{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:18:24Z","timestamp":1782584304752,"version":"3.54.5"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Orthop Relat Res"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s11999-009-1076-3","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T18:37:01Z","timestamp":1252521421000},"page":"3273-3282","source":"Crossref","is-referenced-by-count":51,"title":["Differential Expression of Vascular Endothelial Growth Factor in Glucocorticoid-related Osteonecrosis of the Femoral Head"],"prefix":"10.1097","volume":"467","author":[{"given":"Deike","family":"Varoga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf","family":"Drescher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Pufe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godo","family":"Groth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pufe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2009,9,10]]},"reference":[{"key":"1076_CR1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1210\/endo.142.2.8112","volume":"142","author":"N Akeno","year":"2001","unstructured":"Akeno N, Czyzyk-Krzeska MF, Gross TS, Clemens TL. Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha. Endocrinology. 2001;142:959\u2013962.","journal-title":"Endocrinology."},{"key":"1076_CR2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.aanat.2008.02.004","volume":"190","author":"MJ Blumer","year":"2008","unstructured":"Blumer MJ, Longato S, Fritsch H. Structure, formation and role of cartilage canals in the developing bone. Ann Anat. 2008;190:305\u2013315.","journal-title":"Ann Anat."},{"key":"1076_CR3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1177\/154405910708601006","volume":"86","author":"J Dai","year":"2007","unstructured":"Dai J, Rabie AB. VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res. 2007;86:937\u2013950.","journal-title":"J Dent Res"},{"key":"1076_CR4","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1312256","volume":"255","author":"C Vries de","year":"1992","unstructured":"de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992;255:989\u2013991.","journal-title":"Science"},{"key":"1076_CR5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s001099900019","volume":"77","author":"N Ferrara","year":"1999","unstructured":"Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 1999;77:527\u2013543.","journal-title":"J Mol Med"},{"key":"1076_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/0301-620X.67B1.3155745","volume":"67","author":"RP Ficat","year":"1985","unstructured":"Ficat RP. Idiopathic bone necrosis of the femoral head: early diagnosis and treatment. J Bone Joint Surg Br. 1985;67:3\u20139.","journal-title":"J Bone Joint Surg Br"},{"key":"1076_CR7","first-page":"18","volume":"66","author":"JW Gardeniers","year":"1992","unstructured":"Gardeniers JW. A new international classification of osteonecrosis of the ARCO Committee on terminology and classification. J Jpn Orthop Assoc. 1992;66:18\u201320.","journal-title":"J Jpn Orthop Assoc."},{"key":"1076_CR8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","volume":"5","author":"HP Gerber","year":"1999","unstructured":"Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999;5:623\u2013628.","journal-title":"Nat Med"},{"key":"1076_CR9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-199701000-00007","volume":"334","author":"CJ Glueck","year":"1997","unstructured":"Glueck CJ, Freiberg R, Tracy T, Stroop D, Wang P. Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis. Clin Orthop Relat Res. 1997;334:43\u201356.","journal-title":"Clin Orthop Relat Res"},{"key":"1076_CR10","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1172\/JCI117258","volume":"93","author":"S Harada","year":"1994","unstructured":"Harada S, Nagy JA, Sullivan KA, Thomas KA, Endo N, Rodan GA, Rodan SB. Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest. 1994;93:2490\u20132496.","journal-title":"J Clin Invest"},{"key":"1076_CR11","first-page":"76","volume":"313","author":"S Harada","year":"1995","unstructured":"Harada S, Rodan SB, Rodan GA. Expression and regulation of vascular endothelial growth factor in osteoblasts. Clin Orthop Relat Res. 1995;313:76\u201380.","journal-title":"Clin Orthop Relat Res"},{"key":"1076_CR12","first-page":"41","volume":"277","author":"JP Jones Jr","year":"1992","unstructured":"Jones JP Jr. Intravascular coagulation and osteonecrosis. Clin Orthop Relat Res. 1992;277:41\u201353.","journal-title":"Clin Orthop Relat Res"},{"key":"1076_CR13","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1177\/00220345010800100401","volume":"80","author":"M Kaku","year":"2001","unstructured":"Kaku M, Kohno S, Kawata T, Fujita I, Tokimasa C, Tsutsui K, Tanne K. Effects of vascular endothelial growth factor on osteoclast induction during tooth movement in mice. J Dent Res. 2001;80:1880\u20131883.","journal-title":"J Dent Res"},{"key":"1076_CR14","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1359\/jbmr.040911","volume":"19","author":"HK Kim","year":"2004","unstructured":"Kim HK, Bian H, Randall T, Garces A, Gerstenfeld LC, Einhorn TA. Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis. J Bone Miner Res. 2004;19:2041\u20132048.","journal-title":"J Bone Miner Res"},{"key":"1076_CR15","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.2106\/00004623-198769080-00017","volume":"69","author":"J Landmann","year":"1987","unstructured":"Landmann J, Renner N, Gachter A, Thiel G, Harder F. Cyclosporin A and osteonecrosis of the femoral head. J Bone Joint Surg Am. 1987;69:1226\u20131228.","journal-title":"J Bone Joint Surg Am"},{"key":"1076_CR16","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s001980200120","volume":"13","author":"P Martinez","year":"2002","unstructured":"Martinez P, Esbrit P, Rodrigo A, Alvarez-Arroyo MV, Martinez ME. Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells. Osteoporos Int. 2002;13:874\u2013881.","journal-title":"Osteoporos Int"},{"key":"1076_CR17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/labinvest.3780017","volume":"80","author":"K Migita","year":"2000","unstructured":"Migita K, Tanaka H, Okamoto K, Yoshikawa N, Ichinose Y, Urayama S, Yamasaki S, Ida H, Kawabe Y, Kawakami A, Eguchi K. FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts. Lab Invest. 2000;80:135\u2013141.","journal-title":"Lab Invest"},{"key":"1076_CR18","first-page":"79","volume":"277","author":"K Ohzono","year":"1992","unstructured":"Ohzono K, Takaoka K, Saito S, Saito M, Matsui M, Ono K. Intraosseous arterial architecture in nontraumatic avascular necrosis of the femoral head: microangiographic and histologic study. Clin Orthop Relat Res. 1992;277:79\u201388.","journal-title":"Clin Orthop Relat Res"},{"key":"1076_CR19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S8756-3282(00)80937-0","volume":"26","author":"AM Parfitt","year":"2000","unstructured":"Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone. 2000;26:319\u2013323.","journal-title":"Bone."},{"key":"1076_CR20","first-page":"389","volume":"29","author":"H Plenk Jr","year":"2000","unstructured":"Plenk H Jr, Hofmann S, Breitenseher M, Urban M. [Pathomorphological aspects and repair mechanisms of femur head necrosis] [in German]. Orthopade. 2000;29:389\u2013402.","journal-title":"Orthopade."},{"key":"1076_CR21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00223-006-0275-0","volume":"80","author":"T Pufe","year":"2007","unstructured":"Pufe T, Claassen H, Scholz-Ahrens KE, Varoga D, Drescher W, Franke AT, Wruck C, Petersen W, Cellarius C, Schrezenmeir J, Gl\u00fcer CC. Influence of estradiol on vascular endothelial growth factor expression in bone: a study in G\u00f6ttingen miniature pigs and human osteoblasts. Calcif Tissue Int. 2007;80:184\u2013191.","journal-title":"Calcif Tissue Int"},{"key":"1076_CR22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.1527","volume":"202","author":"T Pufe","year":"2004","unstructured":"Pufe T, Harde V, Petersen W, Goldring M, Tillmann B, Mentlein R. Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes. J Pathol. 2004;202:367\u2013374.","journal-title":"J Pathol"},{"key":"1076_CR23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bone.2003.08.002","volume":"33","author":"T Pufe","year":"2003","unstructured":"Pufe T, Scholz-Ahrens KE, Franke AT, Petersen W, Mentlein R, Varoga D, Tillmann B, Schrezenmeir J, Gl\u00fcer CC. The role of vascular endothelial growth factor in glucocorticoid-induced bone loss: evaluation in a minipig model. Bone. 2003;33:869\u2013876.","journal-title":"Bone."