{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:30:19Z","timestamp":1788571819599,"version":"build-2803163510"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12010-023-04392-2","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T11:46:43Z","timestamp":1677757603000},"page":"6256-6275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Caesalpinia bonducella Counteracts Paracetamol-Instigated Hepatic Toxicity via Modulating TNF-\u03b1 and IL-6\/10 Expression and Bcl-2 and Caspase-8\/3 Signalling"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-2480","authenticated-orcid":false,"given":"Sangeetha","family":"Nithiyanandam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-5971","authenticated-orcid":false,"given":"Sabina Evan","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"4392_CR1","doi-asserted-by":"publisher","unstructured":"Nazir, N., Muhammad, J., Ghaffar, R., Nisar, M., Zahoor, M., Uddin, F., \u2026 Alotaibi, A. (2021). Phytochemical profiling and antioxidant potential of Daphne mucronata Royle and action against paracetamol-induced hepatotoxicity and nephrotoxicity in rabbits. Saudi Journal of Biological Sciences, 28(9), 5290\u20135301. https:\/\/doi.org\/10.1016\/j.sjbs.2021.05.051","DOI":"10.1016\/j.sjbs.2021.05.051"},{"key":"4392_CR2","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.biopha.2017.10.055","volume":"96","author":"HA El-Bakry","year":"2017","unstructured":"El-Bakry, H. A., El-Sherif, G., & Rostom, R. M. (2017). Therapeutic dose of green tea extract provokes liver damage and exacerbates paracetamol-induced hepatotoxicity in rats through oxidative stress and caspase 3-dependent apoptosis. Biomedicine & Pharmacotherapy, 96, 798\u2013811. https:\/\/doi.org\/10.1016\/j.biopha.2017.10.055","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"4392_CR3","doi-asserted-by":"publisher","unstructured":"Mao, G.-J., Gao, G.-Q., Dong, W.-P., Wang, Q.-Q., Wang, Y.-Y., Li, Y., \u2026 Zhang, G. (2021). A two-photon excited near-infrared fluorescent probe for imaging peroxynitrite during drug-induced hepatotoxicity and its remediation. Talanta, 221, 121607. https:\/\/doi.org\/10.1016\/j.talanta.2020.121607","DOI":"10.1016\/j.talanta.2020.121607"},{"key":"4392_CR4","doi-asserted-by":"publisher","unstructured":"Bourhia, M., Ullah, R., S. Alqahtani, A., & Ibenmoussa, S. (2020). Evidence of drug-induced hepatotoxicity in the Maghrebian population. Drug and Chemical Toxicology, 0(0), 1\u20135. https:\/\/doi.org\/10.1080\/01480545.2020.1797088","DOI":"10.1080\/01480545.2020.1797088"},{"key":"4392_CR5","doi-asserted-by":"publisher","unstructured":"Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., \u2026 Kevin Park, B. (2017). 4.13 - Drug-induced liver injury: Mechanism-informed prediction in drug development. In S. Chackalamannil, D. Rotella, & S. E. Ward (Eds.), Comprehensive Medicinal Chemistry III (pp. 217\u2013238). Oxford: Elsevier. https:\/\/doi.org\/10.1016\/B978-0-12-409547-2.12384-4","DOI":"10.1016\/B978-0-12-409547-2.12384-4"},{"key":"4392_CR6","doi-asserted-by":"publisher","unstructured":"Maheshwari, A., & Ranka, S. (2019). Chapter 130 - Drug-induced liver injury. In C. J. Yeo (Ed.), Shackelford\u2019s Surgery of the Alimentary Tract, 2 Volume Set (Eighth Edition) (Vol. 2, pp. 1524\u20131531). Philadelphia. https:\/\/doi.org\/10.1016\/B978-0-323-40232-3.00130-8","DOI":"10.1016\/B978-0-323-40232-3.00130-8"},{"key":"4392_CR7","doi-asserted-by":"publisher","first-page":"106484","DOI":"10.1016\/j.prostaglandins.2020.106484","volume":"151","author":"L Li","year":"2020","unstructured":"Li, L., Wang, H., & Jones, J. W. (2020). Sphingolipid metabolism as a marker of