{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:29:51Z","timestamp":1790980191639,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Treat Options Neurol"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1007\/s11940-003-0039-3","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:13:33Z","timestamp":1181078013000},"page":"329-341","source":"Crossref","is-referenced-by-count":63,"title":["Branched-chain ketoacyl dehydrogenase deficiency: Maple syrup disease"],"prefix":"10.1007","volume":"5","author":[{"given":"Kevin A.","family":"Strauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Holmes","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"39_CR1","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"DT Chuang","year":"2001","unstructured":"Chuang DT, Shih VE: Maple syrup urine disease (branched-chain ketoaciduria). In The Metabolic and Molecular Basis of Inherited Disease, edn 8. Edited by Scriver CR, Beaudet AL, Valle D, Sly WS. New York: McGraw-Hill; 2001.","edition":"edn 8"},{"key":"39_CR2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/ajcn\/68.1.72","volume":"68","author":"A Suryawan","year":"1998","unstructured":"Suryawan A, Hawes JW, Harris RA, et al.: A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr 1998, 68:72\u201381. Exhaustive study on human material shows distribution of whole body transamination and oxidation of BCAAs, and how these differ substantially from the rat.","journal-title":"Am J Clin Nutr"},{"key":"39_CR3","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1542\/peds.109.6.999","volume":"109","author":"DH Morton","year":"2002","unstructured":"Morton DH, Strauss KA, Robinson DL, et al.: Diagnosis and treatment of maple syrup disease: a study of 36 patients. Pediatrics 2002, 109:999\u20131008. This paper describes management and outcome of a large cohort of prospectively treated infants with classic disease, amounting to 219 patient years of follow-up. Principles of neonatal management are presented in detail.","journal-title":"Pediatrics"},{"key":"39_CR4","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1471-4159.1992.tb09409.x","volume":"59","author":"PR Dodd","year":"1992","unstructured":"Dodd PR, Williams SH, Gundlach AL, et al.: Glutamate and gamma-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves. J Neurochem 1992, 59:582\u2013590.","journal-title":"J Neurochem"},{"key":"39_CR5","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1056\/NEJM198212093072405","volume":"307","author":"AM DiGeorge","year":"1982","unstructured":"DiGeorge AM, Rezvani I, Garibaldi LR, Schwartz M: Prospective study of maple-syrup-urine disease for the first four days of life. N Engl J Med 1982, 307:1492\u20131495.","journal-title":"N Engl J Med"},{"key":"39_CR6","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1056\/NEJM199612193352507","volume":"335","author":"WE Mitch","year":"1996","unstructured":"Mitch WE, Goldberg AL: Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway. N Engl J Med 1996, 335:1897\u20131905.","journal-title":"N Engl J Med"},{"key":"39_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0022-3476(05)81035-2","volume":"119","author":"GN Thompson","year":"1991","unstructured":"Thompson GN, Francis DE, Halliday D: Acute illness in maple syrup urine disease: dynamics of protein metabolism and implications for management. J Pediatr 1991, 119:35\u201341.","journal-title":"J Pediatr"},{"key":"39_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1177\/0148607198022003156","volume":"22","author":"HR Chang","year":"1998","unstructured":"Chang HR, Bistrian B: The role of cytokines in the catabolic consequences of infection and injury. JPEN J Parenter Enteral Nutr 1998, 22:156\u2013166.