{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:49:17Z","timestamp":1790596157604,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["LQ18C010006"],"award-info":[{"award-number":["LQ18C010006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY19C010005"],"award-info":[{"award-number":["LY19C010005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12010-019-03164-1","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T10:01:54Z","timestamp":1573812114000},"page":"1187-1200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficient biocatalyst of L-DOPA with Escherichia coli expressing a tyrosine phenol-lyase mutant from Kluyvera intermedia"],"prefix":"10.1007","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-6157","authenticated-orcid":false,"given":"Wei","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-754X","authenticated-orcid":false,"given":"Shuang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-8859","authenticated-orcid":false,"given":"Yanming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-4667","authenticated-orcid":false,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"issue":"2","key":"3164_CR1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00253-014-6215-4","volume":"99","author":"K Min","year":"2015","unstructured":"Min, K., Park, K., Park, D. H., & Yoo, Y. J. (2015). Overview on the biotechnological production of L-DOPA. Applied Microbiology and Biotechnology, 99(2), 575\u2013584.","journal-title":"Applied Microbiology and Biotechnology"},{"key":"3164_CR2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0065-2164(08)70431-3","volume":"19","author":"H Yamada","year":"1975","unstructured":"Yamada, H., & Kumagai, H. (1975). Synthesis of L-tyrosine-related amino acids by beta-tyrosinase. Advances in Applied Microbiology, 19, 249\u2013288.","journal-title":"Advances in Applied Microbiology"},{"key":"3164_CR3","unstructured":"Tsao, G. T., Cao, N., & Gong, C. S. (1999). Hemicellulose Conversion. In Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation (Vol. 19, pp. 249\u2013288). Wiley Inc.. ISBN: 0-471-13822-3."},{"issue":"3","key":"3164_CR4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jbiotec.2004.08.016","volume":"115","author":"T Koyanagi","year":"2005","unstructured":"Koyanagi, T., Katayama, T., Suzuki, H., Nakazawa, H., Yokozeki, K., & Kumagai, H. (2005). Effective production of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) with Erwinia herbicola cells carrying a mutant transcriptional regulator TyrR. Journal of Biotechnology, 115(3), 303\u2013306.","journal-title":"Journal of Biotechnology"},{"issue":"14","key":"3164_CR5","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1007\/s00253-019-09851-7","volume":"103","author":"D Tan","year":"2019","unstructured":"Tan, D., Zhao, J. P., Ran, G. Q., Zhu, X. L., Ding, Y., & Lu, X. Y. (2019). Highly efficient biocatalytic synthesis of L-DOPA using in situ immobilized Verrucomicrobium spinosum tyrosinase on polyhydroxyalkanoate nano-granules. Applied Microbiology and Biotechnology, 103(14), 5663\u20135678.","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"1-2","key":"3164_CR6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jbiotec.2010.01.002","volume":"146","author":"K Min","year":"2010","unstructured":"Min, K., Park, D. H., & Yoo, Y. J. (2010). Electroenzymatic synthesis of l-DOPA. Journal of Biotechnology, 146(1-2), 40\u201344.","journal-title":"Journal of Biotechnology"},{"issue":"5","key":"3164_CR7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00726-016-2174-7","volume":"48","author":"P Agarwal","year":"2016","unstructured":"Agarwal, P., Pareek, N., Dubey, S., Singh, J., & Singh, R. P. (2016). Aspergillus niger PA2: a novel strain for extracellular biotransformation of l-tyrosine into l-DOPA. Amino Acids, 48(5), 1253\u20131262.","journal-title":"Amino