hepatotoxicity in drug-induced liver injury. Prostaglandins & Other Lipid Mediators, 151, 106484. https:\/\/doi.org\/10.1016\/j.prostaglandins.2020.106484","journal-title":"Prostaglandins & Other Lipid Mediators"},{"issue":"2","key":"4392_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.14218\/JCTH.2015.00052","volume":"4","author":"E Yoon","year":"2016","unstructured":"Yoon, E., Babar, A., Choudhary, M., Kutner, M., & Pyrsopoulos, N. (2016). Acetaminophen-induced hepatotoxicity A comprehensive update. Journal of Clinical and Translational Hepatology, 4(2), 131\u2013142. https:\/\/doi.org\/10.14218\/JCTH.2015.00052","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"4392_CR9","unstructured":"Tittarelli, R., Pellegrini, M., Scarpellini, M. G., Marinelli, E., Bruti, V., di Luca, N. M., \u2026 Zaami, S. (2017). Hepatotoxicity of paracetamol and related fatalities. European Review for Medical and Pharmacological Sciences, 21(1 Suppl), 95\u2013101."},{"key":"4392_CR10","doi-asserted-by":"publisher","unstructured":"Islam, M. T., Quispe, C., Islam, Md. A., Ali, E. S., Saha, S., Asha, U. H., \u2026 Sharifi-Rad, J. (2021). Effects of nerol on paracetamol-induced liver damage in Wistar albino rats. Biomedicine & Pharmacotherapy, 140, 111732. https:\/\/doi.org\/10.1016\/j.biopha.2021.111732","DOI":"10.1016\/j.biopha.2021.111732"},{"issue":"12","key":"4392_CR11","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.3390\/ijms19123776","volume":"19","author":"SB Subramanya","year":"2018","unstructured":"Subramanya, S. B., Venkataraman, B., Meeran, M. F. N., Goyal, S. N., Patil, C. R., & Ojha, S. (2018). Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury. International Journal of Molecular Sciences, 19(12), 3776. https:\/\/doi.org\/10.3390\/ijms19123776","journal-title":"International Journal of Molecular Sciences"},{"key":"4392_CR12","doi-asserted-by":"publisher","unstructured":"Pritchard, M. T., & Apte, U. (2015). Chapter 2 - Models to study liver regeneration. In U. Apte (Ed.), Liver Regeneration (pp. 15\u201340). Boston: Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-420128-6.00002-6","DOI":"10.1016\/B978-0-12-420128-6.00002-6"},{"key":"4392_CR13","doi-asserted-by":"publisher","unstructured":"Moles, A., Torres, S., Baulies, A., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2018). Mitochondrial\u2013lysosomal axis in acetaminophen hepatotoxicity. Frontiers in Pharmacology, 9. https:\/\/doi.org\/10.3389\/fphar.2018.00453","DOI":"10.3389\/fphar.2018.00453"},{"key":"4392_CR14","doi-asserted-by":"publisher","unstructured":"El-Boshy, M., BaSalamah, M. A., Ahmad, J., Idris, S., Mahbub, A., Abdelghany, A. H., \u2026 Refaat, B. (2019). Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat. Free Radical Biology and Medicine, 141, 310\u2013321. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.06.030","DOI":"10.1016\/j.freeradbiomed.2019.06.030"},{"key":"4392_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ejphar.2014.01.022","volume":"726","author":"M Yayla","year":"2014","unstructured":"Yayla, M., Halici, Z., Unal, B., Bayir, Y., Akpinar, E., & Gocer, F. (2014). Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats. European Journal of Pharmacology, 726, 87\u201395. