{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:23:13Z","timestamp":1791328993571,"version":"4.3.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T00:00:00Z","timestamp":1407542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s12010-014-1084-y","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T06:02:27Z","timestamp":1407477747000},"page":"1309-1330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Chitosan-Assisted Immunotherapy for Intervention of Experimental Leishmaniasis via Amphotericin B-Loaded Solid Lipid Nanoparticles"],"prefix":"10.1007","volume":"174","author":[{"given":"Vineet","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek K.","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Asthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K.","family":"Chourasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,9]]},"reference":[{"key":"1084_CR1","doi-asserted-by":"crossref","first-page":"805108","DOI":"10.1155\/2013\/805108","volume":"2013","author":"A Strazzulla","year":"2013","unstructured":"Strazzulla, A., Cocuzza, S., Pinzone, M. R., Postorino, M. C., Cosentino, S., Serra, A., Cacopardo, B., & Nunnari, G. (2013). Mucosal leishmaniasis: an underestimated presentation of a neglected disease. BioMed Research International, 2013, 805108.","journal-title":"BioMed Research International"},{"key":"1084_CR2","first-page":"238","volume":"119","author":"A Awasthi","year":"2004","unstructured":"Awasthi, A., Mathur, R. K., & Saha, B. (2004). Immune response to Leishmania infection. The Indian Journal of Medical Research, 119, 238\u2013258.","journal-title":"The Indian Journal of Medical Research"},{"key":"1084_CR3","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","volume":"366","author":"HW Murray","year":"2005","unstructured":"Murray, H. W., Berman, J. D., Davies, C. R., & Saravia, N. G. (2005). Advances in leishmaniasis. Lancet, 366, 1561\u20131577.","journal-title":"Lancet"},{"key":"1084_CR4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2011.05.011","volume":"51","author":"T Assche Van","year":"2011","unstructured":"Van Assche, T., Deschacht, M., da Luz, R. A., Maes, L., & Cos, P. (2011). Leishmania-macrophage interactions: insights into the redox biology. Free Radical Biology, 51, 337\u2013351.","journal-title":"Free Radical Biology"},{"key":"1084_CR5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/138920009788898019","volume":"10","author":"M Baginski","year":"2009","unstructured":"Baginski, M., & Czub, J. (2009). Amphotericin B and its new derivatives\u2014mode of action. Current Drug Metabolism, 10, 459\u2013469.","journal-title":"Current Drug Metabolism"},{"key":"1084_CR6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0966-842X(03)00117-3","volume":"11","author":"FC Odds","year":"2003","unstructured":"Odds, F. C., Brown, A. J. P., & Gow, N. A. R. (2003). Antifungal agents: mechanisms of action. Trends in Microbiology, 11, 272\u2013279.","journal-title":"Trends in Microbiology"},{"key":"1084_CR7","doi-asserted-by":"crossref","first-page":"18266","DOI":"10.1021\/ja1074344","volume":"132","author":"A Neumann","year":"2010","unstructured":"Neumann, A., Baginski, M., & Czub, J. (2010). How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its membrane targets. Journal of the American Chemical Society, 132, 18266\u201318272.","journal-title":"Journal of the American Chemical Society"},{"key":"1084_CR8","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/j.bbamem.2007.06.017","volume":"1768","author":"J Czub","year":"2007","unstructured":"Czub, J., Borowski, E., & Baginski, M. (2007). Interactions of amphotericin B derivatives with lipid membranes\u2014a molecular dynamics study. Biochimica et Biophysica, 1768, 2616\u20132626.","journal-title":"Biochimica et Biophysica"},{"key":"1084_CR9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1128\/AAC.34.2.183","volume":"34","author":"J Brajtburg","year":"1990","unstructured":"Brajtburg, J., Powderly, W. G., Kobayashi, G. S., & Medoff, G. (1990). Amphotericin B: current understanding of mechanisms of action. Antimicrobial Agents and Chemotherapy, 34, 183\u2013188.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"1084_CR10","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/mp300320d","volume":"9","author":"S Jain","year":"2012","unstructured":"Jain, S., Valvi, P. U., Swarnakar, N. K., & Thanki, K. (2012). Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B. Molecular Pharmaceutics, 9, 2542\u20132553.","journal-title":"Molecular Pharmaceutics"},{"key":"1084_CR11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ijpharm.2013.07.035","volume":"454","author":"TTH Pham","year":"2013","unstructured":"Pham, T. T. H., Loiseau, P. M., & Barratt, G. (2013). Strategies for the design of orally bioavailable antileishmanial treatments. International Journal of Pharmaceutics, 454, 539\u2013552.","journal-title":"International Journal of Pharmaceutics"},{"key":"1084_CR12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1166\/jbn.2011.1332","volume":"7","author":"PA Patel","year":"2011","unstructured":"Patel, P. A., & Patravale, V. B. (2011). AmbiOnp: solid lipid nanoparticles of amphotericin B for oral administration. Journal of Biomedical Nanotechnology, 7, 632\u2013639.","journal-title":"Journal of Biomedical Nanotechnology"},{"key":"1084_CR13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/10717540590952591","volume":"12","author":"SK Jain","year":"2005","unstructured":"Jain, S. K., Chourasia, M. K., Masuriha, R., Soni, V., Jain, A., Jain, N. K., & Gupta, Y. (2005). Solid lipid nanoparticles bearing flurbiprofen for transdermal delivery. Drug Delivery, 12, 207\u2013215.","journal-title":"Drug Delivery"},{"key":"1084_CR14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpharm.2004.07.019","volume":"284","author":"JE Kipp","year":"2004","unstructured":"Kipp, J. E. (2004). The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. International Journal of Pharmaceutics, 284, 109\u2013122.","journal-title":"International Journal of Pharmaceutics"},{"key":"1084_CR15","doi-asserted-by":"crossref","first-page":"750891","DOI":"10.1155\/2012\/750891","volume":"2012","author":"P Severino","year":"2012","unstructured":"Severino, P., Andreani, T., Macedo, A. S., Fangueiro, J. F., Santana, M. H., Silva, A. M., & Souto, E. B. (2012). Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. Journal of Drug Delivery, 2012, 750891.","journal-title":"Journal of Drug Delivery"},{"key":"1084_CR16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ejps.2009.02.021","volume":"37","author":"SH Jung","year":"2009","unstructured":"Jung, S. H., Lim, D. H., Jung, S. H., Lee, J. E., Jeong, K.-S., Seong, H., & Shin, B. C. (2009). Amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics. European Journal of Pharmaceutical Sciences, 37, 313\u2013320.","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"1084_CR17","first-page":"567","volume":"40","author":"ZX Ma","year":"2011","unstructured":"Ma, Z. X., & Zhao, L. H. (2011). Polysaccharides activate signaling pathways of macrophage. Zhejiang Da Xue Xue Bao. Yi Xue Ban, 40, 567\u2013572.","journal-title":"Zhejiang Da Xue Xue Bao. Yi Xue Ban"},{"key":"1084_CR18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-3659(01)00549-1","volume":"79","author":"F Ahsan","year":"2002","unstructured":"Ahsan, F., Rivas, I. P., Khan, M. A., & Torres Su\u00e1rez, A. I. (2002). Targeting to macrophages: role of physicochemical properties of particulate carriers\u2014liposomes and microspheres\u2014on the phagocytosis by macrophages. Journal of Controlled Release, 79, 29\u201340.","journal-title":"Journal of Controlled Release"},{"key":"1084_CR19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/cmi.2009.6","volume":"6","author":"G Li","year":"2009","unstructured":"Li, G., Liu, Z., Liao, B., & Zhong, N. (2009). Induction of Th1-type immune response by chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen Der p 2 for oral vaccination in mice. Cellular & Molecular Immunology, 6, 45\u201350.","journal-title":"Cellular & Molecular Immunology"},{"key":"1084_CR20","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1128\/AAC.01984-12","volume":"57","author":"S Asthana","year":"2013","unstructured":"Asthana, S., Jaiswal, A. K., Gupta, P. K., Pawar, V. K., Dube, A., & Chourasia, M. K. (2013). Immunoadjuvant chemotherapy of visceral leishmaniasis in hamsters using amphotericin B encapsulated nano-emulsion template based chitosan nanocapsules. Antimicrobial Agents and Chemotherapy, 57, 1714\u20131722.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"1084_CR21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/02652048.2011.559281","volume":"28","author":"S Kunjachan","year":"2011","unstructured":"Kunjachan, S., Gupta, S., Dwivedi, A. K., Dube, A., & Chourasia, M. K. (2011). Chitosan-based macrophage-mediated drug targeting for the treatment of experimental visceral leishmaniasis. Journal of Microencapsulation, 28, 301\u2013310.","journal-title":"Journal of Microencapsulation"},{"key":"1084_CR22","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jconrel.2004.01.005","volume":"95","author":"V Venkateswarlu","year":"2004","unstructured":"Venkateswarlu, V., & Manjunath, K. (2004). Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. Journal of Controlled Release, 95, 627\u2013638.","journal-title":"Journal of Controlled Release"},{"key":"1084_CR23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s11095-008-9800-3","volume":"26","author":"C Vauthier","year":"2009","unstructured":"Vauthier, C., & Bouchemal, K. (2009). Methods for the preparation and manufacture of polymeric nanoparticles. Pharmaceutical Research, 26, 1025\u20131058.","journal-title":"Pharmaceutical Research"},{"key":"1084_CR24","doi-asserted-by":"crossref","first-page":"E903","DOI":"10.1208\/aapsj070488","volume":"7","author":"C Silva","year":"2005","unstructured":"Silva, C., Ribeiro, A., Figueiredo, M., Ferreira, D., & Veiga, F. (2005). Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification\/internal gelation. The AAPS Journal, 7, E903\u2013E913.","journal-title":"The AAPS Journal"},{"key":"1084_CR25","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ejpb.2007.12.003","volume":"69","author":"L Zhang","year":"2008","unstructured":"Zhang, L., Liu, L., Qian, Y., & Chen, Y. (2008). The effects of cryoprotectants on the freeze-drying of ibuprofen-loaded solid lipid microparticles (SLM). European Journal of Pharmaceutics and Biopharmaceutics, 69, 750\u2013759.","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"1084_CR26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0168-3659(94)90047-7","volume":"30","author":"C Schwarz","year":"1994","unstructured":"Schwarz, C., Mehnert, W., Lucks, J. S., & M\u00fcller, R. H. (1994). Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. Journal of Controlled Release, 30, 83\u201396.","journal-title":"Journal of Controlled Release"},{"key":"1084_CR27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rinphs.2011.10.002","volume":"1","author":"MK Chourasia","year":"2011","unstructured":"Chourasia, M. K., Kang, L., & Chan, S. Y. (2011). Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results in Pharma Sciences, 1, 60\u201367.","journal-title":"Results in Pharma Sciences"},{"key":"1084_CR28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s11095-006-9222-z","volume":"24","author":"KK Nishi","year":"2007","unstructured":"Nishi, K. K., Antony, M., Mohanan, P. V., Anilkumar, T. V., Loiseau, P. M., & Jayakrishnan, A. (2007). Amphotericin B-gum arabic conjugates: synthesis, toxicity, bioavailability, and activities against Leishmania and fungi. Pharmaceutical Research, 24, 971\u2013980.","journal-title":"Pharmaceutical Research"},{"key":"1084_CR29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0168-3659(99)00007-3","volume":"59","author":"SC Yang","year":"1999","unstructured":"Yang, S. C., Lu, L. F., Cai, Y., Zhu, J. B., Liang, B. W., & Yang, C. Z. (1999). Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. Journal of Controlled Release, 59, 299\u2013307.","journal-title":"Journal of Controlled Release"},{"key":"1084_CR30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1166\/jbn.2011.1196","volume":"7","author":"P Singh","year":"2011","unstructured":"Singh, P., Gupta, A., Jaiswal, A., Dube, A., Mishra, S., & Chaurasia, M. K. (2011). Design and development of amphotericin B bearing polycaprolactone microparticles for macrophage targeting. Journal of Biomedical Nanotechnology, 7, 50\u201351.","journal-title":"Journal of Biomedical Nanotechnology"},{"key":"1084_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.exppara.2012.11.014","volume":"133","author":"S Elcicek","year":"2013","unstructured":"Elcicek, S., Bagirova, M., & Allahverdiyev, A. M. (2013). Generation of avirulent Leishmania parasites and induction of nitric oxide production in macrophages by using polyacrylic acid. Experimental Parasitology, 133, 237\u2013242.","journal-title":"Experimental Parasitology"},{"key":"1084_CR32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1517\/17425247.2013.751370","volume":"10","author":"NK Jain","year":"2013","unstructured":"Jain, N. K., Mishra, V., & Mehra, N. K. (2013). Targeted drug delivery to macrophages. Expert Opinion on Drug Delivery, 10, 353\u2013367.","journal-title":"Expert Opinion on Drug Delivery"},{"key":"1084_CR33","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.vaccine.2006.11.034","volume":"25","author":"DA Zaharoff","year":"2007","unstructured":"Zaharoff, D. A., Rogers, C. J., Hance, K. W., Schlom, J., & Greiner, J. W. (2007). Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. Vaccine, 25, 2085\u20132094.","journal-title":"Vaccine"},{"key":"1084_CR34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/AAC.27.2.172","volume":"27","author":"J Brajtburg","year":"1985","unstructured":"Brajtburg, J., Elberg, S., Schwartz, D. R., Vertut-Croquin, A., Schlessinger, D., Kobayashi, G. S., & Medoff, G. (1985). Involvement of oxidative damage in erythrocyte lysis induced by amphotericin B. Antimicrobial Agents and Chemotherapy, 27, 172\u2013176.