{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:32:44Z","timestamp":1784871164671,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s12010-021-03765-9","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T04:03:05Z","timestamp":1637208185000},"page":"368-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats"],"prefix":"10.1007","volume":"194","author":[{"given":"R.","family":"Vidya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kalaivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Amudha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"issue":"11","key":"3765_CR1","first-page":"39","volume":"1","author":"S Thevasundari","year":"2011","unstructured":"Thevasundari, S., & Rajendran, A. (2011). Antibacterial potential and phytochemical analysis of Heterostemma tanjorense (wight and arn). World Journal of Science and Technology, 1(11), 39\u201345.","journal-title":"World Journal of Science and Technology"},{"key":"3765_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.nano.2005.03.002","volume":"1","author":"ES Kawasaki","year":"2005","unstructured":"Kawasaki, E. S., & Player, A. (2005). Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer. Nanomedicine, 1, 101\u2013109.","journal-title":"Nanomedicine"},{"key":"3765_CR3","first-page":"69","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA: A Cancer Journal for Clinicians, 61, 69\u201390.","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"1","key":"3765_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/labinvest.2013.126","volume":"94","author":"Q Wei","year":"2014","unstructured":"Wei, Q., Mu, K., Li, T., Zhang, Y., Yang, Z., Jia, X., Zhao, W., Huai, W., Guo, P., & Han, L. (2014). Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Laboratory Investigation, 94(1), 52\u201362.","journal-title":"Laboratory Investigation"},{"issue":"2","key":"3765_CR5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s13277-013-1224-y","volume":"35","author":"XL Zhu","year":"2014","unstructured":"Zhu, X. L., Wang, Y. L., Chen, J. P., Duan, L. L., Cong, P. F., Qu, Y. C., Ling, J. L., & Zhang, M. X. (2014). Alternol inhibits migration and invasion of human hepatocellular carcinoma cells by targeting epithelial-to-mesenchymal transition. Tumour Biology, 35(2), 1627\u20131635.","journal-title":"Tumour Biology"},{"key":"3765_CR6","doi-asserted-by":"crossref","unstructured":"Sun, H., Yu, L., Wei, H., & Liu, G. (2012) A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine initiated and phenobarbital-promoted mice tumor model. Journal of Biomedicine and Biotechnology 584\u2013728.","DOI":"10.1155\/2012\/584728"},{"key":"3765_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.cbi.2007.09.003","volume":"171","author":"V Sivaramakrishnan","year":"2008","unstructured":"Sivaramakrishnan, V., Shilpa, P. N., Praveen-Kumar, V. R., & Niranjali-Devaraj, S. (2008). Attenuation of N-nitrosodiethylamine induced hepatocellular carcinogenesis by a novel flavonol- Morin. Chemico-Biological Interactions, 171, 79\u201388.","journal-title":"Chemico-Biological Interactions"},{"key":"3765_CR8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.arabjc.2010.04.008","volume":"3","author":"AEM Nour","year":"2010","unstructured":"Nour, A. E. M., Eftaiha, A., Al-Warthan, A., & Ammar, R. A. (2010). Synthesis and applications of silver nanoparticles. Arabian Journal of Chemistry, 3, 135\u2013140.","journal-title":"Arabian Journal of Chemistry"},{"key":"3765_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.colsurfb.2009.05.018","volume":"73","author":"AK Jha","year":"2009","unstructured":"Jha, A. K., Prasad, K., Prasad, K., & Kulkarni, A. R. (2009). Plant system: Nature\u2019s nanofactory. Colloids and Surfaces B, Biointerfaces, 73, 219\u2013223.","journal-title":"Colloids and Surfaces B, Biointerfaces"},{"issue":"4","key":"3765_CR10","first-page":"1","volume":"1","author":"JS Devi","year":"2012","unstructured":"Devi, J. S., & Bhimba, B. V. (2012). Anticancer activity of silver nanoparticles synthesized by the seaweed Ulva lactuca in vitro. Open Access Science Report, 1(4), 1\u20134.","journal-title":"Open Access Science Report"},{"issue":"2","key":"3765_CR11","first-page":"1","volume":"1","author":"SB Prasad","year":"2010","unstructured":"Prasad, S. B., Nicol, B. M., & RosangkimaAmenla, G. (2010). Modulatory effect of ascorbic acid (vitamin C) on cyclophosphamide-mediated antitumor activity and mutagenicity in mice bearing ascites daltons lymphomaa. International Journal of Pharma and Bio Sciences, 1(2), 1\u201320.","journal-title":"International Journal of Pharma and Bio Sciences"},{"key":"3765_CR12","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1042\/bj0830114","volume":"83","author":"PN Magee","year":"1962","unstructured":"Magee, P. N., & Farber, E. (1962). Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo. The Biochemical Journal, 83, 114\u2013124.","journal-title":"The Biochemical Journal"},{"issue":"3","key":"3765_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11130-009-0124-1","volume":"64","author":"GE Lester","year":"2009","unstructured":"Lester, G. E., Jifon, J. L., & Crosby, K. M. (2009). Superoxide dismutase activity in mesocarp tissue from divergent Cucumis melo L. genotypes. Plant Foods for Human Nutrition, 64(3), 205\u2013211.","journal-title":"Plant Foods for Human Nutrition"},{"key":"3765_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2229-4-9","volume":"4","author":"PS Ritschel","year":"2004","unstructured":"Ritschel, P. S., Lins, T. C., Tristan, R. L., Buso, G. S., Buso, J. S., & Ferreira, M. E. (2004). Development of microsatell markers from an enriched genomic library for genetic analysis of melon (Cucumis melo L.). BMC Plant Biology, 4, 9.","journal-title":"BMC Plant Biology"},{"issue":"8","key":"3765_CR15","first-page":"52","volume":"2","author":"M Parlie","year":"2011","unstructured":"Parlie, M., & Singh, K. (2011). Musk melon is eat must-melon. International Journal of Pharmaceutical Science and Review Research, 2(8), 52\u201357.","journal-title":"International Journal of Pharmaceutical Science and Review Research"},{"issue":"5","key":"3765_CR16","first-page":"99","volume":"5","author":"R Vidya","year":"2020","unstructured":"Vidya, R., & Kalaivani, K. (2020). Green synthesis of silver nanoparticles and its characterization using Cucumis melo (L). Fruit extract. International Journal of Botany Studies, 5(5), 99\u2013103.","journal-title":"International Journal of Botany Studies"},{"key":"3765_CR17","doi-asserted-by":"publisher","first-page":"04","DOI":"10.1016\/j.cbi.2006.03.007","volume":"161","author":"G Ramakrishnan","year":"2006","unstructured":"Ramakrishnan, G., Raghavendran, H. R., Vinodhkumar, R., & Devaki, T. (2006). Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chemico-Biological Interactions, 161, 04\u2013114.","journal-title":"Chemico-Biological Interactions"},{"key":"3765_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cbi.2009.02.004","volume":"180","author":"V Sivaramakrishnan","year":"2009","unstructured":"Sivaramakrishnan, V., & Devaraj, S. N. (2009). Morin regulates the expression of NF-k B-p65, COX-2 and Matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chemico-Biological Interactions, 180, 353\u2013359.","journal-title":"Chemico-Biological Interactions"},{"key":"3765_CR19","first-page":"152","volume":"311","author":"EJ King","year":"1934","unstructured":"King, E. J., & Armstrong, A. R. (1934). Estimation of alkaline phosphatase. Canadian Medical Association Journal, 311, 152\u2013156.","journal-title":"Canadian Medical Association Journal"},{"issue":"1","key":"3765_CR20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman, S., & Frankel, S. A. (1957). Calorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminase. American Journal of Clinical Pathology, 28(1), 56\u201363.","journal-title":"American Journal of Clinical Pathology"},{"key":"3765_CR21","unstructured":"King J. (1954). In the hydrolases - Acid and alkaline phosphatase. Practical Clinical Enzymology. London: Kerstin Company Ltd. pp. 191\u2013208."},{"issue":"1","key":"3765_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/jnci\/60.1.19","volume":"60","author":"S Sell","year":"1978","unstructured":"Sell, S., & Beckar, F. F. (1978). Alpha fetoprotein. National Cancer Institute, 60(1), 19\u201326.","journal-title":"National Cancer Institute"},{"key":"3765_CR23","unstructured":"De Vita, V. T., Hellman, S, & Rosenberg, S. A. (1993). (Editors). Cancer: Principle and practice of oncology, 4th Edition. JB. Lippincott Company, Philadelphia."