{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:10:30Z","timestamp":1790615430261,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Treat Options Neurol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s11940-017-0458-1","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T06:56:34Z","timestamp":1493708194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Sleep Disturbances in the Prodromal Stage of Parkinson Disease"],"prefix":"10.1007","volume":"19","author":[{"given":"Ahmed","family":"Al-Qassabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed-Mohammad","family":"Fereshtehnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Postuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"issue":"9996","key":"458_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia LV, Lang AE. Parkinson\u2019s disease. Lancet. 2015;386(9996):896\u2013912. doi: 10.1016\/S0140-6736(14)61393-3 .","journal-title":"Lancet"},{"issue":"2","key":"458_CR2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging. 2003;24(2):197\u2013211.","journal-title":"Neurobiol Aging"},{"key":"458_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bmb\/ldn013","volume":"86","author":"CA Davie","year":"2008","unstructured":"Davie CA. A review of Parkinson\u2019s disease. Br Med Bull. 2008;86:109\u201327. doi: 10.1093\/bmb\/ldn013 .","journal-title":"Br Med Bull"},{"issue":"6","key":"458_CR4","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","volume":"167","author":"TR Sampson","year":"2016","unstructured":"Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease. Cell. 2016;167(6):1469\u201380 e12. doi: 10.1016\/j.cell.2016.11.018 .","journal-title":"Cell"},{"issue":"5","key":"458_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/mds.24996","volume":"27","author":"RB Postuma","year":"2012","unstructured":"Postuma RB, Aarsland D, Barone P, Burn DJ, Hawkes CH, Oertel W, et al. Identifying prodromal Parkinson\u2019s disease: pre-motor disorders in Parkinson\u2019s disease. Mov Disord. 2012;27(5):617\u201326. doi: 10.1002\/mds.24996 .","journal-title":"Mov Disord"},{"key":"458_CR6","first-page":"155","volume-title":"The rat nervous sytem","author":"BE Jones","year":"1995","unstructured":"Jones BE. Reticular formation: cytoarchitecture, transmitters, and projections. In: Paxinos G, editor. The rat nervous sytem. 2nd ed. San Diego: Academic Press; 1995. p. 155\u201371.","edition":"2nd"},{"issue":"4","key":"458_CR7","first-page":"811","volume":"27","author":"RA Espana","year":"2004","unstructured":"Espana RA, Scammell TE. Sleep neurobiology for the clinician. Sleep. 2004;27(4):811\u201320.","journal-title":"Sleep"},{"issue":"49","key":"458_CR8","doi-asserted-by":"publisher","first-page":"11231","DOI":"10.1523\/JNEUROSCI.1724-05.2005","volume":"25","author":"D Popa","year":"2005","unstructured":"Popa D, Lena C, Fabre V, Prenat C, Gingrich J, Escourrou P, et al. Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J Neurosci. 2005;25(49):11231\u20138. doi: 10.1523\/JNEUROSCI.1724-05.2005 .","journal-title":"J Neurosci"},{"issue":"1","key":"458_CR9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0006-8993(90)90733-R","volume":"510","author":"GM Halliday","year":"1990","unstructured":"Halliday GM, Blumbergs PC, Cotton RG, Blessing WW, Geffen LB. Loss of brainstem serotonin- and substance P-containing neurons in Parkinson\u2019s disease. Brain Res. 1990;510(1):104\u20137.","journal-title":"Brain Res"},{"issue":"Pt 10","key":"458_CR10","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1093\/brain\/awv215","volume":"138","author":"Z Qamhawi","year":"2015","unstructured":"Qamhawi Z, Towey D, Shah B, Pagano G, Seibyl J, Marek K, et al. Clinical correlates of raphe serotonergic dysfunction in early Parkinson\u2019s disease. Brain. 2015;138(Pt 10):2964\u201373. doi: 10.1093\/brain\/awv215 .","journal-title":"Brain"},{"issue":"4","key":"458_CR11","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/ana.22691","volume":"71","author":"V Kotagal","year":"2012","unstructured":"Kotagal V, Albin RL, Muller ML, Koeppe RA, Chervin RD, Frey KA, et al. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Ann Neurol. 