{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:01:46Z","timestamp":1791021706299,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s12010-025-05249-6","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:32:40Z","timestamp":1746171160000},"page":"4516-4527","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Untargeted Metabolomics Revealed Metabolomic Profile in Patients with Primary Systemic Sclerosis"],"prefix":"10.1007","volume":"197","author":[{"given":"Jinling","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinglang","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"5249_CR1","doi-asserted-by":"publisher","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","volume":"1","author":"Y Allanore","year":"2015","unstructured":"Allanore, Y., Simms, R., Distler, O., et al. (2015). Systemic sclerosis. Nature Reviews Disease Primers, 1, 15002. https:\/\/doi.org\/10.1038\/nrdp.2015.2","journal-title":"Nature Reviews Disease Primers"},{"key":"5249_CR2","doi-asserted-by":"publisher","first-page":"109267","DOI":"10.1016\/j.clim.2023.109267","volume":"248","author":"J Tian","year":"2023","unstructured":"Tian, J., Kang, S., Zhang, D., et al. (2023). Global, regional, and national incidence and prevalence of systemic sclerosis. Clinical Immunology, 248, 109267. https:\/\/doi.org\/10.1016\/j.clim.2023.109267","journal-title":"Clinical Immunology"},{"issue":"4","key":"5249_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jbspin.2019.09.015","volume":"87","author":"E Zanatta","year":"2020","unstructured":"Zanatta, E., Codullo, V., Avouac, J., & Allanore, Y. (2020). Systemic sclerosis: Recent insight in clinical management. Joint, Bone, Spine, 87(4), 293\u2013299. https:\/\/doi.org\/10.1016\/j.jbspin.2019.09.015","journal-title":"Joint, Bone, Spine"},{"issue":"10373","key":"5249_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/S0140-6736(22)01692-0","volume":"401","author":"ER Volkmann","year":"2023","unstructured":"Volkmann, E. R., Andr\u00e9asson, K., & Smith, V. (2023). Systemic sclerosis. The Lancet, 401(10373), 304\u2013318. https:\/\/doi.org\/10.1016\/S0140-6736(22)01692-0","journal-title":"The Lancet"},{"issue":"1","key":"5249_CR5","doi-asserted-by":"publisher","first-page":"7626","DOI":"10.1038\/s41598-018-25992-7","volume":"8","author":"F Murgia","year":"2018","unstructured":"Murgia, F., Svegliati, S., Poddighe, S., et al. (2018). Metabolomic profile of systemic sclerosis patients. Science and Reports, 8(1), 7626. https:\/\/doi.org\/10.1038\/s41598-018-25992-7","journal-title":"Science and Reports"},{"issue":"1","key":"5249_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/nyas.13736","volume":"1421","author":"C Bellocchi","year":"2018","unstructured":"Bellocchi, C., Fern\u00e1ndez-Ochoa, \u00c1., Montanelli, G., et al. (2018). Microbial and metabolic multi-omic correlations in systemic sclerosis patients. Annals of the New York Academy of Sciences, 1421(1), 97\u2013109. https:\/\/doi.org\/10.1111\/nyas.13736","journal-title":"Annals of the New York Academy of Sciences"},{"key":"5249_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jpba.2018.09.021","volume":"162","author":"\u00c1 Fern\u00e1ndez-Ochoa","year":"2019","unstructured":"Fern\u00e1ndez-Ochoa, \u00c1., Quirantes-Pin\u00e9, R., Borr\u00e1s-Linares, I., et al. (2019). Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients. Journal of Pharmaceutical and Biomedical Analysis, 162, 82\u201390. https:\/\/doi.org\/10.1016\/j.jpba.2018.09.021","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"3","key":"5249_CR8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/biomedicines10030607","volume":"10","author":"T B\u00f6gl","year":"2022","unstructured":"B\u00f6gl, T., Mlynek, F., Himmelsbach, M., Sepp, N., Buchberger, W., & Geroldinger-Simi\u0107, M. (2022). Plasma metabolomic profiling reveals four possibly disrupted mechanisms in systemic sclerosis. Biomedicines, 10(3), 607. https:\/\/doi.org\/10.3390\/biomedicines10030607","journal-title":"Biomedicines"},{"key":"5249_CR9","doi-asserted-by":"publisher","first-page":"585161","DOI":"10.3389\/fmolb.2020.585161","volume":"7","author":"Z