},{"key":"1076_CR24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00441-002-0605-0","volume":"309","author":"T Pufe","year":"2002","unstructured":"Pufe T, Wildemann B, Petersen W, Mentlein R, Raschke M, Schmidmaier G. Quantitative measurement of the splice variants 120 and 164 of the angiogenic peptide vascular endothelial growth factor in the time flow of fracture healing: a study in the rat. Cell Tissue Res. 2002;309:387\u2013392.","journal-title":"Cell Tissue Res"},{"key":"1076_CR25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1079\/BJN2002661","volume":"88","author":"KE Scholz-Ahrens","year":"2002","unstructured":"Scholz-Ahrens KE, Acil Y, Schrezenmeir J. Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats. Br J Nutr. 2002;88:365\u2013377.","journal-title":"Br J Nutr"},{"key":"1076_CR26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2106\/00004623-197961060-00008","volume":"61","author":"PJ Stern","year":"1979","unstructured":"Stern PJ, Watts HG. Osteonecrosis after renal transplantation in children. J Bone Joint Surg Am. 1979;61:851\u2013856.","journal-title":"J Bone Joint Surg Am"},{"key":"1076_CR27","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/0006-291X(92)90483-2","volume":"187","author":"BI Terman","year":"1992","unstructured":"Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, B\u00f6hlen P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun. 1992;187:1579\u20131586.","journal-title":"Biochem Biophys Res Commun"},{"key":"1076_CR28","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1359\/jbmr.2000.15.12.2371","volume":"15","author":"H Tokuda","year":"2000","unstructured":"Tokuda H, Kozawa O, Uematsu T. Basic fibroblast growth factor stimulates vascular endothelial growth factor release in osteoblasts: divergent regulation by p42\/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase. J Bone Miner Res. 2000;15:2371\u20132379.","journal-title":"J Bone Miner Res"},{"key":"1076_CR29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1302\/0301-620X.45B2.402","volume":"45","author":"J Trueta","year":"1963","unstructured":"Trueta J. The role of the vessels in osteogenesis. J Bone Joint Surg Br. 1963;45:402\u2013418.","journal-title":"J Bone Joint Surg Br"},{"key":"1076_CR30","first-page":"6","volume":"334","author":"J Trueta","year":"1997","unstructured":"Trueta J. The normal vascular anatomy of the femoral head in adult man. 1953. Clin Orthop Relat Res. 1997;334:6\u201314.","journal-title":"Clin Orthop Relat Res"},{"key":"1076_CR31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1302\/0301-620X.42B3.571","volume":"42","author":"J Trueta","year":"1960","unstructured":"Trueta J, Amato VP. The vascular contribution to osteogenesis. J Bone Joint Surg Br. 1960;42:571\u2013587.","journal-title":"J Bone Joint Surg Br"},{"key":"1076_CR32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0272-6386(99)70414-2","volume":"33","author":"DL Veenstra","year":"1999","unstructured":"Veenstra DL, Best JH, Hornberger J, Sullivan SD, Hricik DE. Incidence and long-term cost of steroid-related side effects after renal transplantation. Am J Kidney Dis. 1999;33:829\u2013839.","journal-title":"Am J Kidney Dis"},{"key":"1076_CR33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.matbio.2008.06.005","volume":"27","author":"Q Yang","year":"2008","unstructured":"Yang Q, McHugh KP, Patntirapong S, Gu X, Wunderlich L, Hauschka PV. VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and \u03b23-integrin. Matrix Biol. 2008;27:589\u2013599.","journal-title":"Matrix Biol"}],"container-title":["Clinical Orthopaedics and Related Research\u00ae"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003086-200912000-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:35:02Z","timestamp":1617928502000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11999-009-1076-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,10]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["1076"],"URL":"https:\/\/doi.org\/10.1007\/s11999-009-1076-3","relation":{},"ISSN":["0009-921X","1528-1132"],"issn-type":[{"value":"0009-921X","type":"print"},{"value":"1528-1132","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,10]]}}}