{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:37:18Z","timestamp":1773830238579,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s12010-024-04976-6","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T04:01:30Z","timestamp":1718596890000},"page":"8555-8571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["LCMS Based Untargeted Metabolic Profiling Revealed a Strong Association of Nanoselenium Treated Sesame (Sesamum indicum) Seed Bioactive Compounds as Novel Potential Disease Targets- A Nano-bioinformatics Approach"],"prefix":"10.1007","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-9606","authenticated-orcid":false,"given":"Ilyas","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-7708","authenticated-orcid":false,"given":"Zia-ur-Rehman","family":"Mashwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohaib","family":"Younas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayyaba","family":"Yousaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"4976_CR1","doi-asserted-by":"crossref","unstructured":"Yang, F. et al. (2012). Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles. International Journal of Nanomedicine, 835-844","DOI":"10.2147\/IJN.S28278"},{"key":"4976_CR2","doi-asserted-by":"crossref","unstructured":"Ocsoy, I. et al. (2018). Nanotechnology in plants. Plant Genetics and Molecular Biology, 263-275","DOI":"10.1007\/10_2017_53"},{"issue":"1","key":"4976_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-014-0028-6","volume":"12","author":"A Husen","year":"2014","unstructured":"Husen, A., & Siddiqi, K. S. (2014). Plants and microbes assisted selenium nanoparticles: Characterization and application. Journal of nanobiotechnology, 12(1), 1\u201310.","journal-title":"Journal of nanobiotechnology"},{"key":"4976_CR4","doi-asserted-by":"crossref","unstructured":"Hosnedlova, B. et al. (2018). Nano-selenium and its nanomedicine applications: A critical review. International journal of nanomedicine, 2107-2128","DOI":"10.2147\/IJN.S157541"},{"issue":"1","key":"4976_CR5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.colsurfb.2011.06.031","volume":"88","author":"W Zhang","year":"2011","unstructured":"Zhang, W., et al. (2011). Biosynthesis and structural characteristics of selenium nanoparticles by Pseudomonas alcaliphila. Colloids and Surfaces B: Biointerfaces, 88(1), 196\u2013201.","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"4976_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.trac.2017.08.007","volume":"96","author":"M Castro-Puyana","year":"2017","unstructured":"Castro-Puyana, M., et al. (2017). Reprint of: Application of mass spectrometry-based metabolomics approaches for food safety, quality and traceability. TrAC Trends in Analytical Chemistry, 96, 62\u201378.","journal-title":"TrAC Trends in Analytical Chemistry"},{"key":"4976_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.aca.2015.12.042","volume":"909","author":"L Cuadros-Rodr\u00edguez","year":"2016","unstructured":"Cuadros-Rodr\u00edguez, L., et al. (2016). Chromatographic fingerprinting: An innovative approach for food\u2019identitation\u2019and food authentication\u2013A tutorial. Analytica Chimica Acta, 909, 9\u201323.","journal-title":"Analytica Chimica Acta"},{"issue":"6","key":"4976_CR8","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/mrc.4850","volume":"57","author":"A Verma","year":"2019","unstructured":"Verma, A., Parihar, R., & Baishya, B. (2019). Identification of metabolites in coriander seeds (Coriandrum Sativum L.) aided by ultrahigh resolution total correlation NMR spectroscopy. Magnetic Resonance in Chemistry, 57(6), 304\u2013316.","journal-title":"Magnetic Resonance in Chemistry"},{"issue":"9","key":"4976_CR9","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1021\/jf200591d","volume":"59","author":"A Scalbert","year":"2011","unstructured":"Scalbert, A., et al. (2011). Databases on food phytochemicals and their health-promoting effects. Journal of agricultural and food chemistry, 59(9), 4331\u20134348.","journal-title":"Journal of agricultural and food chemistry"},{"key":"4976_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jpba.2018.05.046","volume":"158","author":"MA Farag","year":"2018","unstructured":"Farag, M. A., Elsebai, M. F., & Khattab, A. R. (2018). Metabolome based classification of artichoke leaf: A prospect for phyto-equivalency of its different leaf origins and commercial preparations. Journal of Pharmaceutical and Biomedical Analysis, 158, 151\u2013159.","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"3","key":"4976_CR11","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1021\/acsomega.2c07084","volume":"8","author":"I Ahmad","year":"2023","unstructured":"Ahmad, I., et al. (2023). Phytomediated selenium nanoparticles improved physio-morphological, antioxidant, and oil bioactive compounds of sesame under induced biotic stress. ACS omega, 8(3), 3354\u20133366.","journal-title":"ACS omega"},{"key":"4976_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12011-014-9891-0","volume":"157","author":"KS Prasad","year":"2014","unstructured":"Prasad, K. S., & Selvaraj, K. (2014). Biogenic synthesis of selenium nanoparticles and their effect on As (III)-induced toxicity on human lymphocytes. Biological trace element research, 157, 275\u2013283.","journal-title":"Biological trace element research"},{"key":"4976_CR13","doi-asserted-by":"crossref","unstructured":"Javed, B., Mashwani, Z.-u.