Acids"},{"key":"3164_CR8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.procbio.2012.04.005","volume":"47","author":"MI Ch\u00e1vez-B\u00e9jar","year":"2012","unstructured":"Ch\u00e1vez-B\u00e9jar, M. I., B\u00e1ez-Viveros, J. L., Mart\u00ednez, A., Bol\u00edvar, F., & Gosset, G. (2012). Biotechnological production of l-tyrosine and derived compounds. Process Biochemistry, 47, 1017\u20131026.","journal-title":"Process Biochemistry"},{"key":"3164_CR9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jbiotec.2017.11.004","volume":"265","author":"M Harir","year":"2018","unstructured":"Harir, M., Bellahcene, M., Baratto, M. C., Pollini, S., Rossolini, G. M., Trabalzini, L., Fatarella, E., & Pogni, R. (2018). Isolation and characterization of a novel tyrosinase produced by Sahara soil actinobacteria and immobilization on nylon nanofiber membranes. Journal of Biotechnology, 265, 54\u201364.","journal-title":"Journal of Biotechnology"},{"issue":"2","key":"3164_CR10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.talanta.2009.08.032","volume":"80","author":"K Min","year":"2009","unstructured":"Min, K., & Yoo, Y. J. (2009). Amperometric detection of dopamine based on tyrosinase-SWNTs-Ppy composite electrode. Talanta, 80(2), 1007\u20131011.","journal-title":"Talanta"},{"key":"3164_CR11","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1039\/C4GC00565A","volume":"16","author":"T Li","year":"2014","unstructured":"Li, T., & Li, X. (2014). Comprehensive mass analysis for chemical processes, a case study on L-Dopa manufacture. Green Chemistry, 16, 4241\u20134256.","journal-title":"Green Chemistry"},{"key":"3164_CR12","first-page":"493","volume":"37","author":"H Enei","year":"1973","unstructured":"Enei, H., Matsui, H., Nakazawa, H., Okumura, S., & Yamada, H. (1973). Synthesis of L-tyrosine or 3,4-dihydroxypheny-L-alanine from L-serine and phenol or pyrocathechol. Agricultural and Biological Chemistry, 37, 493\u2013499.","journal-title":"Agricultural and Biological Chemistry"},{"key":"3164_CR13","first-page":"5564","volume":"273","author":"SG Lee","year":"2006","unstructured":"Lee, S. G., Hong, S. P., Kim, D. Y., Song, J. J., Ro, H. S., & Sung, M. H. (2006). Inactivation of tyrosine phenol-lyase by Pictet-Spengler reaction and alleviation by T15A mutation on intertwined N-terminal arm. Federation of European Biochemical Societies Journal, 273, 5564\u20135573.","journal-title":"Federation of European Biochemical Societies Journal"},{"issue":"9","key":"3164_CR14","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1128\/AEM.59.9.3070-3075.1993","volume":"59","author":"F Foor","year":"1993","unstructured":"Foor, F., Morin, N., & Bostian, K. A. (1993). Production of l-dihydroxyphenylalanine in Escherichia coli with the tyrosine phenol-lyase gene cloned from Erwinia herbicola. Applied and Environmental Microbiology, 59(9), 3070\u20133075.","journal-title":"Applied and Environmental Microbiology"},{"key":"3164_CR15","first-page":"7503","volume":"5","author":"A Dennig","year":"2015","unstructured":"Dennig, A., Busto, E., Kroutil, W., & Faber, K. (2015). Biocatalytic onepot synthesis of L-tyrosine derivatives from monosubstituted benzenes, pyruvate, and ammonia. American Chemical Society Catalysis, 5, 7503\u20137506.","journal-title":"American Chemical Society Catalysis"},{"issue":"18","key":"3164_CR16","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1128\/JB.179.18.5914-5921.1997","volume":"179","author":"HQ Smith","year":"1997","unstructured":"Smith, H. Q., & Somerville, R. L. (1997). The tpl promoter of Citrobacter freundii is activated by the TyrR protein. Journal of Bacteriology, 179(18), 5914\u20135921.","journal-title":"Journal of Bacteriology"},{"issue":"1","key":"3164_CR17","first-page":"116","volume":"17","author":"DY Kim","year":"2007","unstructured":"Kim, D. Y., Rha, E., Choi, S. L., Song, J. J., Hong, S. P., Sung, M. H., & Lee, S. G. (2007). Development of bioreactor system for l-tyrosine