{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:02:18Z","timestamp":1779894138538,"version":"3.53.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s12010-022-03993-7","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T08:02:55Z","timestamp":1654934575000},"page":"5083-5099","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["GC\u2013MS Analysis of Bioactive Compounds of Flower Extracts of Calycopteris floribunda Lam.: A Multi Potent Medicinal Plant"],"prefix":"10.1007","volume":"194","author":[{"given":"Sunil B.","family":"Yarazari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jayaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"issue":"2","key":"3993_CR1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jep.2012.07.003","volume":"143","author":"P Bhat","year":"2012","unstructured":"Bhat, P., Hegde, G., & Hegde, G. R. (2012). Ethnomedicinal practices in different communities of Uttara Kannada district of Karnataka for treatment of wounds. Journal of ethnopharmacology, 143(2), 501\u2013514.","journal-title":"Journal of ethnopharmacology"},{"issue":"5","key":"3993_CR2","first-page":"2504","volume":"11","author":"AG Nagannawar","year":"2020","unstructured":"Nagannawar, A. G., & Jayaraj, M. (2020). GC-MS analysis of bioactive compounds from ethanolic extract of whole plant of Mollugo oppositifolia Linn and their pharmacological activities. International Journal of Pharmaceutical Sciences and Research, 11(5), 2504\u20132509.","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"issue":"4","key":"3993_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22159\/ijcr.2020v4i4.131","volume":"4","author":"C Azhagumeena","year":"2020","unstructured":"Azhagumeena, C., & Bharathi, P. R. (2020). A review on phytochemistry and pharmacology of Calycopteris floribunda Lam. International Journal of Chemistry Research, 4(4), 1\u20138.","journal-title":"International Journal of Chemistry Research"},{"key":"3993_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0378-8741(95)01274-H","volume":"47","author":"MJ Bhandary","year":"1995","unstructured":"Bhandary, M. J., Chandrashekar, K. R., & Kaveriappa, K. M. (1995). Medical ethnobotany of the Siddis of Uttara Kannada district, Karnataka, India. Journal of Ethnopharmacology, 47, 149\u2013158.","journal-title":"Journal of Ethnopharmacology"},{"issue":"6","key":"3993_CR5","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1042\/bj0281964","volume":"28","author":"AN Ratnagiriswaran","year":"1934","unstructured":"Ratnagiriswaran, A. N., Sehra, K. B., & Venkataraman, K. (1934). The anthelminthic constituent of the leaves of Calycopteris floribunda Lam. Biochemical Journal, 28(6), 1964\u20131967.","journal-title":"Biochemical Journal"},{"issue":"3","key":"3993_CR6","first-page":"53","volume":"2","author":"MC Eswaraiah","year":"2010","unstructured":"Eswaraiah, M. C., & Satyanarayana, T. (2010). Hepatoprotective activity of extracts from stem of Calycopteris floribunda Lam. against carbon tetrachloride induced toxicity in rats. International Journal of Pharmacognosy and Phytochemical Research, 2(3), 53\u201357.","journal-title":"International Journal of Pharmacognosy and Phytochemical Research"},{"issue":"2","key":"3993_CR7","first-page":"99","volume":"5","author":"GM Pavithra","year":"2013","unstructured":"Pavithra, G. M., Naik, A. S., Siddiqua, S., Vinayaka, K. S., Kekuda, P. T. R., & Mukunda, S. (2013). Antioxidant and antibacterial activity of flower of Calycopteris floribunda Lam., Humboldtia brunonis Wall and Kydia calycina Roxb. International Journal of Drug Development & Research, 5(2), 99\u2013102.","journal-title":"International Journal of Drug Development & Research"},{"issue":"2","key":"3993_CR8","first-page":"57","volume":"3","author":"T Satyanarayana","year":"2009","unstructured":"Satyanarayana, T., Eswaraiah, M. C., Bharathi, A., & Srinivas, M. (2009). Anti \u2013inflammatory activity of stem of Calycopteris floribunda Lam. Journal of Pharmacy and Chemistry, 3(2), 