{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:00:08Z","timestamp":1789095608698,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s12010-022-03843-6","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:02:52Z","timestamp":1646481772000},"page":"4783-4799","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antinociceptive and Anti-inflammatory Effect of Corynoline in Different Nociceptive and Inflammatory Experimental Models"],"prefix":"10.1007","volume":"194","author":[{"given":"Feng","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"issue":"1","key":"3843_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1080\/00207454.2018.1503178","volume":"129","author":"J Wang","year":"2019","unstructured":"Wang, J. (2019). Glial endocannabinoid system in pain modulation. International Journal of Neuroscience, 129(1), 94\u2013100.","journal-title":"International Journal of Neuroscience"},{"issue":"6","key":"3843_CR2","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1007\/s10753-015-0212-3","volume":"38","author":"HL Wang","year":"2015","unstructured":"Wang, H. L., Li, Y. X., Niu, Y. T., Zheng, J., Wu, J., Shi, G. J., Ma, L., Niu, Y., Sun, T., & Yu, J. Q. (2015). Observing anti-inflammatory and anti-nociceptive activities of glycyrrhizin through regulating COX-2 and pro-inflammatory cytokines expressions in mice. Inflammation, 38(6), 2269\u20132278.","journal-title":"Inflammation"},{"issue":"1","key":"3843_CR3","first-page":"40","volume":"1","author":"N Bektas","year":"2015","unstructured":"Bektas, N., Nemutlu, D., Ulugbay, G., & Arslan, R. (2015). The role of muscarinic receptors in pain modulation. World J pharm med, 1(1), 40\u201349.","journal-title":"World J pharm med"},{"key":"3843_CR4","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.biopha.2017.12.001","volume":"96","author":"S Ronchetti","year":"2017","unstructured":"Ronchetti, S., Migliorati, G., & Delfino, D. V. (2017). Association of inflammatory mediators with pain perception. Biomedicine & Pharmacotherapy, 96, 1445\u20131452.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"8","key":"3843_CR5","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/molecules21080975","volume":"21","author":"C Yang","year":"2016","unstructured":"Yang, C., Zhang, C., Wang, Z., Tang, Z., Kuang, H., & Kong, A. N. (2016). Corynoline isolated from Corydalis bungeana Turcz exhibits anti-inflammatory effects via modulation of Nfr2 and MAPKs. Molecules, 21(8), 975.","journal-title":"Molecules"},{"issue":"4","key":"3843_CR6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4062\/biomolther.2014.052","volume":"22","author":"BO Cho","year":"2014","unstructured":"Cho, B. O., Ryu, H. W., So, Y., Lee, C. W., Jin, C. H., Yook, H. S., Jeong, Y. W., Park, J. C., & Jeong, I. Y. (2014). Anti-inflammatory effect of mangostenone F in lipopolysaccharide-stimulated RAW264. 7 macrophages by suppressing NF-\u03baB and MAPK activation. Biomol Ther, 22(4), 288.","journal-title":"Biomol Ther"},{"key":"3843_CR7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbi.2015.07.014","volume":"50","author":"JE Hartung","year":"2015","unstructured":"Hartung, J. E., Eskew, O., Wong, T., Tchivileva, I. E., Oladosu, F. A., O\u2019Buckley, S. C., & Nackley, A. G. (2015). Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation. Brain, behavior, and immunity, 50, 196\u2013202.","journal-title":"Brain, behavior, and immunity"},{"issue":"10","key":"3843_CR8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/17512433.2018.1516143","volume":"11","author":"G Garc\u00eda-Rayado","year":"2018","unstructured":"Garc\u00eda-Rayado, G., Navarro, M., & Lanas, A. (2018). NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs. Expert review of clinical pharmacology, 11(10), 1031\u20131043.","journal-title":"Expert review of clinical pharmacology"},{"issue":"6","key":"3843_CR9","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s10787-020-00746-y","volume":"28","author":"SM Jaffal","year":"2020","unstructured":"Jaffal, S. M., Oran, S. A., & Alsalem, M. (2020). Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models. Inflammopharmacology, 28(6), 1567\u201377.","journal-title":"Inflammopharmacology"},{"issue":"12","key":"3843_CR10","doi-asserted-by":"publisher","first-page":"E2392","DOI":"10.3390\/ijms18122392","volume":"18","author":"E S\u00e1 R de C\u00e1ssia da Silveira","year":"2017","unstructured":"de C\u00e1ssia da Silveira, E S\u00e1. R., Lima, T. C., de N\u00f3brega, F. R., de Brito, A. E. M., & de Sousa, D. P. (2017). Analgesic-like activity of essential oil constituents: An update. Int J Mol Sci, 18(12), E2392.