{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:13:34Z","timestamp":1768626814666,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Science and Technology Fund Project of the Guizhou Provincial Health Commission","award":["Gzwkj2021-270"],"award-info":[{"award-number":["Gzwkj2021-270"]}]},{"name":"the Science and Technology Fund Project of the Guizhou Provincial Health Commission","award":["Gzwkj2022-131"],"award-info":[{"award-number":["Gzwkj2022-131"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s12010-024-04986-4","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T08:02:37Z","timestamp":1718438557000},"page":"8493-8512","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac Fibroblasts Enhance MMP2 Activity to Suppress Gap Junction Function in Cardiomyocytes"],"prefix":"10.1007","volume":"196","author":[{"given":"Xue","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingju","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9622-1837","authenticated-orcid":false,"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"4986_CR1","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/s0140-6736(18)32203-7","volume":"392","author":"GA Roth","year":"2018","unstructured":"Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., et al. (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1736\u20131788. https:\/\/doi.org\/10.1016\/s0140-6736(18)32203-7","journal-title":"Lancet"},{"key":"4986_CR2","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.ijcard.2012.11.065","volume":"168","author":"S Khatibzadeh","year":"2013","unstructured":"Khatibzadeh, S., Farzadfar, F., Oliver, J., Ezzati, M., & Moran, A. (2013). Worldwide risk factors for heart failure: A systematic review and pooled analysis. International Journal of Cardiology, 168, 1186\u20131194. https:\/\/doi.org\/10.1016\/j.ijcard.2012.11.065","journal-title":"International Journal of Cardiology"},{"key":"4986_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/jci62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy, D. J., & Yellon, D. M. (2013). Myocardial ischemia-reperfusion injury: A neglected therapeutic target. The Journal of Clinical Investigation, 123, 92\u2013100. https:\/\/doi.org\/10.1172\/jci62874","journal-title":"The Journal of Clinical Investigation"},{"key":"4986_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fphar.2020.00367","volume":"11","author":"N Zhu","year":"2020","unstructured":"Zhu, N., Li, J., Li, Y., Zhang, Y., Du, Q., Hao, P., et al. (2020). Berberine protects against simulated ischemia\/reperfusion injury-induced H9C2 cardiomyocytes apoptosis in vitro and myocardial ischemia\/reperfusion-induced apoptosis in vivo by regulating the mitophagy-mediated HIF-1\u03b1\/BNIP3 pathway. Frontiers in Pharmacology, 11, 367. https:\/\/doi.org\/10.3389\/fphar.2020.00367","journal-title":"Frontiers in Pharmacology"},{"key":"4986_CR5","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","volume":"34","author":"GM Fr\u00f6hlich","year":"2013","unstructured":"Fr\u00f6hlich, G. M., Meier, P., White, S. K., Yellon, D. M., & Hausenloy, D. J. (2013). Myocardial reperfusion injury: Looking beyond primary PCI. European Heart Journal, 34, 1714\u20131722. https:\/\/doi.org\/10.1093\/eurheartj\/eht090","journal-title":"European Heart Journal"},{"key":"4986_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.yjmcc.2022.12.002","volume":"175","author":"M Haugsten Hansen","year":"2023","unstructured":"Haugsten Hansen, M., Sadredini, M., Hasic, A., Anderson, M. E., Sjaastad, I., & Korseberg Stokke, M. (2023). CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKII\u03b4 at methionines 281\/282 is not a determining factor. Journal of Molecular and Cellular Cardiology, 175, 49\u201361. https:\/\/doi.org\/10.1016\/j.yjmcc.2022.12.002","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"4986_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.03.012","volume":"84","author":"KP Hammer","year":"2015","unstructured":"Hammer, K. P., Ljubojevic, S., Ripplinger, C. M., Pieske, B. M., & Bers, D. M. (2015). Cardiac myocyte alternans in intact heart: Influence of cell\u2013cell coupling and \u03b2-adrenergic stimulation. Journal of Molecular and Cellular Cardiology, 84, 1\u20139. https:\/\/doi.org\/10.1016\/j.yjmcc.2015.03.012","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"4986_CR8","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1126\/science.adh9925","volume":"381","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Li, Q., Tao, B., Angelini, M., Ramadoss, S., Sun, B., et al. (2023). Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis. Science, 381, 1480\u20131487. https:\/\/doi.org\/10.1126\/science.adh9925","journal-title":"Science"},{"key":"4986_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-3-319-55330-6_12","volume":"982","author":"K Boengler","year":"2017","unstructured":"Boengler, K., & Schulz, R. (2017). Connexin 43 and mitochondria in cardiovascular health and disease. Advances in Experimental Medicine and Biology, 982, 227\u2013246. https:\/\/doi.org\/10.1007\/978-3-319-55330-6_12","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"4986_CR10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/cvr\/cvp227","volume":"83","author":"A Rodriguez-Sinovas","year":"2009","unstructured":"Rodriguez-Sinovas, A. (2009). Cx43 phosphorylation and cardioprotection. Cardiovascular Research, 83, 613\u2013614. https:\/\/doi.org\/10.1093\/cvr\/cvp227","journal-title":"Cardiovascular Research"},{"key":"4986_CR11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3390\/biology11040489","volume":"11","author":"Y-H Guo","year":"2022","unstructured":"Guo, Y.-H., & Yang, Y.-Q. (2022). Atrial fibrillation: Focus on myocardial connexins and gap junctions. Biology, 11, 489. https:\/\/doi.org\/10.3390\/biology11040489","journal-title":"Biology"},{"key":"4986_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvw004","volume":"109","author":"S Morel","year":"2016","unstructured":"Morel, S., Christoffersen, C., Axelsen, L. N., Montecucco, F., Rochemont, V., Frias, M. A., et al. (2016). Sphingosine-1-phosphate reduces ischaemia\u2013reperfusion injury by phosphorylating the gap junction protein Connexin43. Cardiovascular Research, 109, 385\u2013396. https:\/\/doi.org\/10.1093\/cvr\/cvw004","journal-title":"Cardiovascular Research"},{"key":"4986_CR13","doi-asserted-by":"publisher","first-page":"e852","DOI":"10.1002\/iid3.852","volume":"11","author":"L An","year":"2023","unstructured":"An, L., Gao, H., Zhong, Y., Liu, Y., Cao, Y., Yi, J., et al. (2023). The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia. Immunity Inflammation and Disease, 11, e852. https:\/\/doi.org\/10.1002\/iid3.852","journal-title":"Immunity Inflammation and Disease"},{"key":"4986_CR14","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1007\/s12265-022-10256-7","volume":"15","author":"J Yi","year":"2022","unstructured":"Yi, J., Duan, H., Chen, K., Wen, C., Cao, Y., & Gao, H. (2022). Cardiac electrophysiological changes and downregulated connexin 43 Prompts reperfusion arrhythmias induced by hypothermic ischemia\u2013reperfusion injury in isolated rat hearts. Journal of Cardiovascular Translational Research, 15, 1464\u20131473. https:\/\/doi.org\/10.1007\/s12265-022-10256-7","journal-title":"Journal of Cardiovascular Translational Research"},{"key":"4986_CR15","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1161\/circresaha.116.309538","volume":"119","author":"MC Woodall","year":"2016","unstructured":"Woodall, M. C., Woodall, B. P., Gao, E., Yuan, A., & Koch, W. J. (2016). Cardiac fibroblast GRK2 deletion enhances contractility and remodeling following ischemia\/reperfusion injury. Circulation Research, 119, 1116\u20131127. https:\/\/doi.org\/10.1161\/circresaha.116.309538","journal-title":"Circulation Research"},{"key":"4986_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","volume":"588","author":"M Litvi\u0148ukov\u00e1","year":"2020","unstructured":"Litvi\u0148ukov\u00e1, M., Talavera-L\u00f3pez, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., et al. (2020). Cells of the adult human heart. Nature, 588, 466\u2013472. https:\/\/doi.org\/10.1038\/s41586-020-2797-4","journal-title":"Nature"},{"key":"4986_CR17","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3390\/mi12111351","volume":"12","author":"J