{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:36:13Z","timestamp":1768836973954,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s12010-023-04523-9","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T09:04:42Z","timestamp":1682586282000},"page":"160-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of Potential Insulinotropic Cytotoxins from Indian Cobra Snake Venom Using High-Resolution Mass Spectrometry and Analyzing Their Possible Interactions with Potassium Channel Receptors by In Silico Studies"],"prefix":"10.1007","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-1494","authenticated-orcid":false,"given":"Upendra","family":"Gunta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangadhar P.","family":"Vadla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopi","family":"Kadiyala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilipkumar Reddy","family":"Kandula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mastan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"issue":"6","key":"4523_CR1","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.2337\/dc11-0442","volume":"34","author":"FB Hu","year":"2011","unstructured":"Hu, F. B. (2011). Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care, 34(6), 1249\u20131257.","journal-title":"Diabetes Care"},{"key":"4523_CR2","doi-asserted-by":"publisher","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","volume":"157","author":"P Saeedi","year":"2019","unstructured":"Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., & Shaw, J. E. (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice, 157, 107843.","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"11","key":"4523_CR3","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2522\/ptj.20080008","volume":"88","author":"WT Cade","year":"2008","unstructured":"Cade, W. T. (2008). Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Physical Therapy, 88(11), 1322\u20131335.","journal-title":"Physical Therapy"},{"key":"4523_CR4","doi-asserted-by":"publisher","unstructured":"Cerf, M. E. (2013). Beta cell dysfunction and insulin resistance.\u00a0Frontiers in Endocrinology\u00a0(Lausanne), 4, 37. https:\/\/doi.org\/10.3389\/fendo.2013.00037","DOI":"10.3389\/fendo.2013.00037"},{"issue":"3","key":"4523_CR5","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3390\/ijms23031445","volume":"23","author":"M Akbarian","year":"2022","unstructured":"Akbarian, M., Khani, A., Eghbalpour, S., & Uversky, V. N. (2022). Bioactive peptides: Synthesis, sources, applications, and proposed mechanisms of action. International Journal of Molecular Sciences, 23(3), 1445.","journal-title":"International Journal of Molecular Sciences"},{"issue":"10","key":"4523_CR6","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.3390\/molecules24101846","volume":"24","author":"BE Sarmiento","year":"2019","unstructured":"Sarmiento, B. E., Santos Menezes, L. F., & Schwartz, E. F. (2019). Insulin release mechanism modulated by toxins isolated from animal venoms: From basic research to drug development prospects. Molecules, 24(10), 1846.","journal-title":"Molecules"},{"issue":"10","key":"4523_CR7","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.3390\/molecules25102293","volume":"25","author":"BG de la Torre","year":"2020","unstructured":"de la Torre, B. G., & Albericio, F. (2020). Peptide therapeutics 2.0. Molecules, 25(10), 2293.","journal-title":"Molecules"},{"issue":"47","key":"4523_CR8","doi-asserted-by":"publisher","first-page":"33824","DOI":"10.1074\/jbc.M113.503664","volume":"288","author":"R Wang","year":"2013","unstructured":"Wang, R., McGrath, B. C., Kopp, R. F., Roe, M. W., Tang, X., Chen, G., & Cavener, D. R. (2013). Insulin secretion and Ca2+ dynamics in \u03b2-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. Journal of Biological Chemistry, 288(47), 33824\u201333836.","journal-title":"Journal of Biological Chemistry"},{"issue":"12","key":"4523_CR9","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1002\/cbic.201200081","volume":"13","author":"TTN Nguyen","year":"2012","unstructured":"Nguyen, T. T. N., Folch, B., L\u00e9tourneau, M., Vaudry, D., Truong, N. H., Doucet, N., Chatenet, D., & Fournier, A. (2012). Cardiotoxin-I: An unexpectedly potent insulinotropic agent. ChemBioChem, 13(12), 1805\u20131812.","journal-title":"ChemBioChem"},{"issue":"11","key":"4523_CR10","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3390\/toxins10110474","volume":"10","author":"A Munawar","year":"2018","unstructured":"Munawar, A., Ali, S. A., Akrem, A., & Betzel, C. (2018). Snake venom peptides: Tools of biodiscovery. Toxins, 