Smolenska","year":"2020","unstructured":"Smolenska, Z., Zabielska-Kaczorowska, M., Wojteczek, A., Kutryb-Zajac, B., & Zdrojewski, Z. (2020). Metabolic pattern of systemic sclerosis: Association of changes in plasma concentrations of amino acid-related compounds with disease presentation. Frontiers in Molecular Biosciences, 7, 585161. https:\/\/doi.org\/10.3389\/fmolb.2020.585161","journal-title":"Frontiers in Molecular Biosciences"},{"key":"5249_CR10","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ijcard.2017.04.024","volume":"241","author":"M Deidda","year":"2017","unstructured":"Deidda, M., Piras, C., Dessalvi, C. C., et al. (2017). Distinctive metabolomic fingerprint in scleroderma patients with pulmonary arterial hypertension. International Journal of Cardiology, 241, 401\u2013406. https:\/\/doi.org\/10.1016\/j.ijcard.2017.04.024","journal-title":"International Journal of Cardiology"},{"key":"5249_CR11","doi-asserted-by":"publisher","first-page":"155587","DOI":"10.1016\/j.metabol.2023.155587","volume":"144","author":"M Guo","year":"2023","unstructured":"Guo, M., Liu, D., Jiang, Y., et al. (2023). Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis. Metabolism, 144, 155587. https:\/\/doi.org\/10.1016\/j.metabol.2023.155587","journal-title":"Metabolism"},{"issue":"10","key":"5249_CR12","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/art.40547","volume":"70","author":"Y Allanore","year":"2018","unstructured":"Allanore, Y., Distler, O., Jagerschmidt, A., et al. (2018). Lysophosphatidic acid receptor 1 antagonist SAR100842 for patients with diffuse cutaneous systemic sclerosis: A double-blind, randomized, eight-week placebo-controlled study followed by a sixteen-week open-label extension study. Arthritis & Rhematology, 70(10), 1634\u20131643. https:\/\/doi.org\/10.1002\/art.40547","journal-title":"Arthritis & Rhematology"},{"key":"5249_CR13","doi-asserted-by":"publisher","first-page":"1475528","DOI":"10.3389\/fimmu.2024.1475528","volume":"15","author":"Q Yao","year":"2024","unstructured":"Yao, Q., Tan, W., & Bai, F. (2024). Gut microbiome and metabolomics in systemic sclerosis: Feature, link and mechanisms. Frontiers in Immunology, 15, 1475528. https:\/\/doi.org\/10.3389\/fimmu.2024.1475528","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"5249_CR14","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.55563\/clinexprheumatol\/jof7nx","volume":"41","author":"TC Tan","year":"2023","unstructured":"Tan, T. C., Chandrasekaran, L., Leung, Y. Y., Purbojati, R., Pettersson, S., & Low, A. H. L. (2023). Gut microbiome profiling in systemic sclerosis: A metagenomic approach. Clinical and Experimental Rheumatology, 41(8), 1578\u20131588. https:\/\/doi.org\/10.55563\/clinexprheumatol\/jof7nx","journal-title":"Clinical and Experimental Rheumatology"},{"key":"5249_CR15","doi-asserted-by":"publisher","first-page":"1215039","DOI":"10.3389\/fmolb.2023.1215039","volume":"10","author":"V Morales-Gonz\u00e1lez","year":"2023","unstructured":"Morales-Gonz\u00e1lez, V., Galeano-S\u00e1nchez, D., Covaleda-Vargas, J. E., Rodriguez, Y., Monsalve, D. M., Pardo-Rodriguez, D., Cala, M. P., Acosta-Ampudia, Y., & Ram\u00edrez-Santana, C. (2023). Metabolic fingerprinting of systemic sclerosis: a systematic review. Frontiers in Molecular, 10, 1215039. https:\/\/doi.org\/10.3389\/fmolb.2023.1215039","journal-title":"Frontiers in Molecular"},{"issue":"37","key":"5249_CR16","doi-asserted-by":"publisher","first-page":"26873","DOI":"10.1039\/d4ra03019b","volume":"14","author":"U Singh","year":"2024","unstructured":"Singh, U., Emwas, A. H., & Jaremko, M. (2024). Enhancement of weak signals by applying a suppression method to high-intense methyl and methylene signals of lipids in NMR spectroscopy. RSC Advances, 14(37), 26873\u201326883. https:\/\/doi.org\/10.1039\/d4ra03019b","journal-title":"RSC Advances"},{"issue":"1","key":"5249_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11306-023-02069-9","volume":"20","author":"U