2012;71(4):560\u20138. doi: 10.1002\/ana.22691 .","journal-title":"Ann Neurol"},{"issue":"7","key":"458_CR12","doi-asserted-by":"publisher","first-page":"e40166","DOI":"10.1371\/journal.pone.0040166","volume":"7","author":"IM Lelieveld","year":"2012","unstructured":"Lelieveld IM, Muller ML, Bohnen NI, Koeppe RA, Chervin RD, Frey KA, et al. The role of serotonin in sleep disordered breathing associated with Parkinson disease: a correlative [11C]DASB PET imaging study. PLoS One. 2012;7(7):e40166. doi: 10.1371\/journal.pone.0040166 .","journal-title":"PLoS One"},{"issue":"3","key":"458_CR13","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","volume":"88","author":"HL Haas","year":"2008","unstructured":"Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system. Physiol Rev. 2008;88(3):1183\u2013241. doi: 10.1152\/physrev.00043.2007 .","journal-title":"Physiol Rev"},{"issue":"7","key":"458_CR14","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.neurobiolaging.2011.01.004","volume":"33","author":"L Shan","year":"2012","unstructured":"Shan L, Liu CQ, Balesar R, Hofman MA, Bao AM, Swaab DF. Neuronal histamine production remains unaltered in Parkinson\u2019s disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus. Neurobiol Aging. 2012;33(7):1343\u20134. doi: 10.1016\/j.neurobiolaging.2011.01.004 .","journal-title":"Neurobiol Aging"},{"issue":"28","key":"458_CR15","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1523\/JNEUROSCI.1887-05.2005","volume":"25","author":"MG Lee","year":"2005","unstructured":"Lee MG, Hassani OK, Jones BE. Discharge of identified orexin\/hypocretin neurons across the sleep-waking cycle. J Neurosci. 2005;25(28):6716\u201320. doi: 10.1523\/JNEUROSCI.1887-05.2005 .","journal-title":"J Neurosci"},{"issue":"23","key":"458_CR16","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"C Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18(23):9996\u201310015.","journal-title":"J Neurosci"},{"issue":"9197","key":"458_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","volume":"355","author":"S Nishino","year":"2000","unstructured":"Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000;355(9197):39\u201340. doi: 10.1016\/S0140-6736(99)05582-8 .","journal-title":"Lancet"},{"issue":"Pt 6","key":"458_CR18","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/brain\/awm097","volume":"130","author":"TC Thannickal","year":"2007","unstructured":"Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson\u2019s disease. Brain. 2007;130(Pt 6):1586\u201395. doi: 10.1093\/brain\/awm097 .","journal-title":"Brain"},{"issue":"4","key":"458_CR19","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0306-4522(83)90108-2","volume":"10","author":"MM Mesulam","year":"1983","unstructured":"Mesulam MM, Mufson EJ, Wainer BH, Levey AI. Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience. 1983;10(4):1185\u2013201.","journal-title":"Neuroscience"},{"issue":"3","key":"458_CR20","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/jn.2000.84.3.1627","volume":"84","author":"A Duque","year":"2000","unstructured":"Duque A, Balatoni B, Detari L, Zaborszky L. EEG correlation of the discharge properties of identified neurons in the basal forebrain. J Neurophysiol. 2000;84(3):1627\u201335.","journal-title":"J Neurophysiol"},{"issue":"2","key":"458_CR21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0006-8993(94)01399-3","volume":"671","author":"F Marrosu","year":"1995","unstructured":"Marrosu F, Portas C, Mascia MS, Casu MA, Fa M, Giagheddu M, et al. Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats. Brain Res. 1995;671(2):329\u201332.","journal-title":"Brain Res"},{"key":"458_CR22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0031-9384(70)90061-2","volume":"5","author":"AG Karczmar","year":"1970","unstructured":"Karczmar AG, Longo A, de Carolis S. A pharmacological model of paradoxical sleep: the role of cholinergic and monoaminergic neurons. Physiol Behav. 1970;5:175\u201382.","journal-title":"Physiol Behav"},{"issue":"7","key":"458_CR23","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1113\/jphysiol.2014.271304","volume":"592","author":"ZA Torontali","year":"2014","unstructured":"Torontali ZA, Grace KP, Horner RL, Peever JH. Cholinergic involvement in control of REM sleep paralysis. J Physiol. 2014;592(7):1425\u20136. doi: 10.1113\/jphysiol.2014.271304 .","journal-title":"J Physiol"},{"key":"458_CR24","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/S1353-8020(11)70174-2","volume":"18","author":"N Pavese","year":"2012","unstructured":"Pavese N, Metta V, Simpson BS, Marphy TA, Ramlackhansingh A, Chaudhuri KR, et al. Sleep regulatory centres dysfunction in Parkinson\u2019s disease patients with excessive daytime sleepiness. Parkinsonism Relat Disord. 2012;18:S24\u2013S5.","journal-title":"Parkinsonism Relat Disord"},{"key":"458_CR25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-08-027391-4.50036-8","volume-title":"Advances in dopamine research","author":"O Lindvall","year":"1982","unstructured":"Lindvall O, Bjorklund A. Neuroanatomy of central dopamine pathways: review of recent progress. In: Keal M, editor. Advances in dopamine research. New York: Pergamon Press; 1982. p. 297\u2013311."