57\u201359.","journal-title":"Journal of Pharmacy and Chemistry"},{"key":"3993_CR9","first-page":"215","volume":"5","author":"KS Vinayaka","year":"2009","unstructured":"Vinayaka, K. S., Kekuda, T. P., Shivakumar, B., & Shravanakumara, S. (2009). Anti-dermatophyte activity of methanol and aqueous extracts of Calycopteris floribunda Lam. leaves. Natural Products: An Indian Journal, 5, 215\u2013219.","journal-title":"Natural Products: An Indian Journal"},{"key":"3993_CR10","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1002\/ptr.2539","volume":"22","author":"HA Ali","year":"2008","unstructured":"Ali, H. A., Chowdhury, A. A., Rahman, A. K., Borkowski, T., Nahar, L., & Sarker, S. D. (2008). Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo2 colon cancer cell line in vitro. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22, 1684\u20131687.","journal-title":"Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives"},{"key":"3993_CR11","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1021\/jm00036a012","volume":"37","author":"ME Wall","year":"1994","unstructured":"Wall, M. E., Wani, M. C., Fullas, F., Oswald, J. B., Brown, D. M., Santisuk, T., & Farnsworth, N. R. (1994). Plant antitumor agents. 31.1 The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of Medicinal Chemistry, 37, 1465\u20131470.","journal-title":"Journal of Medicinal Chemistry"},{"key":"3993_CR12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.phytol.2015.02.004","volume":"11","author":"K Suttaratrungse","year":"2015","unstructured":"Suttaratrungse, K., Chanhan, P., Kanokmedhakul, K., Moosophon, P., & Kanokmedhakul, S. (2015). Two new flavonols from Flower of Getonia floribunda Roxb. Phytochemistry Letters, 11, 316\u2013319.","journal-title":"Phytochemistry Letters"},{"issue":"9","key":"3993_CR13","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1021\/np990182e","volume":"62","author":"R Mayer","year":"1999","unstructured":"Mayer, R. (1999). Calycopterones and calyflorenones, novel biflavonoids from Calycopteris floribunda Lam. Journal of natural products, 62(9), 1274\u20131278.","journal-title":"Journal of natural products"},{"key":"3993_CR14","doi-asserted-by":"publisher","first-page":"0931","DOI":"10.1007\/s11771-009-0155-7","volume":"16","author":"JJ Liu","year":"2009","unstructured":"Liu, J. J., Yang, D. L., Zhang, Y., Yuan, Y., Cao, F. X., Zhao, J. M., & Peng, X. B. (2009). Chemical component and antimicrobial activity of volatile oil of Calycopteris floribunda. Journal of Central South University of Technology, 16, 0931\u20130935.","journal-title":"Journal of Central South University of Technology"},{"key":"3993_CR15","unstructured":"Hegde, S., Jayaraj, M. and Bhandarkar, A. V. (2015). Pharmacognostic studies and preliminary phytochemical analysis of cold and hot extracts of leaf of Tinospora malabarica Miers - An important medicinal plant. International Journal of Pharmaceutical Sciences Review and Research, 34(2), 04, 19\u201325."},{"key":"3993_CR16","unstructured":"Kokate, C. K., Purohot , A.P and Gokhale. S.B. (2014). Pharmacognosy 50th Ed. (7.16\u20137.19) Nirali publication."},{"issue":"5","key":"3993_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/22311866.2017.1400923","volume":"7","author":"P Banakar","year":"2017","unstructured":"Banakar, P., & Jayaraj, M. (2017). Pharmacognosy, phytochemistry and GC-MS analysis of ethanolic stem extract of Waltheria indica L. - A potent medicinal plant. Journal of Biologically Active Products from Nature, 7(5), 369\u2013378.","journal-title":"Journal of Biologically Active Products from Nature"},{"issue":"1","key":"3993_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s12010-021-03745-z","volume":"194","author":"SP Sethuraman","year":"2021","unstructured":"Sethuraman, S. P., & Ramachandran, K. P. (2021). Chemical profiling of volatile bioactives in Luisia tenuifolia Blume successive extracts by GC\u2013MS analysis. Applied Biochemistry and Biotechnology., 194(1), 84\u201398.","journal-title":"Applied Biochemistry and Biotechnology."