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"39_CR9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0887-8994(92)90038-Z","volume":"8","author":"A Kamei","year":"1992","unstructured":"Kamei A, Takashima S, Chan F, Becker LE: Abnormal dendritic development in maple syrup urine disease. Pediatr Neurol 1992, 8:145\u2013147.","journal-title":"Pediatr Neurol"},{"key":"39_CR10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/vr.123.16.423","volume":"123","author":"SJ Duffell","year":"1988","unstructured":"Duffell SJ, Harper PA, Healy PJ, Dennis JA: Congenital hypomyelinogenesis of Hereford calves. Vet Rec 1988, 123:423\u2013424.","journal-title":"Vet Rec"},{"key":"39_CR11","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/j.1471-4159.1966.tb05882.x","volume":"13","author":"AL Prensky","year":"1966","unstructured":"Prensky AL, Moser HW: Brain lipids, proteolipids, and free amino acids in maple syrup urine disease. J Neurochem 1966, 13:863\u2013874.","journal-title":"J Neurochem"},{"key":"39_CR12","first-page":"109","volume":"53","author":"T Taketomi","year":"1983","unstructured":"Taketomi T, Kunishita T, Hara A, Mizushima S: Abnormal protein and lipid compositions of the cerebral myelin of a patient with maple syrup urine disease. Jpn J Exp Med 1983, 53:109\u2013116.","journal-title":"Jpn J Exp Med"},{"key":"39_CR13","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1007\/BF02562227","volume":"34","author":"MA Crawford","year":"1999","unstructured":"Crawford MA, Bloom M, Broadhurst CL, et al.: Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. Lipids 1999, 34(suppl):S39-S47. A clear and insightful discussion on the biologic importance of cerebral lipid composition written from an evolutionary and anthropologic, rather than molecular, perspective.","journal-title":"Lipids"},{"key":"39_CR14","first-page":"97","volume":"48","author":"NG Bazan","year":"1990","unstructured":"Bazan NG, Scott BL: Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. Ups J Med Sci 1990, 48(suppl):97\u2013107.","journal-title":"Ups J Med Sci"},{"key":"39_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0006-8993(00)02129-6","volume":"862","author":"N Itokazu","year":"2000","unstructured":"Itokazu N, Ikegaya Y, Nishikawa M, Matsuki N: Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. Brain Res 2000, 862:211\u2013216.","journal-title":"Brain Res"},{"key":"39_CR16","first-page":"295","volume":"2","author":"BC Davidson","year":"1988","unstructured":"Davidson BC, Cantrill RC, Kurstjens NP, Patton J: Polyenoic fatty acid deprivation of juvenile cats modulates 3H-dopamine release from presynaptic receptors in caudate slices. In Vivo 1988, 2:295\u2013298.","journal-title":"In Vivo"},{"key":"39_CR17","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1073\/pnas.042698699","volume":"99","author":"K Kitajka","year":"2002","unstructured":"Kitajka K, Puskas LG, Zvara A, et al.: The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. Proc Natl Acad Sci U S A 2002, 99:2619\u20132624. Using microarray technology to categorize messenger RNA expression patterns in brain, Kitajka et al. show profound alterations in transcriptional regulation in omega-3 fatty acid deficient animals, with over 60 brain-restricted genes showing \u00b1threefold change in expression.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"39_CR18","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1203\/00006450-200203000-00003","volume":"51","author":"M Champoux","year":"2002","unstructured":"Champoux M, Hibbeln JR, Shannon C, et al.: Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. Pediatr Res 2002, 51:273\u2013281. In a living primate, omega-3 fatty acid deficiency, as an isolated variable, alters behavior of the mature animal.","journal-title":"Pediatr Res"},{"key":"39_CR19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/1098-2396(200008)37:2<90::AID-SYN2>3.0.CO;2-Z","volume":"37","author":"C Young","year":"2000","unstructured":"Young C, Gean PW, Chiou LC, Shen YZ: Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. Synapse 2000, 37:90\u201394.","journal-title":"Synapse"},{"key":"39_CR20","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1042\/0264-6021:3580693","volume":"358","author":"T