synthesis using thermostable tyrosine phenol-lyase. Journal of Microbiology and Biotechnology, 17(1), 116\u2013122.","journal-title":"Journal of Microbiology and Biotechnology"},{"key":"3164_CR18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1271\/bbb.90019","volume":"73","author":"T Koyanagi","year":"2009","unstructured":"Koyanagi, T., Katayama, T., Suzuki, H., Onishi, A., Yokozeki, K., & Kumagai, H. (2009). Hyperproduction of 3,4-Dihydroxyphenyll-alanine (l-Dopa) using Erwinia herbicola cells carrying a mutant transcriptional regulator TyrR. Bioscience, Biotechnology, and Biochemistry, 73, 1221\u20131223.","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"3164_CR19","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1007\/s12010-013-0491-9","volume":"171","author":"M Chandel","year":"2013","unstructured":"Chandel, M., & Azmi, W. (2013). Purification and characterization of tyrosine phenol lyase from Citrobacter freundii. Applied Biochemistry and Biotechnology, 171, 2040\u20132052.","journal-title":"Applied Biochemistry and Biotechnology"},{"key":"3164_CR20","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00449-018-1962-8","volume":"41","author":"XL Tang","year":"2018","unstructured":"Tang, X. L., Liu, X., Suo, H., Wang, Z. C., Zheng, R. C., & Zheng, Y. G. (2018). Process development for efficient biosynthesis of l-DOPA with recombinant Escherichia coli harboring tyrosine phenol lyase from Fusobacterium nucleatum. Bioprocess and Biosytems Engineering, 41, 1347\u20131354.","journal-title":"Bioprocess and Biosytems Engineering"},{"key":"3164_CR21","volume-title":"Organismal and Molecular Malacology","author":"MA Dar","year":"2017","unstructured":"Dar, M. A., Pawar, K. D., & Pandit, R. S. (2017). Gut microbiome analysis of snails: a biotechnological approach. In S. Ray (Ed.), Organismal and Molecular Malacology. Rijeka Croatia, European Union: Intech Publishers ISBN-978-9535154075."},{"issue":"5","key":"3164_CR22","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.biortech.2008.09.044","volume":"100","author":"M Chandel","year":"2009","unstructured":"Chandel, M., & Azmi, W. (2009). Optimization of process parameters for the production of tyrosine phenol lyase by Citrobacter freundii MTCC 2424. Bioresource Technology, 100(5), 1840\u20131846.","journal-title":"Bioresource Technology"},{"key":"3164_CR23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ab.2018.08.026","volume":"560","author":"XL Tang","year":"2018","unstructured":"Tang, X. L., Suo, H., Zheng, R. C., & Zheng, Y. G. (2018). An efficient colorimetric high-throughput screening method for synthetic activity of tyrosine phenol-lyase. Analytical Biochemistry, 560, 7\u201311.","journal-title":"Analytical Biochemistry"},{"key":"3164_CR24","volume-title":"Comp Life 2005, LNBI 3695, pp 163-174","author":"E Krissinel","year":"2005","unstructured":"Krissinel, E., & Henrick, K. (2005). Detection of protein assemblies in crystals. In M. R. Berthold (Ed.), Comp Life 2005, LNBI 3695, pp 163-174."},{"key":"3164_CR25","doi-asserted-by":"crossref","first-page":"W320","DOI":"10.1093\/nar\/gku316","volume":"42","author":"X Robert","year":"2014","unstructured":"Robert, X., & Gouet, P. (2014). Deciphering key features in protein structures with the new ENDscript server. Nucleic Acids Research, 42, W320\u2013W324.","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"3164_CR26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1253\/circj.71.688","volume":"71","author":"M Abe","year":"2007","unstructured":"Abe, M., Iwaoka, M., Nakamura, T., Kitta, Y., Takona, H., Kodama, Y., Kawabata, K., Obata, J., Mende, A., Kobayashi, T., Fujioka, D., Saito, Y., Hasebe, H., & Kugiyama, K. (2007). Association of high level of plasma free dopamine with future coronary artery disease. Circulation Journal, 71(5), 688\u2013692.","journal-title":"Circulation