},{"issue":"1","key":"458_CR26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2869.2000.00201.x","volume":"9","author":"DB Rye","year":"2000","unstructured":"Rye DB, Bliwise DL, Dihenia B, Gurecki P. FAST TRACK: daytime sleepiness in Parkinson\u2019s disease. J Sleep Res. 2000;9(1):63\u20139.","journal-title":"J Sleep Res"},{"issue":"8","key":"458_CR27","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00415-006-0483-6","volume":"254","author":"S Happe","year":"2007","unstructured":"Happe S, Baier PC, Helmschmied K, Meller J, Tatsch K, Paulus W. Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson\u2019s disease. J Neurol. 2007;254(8):1037\u201343. doi: 10.1007\/s00415-006-0483-6 .","journal-title":"J Neurol"},{"issue":"5","key":"458_CR28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/sleep\/26.5.507","volume":"26","author":"I Eisensehr","year":"2003","unstructured":"Eisensehr I, Linke R, Tatsch K, Kharraz B, Gildehaus JF, Wetter CT, et al. Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson\u2019s disease, and controls. Sleep. 2003;26(5):507\u201312.","journal-title":"Sleep"},{"issue":"3","key":"458_CR29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1468-1331.2009.02854.x","volume":"17","author":"YK Kim","year":"2010","unstructured":"Kim YK, Yoon IY, Kim JM, Jeong SH, Kim KW, Shin YK, et al. The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. Eur J Neurol. 2010;17(3):487\u201392. doi: 10.1111\/j.1468-1331.2009.02854.x .","journal-title":"Eur J Neurol"},{"issue":"3","key":"458_CR30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1523\/JNEUROSCI.5486-08.2009","volume":"29","author":"MB Dash","year":"2009","unstructured":"Dash MB, Douglas CL, Vyazovskiy VV, Cirelli C, Tononi G. Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. J Neurosci. 2009;29(3):620\u20139. doi: 10.1523\/JNEUROSCI.5486-08.2009 .","journal-title":"J Neurosci"},{"issue":"6","key":"458_CR31","doi-asserted-by":"publisher","first-page":"R2041","DOI":"10.1152\/ajpregu.90541.2008","volume":"295","author":"J John","year":"2008","unstructured":"John J, Ramanathan L, Siegel JM. Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats. Am J Physiol Regul Integr Comp Physiol. 2008;295(6):R2041\u20139. doi: 10.1152\/ajpregu.90541.2008 .","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"8","key":"458_CR32","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.sleep.2013.02.004","volume":"14","author":"PH Luppi","year":"2013","unstructured":"\u2022\u2022 Luppi PH, Clement O, Valencia Garcia S, Brischoux F, Fort P. New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine. Sleep Med. 2013;14(8):714\u20138. doi: 10.1016\/j.sleep.2013.02.004 .This paper provides an updated review on the latest discoveries on the pathophysiology of RBD, as the main prodromal sleep disorder in PD.","journal-title":"Sleep Med"},{"issue":"Pt 7","key":"458_CR33","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1093\/brain\/awt152","volume":"136","author":"D Garcia-Lorenzo","year":"2013","unstructured":"Garcia-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, et al. The coeruleus\/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson\u2019s disease. Brain. 2013;136(Pt 7):2120\u20139. doi: 10.1093\/brain\/awt152 .","journal-title":"Brain"},{"issue":"7","key":"458_CR34","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1136\/jnnp-2011-301817","volume":"84","author":"K Del Tredici","year":"2013","unstructured":"Del Tredici K, Braak H. Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson\u2019s disease-related dementia. J Neurol Neurosurg Psychiatry. 2013;84(7):774\u201383. doi: 10.1136\/jnnp-2011-301817 .","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 4","key":"458_CR35","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/brain\/aww006","volume":"139","author":"M Ehrminger","year":"2016","unstructured":"\u2022 Ehrminger M, Latimier A, Pyatigorskaya N, Garcia-Lorenzo D, Leu-Semenescu S, Vidailhet M, et al. The coeruleus\/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder. Brain. 2016;139(Pt 4):1180\u20138. doi: 10.1093\/brain\/aww006 .Using magnetic resonance imaging, authors have investigated the pathophysiology of RBD, which is the strongest prodromal feature of PD.","journal-title":"Brain"},{"key":"458_CR36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00005053-193003000-00001","volume":"71","author":"C Von Economo","year":"1930","unstructured":"Von Economo C. Sleep as a problem of localization. J Nerv Ment Dis. 1930;71:249\u201359.","journal-title":"J Nerv Ment Dis"},{"issue":"12","key":"458_CR37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","volume":"24","author":"CB Saper","year":"2001","unstructured":"Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24(12):726\u201331.","journal-title":"Trends Neurosci"},{"issue":"6","key":"458_CR38","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/nan.12024","volume":"39","author":"ME Kalaitzakis","year":"2013","unstructured":"Kalaitzakis ME, Gentleman SM, Pearce RK. Disturbed sleep in Parkinson\u2019s disease: anatomical and pathological correlates. Neuropathol Appl Neurobiol. 