},{"key":"3765_CR24","first-page":"95","volume":"9","author":"HC Hogland","year":"1982","unstructured":"Hogland, H. C. (1982). Hematological complications of cancer chemotherapy. Seminars in Oncology, 9, 95\u2013102.","journal-title":"Seminars in Oncology"},{"issue":"4","key":"3765_CR25","first-page":"96","volume":"4","author":"D AlthafFaimumSudaroli","year":"2012","unstructured":"AlthafFaimumSudaroli, D. (2012). Influence of Vitex Leucoxylon Linn on oxidative stress and hepatocarcinogenesis induced by diethylnitrosamine and phenobarbital in rats. International Journal of Toxicology and Pharmacology Research, 4(4), 96\u2013107.","journal-title":"International Journal of Toxicology and Pharmacology Research"},{"key":"3765_CR26","first-page":"9","volume":"3","author":"G Sarantchandra","year":"1996","unstructured":"Sarantchandra, G., Chandre, J., Jayasuder, S., & Murthy, P. B. (1996). Toxicology of Cleistanthus collinus an indigeneous plant acute toxicity study. Indian Journal of Toxicology, 3, 9\u201317.","journal-title":"Indian Journal of Toxicology"},{"key":"3765_CR27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.etap.2013.08.015","volume":"37","author":"DK Ingawale","year":"2014","unstructured":"Ingawale, D. K., Mandlik, S. K., & Naik, S. R. (2014). Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): A critical discussion. Environmental Toxicology and Pharmacology, 37, 118\u2013133.","journal-title":"Environmental Toxicology and Pharmacology"},{"issue":"109","key":"3765_CR28","first-page":"1334","volume":"58","author":"BI Carr","year":"2011","unstructured":"Carr, B. I., Lu, S. N., & Pancoska, P. (2011). Small hepatocellular carcinoma in Chinese patients. Hepato-gastroenterol, 58(109), 1334\u20131342.","journal-title":"Hepato-gastroenterol"},{"issue":"10","key":"3765_CR29","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1007\/s10620-011-1687-x","volume":"56","author":"P Pancoska","year":"2011","unstructured":"Pancoska, P., De Giorgio, M., Fagiuoli, S., & Carr, B. I. (2011). Small HCCs identified by screening. Digestive Diseases and Sciences, 56(10), 3078\u20133085.","journal-title":"Digestive Diseases and Sciences"},{"issue":"3","key":"3765_CR30","first-page":"6","volume":"76","author":"M Sherman","year":"2009","unstructured":"Sherman, M. (2009). Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment Cleveland. Clinic Journal of Medicine, 76(3), 6\u20139.","journal-title":"Clinic Journal of Medicine"},{"key":"3765_CR31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bionut.2011.06.004","volume":"1","author":"N Nandakumar","year":"2011","unstructured":"Nandakumar, N., Jayaprakash, R., Rengarajan, T., Ramesh, V., & Balasubramanian, M. P. (2011). Hesperidin, a natural citrus flavonoglycoside, normalizes lipid peroxidation and membrane bound marker enzymes in 7, 12-Dimethylbenz (a) anthracene induced experimental breast cancer rats. Biomedicine & Preventive Nutrition, 1, 255\u2013262.","journal-title":"Biomedicine & Preventive Nutrition"},{"key":"3765_CR32","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1053\/gast.2001.27971","volume":"121","author":"H Reynaert","year":"2001","unstructured":"Reynaert, H., Vaeyens, F., Qin, H., Hellemans, K., Chatterjee, N., Winand, D., Quartier, E., Schuit, F., Urbain, D., Kumar, U., Patel, Y. C., & Geerts, A. (2001). Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor sub type 1. Gastroenterology, 121, 915\u2013930.","journal-title":"Gastroenterology"},{"key":"3765_CR33","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1600-0676.1990.tb00452.x","volume":"10","author":"WM Fredericks","year":"1990","unstructured":"Fredericks, W. M., Cornelis, J. F., Noorden, V., Aronson, D. C., Maex, F., Bosch, K. S., Jonges, G. N., Vogels, I. M., & James, J. (1990). Quantitative changes in acid phosphatase, alkaline phosphatase and 5\u2019-nucleodidase activity in rat liver after experimentally induced cholestasis. Liver, 10, 158\u2013166.","journal-title":"Liver"},{"key":"3765_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.fra.2013.03.002","volume":"3","author":"OB Oloyede","year":"2013","unstructured":"Oloyede, O. B., Taofeek, O. A., & Yesirat, O. K. (2013). N-nitrosodiethylamine induced redox imbalance in rat liver: Protective role of polyphenolic extract of Blighia sapida arilli. Free Radicals and Antioxidants, 3, 25\u201329.","journal-title":"Free Radicals and Antioxidants"},{"key":"3765_CR35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.4067\/S0716-97602010000100013","volume":"43","author":"K Pradeep","year":"2010","unstructured":"Pradeep, K., Rajmohan, C. V., Gobianand, K., & Karthikeyan, S. (2010). Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats. Biological Research, 43, 113\u2013125.","journal-title":"Biological Research"},{"issue":"7","key":"3765_CR36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s12098-007-0118-7","volume":"74","author":"BR Thapa","year":"2007","unstructured":"Thapa, B. R., & Walia, A. (2007). Liver function tests and their interpretation. Indian Journal of Pediatrics, 74(7), 663\u2013671.","journal-title":"Indian Journal of Pediatrics"},{"issue":"3","key":"3765_CR37","first-page":"182","volume":"2","author":"M Pournima","year":"2012","unstructured":"Pournima, M., Seema, M. J., Manisha, K., & Vilasrao, K. (2012). Biomarkers in Oncology Journal of Applied Pharmaceutical Sciences, 2(3), 182\u2013191.","journal-title":"Biomarkers in Oncology Journal of Applied Pharmaceutical Sciences"},{"issue":"23","key":"3765_CR38","doi-asserted-by":"publisher","first-page":"6880","DOI":"10.1111\/j.1742-4658.2009.07396.x","volume":"276","author":"HT Tan","year":"2009","unstructured":"Tan, H. T., Low, J., Lim, S. G., & Chung, M. C. M. (2009). Serum autoantibodies as biomarkers for early cancer detection. FEBS Journal, 276(23), 6880\u20136904.","journal-title":"FEBS Journal"},{"key":"3765_CR39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cca.2008.05.010","volume":"395","author":"EN Debruyne","year":"2008","unstructured":"Debruyne, E. N., & Delanghe, J. R. (2008). Diagnosing and monitoring hepatocellular carcinoma with alpha-fetoprotein: New aspects and applications. Clinica Chimica Acta, 395, 19\u201326.","journal-title":"Clinica Chimica Acta"},{"key":"3765_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11259-007-0052-1","volume":"31","author":"MC Marchesi","year":"2007","unstructured":"Marchesi, M. C., Conti, M. B., Pieramati, C., Mangili, V., & Fruganti, G. (2007). Assessment and behavior of Alphafetoprotein (AFP), Antigen Cancer15\/3 (CA15\/3), Carcinembryonal Antigen (CEA) in clinical oncology of the dog: Preliminary study. Veterinary Research Communications, 31, 301\u2013304.","journal-title":"Veterinary Research Communications"},{"issue":"3","key":"3765_CR41","first-page":"258","volume":"7","author":"GMA Ragab","year":"2013","unstructured":"Ragab, G. M. A., El-Denshary, E. S., Hassan, A. M., Abdel- Azeim, S. H., Hassan, N. S., Mannaa, F. A., & Abdel-Wahhab, M. A. (2013). Grape (Vitis vinifera) seed extract inhibits the cytotoxicity and oxidative stress in liver of rats treated with carbon tetrachloride. Global Journal of Pharmacology, 7(3), 258\u2013269.","journal-title":"Global Journal of Pharmacology"},{"key":"3765_CR42","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.bionut.2013.03.006","volume":"3","author":"KL Subbaraj","year":"2013","unstructured":"Subbaraj, K. L., Srinivasan, G. K., Rajendran, P. R., & Maruthaiveeran, P. (2013). Limonin-A citrus limonoid, establish anticancer potential by stabilizing lipid peroxidation and antioxidant status against N- nitrosodiethylamine induced experimental hepatocellular carcinoma. Biomedical Preventive Nutrition, 3, 165\u2013171.","journal-title":"Biomedical Preventive Nutrition"},{"key":"3765_CR43","first-page":"2822","volume":"61","author":"R Zimmer","year":"2001","unstructured":"Zimmer, R., & Thomas, P. (2001). Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: Implications on liver metastasis. Cancer Research, 61, 2822\u20132826.","journal-title":"Cancer Research"},{"key":"3765_CR44","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3923\/jpt.2011.218.233","volume":"6","author":"AM Al-Attar","year":"2011","unstructured":"Al-Attar, A. M. (2011). Hepatoprotective influence of vitamin C on thioacetamide-induced liver cirrhosis in Wistar male rats. Journal of Pharmacology and Toxicology, 6, 218\u2013233.","journal-title":"Journal of Pharmacology and Toxicology"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-021-03765-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-021-03765-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-021-03765-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T07:27:53Z","timestamp":1675927673000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-021-03765-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3765"],"URL":"https:\/\/doi.org\/10.1007\/s12010-021-03765-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-771986\/v1","asserted-by":"object"}]},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]},"assertion":[{"value":"31 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}