Singh","year":"2023","unstructured":"Singh, U., Al-Nemi, R., Alahmari, F., Emwas, A. H., & Jaremko, M. (2023). Improving quality of analysis by suppression of unwanted signals through band-selective excitation in NMR spectroscopy for metabolomics studies. Metabolomics, 20(1), 7. https:\/\/doi.org\/10.1007\/s11306-023-02069-9","journal-title":"Metabolomics"},{"issue":"26","key":"5249_CR18","doi-asserted-by":"publisher","first-page":"23651","DOI":"10.1021\/acsomega.3c01688","volume":"8","author":"U Singh","year":"2023","unstructured":"Singh, U., Alsuhaymi, S., Al-Nemi, R., Emwas, A. H., & Jaremko, M. (2023). Compound-specific 1D 1H NMR pulse sequence selection for metabolomics analyses. ACS Omega, 8(26), 23651\u201323663. https:\/\/doi.org\/10.1021\/acsomega.3c01688","journal-title":"ACS Omega"},{"issue":"5","key":"5249_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1752-8062.2010.00218.x","volume":"3","author":"MG Risbano","year":"2010","unstructured":"Risbano, M. G., Meadows, C. A., Coldren, C. D., et al. (2010). Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension. Clinical and Translational Science, 3(5), 210\u2013218. https:\/\/doi.org\/10.1111\/j.1752-8062.2010.00218.x","journal-title":"Clinical and Translational Science"},{"issue":"4","key":"5249_CR20","doi-asserted-by":"publisher","first-page":"e34951","DOI":"10.1371\/journal.pone.0034951","volume":"7","author":"C Cheadle","year":"2012","unstructured":"Cheadle, C., Berger, A. E., Mathai, S. C., et al. (2012). Erythroid-specific transcriptional changes in PBMCs from pulmonary hypertension patients. PLoS One, 7(4), e34951. https:\/\/doi.org\/10.1371\/journal.pone.0034951","journal-title":"PLoS One"},{"issue":"8","key":"5249_CR21","doi-asserted-by":"publisher","first-page":"e12106","DOI":"10.1371\/journal.pone.0012106","volume":"5","author":"SA Pendergrass","year":"2010","unstructured":"Pendergrass, S. A., Hayes, E., Farina, G., et al. (2010). Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One, 5(8), e12106. https:\/\/doi.org\/10.1371\/journal.pone.0012106","journal-title":"PLoS One"},{"issue":"3","key":"5249_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neuint.2010.06.001","volume":"57","author":"KE Tiedje","year":"2010","unstructured":"Tiedje, K. E., Stevens, K., Barnes, S., & Weaver, D. F. (2010). Beta-alanine as a small molecule neurotransmitter. Neurochemistry International, 57(3), 177\u2013188. https:\/\/doi.org\/10.1016\/j.neuint.2010.06.001","journal-title":"Neurochemistry International"},{"issue":"12","key":"5249_CR23","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1016\/j.celrep.2019.08.034","volume":"28","author":"N Ron-Harel","year":"2019","unstructured":"Ron-Harel, N., Ghergurovich, J. M., Notarangelo, G., et al. (2019). T cell activation depends on extracellular alanine. Cell Reports, 28(12), 3011-3021.e4. https:\/\/doi.org\/10.1016\/j.celrep.2019.08.034","journal-title":"Cell Reports"},{"key":"5249_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12970-015-0090-y","volume":"12","author":"ET Trexler","year":"2015","unstructured":"Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., et al. (2015). International society of sports nutrition position stand: Beta-alanine. Journal of the International Society of Sports Nutrition, 12, 30. https:\/\/doi.org\/10.1186\/s12970-015-0090-y","journal-title":"Journal of the International Society of Sports Nutrition"},{"issue":"1","key":"5249_CR25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1080\/15502783.2022.2079384","volume":"19","author":"D Ashtary-Larky","year":"2022","unstructured":"Ashtary-Larky, D., Bagheri, R., Ghanavati, M., et al. (2022). Effects of beta-alanine supplementation on body composition: A GRADE-assessed systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 19(1), 196\u2013218. https:\/\/doi.org\/10.1080\/15502783.2022.2079384","journal-title":"Journal of the International Society of Sports Nutrition"},{"issue":"6","key":"5249_CR26","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/ecco-jcc\/jjad217","volume":"18","author":"H Hashimoto","year":"2024","unstructured":"Hashimoto, H., Takagi, T., Asaeda, K., et al. (2024). D-alanine inhibits murine intestinal inflammation by suppressing IL-12 and IL-23 production in macrophages. Journal of Crohn\u2019s & Colitis, 18(6), 908\u2013919. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad217","journal-title":"Journal of Crohn's & Colitis"},{"issue":"6","key":"5249_CR27","doi-asserted-by":"publisher","first-page":"F667","DOI":"10.1152\/ajprenal.00198.2021","volume":"322","author":"Y Iwata","year":"2022","unstructured":"Iwata, Y., Nakade, Y., Kitajima, S., et al. (2022). Protective effect of d-alanine against acute kidney injury. American Journal of Physiology. Renal Physiology, 322(6), F667\u2013F679. https:\/\/doi.org\/10.1152\/ajprenal.00198.2021","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"20","key":"5249_CR28","doi-asserted-by":"publisher","first-page":"13700","DOI":"10.3390\/ijerph192013700","volume":"19","author":"I Turcu","year":"2022","unstructured":"Turcu, I., Oancea, B., Chicomban, M., et al. (2022). Effect of 8-week \u03b2-alanine supplementation on CRP, IL-6, body composition, and bio-motor abilities in elite male basketball players. International Journal of Environmental Research and Public Health, 19(20), 13700. https:\/\/doi.org\/10.3390\/ijerph192013700","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"1","key":"5249_CR29","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41588-021-00968-y","volume":"54","author":"X Liu","year":"2022","unstructured":"Liu, X., Tong, X., Zou, Y., et al. (2022). Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome. Nature Genetics, 54(1), 52\u201361. https:\/\/doi.org\/10.1038\/s41588-021-00968-y","journal-title":"Nature Genetics"},{"issue":"7","key":"5249_CR30","doi-asserted-by":"publisher","first-page":"6401","DOI":"10.18632\/aging.103035","volume":"12","author":"TT Xu","year":"2020","unstructured":"Xu, T. T., Li, H., Dai, Z., et al. (2020). Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging (Albany NY), 12(7), 6401\u20136414. https:\/\/doi.org\/10.18632\/aging.103035","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"5249_CR31","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.immuni.2023.01.001","volume":"56","author":"L Wang","year":"2023","unstructured":"Wang, L., Li, S., Wang, K., et al. (2023). Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS. Immunity, 56(2), 272-288.e7. https:\/\/doi.org\/10.1016\/j.immuni.2023.01.001","journal-title":"Immunity"},{"key":"5249_CR32","doi-asserted-by":"publisher","first-page":"108702","DOI":"10.1016\/j.intimp.2022.108702","volume":"107","author":"R Zheng","year":"2022","unstructured":"Zheng, R., Kong, M., Wang, S., He, B., & Xie, X. (2022). Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation. International Immunopharmacology, 107, 108702. https:\/\/doi.org\/10.1016\/j.intimp.2022.108702","journal-title":"International Immunopharmacology"},{"issue":"11","key":"5249_CR33","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1016\/j.immuni.2023.09.012","volume":"56","author":"C Zhao","year":"2023","unstructured":"Zhao, C., Ma, Y., Zhang, M., et al. (2023). Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity. Immunity, 56(11), 2508-2522.e6. https:\/\/doi.org\/10.1016\/j.immuni.2023.09.012","journal-title":"Immunity"},{"issue":"9","key":"5249_CR34","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.3390\/ijms22094382","volume":"22","author":"Q Peng","year":"2021","unstructured":"Peng, Q., Wong, C. Y. P., Cheuk, I. W. Y., Teoh, J. Y. C., Chiu, P. K. F., & Ng, C. F. (2021). The emerging clinical role of spermine in prostate cancer. International Journal of Molecular Sciences, 22(9), 4382. https:\/\/doi.org\/10.3390\/ijms22094382","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"5249_CR35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jaci.2020.04.037","volume":"147","author":"GM Carriche","year":"2021","unstructured":"Carriche, G. M., Almeida, L., St\u00fcve, P., et al. (2021). Regulating T-cell differentiation through the polyamine spermidine. Journal of Allergy and Clinical Immunology, 147(1), 