2013;39(6):644\u201353. doi: 10.1111\/nan.12024 .","journal-title":"Neuropathol Appl Neurobiol"},{"key":"458_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fneur.2015.00135","volume":"6","author":"RE Brown","year":"2015","unstructured":"Brown RE, McKenna JT. Turning a negative into a positive: ascending GABAergic control of cortical activation and arousal. Front Neurol. 2015;6:135. doi: 10.3389\/fneur.2015.00135 .","journal-title":"Front Neurol"},{"key":"458_CR40","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.parkreldis.2016.01.020","volume":"24","author":"K Zhu","year":"2016","unstructured":"Zhu K, van Hilten JJ, Marinus J. Course and risk factors for excessive daytime sleepiness in Parkinson\u2019s disease. Parkinsonism Relat Disord. 2016;24:34\u201340. doi: 10.1016\/j.parkreldis.2016.01.020 .","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"458_CR41","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.smrv.2005.01.001","volume":"9","author":"I Arnulf","year":"2005","unstructured":"Arnulf I. Excessive daytime sleepiness in parkinsonism. Sleep Med Rev. 2005;9(3):185\u2013200. doi: 10.1016\/j.smrv.2005.01.001 .","journal-title":"Sleep Med Rev"},{"issue":"9","key":"458_CR42","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1212\/01.wnl.0000183056.89590.0d","volume":"65","author":"RD Abbott","year":"2005","unstructured":"Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, et al. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. 2005;65(9):1442\u20136. doi: 10.1212\/01.wnl.0000183056.89590.0d .","journal-title":"Neurology"},{"issue":"9","key":"458_CR43","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1093\/aje\/kwq478","volume":"173","author":"J Gao","year":"2011","unstructured":"Gao J, Huang X, Park Y, Hollenbeck A, Blair A, Schatzkin A, et al. Daytime napping, nighttime sleeping, and Parkinson disease. Am J Epidemiol. 2011;173(9):1032\u20138. doi: 10.1093\/aje\/kwq478 .","journal-title":"Am J Epidemiol"},{"issue":"10","key":"458_CR44","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/mds.26248","volume":"30","author":"T Simuni","year":"2015","unstructured":"Simuni T, Caspell-Garcia C, Coffey C, Chahine LM, Lasch S, Oertel WH, et al. Correlates of excessive daytime sleepiness in de novo Parkinson\u2019s disease: a case control study. Mov Disord. 2015;30(10):1371\u201381. doi: 10.1002\/mds.26248 .","journal-title":"Mov Disord"},{"issue":"14","key":"458_CR45","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1212\/WNL.0b013e3182a6cbd5","volume":"81","author":"B Mollenhauer","year":"2013","unstructured":"Mollenhauer B, Trautmann E, Sixel-Doring F, Wicke T, Ebentheuer J, Schaumburg M, et al. Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology. 2013;81(14):1226\u201334. doi: 10.1212\/WNL.0b013e3182a6cbd5 .","journal-title":"Neurology"},{"issue":"10","key":"458_CR46","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.5665\/sleep.5040","volume":"38","author":"I Arnulf","year":"2015","unstructured":"\u2022 Arnulf I, Neutel D, Herlin B, Golmard JL, Leu-Semenescu S, Cochen de Cock V, et al. Sleepiness in idiopathic REM sleep behavior disorder and Parkinson disease. Sleep. 2015;38(10):1529\u201335. doi: 10.5665\/sleep.5040 .Findings from this study showed that people with RBD who also had sleepiness converted faster to a neurodegenerative status.","journal-title":"Sleep"},{"key":"458_CR47","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx041","author":"J Zhou","year":"2017","unstructured":"\u2022 Zhou J, Zhang J, Lam SP, Chan JW, Mok V, Chan A, et al. Excessive daytime sleepiness predicts neurodegeneration in idiopathic REM sleep behavior disorder. Sleep. 2017; doi: 10.1093\/sleep\/zsx041 .In this article, authors have shown that individuals with both RBD and excessive daytime somnolence are at a higher risk for conversion to PD.","journal-title":"Sleep"},{"key":"458_CR48","doi-asserted-by":"crossref","unstructured":"Postuma RB, Gagnon JF, Pelletier A, Montplaisir J. Insomnia and somnolence in idiopathic RBD: a prospective cohort study. npj Parkinson\u2019s Disease 2017;3(9).","DOI":"10.1038\/s41531-017-0011-7"},{"issue":"8","key":"458_CR49","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/jamaneurol.2015.0703","volume":"72","author":"SM Fereshtehnejad","year":"2015","unstructured":"Fereshtehnejad SM, Romenets SR, Anang JB, Latreille V, Gagnon JF, Postuma RB. New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol. 2015;72(8):863\u201373. doi: 10.1001\/jamaneurol.2015.0703 .","journal-title":"JAMA Neurol"},{"key":"458_CR50","doi-asserted-by":"crossref","unstructured":"Fereshtehnejad SM, Zeighami Y, Dagher A, Postuma RB. Clinical criteria for subtyping parkinson\u2019s disease: comparison of imaging, CSF and genetic biomarkers and longitudinal progression. Brain. 