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"1084_CR35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/la0520029","volume":"22","author":"H Takahashi","year":"2005","unstructured":"Takahashi, H., Niidome, Y., Niidome, T., Kaneko, K., Kawasaki, H., & Yamada, S. (2005). Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity. Langmuir, 22, 2\u20135.","journal-title":"Langmuir"},{"key":"1084_CR36","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jbm.1270","volume":"59","author":"PJ VandeVord","year":"2002","unstructured":"VandeVord, P. J., Matthew, H. W. T., DeSilva, S. P., Mayton, L., Wu, B., & Wooley, P. H. (2002). Evaluation of the biocompatibility of a chitosan scaffold in mice. Journal of Biomedical Materials Research, 59, 585\u2013590.","journal-title":"Journal of Biomedical Materials Research"},{"key":"1084_CR37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1292\/jvms.67.51","volume":"67","author":"T Mori","year":"2005","unstructured":"Mori, T., Murakami, M., Okumura, M., Kadosawa, T., Uede, T., & Fujinaga, T. (2005). Mechanism of macrophage activation by chitin derivatives. The Journal of Veterinary Medical Science, 67, 51\u201356.","journal-title":"The Journal of Veterinary Medical Science"},{"key":"1084_CR38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/bj2770451","volume":"277","author":"N Basu","year":"1991","unstructured":"Basu, N., Sett, R., & Das, P. K. (1991). Down-regulation of mannose receptors on macrophages after infection with Leishmania donovani. The Biochemical Journal, 277, 451\u2013456.","journal-title":"The Biochemical Journal"},{"key":"1084_CR39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/jac\/37.3.519","volume":"37","author":"P Legrand","year":"1996","unstructured":"Legrand, P., Vertut-Doi, A., & Bolard, J. (1996). Comparative internalization and recycling of different amphotericin B formulations by a macrophage-like cell line. The Journal of Antimicrobial Chemotherapy, 37, 519\u2013533.","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"1084_CR40","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9","volume":"30","author":"C Priv\u00e9","year":"2000","unstructured":"Priv\u00e9, C., & Descoteaux, A. (2000). Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1\/2 during infection of naive macrophages. European Journal of Immunology, 30, 2235\u20132244.","journal-title":"European Journal of Immunology"},{"key":"1084_CR41","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4049\/jimmunol.178.2.1077","volume":"178","author":"Z Yang","year":"2007","unstructured":"Yang, Z., Mosser, D. M., & Zhang, X. (2007). Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. The Journal of Immunology, 178, 1077\u20131085.","journal-title":"The Journal of Immunology"},{"key":"1084_CR42","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1128\/IAI.63.11.4495-4500.1995","volume":"63","author":"D Nandan","year":"1995","unstructured":"Nandan, D., & Reiner, N. E. (1995). Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infection and Immunity, 63, 4495\u20134500.","journal-title":"Infection and Immunity"},{"key":"1084_CR43","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.biomaterials.2008.01.023","volume":"29","author":"C-L Chen","year":"2008","unstructured":"Chen, C.-L., Wang, Y.-M., Liu, C.-F., & Wang, J.-Y. (2008). The effect of water-soluble chitosan on macrophage activation and the attenuation of mite allergen-induced airway inflammation. Biomaterials, 29, 2173\u20132182.","journal-title":"Biomaterials"},{"key":"1084_CR44","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1128\/AAC.36.10.2310","volume":"36","author":"J Barwicz","year":"1992","unstructured":"Barwicz, J., Christian, S., & Gruda, I. (1992). Effects of the aggregation state of amphotericin B on its toxicity to mice. Antimicrobial Agents and Chemotherapy, 36, 2310\u20132315.","journal-title":"Antimicrobial Agents and Chemotherapy"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-014-1084-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12010-014-1084-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-014-1084-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-014-1084-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T01:11:08Z","timestamp":1598145068000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12010-014-1084-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,9]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["1084"],"URL":"https:\/\/doi.org\/10.1007\/s12010-014-1084-y","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,9]]}}}