335-348.e11. https:\/\/doi.org\/10.1016\/j.jaci.2020.04.037","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"11","key":"5249_CR36","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.it.2020.09.007","volume":"41","author":"E Proietti","year":"2020","unstructured":"Proietti, E., Rossini, S., Grohmann, U., & Mondanelli, G. (2020). Polyamines and kynurenines at the intersection of immune modulation. Trends in Immunology, 41(11), 1037\u20131050. https:\/\/doi.org\/10.1016\/j.it.2020.09.007","journal-title":"Trends in Immunology"},{"issue":"12","key":"5249_CR37","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1111\/j.1742-4658.2005.04726.x","volume":"272","author":"N Grandvaux","year":"2005","unstructured":"Grandvaux, N., Gaboriau, F., Harris, J., tenOever, B. R., Lin, R., & Hiscott, J. (2005). Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response. FEBS Journal, 272(12), 3120\u20133131. https:\/\/doi.org\/10.1111\/j.1742-4658.2005.04726.x","journal-title":"FEBS Journal"},{"issue":"1","key":"5249_CR38","doi-asserted-by":"publisher","first-page":"100807","DOI":"10.1016\/j.isci.2019.100807","volume":"23","author":"G Li","year":"2020","unstructured":"Li, G., Ding, H., Yu, X., et al. (2020). Spermidine suppresses inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity. iScience, 23(1), 100807. https:\/\/doi.org\/10.1016\/j.isci.2019.100807","journal-title":"iScience"},{"issue":"2","key":"5249_CR39","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cmet.2019.05.003","volume":"30","author":"DJ Puleston","year":"2019","unstructured":"Puleston, D. J., Buck, M. D., Klein Geltink, R. I., et al. (2019). Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation. Cell Metabolism, 30(2), 352-363.e8. https:\/\/doi.org\/10.1016\/j.cmet.2019.05.003","journal-title":"Cell Metabolism"},{"issue":"23","key":"5249_CR40","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1016\/j.cell.2021.09.031","volume":"184","author":"N Tal","year":"2021","unstructured":"Tal, N., Morehouse, B. R., Millman, A., et al. (2021). Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184(23), 5728-5739.e16. https:\/\/doi.org\/10.1016\/j.cell.2021.09.031","journal-title":"Cell"},{"issue":"38","key":"5249_CR41","doi-asserted-by":"publisher","first-page":"6227","DOI":"10.2174\/0929867331666230712113943","volume":"31","author":"A Murmu","year":"2024","unstructured":"Murmu, A., Banjare, P., Matore, B. W., Roy, P. P., & Singh, J. (2024). 1,3,4-Oxadiazole: An emerging scaffold to inhibit the thymidine phosphorylase as an anticancer agent. Current Medicinal Chemistry, 31(38), 6227\u20136250. https:\/\/doi.org\/10.2174\/0929867331666230712113943","journal-title":"Current Medicinal Chemistry"},{"issue":"2","key":"5249_CR42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/sj.bjp.0705216","volume":"139","author":"S Sengupta","year":"2003","unstructured":"Sengupta, S., Sellers, L. A., Matheson, H. B., & Fan, T. P. D. (2003). Thymidine phosphorylase induces angiogenesis in vivo and in vitro: An evaluation of possible mechanisms. British Journal of Pharmacology, 139(2), 219\u2013231. https:\/\/doi.org\/10.1038\/sj.bjp.0705216","journal-title":"British Journal of Pharmacology"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-025-05249-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-025-05249-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-025-05249-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T01:10:45Z","timestamp":1754356245000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-025-05249-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["5249"],"URL":"https:\/\/doi.org\/10.1007\/s12010-025-05249-6","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"21 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Children\u2019s Hospital of Hunan Province (HCHLL-2024\u2013268).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The informed consent was obtained for experimentation with human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors expressly consent to the publication of their works.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}