Ji","year":"2021","unstructured":"Ji, J., Ren, X., & Zorlutuna, P. (2021). Cardiac cell patterning on customized microelectrode arrays for electrophysiological recordings. Micromachines, 12, 1351. https:\/\/doi.org\/10.3390\/mi12111351","journal-title":"Micromachines"},{"key":"4986_CR18","doi-asserted-by":"publisher","first-page":"H622","DOI":"10.1152\/ajpheart.00781.2006","volume":"292","author":"G Avila","year":"2007","unstructured":"Avila, G., Medina, I. M., Jim\u00e9nez, E., Elizondo, G., & Aguilar, C. I. (2007). Transforming growth factor-\u03b21 decreases cardiac muscle L-type Ca2+ current and charge movement by acting on the Cav1.2 mRNA. American Journal of Physiology. Heart and Circulatory Physiology, 292, H622\u2013H631. https:\/\/doi.org\/10.1152\/ajpheart.00781.2006","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"4986_CR19","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/cvr\/cvp164","volume":"83","author":"DM Pedrotty","year":"2009","unstructured":"Pedrotty, D. M., Klinger, R. Y., Kirkton, R. D., & Bursac, N. (2009). Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. Cardiovascular Research, 83, 688\u2013697. https:\/\/doi.org\/10.1093\/cvr\/cvp164","journal-title":"Cardiovascular Research"},{"key":"4986_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/cvr\/cvu264","volume":"105","author":"JE Cartledge","year":"2015","unstructured":"Cartledge, J. E., Kane, C., Dias, P., Tesfom, M., Clarke, L., McKee, B., et al. (2015). Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators. Cardiovascular Research, 105, 260\u2013270. https:\/\/doi.org\/10.1093\/cvr\/cvu264","journal-title":"Cardiovascular Research"},{"key":"4986_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00395-020-0775-5","volume":"115","author":"RK Adapala","year":"2020","unstructured":"Adapala, R. K., Kanugula, A. K., Paruchuri, S., Chilian, W. M., & Thodeti, C. K. (2020). TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation. Basic Research in Cardiology, 115, 14. https:\/\/doi.org\/10.1007\/s00395-020-0775-5","journal-title":"Basic Research in Cardiology"},{"key":"4986_CR22","doi-asserted-by":"publisher","first-page":"E3436","DOI":"10.1073\/pnas.1717423115","volume":"115","author":"RM Burke","year":"2018","unstructured":"Burke, R. M., Lighthouse, J. K., Quijada, P., Dirkx, R. A., Rosenberg, A., Moravec, C. S., et al. (2018). Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure. Proceedings of the National academy of Sciences of the United States of America, 115, E3436\u2013E3445. https:\/\/doi.org\/10.1073\/pnas.1717423115","journal-title":"Proceedings of the National academy of Sciences of the United States of America"},{"key":"4986_CR23","doi-asserted-by":"publisher","first-page":"863","DOI":"10.7150\/ijbs.24588","volume":"14","author":"J Song","year":"2018","unstructured":"Song, J., Tang, J., & Guo, F. (2018). Identification of inhibitors of MMPS enzymes via a novel computational approach. International Journal of Biological Sciences, 14, 863\u2013871. https:\/\/doi.org\/10.7150\/ijbs.24588","journal-title":"International Journal of Biological Sciences"},{"key":"4986_CR24","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","author":"H Nagase","year":"2006","unstructured":"Nagase, H., Visse, R., & Murphy, G. (2006). Structure and function of matrix metalloproteinases and TIMPs. Cardiovascular Research, 69, 562\u2013573. https:\/\/doi.org\/10.1016\/j.cardiores.2005.12.002","journal-title":"Cardiovascular Research"},{"key":"4986_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.09.016","volume":"77","author":"A DeCoux","year":"2014","unstructured":"DeCoux, A., Lindsey, M. L., Villarreal, F., Garcia, R. A., & Schulz, R. (2014). Myocardial matrix metalloproteinase-2: Inside out and upside down. Journal of Molecular and Cellular Cardiology, 77, 64\u201372. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.09.016","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"4986_CR26","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1002\/jcp.24040","volume":"227","author":"MAM Ali","year":"2012","unstructured":"Ali, M. A. M., Chow, A. K., Kandasamy, A. D., Fan, X., West, L. J., Crawford, B. D., et al. (2012). Mechanisms of cytosolic targeting of matrix metalloproteinase-2. Journal of Cellular Physiology, 227, 3397\u20133404. https:\/\/doi.org\/10.1002\/jcp.24040","journal-title":"Journal of Cellular Physiology"},{"key":"4986_CR27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/s0008-6363(96)00254-4","volume":"33","author":"W Yasmin","year":"1997","unstructured":"Yasmin, W. (1997). Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovascular Research, 33, 422\u2013432. https:\/\/doi.org\/10.1016\/s0008-6363(96)00254-4","journal-title":"Cardiovascular Research"},{"key":"4986_CR28","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s00395-014-0424-y","volume":"109","author":"BG Hughes","year":"2014","unstructured":"Hughes, B. G., & Schulz, R. (2014). Targeting MMP-2 to treat ischemic heart injury. Basic Research in Cardiology, 109, 424. https:\/\/doi.org\/10.1007\/s00395-014-0424-y","journal-title":"Basic Research in Cardiology"},{"key":"4986_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ydbio.2009.10.026","volume":"341","author":"T Rozario","year":"2010","unstructured":"Rozario, T., & DeSimone, D. W. (2010). The extracellular matrix in development and morphogenesis: A dynamic view. Developmental Biology, 341, 126\u2013140. https:\/\/doi.org\/10.1016\/j.ydbio.2009.10.026","journal-title":"Developmental Biology"},{"key":"4986_CR30","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1161\/circresaha.117.310083","volume":"120","author":"AP Landstrom","year":"2017","unstructured":"Landstrom, A. P., Dobrev, D., & Wehrens, X. H. T. (2017). Calcium signaling and cardiac arrhythmias. Circulation Research, 120, 1969\u20131993. https:\/\/doi.org\/10.1161\/circresaha.117.310083","journal-title":"Circulation Research"},{"key":"4986_CR31","doi-asserted-by":"publisher","first-page":"815301","DOI":"10.3389\/fphys.2022.815301","volume":"13","author":"C Zhong","year":"2022","unstructured":"Zhong, C., Zhao, H., Xie, X., Qi, Z., Li, Y., Jia, L., et al. (2022). Protein kinase C-mediated hyperphosphorylation and lateralization of connexin 43 are involved in autoimmune myocarditis-induced prolongation of QRS complex. Frontiers in Physiology, 13, 815301. https:\/\/doi.org\/10.3389\/fphys.2022.815301","journal-title":"Frontiers in Physiology"},{"key":"4986_CR32","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/cvr\/cvr209","volume":"92","author":"O Bikou","year":"2011","unstructured":"Bikou, O., Thomas, D., Trappe, K., Lugenbiel, P., Kelemen, K., Koch, M., et al. (2011). Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model. Cardiovascular Research, 92, 218\u2013225. https:\/\/doi.org\/10.1093\/cvr\/cvr209","journal-title":"Cardiovascular Research"},{"key":"4986_CR33","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/circulationaha.111.057224","volume":"125","author":"DW Van Norstrand","year":"2012","unstructured":"Van Norstrand, D. W., Asimaki, A., Rubinos, C., Dolmatova, E., Srinivas, M., Tester, D. J., et al. (2012). Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation, 125, 474\u2013481. https:\/\/doi.org\/10.1161\/circulationaha.111.057224","journal-title":"Circulation"},{"key":"4986_CR34","doi-asserted-by":"publisher","first-page":"H13","DOI":"10.1152\/ajpheart.00161.2019","volume":"317","author":"MN Sayegh","year":"2019","unstructured":"Sayegh, M. N., Fernandez, N., & Cho, H. C. (2019). Strength-duration relationship as a tool to prioritize cardiac tissue properties that govern electrical excitability. American Journal of Physiology. Heart and Circulatory Physiology, 317, H13\u2013H25. https:\/\/doi.org\/10.1152\/ajpheart.00161.2019","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"4986_CR35","doi-asserted-by":"publisher","first-page":"716721","DOI":"10.3389\/fphys.2021.716721","volume":"12","author":"R Flores-Vergara","year":"2021","unstructured":"Flores-Vergara, R., Olmedo, I., Ar\u00e1nguiz, P., Riquelme, J. A., Vivar, R., & Pedrozo, Z. (2021). Communication between cardiomyocytes and fibroblasts during cardiac ischemia\/reperfusion and remodeling: Roles of TGF-\u03b2, CTGF, the renin angiotensin axis, and non-coding