{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:00:27Z","timestamp":1766138427213,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2021205001","B2019205054","E2022205011"],"award-info":[{"award-number":["B2021205001","B2019205054","E2022205011"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201305"],"award-info":[{"award-number":["31201305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation of Hebei Normal University","award":["L2023J01"],"award-info":[{"award-number":["L2023J01"]}]},{"name":"Teaching Reform project of Hebei Normal University","award":["2021XJJG047"],"award-info":[{"award-number":["2021XJJG047"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12010-023-04673-w","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:02:11Z","timestamp":1693378931000},"page":"3317-3330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High Drug Capacity of Nano-Levodopa-Liposomes: Preparation, In Vitro Release and Brain-Targeted Research"],"prefix":"10.1007","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-7049","authenticated-orcid":false,"given":"Shenna","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-6061","authenticated-orcid":false,"given":"Lina","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"4673_CR1","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1093\/brain\/awu291","volume":"137","author":"I Fishbein","year":"2014","unstructured":"Fishbein, I., Kuo, Y. M., Giasson, B. I., & Nussbaum, R. L. (2014). Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a gaucher mutation. Brain, 137, 3235\u20133247. https:\/\/doi.org\/10.1093\/brain\/awu291","journal-title":"Brain"},{"key":"4673_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.4274\/tjps.galenos.2021.95226","volume":"19","author":"M G\u00fcne\u015f","year":"2022","unstructured":"G\u00fcne\u015f, M., & Karavana, S. Y. (2022). Non-oral drug delivery in Parkinson\u2019s Disease: Current applications and future. Turkish Journal of Pharmaceutical Sciences, 19, 343\u2013352. https:\/\/doi.org\/10.4274\/tjps.galenos.2021.95226","journal-title":"Turkish Journal of Pharmaceutical Sciences"},{"key":"4673_CR3","doi-asserted-by":"publisher","unstructured":"V\u00e1zquez-V\u00e9lez, G. E., & Zoghbi, H. Y. (2021). Parkinson\u2019s disease genetics and pathophysiology. Annual Review of Neuroscience, 44, 87\u2013108. https:\/\/doi.org\/10.1146\/annurev-neuro-100720-034518","DOI":"10.1146\/annurev-neuro-100720-034518"},{"key":"4673_CR4","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/s41418-019-0408-4","volume":"27","author":"M O\u00f1ate","year":"2020","unstructured":"O\u00f1ate, M., Catenaccio, A., Salvadores, N., Saquel, C., Martinez, A., Moreno-Gonzalez, I., Gamez, N., Soto, P., Soto, C., Hetz, C., & Court, F. A. (2020). The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell Death & Differentiation, 27, 1169\u20131185. https:\/\/doi.org\/10.1038\/s41418-019-0408-4","journal-title":"Cell Death & Differentiation"},{"key":"4673_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neubiorev.2015.09.007","volume":"59","author":"CP Weingarten","year":"2015","unstructured":"Weingarten, C. P., Sundman, M. H., Hickey, P., & Chen, N. K. (2015). Neuroimaging of Parkinson\u2019s disease: Expanding views. Neuroscience & Biobehavioral Reviews, 59, 16\u201352. https:\/\/doi.org\/10.1016\/j.neubiorev.2015.09.007","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"4673_CR6","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/sj.bjp.0703379","volume":"130","author":"PA Serra","year":"2000","unstructured":"Serra, P. A., Esposito, G., Enrico, P., Mura, M. A., Migheli, R., Delogu, M. R., Miele, M., Desole, M. S., Grella, G., & Miele, E. (2000). Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: Potential implications to L-DOPA long-term therapy of Parkinson\u2019s disease. British Journal of Pharmacology, 130, 937\u2013945. https:\/\/doi.org\/10.1038\/sj.bjp.0703379","journal-title":"British Journal of Pharmacology"},{"key":"4673_CR7","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","volume":"167","author":"TR Sampson","year":"2016","unstructured":"Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., Chesselet, M. F., Keshavarzian, A., Shannon, K. M., Krajmalnik-Brown, R., Wittung-Stafshede, P., Knight, R., & Mazmanian, S. K. (2016). Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease. Cell, 167, 1469\u20131480. https:\/\/doi.org\/10.1016\/j.cell.2016.11.018","journal-title":"Cell"},{"key":"4673_CR8","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1093\/brain\/awz176","volume":"142","author":"C Rosenblad","year":"2019","unstructured":"Rosenblad, C., Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S., Ag\u00fandez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Bj\u00f6rklund, A., Bezard, E., & Bj\u00f6rklund, T. (2019). Vector-mediated l-3, 4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson\u2019s disease. Brain, 142, 2402\u20132416. https:\/\/doi.org\/10.1093\/brain\/awz176","journal-title":"Brain"},{"key":"4673_CR9","doi-asserted-by":"publisher","first-page":"eabe5948","DOI":"10.1126\/sciadv.abe5948","volume":"7","author":"E Fridjonsdottir","year":"2021","unstructured":"Fridjonsdottir, E., Shariatgorji, R., Nilsson, A., Vallianatou, T., Odell, L. R., Schembri, L. S., Svenningsson, P., Fernagut, P. O., Crossman, A. R., Bezard, E., & Andr\u00e9n, P. E. (2021). Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia. Science Advances, 7, eabe5948. https:\/\/doi.org\/10.1126\/sciadv.abe5948","journal-title":"Science Advances"},{"key":"4673_CR10","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1093\/brain\/awaa181","volume":"143","author":"R Cilia","year":"2020","unstructured":"Cilia, R., Cereda, E., Akpalu, A., Sarfo, F. S., Cham, M., Laryea, R., Obese, V., Oppon, K., Del Sorbo, F., Bonvegna, S., Zecchinelli, A. L., & Pezzoli, G. (2020). Natural history of motor symptoms in Parkinson\u2019s disease and the long-duration response to levodopa. Brain, 143, 2490\u20132501. https:\/\/doi.org\/10.1093\/brain\/awaa181","journal-title":"Brain"},{"key":"4673_CR11","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/S1474-4422(19)30147-4","volume":"18","author":"GA Ford","year":"2019","unstructured":"Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., Pearn, J., Ruddock, S., Sackley, C. M., Saloniki, E. C., Santorelli, G., Walker, M. F., & Farrin, A. J. (2019). Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): A randomised, double-blind, placebo-controlled trial. The Lancet Neurology, 18, 530\u2013538. https:\/\/doi.org\/10.1016\/S1474-4422(19)30147-4","journal-title":"The Lancet Neurology"},{"key":"4673_CR12","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1152\/ajplegacy.1971.221.6.1629","volume":"221","author":"WH Oldendorf","year":"1971","unstructured":"Oldendorf, W. H. (1971). Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. American Journal of Physiology-Legacy Content, 221, 1629\u20131639. https:\/\/doi.org\/10.1152\/ajplegacy.1971.221.6.1629","journal-title":"American Journal of Physiology-Legacy Content"},{"key":"4673_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12951-017-0277-2","volume":"15","author":"X Guo","year":"2017","unstructured":"Guo, X., Zheng, H., Guo, Y., Wang, Y., Anderson, G. J., Ci, Y., Yu, P., Geng, L., & Chang, Y. Z. (2017). Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain. Journal of Nanobiotechnology, 15, 42. https:\/\/doi.org\/10.1186\/s12951-017-0277-2","journal-title":"Journal of Nanobiotechnology"},{"key":"4673_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ijpharm.2013.06.078","volume":"454","author":"L Yuan","year":"2013","unstructured":"Yuan, L., Geng, L., Ge, L., Yu, P., Duan, X., Chen, J., & Chang, Y. (2013). Effect of iron liposomes on anemia of inflammation. International Journal of Pharmaceutics, 454, 82\u201389. https:\/\/doi.org\/10.1016\/j.ijpharm.2013.06.078","journal-title":"International Journal of Pharmaceutics"},{"key":"4673_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.chemphyslip.2013.10.011","volume":"177","author":"YP Patil","year":"2014","unstructured":"Patil, Y. P., & Jadhav, S. (2014). Novel methods for liposome preparation. Chemistry and Physics of Lipids, 177, 8\u201318. https:\/\/doi.org\/10.1016\/j.chemphyslip.2013.10.011","journal-title":"Chemistry and Physics of Lipids"},{"key":"4673_CR16","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1038\/s41467-018-05384-1","volume":"9","author":"J Guan","year":"2018","unstructured":"Guan, J., Shen, Q., Zhang, Z., Jiang, Z., Yang, Y., Lou, M., Qian, J., Lu, W., & Zhan, C. (2018). Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption. Nature Communications, 9, 2982. https:\/\/doi.org\/10.1038\/s41467-018-05384-1","journal-title":"Nature Communications"},{"key":"4673_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11947-010-0328-2","volume":"4","author":"S Neethirajan","year":"2011","unstructured":"Neethirajan, S., & Jayas, D. S. (2011). Nanotechnology for the food and bioprocessing industries. Food and Bioprocess Technology, 4, 39\u201347. https:\/\/doi.org\/10.1007\/s11947-010-0328-2","journal-title":"Food and Bioprocess Technology"},{"key":"4673_CR18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jconrel.2017.05.019","volume":"260","author":"M Agrawal","year":"2018","unstructured":"Agrawal, M., Ajazuddin, Tripathi, D. K., Saraf, S., Saraf, S., Antimisiaris, S. G., Mourtas, S., Hammarlund-Udenaes, M., & Alexander, A. (2018). Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer\u2019s disease. Journal of Controlled Release, 260, 61\u201377. https:\/\/doi.org\/10.1016\/j.jconrel.2017.05.019","journal-title":"Journal of Controlled Release"},{"key":"4673_CR19","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/neuonc\/nov263","volume":"18","author":"X Liu","year":"2016","unstructured":"Liu, X., Madhankumar, A. B., Miller, P. A., Duck, K. A., Hafenstein, S., Rizk, E., Slagle-Webb, B., Sheehan, J. M., Connor, J. R., & Yang, Q. X. (2016). MRI contrast agent for targeting glioma: interleukin-13 labeled liposome encapsulating gadolinium-DTPA. Neuro-Oncology, 18, 691\u2013699. https:\/\/doi.org\/10.1093\/neuonc\/nov263","journal-title":"Neuro-Oncology"},{"key":"4673_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/smll.200400093","volume":"1","author":"EE Connor","year":"2005","unstructured":"Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005). Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small (Weinheim An Der Bergstrasse, Germany), 1, 325\u2013327. https:\/\/doi.org\/10.1002\/smll.200400093","journal-title":"Small (Weinheim An Der Bergstrasse, Germany)"},{"key":"4673_CR21","doi-asserted-by":"publisher","first-page":"e15311","DOI":"10.1097\/MD.0000000000015311","volume":"98","author":"J Peng","year":"2019","unstructured":"Peng, J., & Liang, X. (2019). Progress in research on gold nanoparticles in cancer management. Medicine, 98, e15311. https:\/\/doi.org\/10.1097\/MD.0000000000015311","journal-title":"Medicine"},{"key":"4673_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.procbio.2022.05.01","volume":"119","author":"D Lahiri","year":"2022","unstructured":"Lahiri, D., Nag, M., Dey, A., Sarkar, T., Pati, S., & Ray, R. R. (2022). Nanoparticles based antibacterial vaccines: Novel strategy to combat antimicrobial resistance. Process Biochemistry, 119, 82\u201389. https:\/\/doi.org\/10.1016\/j.procbio.2022.05.01","journal-title":"Process Biochemistry"},{"key":"4673_CR23","doi-asserted-by":"publisher","first-page":"6389","DOI":"10.3390\/molecules26216389","volume":"26","author":"KK Bharadwaj","year":"2021","unstructured":"Bharadwaj, K. K., Rabha, B., Pati, S., Sarkar, T., Choudhury, K. B., Barman, A., Bhattacharjya, D., Srivastava, A., Baishya, D., Edinur, H. A., Kari, Z. A., & Noor, N. H. M. (2021). Green synthesis of gold nanoparticles using plant extracts as beneficial prospect for cancer theranostics. Molecules, 26, 6389. https:\/\/doi.org\/10.3390\/molecules26216389","journal-title":"Molecules"},{"key":"4673_CR24","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1021\/nn102752a","volume":"5","author":"HH Wang","year":"2011","unstructured":"Wang, H. H., Lin, C. A., Lee, C. H., Lin, Y. C., Tseng, Y. M., Hsieh, C. L., Chen, C. H., Tsai, C. H., Hsieh, C. T., Shen, J. L., Chan, W. H., Chang, W. H., & Yeh, H. I. (2011). Fluorescent gold nanoclusters as a biocompatible marker for in vitro and in vivo tracking of endothelial cells. ACS Nano, 5, 4337\u20134344. https:\/\/doi.org\/10.1021\/nn102752a","journal-title":"ACS Nano"},{"key":"4673_CR25","doi-asserted-by":"publisher","first-page":"e2001570","DOI":"10.1002\/adhm.202001570","volume":"10","author":"AC Lima","year":"2021","unstructured":"Lima, A. C., Campos, C. F., Cunha, C., Carvalho, A., Reis, R. L., Ferreira, H., & Neves, N. M. (2021). Biofunctionalized Liposomes to monitor rheumatoid arthritis regression stimulated by Interleukin-23 neutralization. Advanced Healthcare Materials, 10, e2001570. https:\/\/doi.org\/10.1002\/adhm.202001570","journal-title":"Advanced Healthcare Materials"},{"key":"4673_CR26","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.7150\/thno.22621","volume":"8","author":"JR Ashton","year":"2018","unstructured":"Ashton, J. R., Castle, K. D., Qi, Y., Kirsch, D. G., West, J. L., & Badea, C. T. (2018). Dual-energy CT imaging of tumor liposome delivery after gold nanoparticle-augmented radiation