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.022","journal-title":"European Journal of Pharmacology"},{"issue":"7","key":"4392_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jopr.2013.06.023","volume":"7","author":"N Akther","year":"2013","unstructured":"Akther, N., Shawl, A. S., Sultana, S., Chandan, B. K., & Akhter, M. (2013). Hepatoprotective activity of Marrubium vulgare against paracetamol induced toxicity. Journal of Pharmacy Research, 7(7), 565\u2013570. https:\/\/doi.org\/10.1016\/j.jopr.2013.06.023","journal-title":"Journal of Pharmacy Research"},{"issue":"5","key":"4392_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.sjbs.2014.04.001","volume":"21","author":"R Senthilkumar","year":"2014","unstructured":"Senthilkumar, R., Chandran, R., & Parimelazhagan, T. (2014). Hepatoprotective effect of Rhodiola imbricata rhizome against paracetamol-induced liver toxicity in rats. Saudi Journal of Biological Sciences, 21(5), 409\u2013416. https:\/\/doi.org\/10.1016\/j.sjbs.2014.04.001","journal-title":"Saudi Journal of Biological Sciences"},{"issue":"1","key":"4392_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jksus.2012.09.001","volume":"25","author":"Lilaram, & Nazeer Ahamed, R.","year":"2013","unstructured":"Lilaram, & Nazeer Ahamed, R. (2013). Effect of Caesalpinia bonducella seed extract on histoarchitecture of some vital organs and clinical chemistry in female albino rats. Journal of King Saud University - Science, 25(1), 1\u20136. https:\/\/doi.org\/10.1016\/j.jksus.2012.09.001","journal-title":"Journal of King Saud University - Science"},{"issue":"2","key":"4392_CR19","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jep.2009.07.002","volume":"125","author":"S Shukla","year":"2009","unstructured":"Shukla, S., Mehta, A., John, J., Mehta, P., Vyas, S. P., & Shukla, S. (2009). Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds. Journal of Ethnopharmacology, 125(2), 252\u2013256. https:\/\/doi.org\/10.1016\/j.jep.2009.07.002","journal-title":"Journal of Ethnopharmacology"},{"issue":"2","key":"4392_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1254\/jphs.94.177","volume":"94","author":"M Gupta","year":"2004","unstructured":"Gupta, M., Mazumder, U. K., Kumar, R. S., Sivakumar, T., & Vamsi, M. L. M. (2004). Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich Ascites carcinoma in Swiss Albino mice. Journal of Pharmacological Sciences, 94(2), 177\u2013184. https:\/\/doi.org\/10.1254\/jphs.94.177","journal-title":"Journal of Pharmacological Sciences"},{"key":"4392_CR21","first-page":"929","volume":"44","author":"S Shukla","year":"2017","unstructured":"Shukla, S., & Meht, A. (2017). Antioxidant, total phenolics and total flavonoid content of the aqueous extract of Caesalpinia bonducella seeds. Chiang Mai Journal of Science, 44, 929\u2013938.","journal-title":"Chiang Mai Journal of Science"},{"issue":"2","key":"4392_CR22","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1021\/acsomega.9b02857","volume":"5","author":"S Sukumar","year":"2020","unstructured":"Sukumar, S., Rudrasenan, A., & Padmanabhan Nambiar, D. (2020). Green-synthesized rice-shaped copper oxide nanoparticles using Caesalpinia bonducella seed extract and their applications. ACS Omega, 5(2), 1040\u20131051. https:\/\/doi.org\/10.1021\/acsomega.9b02857","journal-title":"ACS Omega"},{"issue":"7","key":"4392_CR23","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.fitote.2006.06.013","volume":"77","author":"DM Kannur","year":"2006","unstructured":"Kannur, D. M., Hukkeri, V. I., & Akki, K. S. (2006). Antidiabetic activity of Caesalpinia bonducella seed extracts in rats. Fitoterapia, 77(7), 546\u2013549. https:\/\/doi.org\/10.1016\/j.fitote.2006.06.013","journal-title":"Fitoterapia"},{"issue":"2","key":"4392_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.17311\/rjmp.2016.127.139","volume":"10","author":"S Manikandaselvi","year":"2016","unstructured":"Manikandaselvi, S., Vadivel, V., & Brindha, P. (2016). Studies on nutraceutical properties of Caesalpinia bonducella L An Indian traditional medicinal plant. Research Journal of Medicinal