RNA molecules. Frontiers in Physiology, 12, 716721. https:\/\/doi.org\/10.3389\/fphys.2021.716721","journal-title":"Frontiers in Physiology"},{"key":"4986_CR36","doi-asserted-by":"publisher","first-page":"e13160","DOI":"10.1111\/eci.13160","volume":"49","author":"YH Kao","year":"2019","unstructured":"Kao, Y. H., Chung, C. C., Cheng, W. L., Lkhagva, B., & Chen, Y. J. (2019). Pitx2c inhibition increases atrial fibroblast activity: Implications in atrial arrhythmogenesis. European Journal of Clinical Investigation, 49, e13160. https:\/\/doi.org\/10.1111\/eci.13160","journal-title":"European Journal of Clinical Investigation"},{"key":"4986_CR37","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1152\/physrev.00027.2010","volume":"91","author":"D Bosco","year":"2011","unstructured":"Bosco, D., Haefliger, J.-A., & Meda, P. (2011). Connexins: Key mediators of endocrine function. Physiological Reviews, 91, 1393\u20131445. https:\/\/doi.org\/10.1152\/physrev.00027.2010","journal-title":"Physiological Reviews"},{"key":"4986_CR38","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.3390\/ijms19092469","volume":"19","author":"J S\u00e1ez","year":"2018","unstructured":"S\u00e1ez, J., & Green, C. (2018). Involvement of connexin hemichannels in the inflammatory response of chronic diseases. International Journal of Molecular Sciences, 19, 2469. https:\/\/doi.org\/10.3390\/ijms19092469","journal-title":"International Journal of Molecular Sciences"},{"key":"4986_CR39","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.preteyeres.2017.06.001","volume":"61","author":"S Roy","year":"2017","unstructured":"Roy, S., Jiang, J. X., Li, A.-F., & Kim, D. (2017). Connexin channel and its role in diabetic retinopathy. Progress in Retinal and Eye Research, 61, 35\u201359. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.06.001","journal-title":"Progress in Retinal and Eye Research"},{"key":"4986_CR40","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.3390\/ijms21176025","volume":"21","author":"LA Cea","year":"2020","unstructured":"Cea, L. A., Fern\u00e1ndez, G., Arias-Bravo, G., Castillo-Ruiz, M., Escamilla, R., Bra\u00f1es, M. C., et al. (2020). Blockade of hemichannels normalizes the differentiation fate of myoblasts and features of skeletal muscles from dysferlin-deficient mice. International Journal of Molecular Sciences, 21, 6025. https:\/\/doi.org\/10.3390\/ijms21176025","journal-title":"International Journal of Molecular Sciences"},{"key":"4986_CR41","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1089\/ten.tea.2011.0707","volume":"18","author":"G Forte","year":"2012","unstructured":"Forte, G., Pagliari, S., Ebara, M., Uto, K., Tam, J. K. V., Romanazzo, S., et al. (2012). Substrate stiffness modulates gene expression and phenotype in neonatal cardiomyocytes in vitro. Tissue Engineering Part A, 18, 1837\u20131848. https:\/\/doi.org\/10.1089\/ten.tea.2011.0707","journal-title":"Tissue Engineering Part A"},{"key":"4986_CR42","doi-asserted-by":"publisher","first-page":"1057200","DOI":"10.3389\/fphys.2022.1057200","volume":"13","author":"AC Ernault","year":"2022","unstructured":"Ernault, A. C., Kawasaki, M., Fabrizi, B., Monta\u00f1\u00e9s-Agudo, P., Amersfoorth, S. C. M., Al-Shama, R. F. M., et al. (2022). Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers. Frontiers in Physiology, 13, 1057200. https:\/\/doi.org\/10.3389\/fphys.2022.1057200","journal-title":"Frontiers in Physiology"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-024-04986-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-024-04986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:21:01Z","timestamp":1735867261000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-024-04986-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["4986"],"URL":"https:\/\/doi.org\/10.1007\/s12010-024-04986-4","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"assertion":[{"value":"5 June 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed. The protocol of the experiments was approved by the Ethics Committee of Guizhou Medical University (approval number: 2303397).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}