{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:23:20Z","timestamp":1791347000208,"version":"4.3.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["81301585"],"award-info":[{"award-number":["81301585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ13H060001"],"award-info":[{"award-number":["LQ13H060001"]}]},{"name":"Zhejiang medical and health science and technology project","award":["2013KYA112"],"award-info":[{"award-number":["2013KYA112"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s11999-016-4866-4","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T14:06:29Z","timestamp":1462370789000},"page":"1818-1826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The NLRP3\/Caspase-1\/Interleukin-1\u03b2 Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration"],"prefix":"10.1097","volume":"474","author":[{"given":"Pan","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Wu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210317","first-page":"2151","article-title":"What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976).","volume":"31","author":"Adams","year":"2006","journal-title":""},{"key":"R5-14-20210317","first-page":"1307","article-title":"Aging and degeneration of the human intervertebral disc. Spine (Phila Pa 1976).","volume":"20","author":"Buckwalter","year":"1995","journal-title":""},{"key":"R6-14-20210317","first-page":"E817","article-title":"Upregulation of tumor necrosis factor alpha and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes. Spine (Phila Pa 1976).","volume":"39","author":"Chen","year":"2014","journal-title":""},{"key":"R7-14-20210317","first-page":"96124374746301","article-title":"Modic changes and disc degeneration caused by inoculation of Propionibacterium acnes inside intervertebral discs of rabbits: a pilot study.","volume":"2016","author":"Chen","year":"2016","journal-title":"Biomed Res Int"},{"key":"R10-14-20210317","first-page":"650","article-title":"Internal disc disruption: a challenge to disc prolapse fifty years on. Spine (Phila Pa 1976).","volume":"11","author":"Crock","year":"1986","journal-title":""},{"key":"R15-14-20210317","first-page":"2543","article-title":"2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine (Phila Pa 1976).","volume":"26","author":"Horner","year":"2001","journal-title":""},{"key":"R20-14-20210317","first-page":"2276","article-title":"The increased signal intensity at the vertebral body endplates after chemonucleolysis demonstrated by magnetic resonance imaging. Spine (Phila Pa 1976).","volume":"18","author":"Kato","year":"1993","journal-title":""},{"key":"R32-14-20210317","first-page":"1355","article-title":"Molecular interactions between human cartilaginous endplates and nucleus pulposus cells. Spine (Phila Pa 1976).","volume":"39","author":"Neidlinger-Wilke","year":"2014","journal-title":""},{"key":"R33-14-20210317","first-page":"1026","article-title":"Tumor necrosis factor-immunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic type 1 or type 2 changes on MRI. Spine (Phila Pa 1976).","volume":"31","author":"Ohtori","year":"2006","journal-title":""},{"key":"R34-14-20210317","first-page":"771","article-title":"Effects of endplate removal on the structural properties of the lower lumbar vertebral bodies. Spine (Phila Pa 1976).","volume":"28","author":"Oxland","year":"2003","journal-title":""},{"key":"R45-14-20210317","first-page":"2700","article-title":"Nutrition of the intervertebral disc. Spine (Phila Pa 1976).","volume":"29","author":"Urban","year":"2004","journal-title":""},{"key":"R47-14-20210317","first-page":"1958","article-title":"Prevalence of vertebral endplate modic changes in degenerative lumbar scoliosis and its associated factors analysis. Spine (Phila Pa 1976).","volume":"37","author":"Wu","year":"2012","journal-title":""}],"container-title":["Clinical Orthopaedics &amp; Related Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11999-016-4866-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11999-016-4866-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1007\/s11999-016-4866-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T16:19:42Z","timestamp":1620922782000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003086-201608000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1007\/s11999-016-4866-4","relation":{},"ISSN":["0009-921X"],"issn-type":[{"value":"0009-921X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}