-title":"Arch Intern Med"},{"key":"21_CR8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2036.1999.00008.x","volume":"13","author":"E Mayer","year":"1999","unstructured":"Mayer E, Naliboff B, Lee O, Munakata J, Chang L: Review article: gender-related differences in functional gastrointestinal disorders. Aliment Pharmacol Ther 1999, 13: 65\u201369.","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1365-2036.2003.01423.x","volume":"17","author":"SD Martinez","year":"2003","unstructured":"Martinez SD, Malagon IB, Garewal HS, et al.: Non-erosive reflux disease (NERD) - acid reflux and symptom patterns. Aliment Pharmacol Ther 2003, 17: 537\u2013545. A paper that describes the acid reflux characteristics of the different sub-groups of NERD.","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR10","first-page":"358","volume":"83","author":"GJ Weiner","year":"1988","unstructured":"Weiner GJ, Morgan TM, Copper JB, et al.: The symptom index: A clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 1988, 83: 358\u2013361.","journal-title":"Am J Gastroenterol"},{"key":"21_CR11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/gut.49.5.624","volume":"49","author":"JH Meyer","year":"2001","unstructured":"Meyer JH, Lembo A, Elashoff JD, et al.: Duodenal fat intensifies the perception of heartburn. Gut 2001, 49: 624\u2013628.","journal-title":"Gut"},{"key":"21_CR12","first-page":"33","volume":"12","author":"JP Waring","year":"2001","unstructured":"Waring JP: Nonerosive reflux disease. Semin Gastrointest Dis 2001, 12: 33\u201337.","journal-title":"Semin Gastrointest Dis"},{"key":"21_CR13","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0016-5085(98)70014-9","volume":"115","author":"R Fass","year":"1998","unstructured":"Fass R, Naliboff B, Higa L, et al.: Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998, 115: 1363\u20131373.","journal-title":"Gastroenterology"},{"key":"21_CR14","first-page":"A","volume":"126","author":"AR Hobson","year":"2004","unstructured":"Hobson AR, Matthews P, Furlong P, Aziz Q: The role of esophageal afferent pathway sensitivity in non-erosive reflux disease (abstract). Gastroenterology 2004, 126: A-18, 128.","journal-title":"Gastroenterology"},{"key":"21_CR15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1572-0241.1999.00925.x","volume":"94","author":"S Rodriguez-Stanley","year":"1999","unstructured":"Rodriguez-Stanley S, Robinson M, Earnest DL, et al.: Esophageal hypersensitivity may be a major cause of heartburn. Am J Gastroenterol 1999, 94: 628\u2013631.","journal-title":"Am J Gastroenterol"},{"key":"21_CR16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10620-005-1282-0","volume":"50","author":"A Siddiqui","year":"2005","unstructured":"Siddiqui A, Rodriguez-Stanley S, Zubaidi S, Miner PB, Jr: Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects. Dig Dis Sci 2005, 50: 81\u201385.","journal-title":"Dig Dis Sci"},{"key":"21_CR17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.37.1.7","volume":"37","author":"KC Trimble","year":"1995","unstructured":"Trimble KC, Pryde A, Heading RC: Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995, 37: 7\u201312.","journal-title":"Gut"},{"key":"21_CR18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/gut.39.2.151","volume":"39","author":"NE Schindlbeck","year":"1996","unstructured":"Schindlbeck NE, Wiebecke B, Klauser AG, et al.: Diagnostic value of histology in non-erosive gastrooesophageal reflux disease. Gut 1996, 39: 151\u2013154.","journal-title":"Gut"},{"key":"21_CR19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2036.2004.01998.x","volume":"20","author":"M Frazzoni","year":"2004","unstructured":"Frazzoni M, De Micheli E, Zentilin P, Savarino V: Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 2004, 20: 81\u201388.","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/gut.40.5.587","volume":"40","author":"RG Watson","year":"1997","unstructured":"Watson RG, Tham TC, Johnston BT, McDougall NI: Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux - the \"sensitive esophagus\". Gut 1997, 40: 587\u2013590.","journal-title":"Gut"},{"key":"21_CR21","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1001\/archinte.160.12.1803","volume":"160","author":"JE