Plants, 10(2), 127\u2013139. https:\/\/doi.org\/10.17311\/rjmp.2016.127.139","journal-title":"Research Journal of Medicinal Plants"},{"issue":"2","key":"4392_CR25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3109\/13880200903085474","volume":"48","author":"S Shukla","year":"2010","unstructured":"Shukla, S., Mehta, A., Mehta, P., Vyas, S. P., & Shivaprasad, H. N. (2010). In vivo immunomodulatory activities of the aqueous extract of bonduc nut Caesalpinia bonducella seeds. Pharmaceutical Biology, 48(2), 227\u2013230. https:\/\/doi.org\/10.3109\/13880200903085474","journal-title":"Pharmaceutical Biology"},{"issue":"1","key":"4392_CR26","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1038\/s41598-021-83316-8","volume":"11","author":"AAE Latif","year":"2021","unstructured":"Latif, A. A. E., Assar, D. H., Elkaw, E. M., Hamza, H. A., Alkhalifah, D. H. M., Hozzein, W. N., & Hamouda, R. A. (2021). Protective role of Chlorella vulgaris with Thiamine against paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats. Scientific Reports, 11(1), 3911. https:\/\/doi.org\/10.1038\/s41598-021-83316-8","journal-title":"Scientific Reports"},{"key":"4392_CR27","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.toxrep.2014.08.009","volume":"1","author":"M Vedi","year":"2014","unstructured":"Vedi, M., Rasool, M., & Sabina, E. P. (2014). Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress. Toxicology Reports, 1, 629\u2013638. https:\/\/doi.org\/10.1016\/j.toxrep.2014.08.009","journal-title":"Toxicology Reports"},{"key":"4392_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.biopha.2017.01.032","volume":"88","author":"S Peter","year":"2017","unstructured":"Peter, S., & J., Basha S, K., Giridharan, R., Lavinya B, U., & Sabina, E. P. (2017). Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach. Biomedicine & Pharmacotherapy, 88, 11\u201318. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.032","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"4392_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47(3), 469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"European Journal of Biochemistry"},{"issue":"2","key":"4392_CR30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","volume":"47","author":"AK Sinha","year":"1972","unstructured":"Sinha, A. K. (1972). Colorimetric assay of catalase. Analytical Biochemistry, 47(2), 389\u2013394. https:\/\/doi.org\/10.1016\/0003-2697(72)90132-7","journal-title":"Analytical Biochemistry"},{"key":"4392_CR31","doi-asserted-by":"publisher","unstructured":"Moron, M. S., Depierre, J. W., & Mannervik, B. (1979). Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et Biophysica Acta (BBA) - General Subjects, 582(1), 67\u201378. https:\/\/doi.org\/10.1016\/0304-4165(79)90289-7","DOI":"10.1016\/0304-4165(79)90289-7"},{"issue":"4073","key":"4392_CR32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G. (1973). Selenium: Biochemical role as a component of glutathione peroxidase. Science, 179(4073), 588\u2013590. https:\/\/doi.org\/10.1126\/science.179.4073.588","journal-title":"Science"},{"issue":"1","key":"4392_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1042\/bj2080129","volume":"208","author":"H Esterbauer","year":"1982","unstructured":"Esterbauer, H., Cheeseman, K. H., Dianzani, M. U., Poli, G., & Slater, T. F. (1982). Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes. Biochemical Journal, 208(1), 129\u2013140. https:\/\/doi.org\/10.1042\/bj2080129","journal-title":"Biochemical Journal"},{"key":"4392_CR34","doi-asserted-by":"publisher","first-page":"143966","DOI":"10.1016\/j.gene.2019.143966","volume":"712","author":"MM Ahmad","year":"2019","unstructured":"Ahmad, M. M., Rezk, N. A., Fawzy, A., & Sabry, M. (2019). Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats. Gene, 712, 143966. https:\/\/doi.org\/10.1016\/j.gene.2019.143966","journal-title":"Gene"},{"key":"4392_CR35","unstructured":"Verma, P. K., Sultana, M., Raina, R., Prawez, S., Pandita, S., Jamwal, N., & Mir, A. H. (n.d.). Hepatoprotective Effects of Ageratum conyzoides L. on Biochemical indices induced by acetaminophen toxicity in Wistar rats. Journal of Applied Pharmaceutical Science, 5."},{"key":"4392_CR36","doi-asserted-by":"publisher","first-page":"e230142","DOI":"10.1155\/2013\/230142","volume":"2013","author":"N Yakubu","year":"2013","unstructured":"Yakubu, N., Oboh, G., & Olalekan, A. A. (2013). Antioxidant and hepatoprotective properties of tofu (curdle soymilk) against acetaminophen-induced liver damage in rats. Biotechnology Research International, 2013, e230142. https:\/\/doi.org\/10.1155\/2013\/230142","journal-title":"Biotechnology Research International"},{"issue":"7","key":"4392_CR37","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.apjtb.2015.03.011","volume":"5","author":"RZ Hamza","year":"2015","unstructured":"Hamza, R. Z., & Al-Harbi, M. S. (2015). Amelioration of paracetamol hepatotoxicity and oxidative stress on mice liver with silymarin and Nigella sativa extract supplements. Asian Pacific Journal of Tropical Biomedicine, 5(7), 521\u2013531. https:\/\/doi.org\/10.1016\/j.apjtb.2015.03.011","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"4392_CR38","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","volume":"17","author":"M Yan","year":"2018","unstructured":"Yan, M., Huo, Y., Yin, S., & Hu, H. (2018). Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biology, 17, 274\u2013283. https:\/\/doi.org\/10.1016\/j.redox.2018.04.019","journal-title":"Redox Biology"},{"issue":"4","key":"4392_CR39","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine, 54(4), 287\u2013293. https:\/\/doi.org\/10.1016\/j.ajme.2017.09.001","journal-title":"Alexandria Journal of Medicine"},{"key":"4392_CR40","doi-asserted-by":"publisher","first-page":"360438","DOI":"10.1155\/2014\/360438","volume":"2014","author":"A Ayala","year":"2014","unstructured":"Ayala, A., Mu\u00f1oz, M. F., & Arg\u00fcelles, S. (2014). Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine and Cellular Longevity, 2014, 360438. https:\/\/doi.org\/10.1155\/2014\/360438","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"4392_CR41","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12199-017-0673-0","volume":"22","author":"MD Shah","year":"2017","unstructured":"Shah, M. D., D\u2019Souza, U. J. A., & Iqbal, M. (2017). The potential protective effect of Commelina nudiflora L against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, mediated by suppression of oxidative stress and inflammation. Environmental Health and Preventive Medicine, 22(1), 66. https:\/\/doi.org\/10.1186\/s12199-017-0673-0","journal-title":"Environmental Health and Preventive Medicine"},{"key":"4392_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.lfs.2019.05.062","volume":"230","author":"F-L Yu","year":"2019","unstructured":"Yu, F.-L., Wu, J.-W., & Zhu, H. (2019). Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver. Life Sciences, 230, 97\u2013103. https:\/\/doi.org\/10.1016\/j.lfs.2019.05.062","journal-title":"Life Sciences"},{"issue":"11","key":"4392_CR43","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1021\/acs.chemrestox.5b00373","volume":"28","author":"MG Leeming","year":"2015","unstructured":"Leeming, M. G., Gamon, L. F., Wille, U., Donald, W. A., & O\u2019Hair, R. A. J. (2015). What are the potential sites of protein arylation by N-acetyl-p-benzoquinone imine (NAPQI)? Chemical Research in Toxicology, 28(11), 2224\u20132233. https:\/\/doi.org\/10.1021\/acs.chemrestox.5b00373","journal-title":"Chemical Research in Toxicology"},{"key":"4392_CR44","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","volume":"15","author":"EB Kurutas","year":"2016","unstructured":"Kurutas, E. B. (2016). The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: Current state. Nutrition Journal, 15, 71. https:\/\/doi.org\/10.1186\/s12937-016-0186-5","journal-title":"Nutrition Journal"},{"issue":"1","key":"4392_CR45","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1080\/13880209.2020.1764058","volume":"58","author":"ZA Zakaria","year":"2020","unstructured":"Zakaria, Z. A., Kamisan, F. H., Kek, T. L., Salleh, Mohd, & Z. (2020). Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats. Pharmaceutical Biology, 58(1), 478\u2013489. https:\/\/doi.org\/10.1080\/13880209.2020.1764058","journal-title":"Pharmaceutical Biology"},{"key":"4392_CR46","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.biopha.2018.05.049","volume":"104","author":"GA Salem","year":"2018","unstructured":"Salem, G. A., Shaban, A., Diab, H. A., Elsaghayer, W. A., Mjedib, M. D., Hnesh, A. M., & Sahu, R. P. (2018). Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats Biomedicine & Pharmacotherapy. Biomedecine & Pharmacotherapie, 104, 366\u2013374. https:\/\/doi.org\/10.1016\/j.biopha.2018.05.049","journal-title":"Biomedecine & Pharmacotherapie"},{"key":"4392_CR47","doi-asserted-by":"publisher","unstructured":"Mahmood, N. D., Mamat, S. S., Kamisan, F. H., Yahya, F., Kamarolzaman, M. F. F., Nasir, N., \u2026 Zakaria, Z. A. (2014). Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia calabura L. leaves. BioMed Research International, 2014, e695678. https:\/\/doi.org\/10.1155\/2014\/695678","DOI":"10.1155\/2014\/695678"},{"key":"4392_CR48","unstructured":"Sumalatha, S., Padma, D., Pai, K. S. R., Kotian, S. R., Kumar, N., & Bhat, K. M. R. (2016). Hepatoprotective activity of aqueous extract of Caesalpenia bonduc against ccl4 induced chronic hepatotoxicity. International Journal of Pharmacy and Pharmaceutical Sciences, 207\u2013211."},{"issue":"4","key":"4392_CR49","doi-asserted-by":"publisher","first-page":"E993","DOI":"10.3390\/ijms20040993","volume":"20","author":"MA Dkhil","year":"2019","unstructured":"Dkhil, M. A., Abdel Moneim, A. E., Hafez, T. A., Mubaraki, M. A., Mohamed, W. F., Thagfan, F. A., & Al-Quraishy, S. (2019). Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity by inducing anti-apoptotic genes and Nrf2\/HO-1 pathway. International Journal of Molecular Sciences, 20(4), E993. https:\/\/doi.org\/10.3390\/ijms20040993","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"4392_CR50","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/cphy.c120026","volume":"3","author":"LJ Dixon","year":"2013","unstructured":"Dixon, L. J., Barnes, M., Tang, H., Pritchard, M. T., & Nagy, L. E. (2013). Kupffer cells in the liver. Comprehensive Physiology, 3(2), 785\u2013797. https:\/\/doi.org\/10.1002\/cphy.c120026","journal-title":"Comprehensive Physiology"},{"issue":"4","key":"4392_CR51","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.bbrc.2014.08.035","volume":"451","author":"R Madhyastha","year":"2014","unstructured":"Madhyastha, R., Madhyastha, H., Pengjam, Y., Nakajima, Y., Omura, S., & Maruyama, M. (2014). NFkappaB activation is essential for miR-21 induction by TGF\u03b21 in high glucose conditions. Biochemical and Biophysical Research Communications, 451(4), 615\u2013621. https:\/\/doi.org\/10.1016\/j.bbrc.2014.08.035","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"4392_CR52","doi-asserted-by":"publisher","unstructured":"Purbasari, B., Madhyastha, R., Madhyastha, H., Nurrahmah, Q. I., Maruyama, M., Nakajima, Y., \u2026 Watanabe, N. (2022). Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome. Pharmacological Reports, 74(1), 189\u2013203. https:\/\/doi.org\/10.1007\/s43440-021-00321-4","DOI":"10.1007\/s43440-021-00321-4"},{"issue":"1","key":"4392_CR53","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","volume":"32","author":"SS Iyer","year":"2012","unstructured":"Iyer, S. S., & Cheng, G. (2012). Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Critical reviews in immunology, 32(1), 23\u201363.","journal-title":"Critical reviews in immunology"},{"key":"4392_CR54","doi-asserted-by":"publisher","unstructured":"Renu, K., Chakraborty, R., Myakala, H., Koti, R., Famurewa, A. C., Madhyastha, H., \u2026 Valsala Gopalakrishnan, A. (2021). Molecular mechanism of heavy metals (lead, chromium, arsenic, mercury, nickel and cadmium) - induced hepatotoxicity \u2013 A review. Chemosphere, 271, 129735. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.129735","DOI":"10.1016\/j.chemosphere.2021.129735"},{"key":"4392_CR55","doi-asserted-by":"publisher","unstructured":"Jiang, W.-P., Deng, J.-S., Huang, S.-S., Wu, S.-H., Chen, C.-C., Liao, J.-C., \u2026 Huang, G.-J. (2021). Sanghuangporus sanghuang mycelium prevents paracetamol-induced hepatotoxicity through regulating the MAPK\/NF-\u03baB, Keap1\/Nrf2\/HO-1, TLR4\/PI3K\/Akt, and CaMKK\u03b2\/LKB1\/AMPK pathways and suppressing oxidative stress and inflammation. Antioxidants, 10(6), 897. https:\/\/doi.org\/10.3390\/antiox10060897","DOI":"10.3390\/antiox10060897"},{"key":"4392_CR56","doi-asserted-by":"publisher","unstructured":"Kessler, B., Rinchai, D., Kewcharoenwong, C., Nithichanon, A., Biggart, R., Hawrylowicz, C. M., \u2026 Lertmemongkolchai, G. (2017). Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei. Scientific Reports, 7(1), 42791. https:\/\/doi.org\/10.1038\/srep42791","DOI":"10.1038\/srep42791"},{"key":"4392_CR57","doi-asserted-by":"publisher","unstructured":"Kawaratani, H., Tsujimoto, T., Douhara, A., Takaya, H., Moriya, K., Namisaki, T., \u2026 Fukui, H. (2013). The effect of inflammatory cytokines in alcoholic liver disease. Mediators of Inflammation, 2013, e495156. https:\/\/doi.org\/10.1155\/2013\/495156","DOI":"10.1155\/2013\/495156"},{"issue":"4\u20135","key":"4392_CR58","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10565-015-9305-x","volume":"31","author":"UL Baskaran","year":"2015","unstructured":"Baskaran, U. L., & Sabina, E. P. (2015). The food supplement coenzyme Q10 and suppression of antitubercular drug-induced hepatic injury in rats: The role of antioxidant defence system, anti-inflammatory cytokine IL-10. Cell Biology and Toxicology, 31(4\u20135), 211\u2013219. https:\/\/doi.org\/10.1007\/s10565-015-9305-x","journal-title":"Cell Biology and Toxicology"},{"issue":"2","key":"4392_CR59","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jep.2009.10.002","volume":"127","author":"H-D Yuan","year":"2010","unstructured":"Yuan, H.-D., Jin, G.-Z., & Piao, G.-C. (2010). Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb against acetaminophen-induced toxicity in mice. Journal of Ethnopharmacology, 127(2), 528\u2013533. https:\/\/doi.org\/10.1016\/j.jep.2009.10.002","journal-title":"Journal of Ethnopharmacology"},{"key":"4392_CR60","doi-asserted-by":"publisher","unstructured":"Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., \u2026 Kroemer, G. (2018). Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation, 25(3), 486\u2013541. https:\/\/doi.org\/10.1038\/s41418-017-0012-4","DOI":"10.1038\/s41418-017-0012-4"},{"issue":"1","key":"4392_CR61","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12541","volume":"277","author":"B Tummers","year":"2017","unstructured":"Tummers, B., & Green, D. R. (2017). Caspase-8; regulating life and death. Immunological reviews, 277(1), 76\u201389. https:\/\/doi.org\/10.1111\/imr.12541","journal-title":"Immunological reviews"},{"issue":"12","key":"4392_CR62","doi-asserted-by":"publisher","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","volume":"7","author":"DR Green","year":"2015","unstructured":"Green, D. R., & Llambi, F. (2015). Cell Death Signaling. Cold Spring Harbor Perspectives in Biology, 7(12), a006080. https:\/\/doi.org\/10.1101\/cshperspect.a006080","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"2","key":"4392_CR63","first-page":"36","volume":"6","author":"H Jaeschke","year":"2020","unstructured":"Jaeschke, H., & Ramachandran, A. (2020). Acetaminophen-induced apoptosis: Facts versus fiction. Journal of Clinical and Translational Research, 6(2), 36\u201347.","journal-title":"Journal of Clinical and Translational Research"},{"issue":"2","key":"4392_CR64","doi-asserted-by":"publisher","first-page":"a008722","DOI":"10.1101\/cshperspect.a008722","volume":"5","author":"JM Hardwick","year":"2013","unstructured":"Hardwick, J. M., & Soane, L. (2013). Multiple functions of BCL-2 family proteins. Cold Spring Harbor Perspectives in Biology, 5(2), a008722. https:\/\/doi.org\/10.1101\/cshperspect.a008722","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"4392_CR65","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12935-015-0204-2","volume":"15","author":"MH Naseri","year":"2015","unstructured":"Naseri, M. H., Mahdavi, M., Davoodi, J., Tackallou, S. H., Goudarzvand, M., & Neishabouri, S. H. (2015). Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer Cell International, 15(1), 55. https:\/\/doi.org\/10.1186\/s12935-015-0204-2","journal-title":"Cancer Cell International"},{"key":"4392_CR66","doi-asserted-by":"publisher","unstructured":"Xu, X.-Y., Wang, Z., Ren, S., Leng, J., Hu, J., Liu, Z., \u2026 Li, W. (2018). Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-\u03b1-mediated caspase-3\/-8\/-9 signaling pathways. Phytomedicine, 51, 128\u2013138. https:\/\/doi.org\/10.1016\/j.phymed.2018.09.234","DOI":"10.1016\/j.phymed.2018.09.234"},{"key":"4392_CR67","doi-asserted-by":"publisher","first-page":"118382","DOI":"10.1016\/j.lfs.2020.118382","volume":"259","author":"S Kucukler","year":"2020","unstructured":"Kucukler, S., Darendelio\u011flu, E., Caglayan, C., Ayna, A., Y\u0131ld\u0131r\u0131m, S., & Kandemir, F. M. (2020). Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. Life Sciences, 259, 118382. https:\/\/doi.org\/10.1016\/j.lfs.2020.118382","journal-title":"Life Sciences"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04392-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-023-04392-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04392-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T05:30:12Z","timestamp":1695187812000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-023-04392-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["4392"],"URL":"https:\/\/doi.org\/10.1007\/s12010-023-04392-2","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]},"assertion":[{"value":"17 February 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Ethics Committee (IAEC) of VIT granted approval (VIT\/IAEC\/17\/Feb2020\/10) in compliance with the standards of the Indian Committee for the Control and Supervision of Experiments on Animals (CPCSEA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}