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However, cyanobacterial productivities tend to be weak compared to heterotrophic microbes. To enhance them, it is necessary to understand the fundamental metabolic mechanisms unique to cyanobacteria. In cyanobacteria, NADPH and ATP regenerated by linear and cyclic electron transfers using light energy are consumed by CO<jats:sub>2<\/jats:sub> fixation in a central metabolic pathway. The previous study demonstrated that the strain deleted a part of respiratory chain complex (\u0394<jats:italic>ndhF1<\/jats:italic>) perturbed NADPH levels and photosynthetic activity in <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803. It is expected that disruption of <jats:italic>ndhF1<\/jats:italic> would result in a decrease in the function of cyclic electron transfer, which controls the ATP\/NAD(P)H production ratio properly. In this study, we evaluated the effects of <jats:italic>ndhF1<\/jats:italic> deletion on central metabolism and photosynthesis by <jats:sup>13<\/jats:sup>C-metabolic flux analysis. As results of culturing the control and \u0394<jats:italic>ndhF1<\/jats:italic> strains in a medium containing [1,2-<jats:sup>13<\/jats:sup>C] glucose and estimating the flux distribution, CO<jats:sub>2<\/jats:sub> fixation rate by RuBisCO was decreased to be less than half in the \u0394<jats:italic>ndhF1<\/jats:italic> strain. In addition, the regeneration rate of NAD(P)H and ATP by the photosystem, which can be estimated from the flux distribution, also decreased to be less than half in the \u0394<jats:italic>ndhF1<\/jats:italic> strain, whereas no significant difference was observed in ATP\/NAD(P)H production ratio between the control and the \u0394<jats:italic>ndhF1<\/jats:italic> strains. Our result suggests that the ratio of utilization of cyclic electron transfer is not reduced in the \u0394<jats:italic>ndhF1<\/jats:italic> strain unexpectedly.<\/jats:p>","DOI":"10.1007\/s12010-024-05138-4","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T08:36:07Z","timestamp":1736930167000},"page":"2944-2957","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["13C-metabolic flux analysis of respiratory chain disrupted strain \u0394ndhF1 of Synechocystis sp. 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