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3843_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-015-0520-z","volume":"15","author":"ZB Dong","year":"2015","unstructured":"Dong, Z. B., Zhang, Y. H., Zhao, B. J., Li, C., Tian, G., Niu, B., Qi, H., Feng, L., & Shao, J. G. (2015). Screening for anti-inflammatory components from Corydalis bungeana Turcz. based on macrophage binding combined with HPLC. BMC complementary and alternative medicine, 15(1), 1.","journal-title":"BMC complementary and alternative medicine"},{"issue":"8","key":"3843_CR12","first-page":"1630","volume":"38","author":"YX Du","year":"2015","unstructured":"Du, Y. X., Zhai, X. T., Zhu, F. X., & Wang, H. (2015). Study on UPLC Fingerprint of Corydalis bungeana. Zhongyaocai Journal of Chinese medicinal materials, 38(8), 1630\u20131633.","journal-title":"Zhongyaocai Journal of Chinese medicinal materials"},{"key":"3843_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.intimp.2017.04.029","volume":"48","author":"Y Liu","year":"2017","unstructured":"Liu, Y., Song, M., Zhu, G., Xi, X., Li, K., Wu, C., & Huang, L. (2017). Corynoline attenuates LPS-induced acute lung injury in mice by activating Nrf2. International Immunopharmacology, 48, 96\u2013101.","journal-title":"International Immunopharmacology"},{"issue":"1","key":"3843_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-2999(74)90195-2","volume":"27","author":"SI Ankier","year":"1974","unstructured":"Ankier, S. I. (1974). New hot plate tests to quantify antinociceptive and narcotic antagonist activities. European Journal of Pharmacology, 27(1), 1\u20134.","journal-title":"European Journal of Pharmacology"},{"key":"3843_CR15","first-page":"412","volume":"18","author":"R Koster","year":"1959","unstructured":"Koster, R. (1959). Acetic acid for analgesic screening. InFed proc, 18, 412.","journal-title":"InFed proc"},{"issue":"2","key":"3843_CR16","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0006-8993(01)03240-1","volume":"924","author":"A Beirith","year":"2002","unstructured":"Beirith, A., Santos, A. R., & Calixto, J. B. (2002). Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain research, 924(2), 219\u2013228.","journal-title":"Brain research"},{"issue":"3","key":"3843_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jep.2007.08.016","volume":"114","author":"AP Luiz","year":"2007","unstructured":"Luiz, A. P., Moura, J. D., Meotti, F. C., Guginski, G., Guimaraes, C. L., Azevedo, M. S., Rodrigues, A. L., & Santos, A. R. (2007). Antinociceptive action of ethanolic extract obtained from roots of Humirianthera ampla Miers. Journal of Ethnopharmacology, 114(3), 355\u2013363.","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"3843_CR18","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jep.2006.08.018","volume":"109","author":"NM Gomes","year":"2007","unstructured":"Gomes, N. M., Rezende, C. M., Fontes, S. P., Matheus, M. E., & Fernandes, P. D. (2007). Antinociceptive activity of Amazonian Copaiba oils. Journal of Ethnopharmacology, 109(3), 486\u2013492.","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"3843_CR19","first-page":"8","volume":"1","author":"AK Agrahari","year":"2010","unstructured":"Agrahari, A. K., Khaliquzzama, M., & Panda, S. K. (2010). Evaluation of analgesic activity of methanolic extract of Trapa natans l. var. Bispinosa roxb. Roots. Int J Curr Pharm Res, 1(1), 8\u201311.","journal-title":"Int J Curr Pharm Res"},{"issue":"1","key":"3843_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2007.01.034","volume":"112","author":"ES De Mattos","year":"2007","unstructured":"De Mattos, E. S., Frederico, M. J., Colle, T. D., De Pieri, D. V., Peters, R. R., & Piovezan, A. P. (2007). Evaluation of antinociceptive activity of Casearia sylvestris and possible mechanism of action. Journal of Ethnopharmacology, 112(1), 1\u20136.","journal-title":"Journal of Ethnopharmacology"},{"issue":"2","key":"3843_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","volume":"110","author":"GF Passos","year":"2007","unstructured":"Passos, G. F., Fernandes, E. S., da Cunha, F. M., Ferreira, J., Pianowski, L. F., Campos, M. M., & Calixto, J. B. (2007). Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea. Journal of Ethnopharmacology, 110(2), 323\u2013333.","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"3843_CR22","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3181\/00379727-143-37397","volume":"143","author":"R Vinegar","year":"1973","unstructured":"Vinegar, R., Truax, J. F., & Selph, J. L. (1973). Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proceedings of the Society for Experimental Biology and Medicine, 143(3), 711\u2013714.","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"issue":"2","key":"3843_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/path.1711340205","volume":"134","author":"JC Edwards","year":"1981","unstructured":"Edwards, J. C., Sedgwick, A. D., & Willoughby, D. A. (1981). The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system. The Journal of Pathology, 134(2), 147\u2013156.","journal-title":"The Journal of Pathology"},{"key":"3843_CR24","first-page":"69","volume":"8","author":"V Zachariou","year":"2014","unstructured":"Zachariou, V., & Carr, F. (2014). Nociception and pain: Lessons from optogenetics. Frontiers in Behavioral Neuroscience, 8, 69.","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"2","key":"3843_CR25","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s11010-020-03948-8","volume":"476","author":"W Weng","year":"2021","unstructured":"Weng, W., Wang, F., He, X., Zhou, K., Wu, X., & Wu, X. (2021). Protective effect of corynoline on the CFA induced rheumatoid arthritis via attenuation of oxidative and inflammatory mediators. Molecular and Cellular Biochemistry, 476(2), 831\u2013839.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"1","key":"3843_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.pbb.2009.04.004","volume":"93","author":"MM De Souza","year":"2009","unstructured":"De Souza, M. M., Pereira, M. A., Ardenghi, J. V., Mora, T. C., Bresciani, L. F., Yunes, R. A., Delle Monache, F., & Cechinel-Filho, V. (2009). Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice. Pharmacology, Biochemistry and Behavior, 93(1), 40\u201346.","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"2","key":"3843_CR27","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1080\/00207454.2019.1667789","volume":"130","author":"G Singh","year":"2020","unstructured":"Singh, G., Kaur, J., Kaur, M., Singh, P., & Bhatti, R. (2020). Anti-nociceptive and anti-inflammatory effect of imperatorin: Evidences for involvement of COX-2, iNOS, NF\u03baB and inflammatory cytokines. International Journal of Neuroscience, 130(2), 176\u2013185.","journal-title":"International Journal of Neuroscience"},{"issue":"3","key":"3843_CR28","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.neuron.2010.09.008","volume":"68","author":"Y Liu","year":"2010","unstructured":"Liu, Y., Samad, O. A., Zhang, L., Duan, B., Tong, Q., Lopes, C., Ji, R. R., Lowell, B. B., & Ma, Q. (2010). VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron, 68(3), 543\u2013556.","journal-title":"Neuron"},{"issue":"3","key":"3843_CR29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1155\/2005\/860354","volume":"10","author":"DK Lam","year":"2005","unstructured":"Lam, D. K., Sessle, B. J., Cairns, B. E., & Hu, J. W. (2005). Neural mechanisms of temporomandibular joint and masticatory muscle pain: A possible role for peripheral glutamate receptor mechanisms. Pain Research & Management, 10(3), 145\u2013152.","journal-title":"Pain Research & Management"},{"issue":"8","key":"3843_CR30","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/molecules21080975","volume":"21","author":"Q Xu","year":"2016","unstructured":"Xu, Q., Wang, Y., Guo, S., Shen, Z., Wang, Y., & Yang, L. (2016). Anti-inflammatory and analgesic MAPKs. Molecules, 21(8), 975.","journal-title":"Molecules"},{"key":"3843_CR31","doi-asserted-by":"crossref","unstructured":"Sani, M. H., Zakaria, Z. A., Balan, T., Teh, L. K., Salleh, M. Z. (2012). Antinociceptive activity of methanol extract of Muntingia calabura leaves and the mechanisms of action involved. Evidence-Based Complementary and Alternative Medicine, 2012.","DOI":"10.1155\/2012\/890361"},{"issue":"5","key":"3843_CR32","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s10787-018-0486-9","volume":"27","author":"G Singh","year":"2019","unstructured":"Singh, G., Bhatti, R., Mannan, R., Singh, D., Kesavan, A., & Singh, P. (2019). Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice. Inflammopharmacology, 27(5), 949\u2013960.","journal-title":"Inflammopharmacology"},{"issue":"5","key":"3843_CR33","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1089\/jmf.2014.3197","volume":"18","author":"DS Tsai","year":"2015","unstructured":"Tsai, D. S., Huang, M. H., Tsai, J. C., Chang, Y. S., Chiu, Y. J., Lin, Y. C., Wu, L. Y., & Peng, W. H. (2015). Analgesic and anti-inflammatory activities of Rosa taiwanensis nakai in mice. Journal of Medicinal Food, 18(5), 592\u2013600.","journal-title":"Journal of Medicinal Food"},{"key":"3843_CR34","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.brainres.2008.11.029","volume":"1251","author":"DK