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The anti-candidal activity and some inhibition performance of <jats:italic>J. rubens<\/jats:italic>\/PVA\/PVP hydrogel were investigated on <jats:italic>Candida tropicalis<\/jats:italic> which is one of the important causes of bloodstream infections. The physicochemical properties of <jats:italic>J. rubens<\/jats:italic>\/PVA\/PVP hydrogel were revealed using FTIR and swelling-absorption tests. The volatile compounds of <jats:italic>J. rubens<\/jats:italic> extracts were examined by GCMS. By mixing the extracts in equal proportions, PVA\/PVP-based hydrogel was prepared. According to the results, Cumulative Drug Release was stable at 25\u00a0\u00b0C for the first 5\u00a0h. The IZ (inhibition zone) and MIC (minimum inhibitory concentration) of <jats:italic>J. rubens<\/jats:italic>\/PVA\/PVP hydrogel were 9.01\u00a0mm and 80.20\u00a0mg\/mL, respectively. It was found that logarithmic reduction and percent reduction were seen as 1.5\u00a0CFU\/mL and 97.5%, respectively, on <jats:italic>C. tropicalis<\/jats:italic> exposed to <jats:italic>J. rubens<\/jats:italic>\/PVA\/PVP hydrogel in the first 5\u00a0min of the incubation. After exposure of <jats:italic>C. tropicalis<\/jats:italic> to <jats:italic>J. rubens<\/jats:italic>\/PVA\/PVP, the number of viable cells transferred from the gel to water was between 76.1 and 73.1% in high glucose medium, while it was between 92.2 and 80.8% for the PVA\/PVP hydrogel under the same conditions. As a result, PVA\/PVP hydrogel was made bioactive with <jats:italic>J. rubens<\/jats:italic> extracts for the first time in this study, and its potential for use as a functional anticandidal hydrogel on <jats:italic>C.<\/jats:italic><jats:italic>tropicalis<\/jats:italic> has been demonstrated.<\/jats:p>","DOI":"10.1007\/s12010-024-04997-1","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T07:01:54Z","timestamp":1720076514000},"page":"8848-8865","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Anti-candidal and Absorbtion Performance of PVA\/PVP-Based Jania rubens Hydrogel on Candida tropicalis and Some Physicochemical Properties of the Hydrogel"],"prefix":"10.1007","volume":"196","author":[{"given":"Meltem","family":"Boran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-3000","authenticated-orcid":false,"given":"Elif Erdogan","family":"Eliuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Ayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"4997_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ptr.2045","volume":"21","author":"NU Karabay-Yavasoglu","year":"2007","unstructured":"Karabay-Yavasoglu, N. 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