{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:38:55Z","timestamp":1793709535029,"version":"4.6.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s11999-010-1645-5","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T11:41:36Z","timestamp":1288698096000},"page":"113-122","source":"Crossref","is-referenced-by-count":76,"title":["Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis"],"prefix":"10.1097","volume":"469","author":[{"given":"Pei-Gen","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afraaz","family":"Irani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Biswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210317","first-page":"7","article-title":"Amstutz, HC., Campbell, P., Kossovsky, N. and Clarke, IC. Mechanism and clinical significance of wear debris-induced osteolysis.","volume":"276","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"R2-18-20210317","first-page":"185","article-title":"Archibeck, MJ., Jacobs, JJ., Roebuck, KA. and Glant, TT. The basic science of periprosthetic osteolysis.","volume":"50","year":"2001","journal-title":"Instr Course Lect"},{"key":"R3-18-20210317","first-page":"57","article-title":"Athanasou, NA., Quinn, J. and Bulstrode, CJ. Resorption of bone by inflammatory cells derived from the joint capsule of hip arthroplasties.","volume":"74","year":"1992","journal-title":"J Bone Joint Surg Br"},{"key":"R26-18-20210317","first-page":"250","article-title":"Ma, T., Ortiz, SG., Huang, Z., Ren, P., Smith, RL. and Goodman, SB. In vivo murine model of continuous intramedullary infusion of particlesa preliminary study.","volume":"88","year":"2009","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"R28-18-20210317","first-page":"19","article-title":"Mansfield, JR., Hoyt, C. and Levenson, RM. Visualization of microscopy-based spectral imaging data from multi-label tissue sections.","volume":"14","year":"2008","journal-title":"Curr Protoc Mol Biol"},{"key":"R30-18-20210317","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2106\/00004623-200306000-00018","article-title":"Orishimo, KF., Claus, AM., Sychterz, CJ. and Engh, CA. Relationship between polyethylene wear and osteolysis in hips with a second-generation porous-coated cementless cup after seven years of follow-up.","volume":"85","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"R31-18-20210317","first-page":"328","article-title":"Ortiz, SG., Ma, T., Epstein, NJ., Smith, RL. and Goodman, SB. Validation and quantification of an in vitro model of continuous infusion of submicron-sized particles.","volume":"84","year":"2008","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"R32-18-20210317","first-page":"440","article-title":"Ortiz, SG., Ma, T., Regula, D., Smith, RL. and Goodman, SB. Continuous intramedullary polymer particle infusion using a murine femoral explant model.","volume":"87","year":"2008","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"R35-18-20210317","first-page":"652","article-title":"Quinn, J., Joyner, C., Triffitt, JT. and Athanasou, NA. Polymethylmethacrylate-induced inflammatory macrophages resorb bone.","volume":"74","year":"1992","journal-title":"J Bone Joint Surg Br"},{"key":"R37-18-20210317","first-page":"1043","article-title":"Ren, W., Markel, DC., Schwendener, R., Ding, Y., Wu, B. and Wooley, PH. Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model.","volume":"85","year":"2008","journal-title":"J Biomed Mater Res A"},{"key":"R41-18-20210317","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2106\/00004623-199274060-00006","article-title":"Schmalzried, TP., Jasty, M. and Harris, TP. Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space.","volume":"74","year":"1992","journal-title":"J Bone Joint Surg Am"}],"container-title":["Clinical Orthopaedics & Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003086-201101000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:42:12Z","timestamp":1786041732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003086-201101000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1007\/s11999-010-1645-5","relation":{},"ISSN":["0009-921X"],"issn-type":[{"value":"0009-921X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}