Lam","year":"2009","unstructured":"Lam, D. K., Sessle, B. J., & Hu, J. W. (2009). Glutamate and capsaicin effects on trigeminal nociception I: Activation and peripheral sensitization of deep craniofacial nociceptive afferents. Brain research, 1251, 130\u2013139.","journal-title":"Brain research"},{"issue":"23","key":"3843_CR35","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1016\/j.lfs.2005.05.032","volume":"77","author":"FA Santos","year":"2005","unstructured":"Santos, F. A., Jeferson, F. A., Santos, C. C., Silveira, E. R., & Rao, V. S. (2005). Antinociceptive effect of leaf essential oil from Croton sonderianus in mice. Life Sciences, 77(23), 2953\u20132963.","journal-title":"Life Sciences"},{"issue":"1","key":"3843_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-015-0658-8","volume":"15","author":"T Afsar","year":"2015","unstructured":"Afsar, T., Khan, M. R., Razak, S., Ullah, S., & Mirza, B. (2015). Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R Parker and its phytochemical analysis. BMC complementary and alternative medicine, 15(1), 1\u20132.","journal-title":"BMC complementary and alternative medicine"},{"key":"3843_CR37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jtemb.2018.02.021","volume":"48","author":"SG Rosa","year":"2018","unstructured":"Rosa, S. G., Br\u00fcning, C. A., Pesarico, A. P., de Souza, A. C., & Nogueira, C. W. (2018). Anti-inflammatory and antinociceptive effects of 2, 2-dipyridyl diselenide through reduction of inducible nitric oxide synthase, nuclear factor-kappa B and c-Jun N-terminal kinase phosphorylation levels in the mouse spinal cord. Journal of Trace Elements in Medicine and Biology, 48, 38\u201345.","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"issue":"1","key":"3843_CR38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jep.2013.12.026","volume":"152","author":"X Niu","year":"2014","unstructured":"Niu, X., Li, Y., Li, W., Hu, H., Yao, H., Li, H., & Mu, Q. (2014). The anti-inflammatory effects of Caragana tangutica ethyl acetate extract. Journal of Ethnopharmacology, 152(1), 99\u2013105.","journal-title":"Journal of Ethnopharmacology"},{"key":"3843_CR39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jep.2016.09.013","volume":"194","author":"C Yang","year":"2016","unstructured":"Yang, C., Zhang, C., Wang, Z., Tang, Z., Kuang, H., & Kong, A. N. (2016). Corynoline isolated from Corydalis bungeana Turcz. exhibits anti-inflammatory effects via modulation of Nfr2 and Corydalis bungeana Turcz. attenuates LPS-induced inflammatory responses via the suppression of NF-\u03baB signaling pathway in vitro and in vivo. J Ethnopharmacol, 194, 153\u201361.","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"3843_CR40","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jep.2014.01.037","volume":"152","author":"XT Zhai","year":"2014","unstructured":"Zhai, X. T., Chen, J. Q., Jiang, C. H., Song, J., Li, D. Y., Zhang, H., Jia, X. B., Tan, W., Wang, S. X., Yang, Y., & Zhu, F. X. (2014). Activity of aqueous extract of Flos populi. J Ethnopharmacol, 152(3), 540\u20135.","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"3843_CR41","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1007\/s10753-018-0807-6","volume":"41","author":"B Liu","year":"2018","unstructured":"Liu, B., Su, K., Wang, J., Wang, J., Xin, Z., Li, F., & Fu, Y. (2018). Corynoline exhibits anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells through activating Nrf2. Inflammation, 41(5), 1640\u20131647.","journal-title":"Inflammation"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-022-03843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-022-03843-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-022-03843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T18:13:57Z","timestamp":1663697637000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-022-03843-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,5]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["3843"],"URL":"https:\/\/doi.org\/10.1007\/s12010-022-03843-6","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,5]]},"assertion":[{"value":"28 January 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical statement for \u201cAntinociceptive and anti-inflammatory effect of bioactive compound in different nociceptive and inflammatory experimental models\u201d.Issue No: BJH202178091","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All authors have their consent to participate.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have their consent to publish their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}