Nii","year":"2001","unstructured":"Nii T, Segawa H, Taketani Y, et al.: Molecular events involved in up-regulating human Na+-independent neutral amino acid-transporter LAT1 during T-cell activation. Biochem J 2001, 358:693\u2013704.","journal-title":"Biochem J"},{"key":"39_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1023\/A:1005668431926","volume":"23","author":"M Wajner","year":"2000","unstructured":"Wajner M, Coelho DM, Barschak AG, et al.: Reduction of large neutral amino acid concentrations in plasma and CSF of patients with maple syrup urine disease during crises. J Inherit Metab Dis 2000, 23:505\u2013512. The metabolic disturbance of MSD is more accurately described by the simultaneous depletion of multiple amino acids, essential and nonessential, as leucine and aKIC concentrations rise.","journal-title":"J Inherit Metab Dis"},{"key":"39_CR22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/clinchem\/41.1.62","volume":"41","author":"DH Chace","year":"1995","unstructured":"Chace DH, Hillman SL, Millington DS, et al.: Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry. Clin Chem 1995, 41:62\u201368.","journal-title":"Clin Chem"},{"key":"39_CR23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1542\/peds.61.2.262","volume":"61","author":"EW Naylor","year":"1978","unstructured":"Naylor EW, Guthrie R: Newborn screening for maple syrup urine disease (branched-chain ketoaaciduria). Pediatr 1978, 61:262\u2013266.","journal-title":"Pediatr"},{"key":"39_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0197-0186(00)00100-5","volume":"38","author":"P Araujo","year":"2001","unstructured":"Araujo P, Wassermann GF, Tallini K, et al.: Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats. Neurochem Int 2001, 38:529\u2013537. A carefully-designed study demonstrating the predicted abnormal amino acid transport phenomena in situ, demonstrating that in addition to blocked influx, enhanced efflux of LNAAs is a mechanism of their depletion by high leucine.","journal-title":"Neurochem Int"},{"key":"39_CR25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1017\/S003329170004294X","volume":"4","author":"G Banos","year":"1974","unstructured":"Banos G, Daniel PM, Moorhouse SR, Pratt OE: Inhibition of entry of some amino acids into the brain, with observations on mental retardation in the aminoacidurias. Psychol Med 1974, 4:262\u2013269.","journal-title":"Psychol Med"},{"key":"39_CR26","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1046\/j.1471-4159.1994.63041508.x","volume":"63","author":"M Yudkoff","year":"1994","unstructured":"Yudkoff M, Daikhin Y, Nissim I, et al.: Inhibition of astrocyte glutamine production by alpha-ketoisocaproic acid. J Neurochem 1994, 63:1508\u20131515.","journal-title":"J Neurochem"},{"key":"39_CR27","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/emboj\/21.4.580","volume":"21","author":"C Meier","year":"2002","unstructured":"Meier C, Ristic Z, Klauser S, Verrey F: Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 2002, 21:580\u2013589.","journal-title":"EMBO J"},{"key":"39_CR28","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0197-0186(01)00077-8","volume":"40","author":"HR Zielke","year":"2002","unstructured":"Zielke HR, Zielke CL, Baab PJ, Collins RM: Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria. Neurochem Int 2002, 40:347\u2013354. The important property of heteroexchange, or \u201ctrans-stimulation,\u201d is demonstrated in vivo.","journal-title":"Neurochem Int"},{"key":"39_CR29","volume-title":"Introduction to the Blood-brain Barrier: Methodology, Biology, and Pathology","author":"QR Smith","year":"1998","unstructured":"Smith QR, Stoll J: Blood-brain barrier amino acid transport. In Introduction to the Blood-brain Barrier: Methodology, Biology, and Pathology. Edited by Pardridge WM. Cambridge: Cambridge University Press; 1998. A clear and concise description of BBB transport of the LNAAs mediated by LAT1, written by two pioneers in the field. A complete list of kinetic parameters (Km, Vmax, and influx rates) is provided."