therapy. Theranostics, 8, 1782\u20131797. https:\/\/doi.org\/10.7150\/thno.22621","journal-title":"Theranostics"},{"key":"4673_CR27","doi-asserted-by":"publisher","unstructured":"Rodrigues, A. R. O., Matos, J. O. G., Dias, N., Almeida, A. M., Pires, B. G., Pereira, A., Ara\u00fajo, A. M., Queiroz, J. P., Castanheira, M. R. P., E. M. S., & Coutinho, P. J. G. (2018). Development of multifunctional liposomes containing magnetic\/plasmonic MnFe2O4\/Au core \/ shell nanoparticles. Pharmaceutics, 11, 10. https:\/\/doi.org\/10.3390\/pharmaceutics11010010","DOI":"10.3390\/pharmaceutics11010010"},{"key":"4673_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s42003-020-1016-z","volume":"3","author":"R Prasad","year":"2020","unstructured":"Prasad, R., Jain, N. K., Yadav, A. S., Chauhan, D. S., Devrukhkar, J., Kumawat, M. K., Shinde, S., Gorain, M., Thakor, A. S., Kundu, G. C., Conde, J., & Srivastava, R. (2020). Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near-infrared light mediated cancer therapy. Communications Biology, 3, 284. https:\/\/doi.org\/10.1038\/s42003-020-1016-z","journal-title":"Communications Biology"},{"key":"4673_CR29","doi-asserted-by":"publisher","unstructured":"Wang, S., Li, W., Sun, K., Zhang, R., Wang, S., & Geng, L. (2019). Study of release kinetics and degradation thermodynamics of ferric citrate liposomes. Chemistry and Physics of Lipids, 225, 104811. https:\/\/doi.org\/10.1016\/j.chemphyslip.2019.104811","DOI":"10.1016\/j.chemphyslip.2019.104811"},{"key":"4673_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jconrel.2009.10.024","volume":"142","author":"C Chen","year":"2010","unstructured":"Chen, C., Han, D., Cai, C., & Tang, X. (2010). An overview of liposome lyophilization and its future potential. Journal of Controlled Release, 142, 299\u2013311. https:\/\/doi.org\/10.1016\/j.jconrel.2009.10.024","journal-title":"Journal of Controlled Release"},{"key":"4673_CR31","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ijpharm.2015.01.016","volume":"479","author":"YD Limasale","year":"2015","unstructured":"Limasale, Y. D., Tezcaner, A., \u00d6zen, C., Keskin, D., & Banerjee, S. (2015). Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells. International Journal of Pharmaceutics, 479, 364\u2013373. https:\/\/doi.org\/10.1016\/j.ijpharm.2015.01.016","journal-title":"International Journal of Pharmaceutics"},{"key":"4673_CR32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/10611860701725381","volume":"16","author":"V Soni","year":"2008","unstructured":"Soni, V., Kohli, D. V., & Jain, S. K. (2008). Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil. Journal of Drug Targeting, 16, 73\u201378. https:\/\/doi.org\/10.1080\/10611860701725381","journal-title":"Journal of Drug Targeting"},{"key":"4673_CR33","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.2147\/IJN.S29369","volume":"7","author":"CJ Wen","year":"2012","unstructured":"Wen, C. J., Zhang, L. W., Al-Suwayeh, S. A., Yen, T. C., & Fang, J. Y. (2012). Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging. International Journal of Nanomedicine, 7, 1599\u20131611. https:\/\/doi.org\/10.2147\/IJN.S29369","journal-title":"International Journal of Nanomedicine"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04673-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-023-04673-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-023-04673-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T16:05:15Z","timestamp":1718121915000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-023-04673-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["4673"],"URL":"https:\/\/doi.org\/10.1007\/s12010-023-04673-w","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"type":"print","value":"0273-2289"},{"type":"electronic","value":"1559-0291"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"16 August 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study and included experimental procedures were approved by the Laboratory Animal Ethical and Welfare Committee (AEWC) of Hebei Normal University (IACUC-167006). All animal housing and experiments were conducted in strict accordance with the institutional guidelines for the care and use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors agree to participate in this work, and they affirm that it is original research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have their consent to publish their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}