2017:[Submitted].","DOI":"10.1093\/brain\/awx118"},{"issue":"11","key":"458_CR51","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1002\/mds.22643","volume":"24","author":"P Barone","year":"2009","unstructured":"Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson\u2019s disease. Mov Disord. 2009;24(11):1641\u20139. doi: 10.1002\/mds.22643 .","journal-title":"Mov Disord"},{"issue":"11","key":"458_CR52","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.parkreldis.2015.09.025","volume":"21","author":"PL Ratti","year":"2015","unstructured":"Ratti PL, Negre-Pages L, Perez-Lloret S, Manni R, Damier P, Tison F, et al. Subjective sleep dysfunction and insomnia symptoms in Parkinson\u2019s disease: insights from a cross-sectional evaluation of the French CoPark cohort. Parkinsonism Relat Disord. 2015;21(11):1323\u20139. doi: 10.1016\/j.parkreldis.2015.09.025 .","journal-title":"Parkinsonism Relat Disord"},{"key":"458_CR53","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.parkreldis.2016.09.010","volume":"33","author":"K Zhu","year":"2016","unstructured":"Zhu K, van Hilten JJ, Marinus J. The course of insomnia in Parkinson\u2019s disease. Parkinsonism Relat Disord. 2016;33:51\u20137. doi: 10.1016\/j.parkreldis.2016.09.010 .","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"458_CR54","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1474-4422(14)70287-X","volume":"14","author":"A Schrag","year":"2015","unstructured":"Schrag A, Horsfall L, Walters K, Noyce A, Petersen I. Prediagnostic presentations of Parkinson\u2019s disease in primary care: a case-control study. Lancet Neurol. 2015;14(1):57\u201364. doi: 10.1016\/S1474-4422(14)70287-X .","journal-title":"Lancet Neurol"},{"issue":"1","key":"458_CR55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2003.08.010","volume":"217","author":"P Braga-Neto","year":"2004","unstructured":"Braga-Neto P, da Silva-Junior FP, Sueli Monte F, de Bruin PF, de Bruin VM. Snoring and excessive daytime sleepiness in Parkinson\u2019s disease. J Neurol Sci. 2004;217(1):41\u20135.","journal-title":"J Neurol Sci"},{"issue":"10","key":"458_CR56","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0954-6111(03)00188-4","volume":"97","author":"B Maria","year":"2003","unstructured":"Maria B, Sophia S, Michalis M, Charalampos L, Andreas P, John ME, et al. Sleep breathing disorders in patients with idiopathic Parkinson\u2019s disease. Respir Med. 2003;97(10):1151\u20137.","journal-title":"Respir Med"},{"issue":"9","key":"458_CR57","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/mds.21002","volume":"21","author":"I Shpirer","year":"2006","unstructured":"Shpirer I, Miniovitz A, Klein C, Goldstein R, Prokhorov T, Theitler J, et al. Excessive daytime sleepiness in patients with Parkinson\u2019s disease: a polysomnography study. Mov Disord. 2006;21(9):1432\u20138. doi: 10.1002\/mds.21002 .","journal-title":"Mov Disord"},{"issue":"12","key":"458_CR58","doi-asserted-by":"publisher","first-page":"e82091","DOI":"10.1371\/journal.pone.0082091","volume":"8","author":"J Zeng","year":"2013","unstructured":"Zeng J, Wei M, Li T, Chen W, Feng Y, Shi R, et al. Risk of obstructive sleep apnea in Parkinson\u2019s disease: a meta-analysis. PLoS One. 2013;8(12):e82091. doi: 10.1371\/journal.pone.0082091 .","journal-title":"PLoS One"},{"issue":"12","key":"458_CR59","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/j.sleep.2014.09.014","volume":"16","author":"V Cochen De Cock","year":"2015","unstructured":"Cochen De Cock V, Benard-Serre N, Driss V, Granier M, Charif M, Carlander B, et al. Supine sleep and obstructive sleep apnea syndrome in Parkinson\u2019s disease. Sleep Med. 2015;16(12):1497\u2013501. doi: 10.1016\/j.sleep.2014.09.014 .","journal-title":"Sleep Med"},{"issue":"4","key":"458_CR60","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3233\/JPD-150602","volume":"5","author":"SG Beland","year":"2015","unstructured":"Beland SG, Postuma RB, Latreille V, Bertrand JA, Panisset M, Chouinard S, et al. Observational study of the relation between Parkinson\u2019s disease and sleep apnea. J Parkinsons Dis. 2015;5(4):805\u201311. doi: 10.3233\/JPD-150602 .","journal-title":"J Parkinsons Dis"},{"issue":"2","key":"458_CR61","doi-asserted-by":"publisher","first-page":"e2293","DOI":"10.1097\/MD.0000000000002293","volume":"95","author":"NC Yeh","year":"2016","unstructured":"Yeh NC, Tien KJ, Yang CM, Wang JJ, Weng SF. Increased risk of Parkinson\u2019s disease in patients with obstructive sleep apnea: a population-based, propensity score-matched, longitudinal follow-up study. Medicine (Baltimore). 