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In the current study, the inhibitory effect of endophytic fungus was explained by direct antifungal activity against fungi causing mucormycosis, ultrastructural, and determination of active compounds in fungal extract. Endophytic\n                    <jats:italic>Aspergillus terreus<\/jats:italic>\n                    was isolated from healthy\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    leaves and identified morphologically and genetically, and was recorded in gene bank with accession number MW444551.1. Phytochemical analysis and gas chromatography-mass spectroscopy (GC\u2013MS) of ethyl acetate crude extract (EACE) of\n                    <jats:italic>A. terreus<\/jats:italic>\n                    were performed. GC\u2013MS results of EACE of\n                    <jats:italic>A. terreus<\/jats:italic>\n                    revealed that fungal extract contains 16 major bioactive compounds with extensive pharmaceutical activities. Furthermore, EACE of\n                    <jats:italic>A. terreus<\/jats:italic>\n                    revealed a promising antifungal activity against fungi causing mucormycosis as\n                    <jats:italic>Rhizopus oryzae<\/jats:italic>\n                    ,\n                    <jats:italic>Mucor racemosus<\/jats:italic>\n                    ,\n                    <jats:italic>and Syncephalastrum racemosum<\/jats:italic>\n                    , where inhibition zones of EACE (10\u00a0mg\/ml) were 20, 37, and 18\u00a0mm, respectively. Minimum inhibitory concentration (MIC) of EACE was 0.3125 toward\n                    <jats:italic>M. racemosus<\/jats:italic>\n                    , while 1.25 and 2.5\u00a0mg\/ml against\n                    <jats:italic>R. oryzae and S. racemosum<\/jats:italic>\n                    , respectively. In the same context, treated\n                    <jats:italic>R. oryzae<\/jats:italic>\n                    ,\n                    <jats:italic>M. racemosus<\/jats:italic>\n                    ,\n                    <jats:italic>and S. racemosum<\/jats:italic>\n                    with EACE of\n                    <jats:italic>A. terreus<\/jats:italic>\n                    revealed elevation of membrane lipid peroxidation which approves membrane leakage. Furthermore, ultrastructure changes were observed which established alteration in both sporangium and hyphal structures; cell membrane and cytoplasm leakage. In conclusion, endophytic\n                    <jats:italic>A. terreus<\/jats:italic>\n                    has an outstanding antifungal activity against fungi causing mucormycosis.\n                  <\/jats:p>","DOI":"10.1007\/s12010-022-03876-x","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T03:38:30Z","timestamp":1648870710000},"page":"3468-3482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Antifungal Activity of Endophytic Aspergillus terreus Extract Against Some Fungi Causing Mucormycosis: Ultrastructural Study"],"prefix":"10.1007","volume":"194","author":[{"given":"Amr H.","family":"Hashem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M.","family":"Shehabeldine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma H.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"3876_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4314\/acsj.v26i1.10","volume":"26","author":"K Gandji","year":"2018","unstructured":"Gandji, K., Chadare, F., Idohou, R., Salako, V., Assogbadjo, A., & Kaka\u00ef, R. 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