Journal"},{"key":"3164_CR27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1023\/A:1005440229420","volume":"20","author":"JY Lee","year":"1998","unstructured":"Lee, J. Y., & Xun, L. (1998). Novel biological process for L-DOPA production from L-tyrosine by p-hydroxyphenylacetate 3-hydroxylase. Biotechnology Letters, 20, 479\u2013482.","journal-title":"Biotechnology Letters"},{"key":"3164_CR28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0141-0229(02)00182-5","volume":"31","author":"G Seetharam","year":"2002","unstructured":"Seetharam, G., & Saville, B. A. (2002). L-DOPA production from tyrosinase immobilized on zeolite. Enzyme and Microbial Technology, 31, 747\u2013753.","journal-title":"Enzyme and Microbial Technology"},{"key":"3164_CR29","first-page":"175","volume-title":"Biotechnology: Current Perspectives and Potential Applications","author":"V Kumar","year":"2007","unstructured":"Kumar, V., & Azmi, W. (2007). Microbial tyrosine phenol lyase and its application in the development of therapeutic compound. In P. S. Trivedi (Ed.), Biotechnology: Current Perspectives and Potential Applications (pp. 175\u2013185). Rajsthan, India: Avishkar Publishers and Distributors."},{"issue":"11","key":"3164_CR30","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1128\/AEM.66.11.4764-4771.2000","volume":"66","author":"T Katayama","year":"2000","unstructured":"Katayama, T., Suzuki, H., Koyanagi, T., & Kumagai, H. (2000). Cloning and random mutagenesis of the Erwinia herbicola tyrR gene for high-level expression of tyrosine phenollyase. Applied and Environmental Microbiology, 66(11), 4764\u20134771.","journal-title":"Applied and Environmental Microbiology"},{"key":"3164_CR31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.enzmictec.2017.11.004","volume":"112","author":"RC Zheng","year":"2017","unstructured":"Zheng, R. C., Tang, X. L., Suo, H., Feng, L. L., Liu, X., Yang, J., & Zheng, Y. G. (2017). Biochemical characterization of a novel tyrosine phenol-lyase from Fusobacterium nucleatum for highly efficient biosynthesis of L-DOPA. Enzyme and Microbial Technology, 112, 88\u201393.","journal-title":"Enzyme and Microbial Technology"},{"issue":"4","key":"3164_CR32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00253-007-1243-y","volume":"77","author":"T L\u00fctke-Eversloh","year":"2007","unstructured":"L\u00fctke-Eversloh, T., Santos, C. N. S., & Stephanopoulos, G. (2007). Perspectives of biotechnological production of L-tyrosine and its application. Applied Microbiology and Biotechnology, 77(4), 751\u2013762.","journal-title":"Applied Microbiology and Biotechnology"},{"key":"3164_CR33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.copbio.2016.05.005","volume":"42","author":"J Wachtmeister","year":"2016","unstructured":"Wachtmeister, J., & Rother, D. (2016). Recent advances in whole cell biocatalysis techniques bridging from investigative to industrial scale. Current Opinion in Biotechnology, 42, 169\u2013177.","journal-title":"Current Opinion in Biotechnology"},{"key":"3164_CR34","first-page":"480","volume":"32","author":"SG Lee","year":"1999","unstructured":"Lee, S. G., Hong, S. P., Kwak, M. S., Esaki, N., & Sung, M. H. (1999). Characterization of thermostable tyrosine phenol-lyase from an obligatory symbiotic thermophile, Symbiobacterium sp. SC-1. Journal of Biochemistry and Molecular Biology, 32, 480\u2013485.","journal-title":"Journal of Biochemistry and Molecular Biology"},{"key":"3164_CR35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/00021369.1972.10860265","volume":"36","author":"H Kumagai","year":"1972","unstructured":"Kumagai, H., Kashima, N., Torii, H., Yamad, H., Enei, H., & Okumura, S. (1972). Purification, crystallization and properties of tyrosine phenol lyase from Erwinia herbicola. Agricultural and Biological Chemistry, 36, 472\u2013482.","journal-title":"Agricultural and Biological Chemistry"},{"issue":"29","key":"3164_CR36","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1021\/bi000063u","volume":"39","author":"B