2016;95(2):e2293. doi: 10.1097\/MD.0000000000002293 .","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"458_CR62","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/jsr.12289","volume":"24","author":"JC Chen","year":"2015","unstructured":"Chen JC, Tsai TY, Li CY, Hwang JH. Obstructive sleep apnea and risk of Parkinson\u2019s disease: a population-based cohort study. J Sleep Res. 2015;24(4):432\u20137. doi: 10.1111\/jsr.12289 .","journal-title":"J Sleep Res"},{"issue":"12","key":"458_CR63","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.5664\/jcsm.5274","volume":"11","author":"JJ Sheu","year":"2015","unstructured":"Sheu JJ, Lee HC, Lin HC, Kao LT, Chung SD. A 5-year follow-up study on the relationship between obstructive sleep apnea and Parkinson disease. J Clin Sleep Med. 2015;11(12):1403\u20138. doi: 10.5664\/jcsm.5274 .","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"458_CR64","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5664\/jcsm.1762","volume":"8","author":"C White","year":"2012","unstructured":"White C, Hill EA, Morrison I, Riha RL. Diagnostic delay in REM sleep behavior disorder (RBD). J Clin Sleep Med. 2012;8(2):133\u20136. doi: 10.5664\/jcsm.1762 .","journal-title":"J Clin Sleep Med"},{"key":"458_CR65","unstructured":"Medicine. AAoS. International classification of sleep disorders. 3rd ed. Darien, USA American Academy of Sleep Medicine; 2014."},{"issue":"5","key":"458_CR66","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.sleep.2010.12.009","volume":"12","author":"BF Boeve","year":"2011","unstructured":"Boeve BF, Molano JR, Ferman TJ, Smith GE, Lin SC, Bieniek K, et al. Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Med. 2011;12(5):445\u201353. doi: 10.1016\/j.sleep.2010.12.009 .","journal-title":"Sleep Med"},{"issue":"5","key":"458_CR67","doi-asserted-by":"publisher","first-page":"475","DOI":"10.5664\/jcsm.2670","volume":"9","author":"BF Boeve","year":"2013","unstructured":"Boeve BF, Molano JR, Ferman TJ, Lin SC, Bieniek K, Tippmann-Peikert M, et al. Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in a community-based sample. J Clin Sleep Med. 2013;9(5):475\u201380. doi: 10.5664\/jcsm.2670 .","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"458_CR68","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/mds.25832","volume":"29","author":"SJ Bolitho","year":"2014","unstructured":"Bolitho SJ, Naismith SL, Terpening Z, Grunstein RR, Melehan K, Yee BJ, et al. Investigating rapid eye movement sleep without atonia in Parkinson\u2019s disease using the rapid eye movement sleep behavior disorder screening questionnaire. Mov Disord. 2014;29(6):736\u201342. doi: 10.1002\/mds.25832 .","journal-title":"Mov Disord"},{"key":"458_CR69","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1471-2377-14-76","volume":"14","author":"M Louter","year":"2014","unstructured":"Louter M, Arends JB, Bloem BR, Overeem S. Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson\u2019s disease. BMC Neurol. 2014;14:76. doi: 10.1186\/1471-2377-14-76 .","journal-title":"BMC Neurol"},{"key":"458_CR70","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.sleep.2016.07.004","volume":"24","author":"RB Postuma","year":"2016","unstructured":"Postuma RB, Montplaisir JY. Large-scale population screening for prodromal PD: a way forward becomes clear. Sleep Med. 2016;24:148. doi: 10.1016\/j.sleep.2016.07.004 .","journal-title":"Sleep Med"},{"key":"458_CR71","doi-asserted-by":"crossref","unstructured":"Ohayon MM, Caulet M, Priest RG. Violent behavior during sleep. J Clin Psychiatry 1997;58(8):369\u2013376; quiz 77.","DOI":"10.4088\/JCP.v58n0808"},{"issue":"4","key":"458_CR72","first-page":"513","volume":"23","author":"HF Chiu","year":"2000","unstructured":"Chiu HF, Wing YK, Lam LC, Li SW, Lum CM, Leung T, et al. Sleep-related injury in the elderly\u2014an epidemiological study in Hong Kong. Sleep. 2000;23(4):513\u20137.","journal-title":"Sleep"},{"issue":"8","key":"458_CR73","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.5665\/sleep.2874","volume":"36","author":"SH Kang","year":"2013","unstructured":"Kang SH, Yoon IY, Lee SD, Han JW, Kim TH, Kim KW. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep. 2013;36(8):1147\u201352. doi: 10.5665\/sleep.2874 .","journal-title":"Sleep"},{"issue":"1","key":"458_CR74","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12883-017-0795-4","volume":"17","author":"J Zhang","year":"2017","unstructured":"Zhang J, Xu CY, Liu J. Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson\u2019s disease. BMC Neurol. 