},{"issue":"4","key":"3993_CR19","first-page":"509","volume":"7","author":"AG Nagannawar","year":"2018","unstructured":"Nagannawar, A. G., & Jayaraj, M. (2018). Pharmacognosy and preliminary phytochemical investigation on Mollugo oppositifolia Linn, a traditional medicinal herb. Journal of Pharmacognosy and Phytochemistry, 7(4), 509\u2013512.","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"issue":"2","key":"3993_CR20","first-page":"57","volume":"4","author":"A Glory","year":"2016","unstructured":"Glory, A., Judin, J., Vasudevan, R., & Sumathi, P. (2016). Preliminary phytochemical content and antibacterial activity of Ukshi (Calycopteris floribunda Lam.) leaves. Journal of Medicinal Plants Studies, 4(2), 57\u201359.","journal-title":"Journal of Medicinal Plants Studies"},{"issue":"1","key":"3993_CR21","first-page":"195","volume":"6","author":"T Tulika","year":"2017","unstructured":"Tulika, T., & Agarwal, M. (2017). Phytochemical screening and GC-MS analysis of bioactive constituents in the ethanolic extract of Pistia stratiotes L. and Eichhornia crassipes (Mart.) Solms. Journal of Pharmacognosy and Phytochemistry, 6(1), 195\u2013206.","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"issue":"11","key":"3993_CR22","first-page":"568","volume":"6","author":"S Arora","year":"2017","unstructured":"Arora, S., & Meena, S. (2017). GC-MS Profiling of Ceropegia bulbosa Roxb. var. bulbosa, an endangered plant from Thar Desert, Rajasthan. The Pharma Innovation Journal, 6(11), 568\u2013573.","journal-title":"The Pharma Innovation Journal"},{"issue":"2","key":"3993_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4314\/thrb.v21i2.6","volume":"21","author":"M Kilonzo","year":"2019","unstructured":"Kilonzo, M., Rubanza, C., Richard, U., & Sangiwa, G. (2019). Antimicrobial activities and phytochemical analysis of extracts from Ormocarpum trichocarpum (Taub.) and Euclea divinorum (Hiern) used as traditional medicines in Tanzania. Tanzania Journal of Health Research, 21(2), 1\u201312.","journal-title":"Tanzania Journal of Health Research"},{"issue":"11","key":"3993_CR24","first-page":"261","volume":"8","author":"GG Beulah","year":"2018","unstructured":"Beulah, G. G., Soris, P. T., & Mohan, V. R. (2018). GC-MS determination of bioactive compounds of Dendrophthoe falcata (L.F) Ettingsh: An epiphytic plant. International Journal of Health Sciences and Research, 8(11), 261\u2013269.","journal-title":"International Journal of Health Sciences and Research"},{"issue":"1","key":"3993_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s12298-016-0407-6","volume":"23","author":"S Vats","year":"2017","unstructured":"Vats, S., & Gupta, T. (2017). Evaluation of bioactive compounds and antioxidant potential of hydroethanolic extract of Moringa oleifera Lam. from Rajasthan, India. Physiology and molecular biology of plants, 23(1), 239\u2013248.","journal-title":"Physiology and molecular biology of plants"},{"issue":"2","key":"3993_CR26","first-page":"3309","volume":"10","author":"V Sivaranjani","year":"2021","unstructured":"Sivaranjani, V., Malarvili, T., Suganthi, K., & Mahalakshmi, S. (2021). Determination of bioactive compounds in Ulva reticulata extract using GC-MS technique. International Journal of Modern Agriculture, 10(2), 3309\u20133314.","journal-title":"International Journal of Modern Agriculture"},{"issue":"3","key":"3993_CR27","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1677\/joe.0.1560551","volume":"156","author":"JF Mutaku","year":"1998","unstructured":"Mutaku, J. F., Many, M. C., Colin, I., Denefand, J. F., & Van den Hove, M. F. (1998). Antigoitrogenic effect of combined supplementation with dl-tocopherol, ascorbic acid and, carotene and of dl-tocopherol alone in the rat. Journal of Endocrinology, 156(3), 551\u2013561.","journal-title":"Journal of Endocrinology"},{"key":"3993_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/bmj.287.6385.81","volume":"287","author":"ML