Sundararaju","year":"2000","unstructured":"Sundararaju, B., Chen, H., Shilcutt, S., & Phillips, R. S. (2000). The role of glutamic acid-69 in the activation of Citrobacter freundii tyrosine phenol-lyase by monovalent cations. Biochemistry, 39(29), 8546\u20138555.","journal-title":"Biochemistry"},{"issue":"43","key":"3164_CR37","doi-asserted-by":"crossref","first-page":"29206","DOI":"10.1074\/jbc.M802061200","volume":"283","author":"D Mili\u0107","year":"2008","unstructured":"Mili\u0107, D., Demidkina, T. V., Faleev, N. G., Matkovi\u0107-Calogovi\u0107, D., & Antson, A. A. (2008). Insights into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoidintermediates. Journal of Biological Chemistry, 283(43), 29206\u201329214.","journal-title":"Journal of Biological Chemistry"},{"key":"3164_CR38","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1002\/anie.201412070","volume":"54","author":"M Pelay-Gimeno","year":"2015","unstructured":"Pelay-Gimeno, M., Glas, A., Koch, O., & Grossmann, T. N. (2015). Structure-based design of inhibitors pf protein-protein interactions: mimicking peptide binding epitopes. Angewandte Chemie International Edition in English, 54, 8896\u20138927.","journal-title":"Angewandte Chemie International Edition in English"},{"issue":"1","key":"3164_CR39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1432-1033.1981.tb06299.x","volume":"117","author":"T Nagasawa","year":"1981","unstructured":"Nagasawa, T., Utagawa, T., Goto, J., Kim, C. J., Tani, Y., Kumagai, H., & Yamada, H. (1981). Syntheses of L-tyrosine-related amino acids by tyrosine phenol-lyase of Citrobacter intermedius. European Journal of Biochemistry, 117(1), 33\u201340.","journal-title":"European Journal of Biochemistry"},{"issue":"38","key":"3164_CR40","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1021\/bi00038a023","volume":"34","author":"HY Chen","year":"1995","unstructured":"Chen, H. Y., Demidkina, T. V., & Phillips, R. S. (1995). Site-directed mutagenesis of tyrosine to phenylalanine in Citrobacter freundii tyrosine phenol-lyase: evidence for dual roles of tyrosine 71 as a general acid catalyst in the reaction mechanism and in cofactor binding. Biochemistry, 34(38), 12276\u201312283.","journal-title":"Biochemistry"},{"key":"3164_CR41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1353-8020(09)70004-5","volume":"15","author":"T Nagatsua","year":"2009","unstructured":"Nagatsua, T., & Sawadab, M. (2009). L-Dopa therapy for Parkinson\u2019s disease: past, present, and future. Parkinsonism & Related Disorders, 15, 3\u20138.","journal-title":"Parkinsonism & Related Disorders"},{"key":"3164_CR42","volume":"9","author":"Y Shao","year":"2014","unstructured":"Shao, Y., Arias-Cordero, E., Guo, H., Bartram, S., & Boland, W. (2014). In vivo Pyro-SIP assessing active gut microbiota of the cotton leafworm, Spodopteralittoralis. Public Library of Science One, 9, e85948.","journal-title":"Public Library of Science One"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-019-03164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12010-019-03164-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-019-03164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:23:18Z","timestamp":1605313398000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12010-019-03164-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["3164"],"URL":"https:\/\/doi.org\/10.1007\/s12010-019-03164-1","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"18 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study is not involving any human participants and\/or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"All the authors mentioned in the manuscript have agreed for authorship, read and approved the manuscript, and given consent for submission and subsequent publication of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}