},{"key":"39_CR30","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1023\/A:1027325620983","volume":"22","author":"HR Zielke","year":"1997","unstructured":"Zielke HR, Huang Y, Baab PJ, et al.: Effect of alphaketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain. Neurochem Res 1997, 22:1159\u20131166.","journal-title":"Neurochem Res"},{"key":"39_CR31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000111436","volume":"18","author":"HR Zielke","year":"1996","unstructured":"Zielke HR, Huang Y, Tildon JT, et al.: Elevation of amino acids in the interstitial space of the rat brain following infusion of large neutral amino and keto acids by microdialysis: alpha-ketoisocaproate infusion. Dev Neurosci 1996, 18:420\u2013425.","journal-title":"Dev Neurosci"},{"key":"39_CR32","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1056\/NEJM199511093331906","volume":"333","author":"ML McManus","year":"1995","unstructured":"McManus ML, Churchwell KB, Strange K: Regulation of cell volume in health and disease. N Engl J Med 1995, 333:1260\u20131266.","journal-title":"N Engl J Med"},{"key":"39_CR33","doi-asserted-by":"crossref","first-page":"C1282","DOI":"10.1152\/ajpcell.1992.263.6.C1282","volume":"263","author":"A Paredes","year":"1992","unstructured":"Paredes A, McManus M, Kwon HM, Strange K: Osmoregulation of Na(+)-inositol cotransporter activity and mRNA levels in brain glial cells. Am J Physiol 1992, 263:C1282-C1288.","journal-title":"Am J Physiol"},{"key":"39_CR34","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/1097-4547(20001115)62:4<480::AID-JNR2>3.0.CO;2-K","volume":"62","author":"L Hertz","year":"2000","unstructured":"Hertz L, Chen Y, Spatz M: Involvement of non-neuronal brain cells in AVP-mediated regulation of water space at the cellular, organ, and whole-body level. J Neurosci Res 2000, 62:480\u2013490.","journal-title":"J Neurosci Res"},{"key":"39_CR35","doi-asserted-by":"crossref","first-page":"C1465","DOI":"10.1152\/ajpcell.2001.280.6.C1465","volume":"280","author":"R Franchi-Gazzola","year":"2001","unstructured":"Franchi-Gazzola R, Visigalli R, Dall\u2019Asta V, et al.: Amino acid depletion activates TonEBP and sodium-coupled inositol transport. Am J Physiol Cell Physiol 2001, 280:C1465-C1474.","journal-title":"Am J Physiol Cell Physiol"},{"key":"39_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/09687680110033756","volume":"18","author":"O Bussolati","year":"2001","unstructured":"Bussolati O, Dall\u2019Asta V, Franchi-Gazzola R, et al.: The role of system A for neutral amino acid transport in the regulation of cell volume. Mol Membr Biol 2001, 18:27\u201338.","journal-title":"Mol Membr Biol"},{"key":"39_CR37","first-page":"E596","volume":"276","author":"D Sarfaraz","year":"1999","unstructured":"Sarfaraz D, Fraser CL: Effects of arginine vasopressin on cell volume regulation in brains astrocyte in culture. Am J Physiol 1999, 276:E596.","journal-title":"Am J Physiol"},{"key":"39_CR38","volume-title":"Textbook of Medical Physiology","author":"AC Guyton","year":"1996","unstructured":"Guyton AC, Hall JE: Integration of renal mechanisms for control of blood volume and extracellular fluid volume. In Textbook of Medical Physiology, edn 9. Edited by Guyton AC, Hall JE. Philadelphia: WB Saunders Company; 1996.","edition":"edn 9"},{"key":"39_CR39","first-page":"F1059","volume":"256","author":"M DePasquale","year":"1989","unstructured":"DePasquale M, Patlak CS, Cserr HF: Brain ion and volume regulation during acute hypernatremia in Brattleboro rats. Am J Physiol (Lond) 1989, 256:F1059-F1064.","journal-title":"Am J Physiol (Lond)"},{"key":"39_CR40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1365-2796.1992.tb00588.x","volume":"232","author":"M Kroll","year":"1992","unstructured":"Kroll M, Juhler M, Lindholm J: Hyponatraemia in acute brain disease. J Intern Med 1992, 232:291\u2013297.","journal-title":"J Intern Med"},{"key":"39_CR41","volume-title":"Tetrahydrobiopterin: Basic Biochemistry and Role in Human Disease","author":"S Kaufman","year":"1997","unstructured":"Kaufman S: Phenylketonuria and its variants. In Tetrahydrobiopterin: Basic Biochemistry and Role in Human Disease. Baltimore: Johns Hopkins University Press; 1997."