2017;17(1):23. doi: 10.1186\/s12883-017-0795-4 .","journal-title":"BMC Neurol"},{"issue":"1","key":"458_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2047-9158-4-1","volume":"4","author":"H Chen","year":"2015","unstructured":"Chen H, Zhao EJ, Zhang W, Lu Y, Liu R, Huang X, et al. Meta-analyses on prevalence of selected Parkinson\u2019s nonmotor symptoms before and after diagnosis. Transl Neurodegener. 2015;4(1):1. doi: 10.1186\/2047-9158-4-1 .","journal-title":"Transl Neurodegener"},{"issue":"3","key":"458_CR76","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/0891988704267465","volume":"17","author":"BF Boeve","year":"2004","unstructured":"Boeve BF, Silber MH, Ferman TJ. REM sleep behavior disorder in Parkinson\u2019s disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol. 2004;17(3):146\u201357. doi: 10.1177\/0891988704267465 .","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"4","key":"458_CR77","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/WNL.48.4.1094","volume":"48","author":"G Plazzi","year":"1997","unstructured":"Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, et al. REM sleep behavior disorders in multiple system atrophy. Neurology. 1997;48(4):1094\u20137.","journal-title":"Neurology"},{"issue":"10","key":"458_CR78","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/mds.26347","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Adler CH, Dugger BN, Hentz JG, Shill HA, Driver-Dunckley E, et al. REM sleep behavior disorder and neuropathology in Parkinson\u2019s disease. Mov Disord. 2015;30(10):1413\u20137. doi: 10.1002\/mds.26347 .","journal-title":"Mov Disord"},{"issue":"4","key":"458_CR79","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2869.2010.00848.x","volume":"19","author":"D Kunz","year":"2010","unstructured":"Kunz D, Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res. 2010;19(4):591\u20136. doi: 10.1111\/j.1365-2869.2010.00848.x .","journal-title":"J Sleep Res"},{"issue":"3","key":"458_CR80","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.sleep.2012.09.018","volume":"14","author":"SJ McCarter","year":"2013","unstructured":"McCarter SJ, Boswell CL, St Louis EK, Dueffert LG, Slocumb N, Boeve BF, et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med. 2013;14(3):237\u201342. doi: 10.1016\/j.sleep.2012.09.018 .","journal-title":"Sleep Med"},{"issue":"1","key":"458_CR81","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5664\/jcsm.27717","volume":"6","author":"RN Aurora","year":"2010","unstructured":"\u2022 Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med. 2010;6(1):85\u201395.This review provides evidence-based guide for symptomatic treatment of RBD with critical appraisal of the clinical trials using different medications.","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"458_CR82","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/ana.24385","volume":"77","author":"RB Postuma","year":"2015","unstructured":"\u2022\u2022 Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, et al. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Ann Neurol. 2015;77(5):830\u20139. doi: 10.1002\/ana.24385 .In this article, original data has been presented on a large multicenter study from 12 different sites on the risk factors of phenoconversion to neurodegenerative state in people with prodromal RBD.","journal-title":"Ann Neurol"},{"issue":"3","key":"458_CR83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1620\/tjem.226.177","volume":"226","author":"T Sasai","year":"2012","unstructured":"Sasai T, Inoue Y, Matsuura M. Effectiveness of pramipexole, a dopamine agonist, on rapid eye movement sleep behavior disorder. Tohoku J Exp Med. 2012;226(3):177\u201381.","journal-title":"Tohoku J Exp Med"},{"issue":"3","key":"458_CR84","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2169\/internalmedicine.55.5464","volume":"55","author":"K Kashihara","year":"2016","unstructured":"Kashihara K, Nomura T, Maeda T, Tsuboi Y, Mishima T, Takigawa H, et al. Beneficial effects of ramelteon on rapid eye movement sleep behavior disorder associated with Parkinson\u2019s disease\u2014results of a multicenter open trial. Intern Med. 2016;55(3):231\u20136. doi: 10.2169\/internalmedicine.55.5464 .","journal-title":"Intern Med"},{"issue":"5","key":"458_CR85","doi-asserted-by":"publisher","first-page":"689","DOI":"10.5664\/jcsm.5796","volume":"12","author":"Y Esaki","year":"2016","unstructured":"Esaki Y, Kitajima T, Koike S, Fujishiro H, Iwata Y, Tsuchiya A, et al. An open-labeled trial of ramelteon in idiopathic rapid eye movement sleep behavior disorder. J Clin Sleep Med. 2016;12(5):689\u201393. doi: 10.5664\/jcsm.5796 .","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"458_CR86","doi-asserted-by":"publisher","first-page":"e89741","DOI":"10.1371\/journal.pone.0089741","volume":"9","author":"A Iranzo","year":"2014","unstructured":"Iranzo A, Fernandez-Arcos A, Tolosa E, Serradell M, Molinuevo JL, Valldeoriola F, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One. 2014;9(2):e89741. doi: 10.1371\/journal.pone.0089741 .","journal-title":"PLoS One"},{"issue":"11","key":"458_CR87","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1212\/WNL.0000000000001364","volume":"84","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Gagnon JF, Bertrand JA, Genier Marchand D, Montplaisir JY. Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. Neurology. 2015;84(11):1104\u201313. doi: 10.1212\/WNL.0000000000001364 .","journal-title":"Neurology"},{"issue":"8","key":"458_CR88","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.sleep.2012.10.009","volume":"14","author":"CH Schenck","year":"2013","unstructured":"Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744\u20138. doi: 10.1016\/j.sleep.2012.10.009 .","journal-title":"Sleep Med"},{"issue":"4","key":"458_CR89","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1136\/jnnp-2011-301232","volume":"83","author":"YK Wing","year":"2012","unstructured":"Wing YK, Li SX, Mok V, Lam SP, Tsoh J, Chan A, et al. Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 2012;83(4):470\u20132. doi: 10.1136\/jnnp-2011-301232 .","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"458_CR90","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1212\/WNL.0000000000001265","volume":"84","author":"P Mahlknecht","year":"2015","unstructured":"Mahlknecht P, Iranzo A, Hogl B, Frauscher B, Muller C, Santamaria J, et al. Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD. Neurology. 2015;84(7):654\u20138. doi: 10.1212\/WNL.0000000000001265 .","journal-title":"Neurology"},{"key":"458_CR91","doi-asserted-by":"crossref","unstructured":"Li Y, Kang Y, Yang Q, Zhang L, Zhang L, Dong F et al. Predictive markers for early conversion of iRBD to neurodegenerative synucleinopathy diseases. Neurology. 2017;[in press].","DOI":"10.1212\/WNL.0000000000003838"},{"key":"458_CR92","doi-asserted-by":"crossref","unstructured":"Fereshtehnejad SM, Montplaisir JY, Pelletier A, Gagnon JF, Berg D, Postuma RB. Validation of the MDS research criteria for prodromal Parkinson\u2019s disease: longitudinal assessment in a REM sleep behavior disorder (RBD) cohort. Mov Disord. 2017:[Submitted].","DOI":"10.1002\/mds.26989"},{"issue":"12","key":"458_CR93","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/mds.26431","volume":"30","author":"D Berg","year":"2015","unstructured":"\u2022 Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B, et al. MDS research criteria for prodromal Parkinson\u2019s disease. Mov Disord. 2015;30(12):1600\u201311. doi: 10.1002\/mds.26431 .In this methodologic article, the Movement Disorders Society has introduced the research criteria for prodromal PD, consisting of two sleep disorders, RBD and excessive daytime somnolence.","journal-title":"Mov Disord"},{"key":"458_CR94","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1749-6632.2009.05115.x","volume":"1184","author":"BF Boeve","year":"2010","unstructured":"Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15\u201354. doi: 10.1111\/j.1749-6632.2009.05115.x .","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"458_CR95","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1055\/s-0029-1237118","volume":"29","author":"JM Siegel","year":"2009","unstructured":"Siegel JM. The neurobiology of sleep. Semin Neurol. 2009;29(4):277\u201396. doi: 10.1055\/s-0029-1237118 .","journal-title":"Semin Neurol"},{"issue":"29","key":"458_CR96","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1523\/JNEUROSCI.0737-09.2009","volume":"29","author":"R Vetrivelan","year":"2009","unstructured":"Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci. 2009;29(29):9361\u20139. doi: 10.1523\/JNEUROSCI.0737-09.2009 .","journal-title":"J Neurosci"}],"container-title":["Current Treatment Options in Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11940-017-0458-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11940-017-0458-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11940-017-0458-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T18:06:57Z","timestamp":1602007617000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11940-017-0458-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":96,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["458"],"URL":"https:\/\/doi.org\/10.1007\/s11940-017-0458-1","relation":{},"ISSN":["1092-8480","1534-3138"],"issn-type":[{"value":"1092-8480","type":"print"},{"value":"1534-3138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]},"article-number":"22"}}