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The present study was designed to evaluate the potential therapeutic effects of Ottelione A (OTTE) against carbon tetrachloride(CCl<jats:sub>4<\/jats:sub>)-induced toxicity in mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Adult male Swiss albino mice were divided into six groups: group I was used as a normal control received olive oil; group II received DMSO; group III received OTTE; group IV received CCl<jats:sub>4<\/jats:sub> in olive oil, (injected i.p) 3 times\/week for 6 weeks; group V received the same CCl<jats:sub>4<\/jats:sub> regimen as group IV followed by OTTE injected for 15 days, and group VI first received OTTE injected for 15 days followed by the same CCl<jats:sub>4<\/jats:sub> regimen as group IV. Some biochemical and histological parameters were investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our results showed that the administration of CCl<jats:sub>4<\/jats:sub> caused hepatotoxicity, as monitored by the significant increase in biochemical parameters concerning the olive oil group. Treatment with OTTE appeare d to be effective against hepatotoxic and liver changes induced by CCl<jats:sub>4<\/jats:sub>, as evidenced by the improvement of the same parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Ottelione A (OTTE) has good antioxidant and therapeutic properties, which can help in preventing CCl<jats:sub>4<\/jats:sub>-induced hepatotoxicity in both pre-treatment and post-treatment modes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s12010-023-04346-8","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T08:03:44Z","timestamp":1675325024000},"page":"5966-5979","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-1751","authenticated-orcid":false,"given":"Rasha Fekry","family":"Zahran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Mahmoud","family":"EL-sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Robert","family":"Hoye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seif-Eldin Nasr","family":"Ayyad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"4346_CR1","doi-asserted-by":"crossref","unstructured":"Rahim, M. 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This work launched after attaining a permission of scientific and ethical committees from Damietta University, research approval code is 3.2.3.3. Biochemical studies on liver diseases.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Research approval code is 3.2.3.3. Biochemical studies on liver diseases and this is the available in our university.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics committee reference numbers"}},{"value":"Not applicable","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}