10(11), 474.","journal-title":"Toxins"},{"issue":"1","key":"4523_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1042\/BJ20040354","volume":"384","author":"S Li","year":"2004","unstructured":"Li, S., Wang, J., Zhang, X., Ren, Y., Wang, N., Zhao, K., Chen, X., Zhao, C., Li, X., Shao, J., Yin, J., West, M. B., Xu, N., & Liu, S. (2004). Proteomic characterization of two snake venoms: Naja naja atra and Agkistrodon halys. Biochemical Journal, 384(1), 119\u2013127.","journal-title":"Biochemical Journal"},{"issue":"4","key":"4523_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.toxicon.2012.05.013","volume":"60","author":"L St\u00e4ndker","year":"2012","unstructured":"St\u00e4ndker, L., Harvey, A. L., F\u00fcrst, S., Mathes, I., Forssmann, W. G., de Motta, G. E., & Beress, L. (2012). Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra. Toxicon, 60(4), 623\u2013631.","journal-title":"Toxicon"},{"issue":"2","key":"4523_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/toxins10020085","volume":"10","author":"JC Quintana-Castillo","year":"2018","unstructured":"Quintana-Castillo, J. C., Vargas, L. J., Segura, C., Estrada-G\u00f3mez, S., Bueno-S\u00e1nchez, J. C., & Alarc\u00f3n, J. C. (2018). Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins, 10(2), 85.","journal-title":"Toxins"},{"key":"4523_CR14","doi-asserted-by":"publisher","first-page":"107187","DOI":"10.1016\/j.microc.2022.107187","volume":"175","author":"J Slagboom","year":"2022","unstructured":"Slagboom, J., Kaal, C., Arrahman, A., Vonk, F. J., Somsen, G. W., Calvete, J. J., W\u00fcster, W., & Kool, J. (2022). Analytical strategies in venomics. Microchemical Journal, 175, 107187.","journal-title":"Microchemical Journal"},{"issue":"20","key":"4523_CR15","first-page":"1","volume":"21","author":"TMA El-Aziz","year":"2020","unstructured":"El-Aziz, T. M. A., Jaquillard, L., Bourgoin-Voillard, S., Martinez, G., Triquigneaux, M., Zoukimian, C., Combemale, S., Hograindleur, J. P., al Khoury, S., Escoffier, J., Michelland, S., Bulet, P., Beroud, R., Seve, M., Arnoult, C., & de Waard, M. (2020). Identification, characterization and synthesis of walterospermin, a sperm motility activator from the egyptian black snake walterinnesia aegyptia venom. International Journal of Molecular Sciences, 21(20), 1\u201325.","journal-title":"International Journal of Molecular Sciences"},{"key":"4523_CR16","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1590\/S1678-91992010000400013","volume":"16","author":"J Vejayan","year":"2010","unstructured":"Vejayan, J., Shin Yee, L., Ponnudurai, G., Ambu, S., & Ibrahim, I. (2010). Protein profile analysis of Malaysian snake venoms by two-dimensional gel electrophoresis. Journal of Venomous Animals and Toxins including Tropical Diseases, 16, 623\u2013630.","journal-title":"Journal of Venomous Animals and Toxins including Tropical Diseases"},{"issue":"1\u20132","key":"4523_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0022-1759(86)90215-2","volume":"94","author":"D Gerlier","year":"1986","unstructured":"Gerlier, D., & Thomasset, N. (1986). Use of MTT colorimetric assay to measure cell activation. Journal of Immunological Methods, 94(1\u20132), 57\u201363.","journal-title":"Journal of Immunological Methods"},{"issue":"1","key":"4523_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nprot.2008.197","volume":"4","author":"L Bordoli","year":"2009","unstructured":"Bordoli, L., Kiefer, F., Arnold, K., Benkert, P., Battey, J., & Schwede, T. (2009). Protein structure homology modeling using SWISS-MODEL workspace. Nature Protocols, 4(1), 1\u201313.","journal-title":"Nature Protocols"},{"issue":"W1","key":"4523_CR19","doi-asserted-by":"publisher","first-page":"W296","DOI":"10.1093\/nar\/gky427","volume":"46","author":"A Waterhouse","year":"2018","unstructured":"Waterhouse, A., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F. T., de Beer, T. A. P., Rempfer, C., Bordoli, L., & Lepore, R. (2018). SWISS-MODEL: Homology modelling of protein structures and complexes. Nucleic Acids Research, 46(W1), W296\u2013W303.","journal-title":"Nucleic Acids Research"},{"issue":"13","key":"4523_CR20","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"T Schwede","year":"2003","unstructured":"Schwede, T., Kopp, J., Guex, N., & Peitsch, M. C. (2003). SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Research, 31(13), 3381\u20133385.","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"4523_CR21","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","volume":"44","author":"S Kim","year":"2016","unstructured":"Kim, S., Thiessen, P. A., Bolton, E. E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B. A., & Wang, J. (2016). PubChem