},{"key":"39_CR42","first-page":"203","volume":"24","author":"OE Pratt","year":"1980","unstructured":"Pratt OE: A new approach to the treatment of phenylketonuria. J Ment Defic Res 1980, 24:203\u2013217.","journal-title":"J Ment Defic Res"},{"key":"39_CR43","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1007\/PL00014370","volume":"159","author":"R Surtees","year":"2000","unstructured":"Surtees R, Blau N: The neurochemistry of phenylketonuria. Eur J Pediatr 2000, 159(suppl):S109-S113. A modern perspective on earlier reviews by Pratt [42] and Kaufman [41].","journal-title":"Eur J Pediatr"},{"key":"39_CR44","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/BF00229626","volume":"109","author":"JP Andrade","year":"1996","unstructured":"Andrade JP, Castanheira-Vale AJ, Paz-Dias PG, et al.: The dendritic trees of neurons from the hippocampal formation of protein-deprived adult rats: a quantitative Golgi study. Exp Brain Res 1996, 109:419\u2013433.","journal-title":"Exp Brain Res"},{"key":"39_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(95)01544-2","volume":"718","author":"JP Andrade","year":"1996","unstructured":"Andrade JP, Castanheira-Vale AJ, Madeira MD: Time scale and extent of neuronal and synaptic loss in the hippocampal formation of malnourished adult rats. Brain Res 1996, 718:1\u201312.","journal-title":"Brain Res"},{"key":"39_CR46","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.1007\/PL00014371","volume":"159","author":"PR Huttenlocher","year":"2000","unstructured":"Huttenlocher PR: The neuropathology of phenylketonuria: human and animal studies. Eur J Padiatr 2000, 159(suppl):S102-S106.","journal-title":"Eur J Padiatr"},{"key":"39_CR47","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0165-3806(92)90183-W","volume":"65","author":"J Royland","year":"1992","unstructured":"Royland J, Konat GW, Kanoh M, Wiggins RC: Down regulation of myelin-specific mRNAs in the mechanism of hypomyelination in the undernourished developing brain. Brain Res Dev Brain Res 1992, 65:223\u2013226.","journal-title":"Brain Res Dev Brain Res"},{"key":"39_CR48","volume-title":"Neuropsychiatry and Clinical Neurosciences","author":"MH Teicher","year":"2002","unstructured":"Teicher MH, Andersen SL, Navalta CP, et al.: Neuropsychiatric disorders of childhood and adolescence. In In Neuropsychiatry and Clinical Neurosciences, edn 4. Edited by Yudofsky SC, Hales RE. Washington, DC: American Psychiatric Publishing; 2002.","edition":"edn 4"},{"key":"39_CR49","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/BF00441411","volume":"148","author":"C Lykkelund","year":"1988","unstructured":"Lykkelund C, Nielsen JB, Lou HC, et al.: Increased neurotransmitter biosynthesis in phenylketonuria induced by phenylalanine restriction or by supplementation of unrestricted diet with large amounts of tyrosine. Eur J Pediatr 1988, 148:238\u2013245.","journal-title":"Eur J Pediatr"}],"container-title":["Current Treatment Options in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11940-003-0039-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11940-003-0039-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11940-003-0039-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11940-003-0039-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T11:33:34Z","timestamp":1652614414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11940-003-0039-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["39"],"URL":"https:\/\/doi.org\/10.1007\/s11940-003-0039-3","relation":{},"ISSN":["1092-8480","1534-3138"],"issn-type":[{"value":"1092-8480","type":"print"},{"value":"1534-3138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}