-R. (2020). Synergistic effects of physicochemical parameters on bio-fabrication of mint silver nanoparticles: Structural evaluation and action against HCT116 colon cancer cells. International journal of nanomedicine, 3621-3637","DOI":"10.2147\/IJN.S254402"},{"issue":"6","key":"4976_CR14","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1093\/mp\/sst080","volume":"6","author":"W Chen","year":"2013","unstructured":"Chen, W., et al. (2013). A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: Application in the study of rice metabolomics. Molecular plant, 6(6), 1769\u20131780.","journal-title":"Molecular plant"},{"key":"4976_CR15","unstructured":"Bitwell, C. et al. (2023). Scientific African"},{"key":"4976_CR16","doi-asserted-by":"crossref","unstructured":"Lu, Y., Pang Z., Xia, J. (2023) Comprehensive investigation of pathway enrichment methods for functional interpretation of LC\u2013MS global metabolomics data. Briefings in Bioinformatics 24(1): bbac553","DOI":"10.1093\/bib\/bbac553"},{"issue":"D1","key":"4976_CR17","doi-asserted-by":"publisher","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","volume":"50","author":"M Gillespie","year":"2022","unstructured":"Gillespie, M., et al. (2022). The reactome pathway knowledgebase 2022. Nucleic acids research, 50(D1), D687\u2013D692.","journal-title":"Nucleic acids research"},{"key":"4976_CR18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1155\/2012\/730746","volume":"2012","author":"G Von White","year":"2012","unstructured":"Von White, G., et al. (2012). Green synthesis of robust, biocompatible silver nanoparticles using garlic extract. Journal of nanomaterials, 2012, 55\u201355.","journal-title":"Journal of nanomaterials"},{"issue":"8","key":"4976_CR19","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/pr7080510","volume":"7","author":"M Reda","year":"2019","unstructured":"Reda, M., et al. (2019). Green synthesis of potent antimicrobial silver nanoparticles using different plant extracts and their mixtures. Processes, 7(8), 510.","journal-title":"Processes"},{"key":"4976_CR20","doi-asserted-by":"crossref","unstructured":"Riaz, M. et al. (2023) Phytobioactive compounds as therapeutic agents for human diseases: A review. Food Science & Nutrition","DOI":"10.1002\/fsn3.3308"},{"issue":"3","key":"4976_CR21","first-page":"1","volume":"22","author":"A Noreen","year":"2020","unstructured":"Noreen, A., Hussain, F., & Shahid, M. (2020). Insights on the antioxidant, antidiabetic, antiamnesic, cytotoxic, thrombolytic and antibiofilm activities of Stevia rebaudiana leaves. Progress in Nutrition, 22(3), 1\u20139.","journal-title":"Progress in Nutrition"},{"issue":"4","key":"4976_CR22","first-page":"159","volume":"75","author":"KR Anilakumar","year":"2010","unstructured":"Anilakumar, K. R., et al. (2010). Nutritional, medicinal and industrial uses of sesame (Sesamum indicum L.) seeds-An overview. Agriculturae Conspectus Scientificus, 75(4), 159\u2013168.","journal-title":"Agriculturae Conspectus Scientificus"},{"key":"4976_CR23","unstructured":"Delves, P.J. Roitt, I. M. (1998) Encyclopedia of immunology. In: Encyclopedia of immunology. p. 145-145"},{"key":"4976_CR24","first-page":"45","volume-title":"Polyphenols: properties, recovery, and applications","author":"L Chen","year":"2018","unstructured":"Chen, L., Cao, H., & Xiao, J. (2018). Polyphenols: Absorption, bioavailability, and metabolomics. Polyphenols: properties, recovery, and applications (pp. 45\u201367). Elsevier."},{"issue":"4","key":"4976_CR25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.aninu.2020.08.002","volume":"6","author":"J Ma","year":"2020","unstructured":"Ma, J., et al. (2020). Dietary polyphenols in lipid metabolism: A role of gut microbiome. Animal nutrition, 6(4), 404\u2013409.","journal-title":"Animal nutrition"},{"issue":"1","key":"4976_CR26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2174\/1389450118666170125144557","volume":"19","author":"P Manikandan","year":"2018","unstructured":"Manikandan, P., & Nagini, S. (2018). Cytochrome P450 structure, function and clinical significance: A review. Current drug targets, 19(1), 38\u201354.","journal-title":"Current drug targets"},{"key":"4976_CR27","doi-asserted-by":"crossref","unstructured":"Ana Maria, A., Oscar Andr\u00e9as, M.-R., Haider, N. B. (2015). Role of nuclear receptors in central nervous system development and associated diseases. Journal of experimental neuroscience, 9: JEN.S25480","DOI":"10.4137\/JEN.S25480"},{"key":"4976_CR28","unstructured":"Lennarz, W.J., Lane, M.D. (2013). Encyclopedia of biological chemistry. Academic Press"},{"key":"4976_CR29","unstructured":"Smith, C. (2023). A novel in vitro study elucidating the molecular mechanism of B-RAF by phosphorylation, dimerization, and ATP-competitive inhibitors. Saint Joseph\u2019s University"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04976-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-024-04976-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04976-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:21:14Z","timestamp":1735867274000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-024-04976-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["4976"],"URL":"https:\/\/doi.org\/10.1007\/s12010-024-04976-6","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"assertion":[{"value":"5 June 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve animals or humans, no ethical approval required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"This study does not involve informant\u2019s data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}