substance and compound databases. Nucleic Acids Research, 44(D1), D1202\u2013D1213.","journal-title":"Nucleic Acids Research"},{"issue":"suppl_2","key":"4523_CR22","doi-asserted-by":"publisher","first-page":"W623","DOI":"10.1093\/nar\/gkp456","volume":"37","author":"Y Wang","year":"2009","unstructured":"Wang, Y., Xiao, J., Suzek, T. O., Zhang, J., Wang, J., & Bryant, S. H. (2009). PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Research, 37(suppl_2), W623\u2013W633.","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"4523_CR23","doi-asserted-by":"publisher","first-page":"e10234","DOI":"10.1002\/btm2.10234","volume":"6","author":"A Ali","year":"2021","unstructured":"Ali, A., Kuo, W. W., Kuo, C. H., Lo, J. F., Chen, M. Y., Daddam, J. R., Ho, T. J., Viswanadha, V. P., Shibu, M. A., & Huang, C. Y. (2021). E3 ligase activity of carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton\u2019s jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages. Bioengineering & Translational Medicine, 6(3), e10234.","journal-title":"Bioengineering & Translational Medicine"},{"issue":"8","key":"4523_CR24","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1107\/S0907444912016459","volume":"68","author":"I Raj","year":"2012","unstructured":"Raj, I., Kumar, S., & Gourinath, S. (2012). The narrow active-site cleft of O-acetylserine sulfhydrylase from Leishmania donovani allows complex formation with serine acetyltransferases with a range of C-terminal sequences. Acta Crystallographica Section D: Biological Crystallography, 68(8), 909\u2013919.","journal-title":"Acta Crystallographica Section D: Biological Crystallography"},{"issue":"4","key":"4523_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00894-016-2945-9","volume":"22","author":"PA Meetei","year":"2016","unstructured":"Meetei, P. A., Rathore, R. S., Prabhu, N. P., & Vindal, V. (2016). Modeling of babesipain-1 and identification of natural and synthetic leads for bovine babesiosis drug development. Journal of Molecular Modeling, 22(4), 1\u201314.","journal-title":"Journal of Molecular Modeling"},{"issue":"7","key":"4523_CR26","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1080\/07391102.2015.1078115","volume":"34","author":"CD Churchill","year":"2016","unstructured":"Churchill, C. D., Klobukowski, M., & Tuszynski, J. A. (2016). Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide\u2013tubulin pharmacophore. Journal of Biomolecular Structure and Dynamics, 34(7), 1455\u20131469.","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"4523_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","volume-title":"Chemical biology","author":"S Dallakyan","year":"2015","unstructured":"Dallakyan, S., & Olson, A. J. (2015). Small-molecule library screening by docking with PyRx. Chemical biology (pp. 243\u2013250). New York, NY: Humana Press."},{"issue":"9","key":"4523_CR28","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.3390\/molecules27092834","volume":"27","author":"C Gnanaraj","year":"2022","unstructured":"Gnanaraj, C., Sekar, M., Fuloria, S., Swain, S. S., Gan, S. H., Chidambaram, K., Rani, N. N. I. M., Balan, T., Stephenie, S., Lum, P. T., & Jeyabalan, S. (2022). In silico molecular docking analysis of karanjin against alzheimer\u2019s and parkinson\u2019s diseases as a potential natural lead molecule for new drug design, development and therapy. Molecules, 27(9), 2834.","journal-title":"Molecules"},{"issue":"2","key":"4523_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O., & Olson, A. J. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455\u2013461.","journal-title":"Journal of Computational Chemistry"},{"issue":"10","key":"4523_CR30","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrd1197","volume":"2","author":"RJ Lewis","year":"2003","unstructured":"Lewis, R. J., & Garcia, M. L. (2003). Therapeutic potential of venom peptides. Nature Reviews Drug Discovery, 2(10), 790\u2013802.","journal-title":"Nature Reviews Drug Discovery"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04523-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-023-04523-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04523-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:36:52Z","timestamp":1705477012000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-023-04523-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["4523"],"URL":"https:\/\/doi.org\/10.1007\/s12010-023-04523-9","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,27]]},"assertion":[{"value":"11 April 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}