Chiswick","year":"1983","unstructured":"Chiswick, M. L., Johnson, M., Woodhall, C., Gowland, M., Davies, J., Toner, N., & Sims, D. G. (1983). Protective effect of vitamin E (DL-alpha-tocopherol) against intraventricular haemorrhage in premature babies. British Medical Journal, 287, 81\u201384.","journal-title":"British Medical Journal"},{"issue":"3","key":"3993_CR29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.21474\/IJAR01\/6700","volume":"6","author":"AB Delicia","year":"2018","unstructured":"Delicia, A. B., & Shyam, K. V. (2018). GC-MS analysis of bioactive compounds and antimicrobial activity of Cryptococcus rajasthanensis KY627764 isolated from Bombyx mori gut. Microflora. International Journal Advanced Research, 6(3), 525\u2013538.","journal-title":"Microflora. International Journal Advanced Research"},{"key":"3993_CR30","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1211\/0022357011777909","volume":"53","author":"MA Fern\u00e1ndez","year":"2001","unstructured":"Fern\u00e1ndez, M. A., de las Heras, B., Garcia, M. D., S\u00e1enz, M. T., & Villar, A. (2001). New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. Journal of Pharmacy and Pharmacology, 53, 1533\u20131539.","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"4","key":"3993_CR31","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s12088-016-0609-1","volume":"56","author":"I Faridha Begum","year":"2016","unstructured":"Faridha Begum, I., Mohankumar, R., Jeevan, M., & Ramani, K. (2016). GC\u2013MS analysis of bio-active molecules derived from Paracoccus pantotrophus FMR19 and the antimicrobial activity against bacterial pathogens and MDROs. Indian journal of microbiology, 56(4), 426\u2013432.","journal-title":"Indian journal of microbiology"},{"issue":"5","key":"3993_CR32","first-page":"2005","volume":"9","author":"P Banakar","year":"2018","unstructured":"Banakar, P., & Jayaraj, M. (2018). GC-MS analysis of bioactive compounds from ethanolic leaf extract of Waltheria indica Linn. and their pharmacological activities. International Journal of Pharmaceutical Sciences and Research, 9(5), 2005\u20132010.","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"issue":"5","key":"3993_CR33","first-page":"2415","volume":"11","author":"GJ Reddy","year":"2020","unstructured":"Reddy, G. J., Reddy, K. B., & Reddy, G. S. (2020). GC-MS analysis and in-vitro anti-diabetic activity of bioactive fractions of Feronia elephantum fruit. International Journal of Pharmaceutical Sciences and Research, 11(5), 2415\u20132424.","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"issue":"04","key":"3993_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.7324\/JAPS.2015.50419","volume":"5","author":"MS Abdelhamid","year":"2015","unstructured":"Abdelhamid, M. S., Kondratenko, E. I., & Lomteva, N. A. (2015). GC-MS analysis of phytocomponents in the ethanolic extract of Nelumbo nucifera Gaertn. seeds from Russia. Journal of Applied Pharmaceutical Science, 5(04), 115\u2013118.","journal-title":"Journal of Applied Pharmaceutical Science"},{"issue":"2","key":"3993_CR35","first-page":"383","volume":"6","author":"M Amudha","year":"2014","unstructured":"Amudha, M., & Rani, S. (2014). Assessing the bioactive constituents of Cadaba fruticosa (L.) Druce through GC-MS. International Journal of Pharmacy and Pharmaceutical Sciences, 6(2), 383\u2013385.","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"3993_CR36","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.antiviral.2009.05.002","volume":"83","author":"GF Wanga","year":"2009","unstructured":"Wanga, G. F., Shia, L. P., Rena, Y. D., Liu, Q. F., Liu, H. F., Zhang, R. J., Lie, Z., Zhua, F. H., Hea, P. L., Tanga, W., Taoe, P. Z., Chuan, L. C., Zhao, W. M., & Zuo, J. P. (2009). Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research, 83, 186\u2013190.","journal-title":"Antiviral Research"},{"issue":"4","key":"3993_CR37","first-page":"304","volume":"3","author":"G Rajeswari","year":"2012","unstructured":"Rajeswari, G., Murugan, M., & Mohan, V. R. (2012). GC-MS analysis of bioactive components of Hugonia mystax L. (Linaceae). Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3(4), 304\u2013308.","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"issue":"2","key":"3993_CR38","first-page":"454","volume":"30","author":"R Kalsoom","year":"2020","unstructured":"Kalsoom, R., Haider, M. S., & Chohan, S. (2020). Phytochemical analysis and antifungal activity of some medicinal plants against Alternaria species isolated from onion. The Journal of Animal & Plant Sciences, 30(2), 454\u2013460.","journal-title":"The Journal of Animal & Plant Sciences"},{"issue":"4","key":"3993_CR39","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.15666\/aeer\/1904_29152928","volume":"19","author":"B Khan","year":"2021","unstructured":"Khan, B., Jabeen, K., Kanwal, Q., & Iqbal, S. (2021). Phytochemical constituents of pencil tree (Euphorbia tirucalli L.) as antifungal agent against mango anthracnose disease. Applied Ecology and Environmental Research, 19(4), 2915\u20132928.","journal-title":"Applied Ecology and Environmental Research"},{"issue":"1","key":"3993_CR40","first-page":"1445","volume":"7","author":"S Arora","year":"2018","unstructured":"Arora, S., & Kumar, G. (2018). Phytochemical screening of root, stem and leaves of Cenchrus biflorus Roxb. Journal of Pharmacognosy and Phytochemistry, 7(1), 1445\u20131450.","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"issue":"5","key":"3993_CR41","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/S0031-9422(00)97787-2","volume":"28","author":"Y Xiu-Zhen","year":"1989","unstructured":"Xiu-Zhen, Y., Yao-Haur, K., Tsong-Jyh, L., To-Shii, S., Chung-Hsiung, C., Mcphail, D. R., Mcphail, A. T., & Lees, K. H. (1989). Cytotoxic components of Diospyros morrisiana Hance. Phytochemistry, 28(5), 1541\u201315431.","journal-title":"Phytochemistry"},{"issue":"3","key":"3993_CR42","first-page":"148","volume":"9","author":"MF Koudehi","year":"2020","unstructured":"Koudehi, M. F., Ardalan, A. A., & Zibaseresht, R. (2020). Chemical constituents of an Iranian grown Capsicum annuum L. and their cytotoxic activities evaluation. Organic and Medicinal Chemistry International Journal, 9(3), 148\u2013154.","journal-title":"Organic and Medicinal Chemistry International Journal"},{"issue":"16","key":"3993_CR43","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1080\/14786419.2018.1531406","volume":"34","author":"RV Nair","year":"2020","unstructured":"Nair, R. V., Jayasree, D. V., Biju, P. G., & Baby, S. (2020). Anti-inflammatory and anticancer activities of erythrodiol-3-acetate and 2, 4-di-tert-butylphenol isolated from Humboldtia unijuga Bedd. Natural Product Research, 34(16), 2319\u20132322.","journal-title":"Natural Product Research"},{"issue":"2","key":"3993_CR44","first-page":"e15081","volume":"45","author":"FK Ofosu","year":"2020","unstructured":"Ofosu, F. K., Chelliah, R., Daliri, E. B. M., Saravanakumar, K., Wang, M. H., & Oh, D. H. (2020). Antibacterial activities of volatile compounds in cereals and cereal by-products. Journal of Food Processing and Preservation, 45(2), e15081.","journal-title":"Journal of Food Processing and Preservation"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-022-03993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-022-03993-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-022-03993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T05:29:49Z","timestamp":1666416589000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-022-03993-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["3993"],"URL":"https:\/\/doi.org\/10.1007\/s12010-022-03993-7","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,11]]},"assertion":[{"value":"27 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors have agreed to participate in the publication of the paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have agreed to publish the paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of Interest"}}]}}