Richter","year":"2000","unstructured":"Richter JE, Campbell DR, Kahrilas PJ, et al.: Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch Intern Med 2000, 160: 1803\u20131809.","journal-title":"Arch Intern Med"},{"key":"21_CR22","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1046\/j.1365-2036.2000.00882.x","volume":"14","author":"R Fass","year":"2000","unstructured":"Fass R, Murthy U, Hayden CW, et al.: Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-esophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy - a prospective, randomized, multi-centre study. Aliment Pharmacol Ther 2000, 14: 1595\u20131603.","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR23","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1378\/chest.127.5.1658","volume":"127","author":"R Fass","year":"2005","unstructured":"Fass R, Quan SF, O\u2019Connor GT, et al.: Predictors of heartburn during sleep in a large prospective cohort study. Chest 2005, 127: 1658\u20131666.","journal-title":"Chest"},{"key":"21_CR24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1136\/gut.35.4.447","volume":"35","author":"JM Marrero","year":"1994","unstructured":"Marrero JM, de Caestecker JS, Maxwell JD: Effect of famotidine on oesophageal sensitivity in gastro-oesophageal reflux disease. Gut 1994, 35: 447\u2013450.","journal-title":"Gut"},{"key":"21_CR25","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1365-2036.2004.02217.x","volume":"20","author":"S Rodriguez-Stanley","year":"2004","unstructured":"Rodriguez-Stanley S, Ciociola AA, Zubaidi S, et al.: A single dose of ranitidine 150 mg modulates oesophageal acid sensitivity in patients with functional heartburn. Aliment Pharmacol Ther 2004, 20: 975\u2013982.","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0016-5085(87)90979-6","volume":"92","author":"RE Clouse","year":"1987","unstructured":"Clouse RE, Lustman PJ, Eckert TC, et al.: Low-dose trazodone for symptomatic patients with esophageal contraction abnormalities. A double-blind, placebo-controlled trial. Gastroenterology 1987, 92: 1027\u20131036.","journal-title":"Gastroenterology"},{"key":"21_CR27","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJM199405193302003","volume":"330","author":"RO Cannon 3rd","year":"1994","unstructured":"Cannon RO, 3rd, Quyyumi AA, Mincemoyer R, et al.: Imipramine in patients with chest pain despite normal coronary angiograms. N Engl J Med 1994, 330: 1411\u20131417.","journal-title":"N Engl J Med"},{"key":"21_CR28","first-page":"A481, 2600","volume":"18","author":"P Fenton","year":"2000","unstructured":"Fenton P, Terry ML, Galloway KD, et al.: Is there a role for laparoscopic fundoplication in patients with non-erosive reflux disease (NERD)? (abstract). Gastroenterology 2000, 18: A481, 2600.","journal-title":"Gastroenterology"},{"key":"21_CR29","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0140-6736(00)02758-6","volume":"356","author":"S Sarkar","year":"2000","unstructured":"Sarkar S, Aziz Q, Woolf CJ, et al.: Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000, 356: 1154\u20131159.","journal-title":"Lancet"},{"key":"21_CR30","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1046\/j.1365-2036.2000.00854.x","volume":"14","author":"PJ Kahrilas","year":"2000","unstructured":"Kahrilas PJ, Quigley EM, Castell DO, Spechler SJ: The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2000, 14: 1503\u20131509.","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Current Treatment Options in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-005-0021-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11938-005-0021-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11938-005-0021-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:57:01Z","timestamp":1559437021000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11938-005-0021-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["21"],"URL":"https:\/\/doi.org\/10.1007\/s11938-005-0021-0","relation":{},"ISSN":["1092-8472","1534-309X"],"issn-type":[{"value":"1092-8472","type":"print"},{"value":"1534-309X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}