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Nature communications, 13(1), 674.","journal-title":"Nature communications"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-024-04887-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:18:35Z","timestamp":1732789115000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-024-04887-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["4887"],"URL":"https:\/\/doi.org\/10.1007\/s12010-024-04887-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3341201\/v1","asserted-by":"object"}]},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"assertion":[{"value":"12 February 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of The Second Hospital of Hebei Medical University (Date: 2023.7.26\/No.2023-AE011).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"This study did not involve human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"This study did not involve human subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"BALB\/c nude mice are raised in cages in SPF grade animal rooms (4 animals per cage); given appropriate lighting; sterile standard water, and feed; maintained at an ambient temperature of 24\u201325\u00a0\u00b0C; and allowed to eat and move freely. Use an appropriate amount of animals in the experiment and follow standardized operating procedures for feeding and transportation. Care for experimental animals and minimize their pain. Inject glioma cells into the armpits of mice and pay attention to gentle and sterile actions when injecting the cells. After injection, add antibiotics to the drinking water of the mice for 3\u00a0days and measure the animal\u2019s weight daily. Measure the longest and shortest parts of the tumor using a vernier caliper every 7\u00a0days to calculate the tumor volume. Terminate the experiment when the following endpoint indicators appear: (1) The experiment lasts until 28\u00a0days. (2) The size of the tumor is close to 1000 mm<sup>3<\/sup>. (3) When the weight loss of an animal reaches 20%, or the animal exhibits cachexia or consumptive symptoms. (4) Incurable wounds or repetitive self-harm occur. After anesthesia, the experimental animals were euthanized due to cervical dislocation, and the tumor was removed and weighed. The animal welfare practices and animal experimental protocols were strictly consistent with the related ethics regulations of the Ethics Committee of The Second Hospital of Hebei Medical University.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Animals"}}]}}