{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:16:59Z","timestamp":1788898619736,"version":"build-2803163510"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12010-025-05486-9","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:23:00Z","timestamp":1768555380000},"page":"2448-2473","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the In Vitro Neuroprotective Potential of Aegiceras corniculatum against MPTP-induced Toxicity"],"prefix":"10.1007","volume":"198","author":[{"given":"Nitu","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaddi Damodara","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2445-8118","authenticated-orcid":false,"given":"Santosh","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"5486_CR1","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.jconrel.2020.11.021","volume":"330","author":"A Akhtar","year":"2021","unstructured":"Akhtar, A., Andleeb, A., Waris, T. S., Bazzar, M., Moradi, A. R., Awan, N. R., & Yar, M. (2021). Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics. Journal of Controlled Release, 330, 1152\u20131167.","journal-title":"Journal of Controlled Release"},{"key":"5486_CR2","doi-asserted-by":"publisher","first-page":"172260","DOI":"10.1016\/j.scitotenv.2024.172260","volume":"928","author":"ME Newell","year":"2024","unstructured":"Newell, M. E., Babbrah, A., Aravindan, A., Rathnam, R., Kiernan, R., Driver, E. M., Bowes, D. A., & Halden, R. U. (2024). Prevalence rates of neurodegenerative diseases versus human exposures to heavy metals across the United States. Science of the Total Environment, 928, Article 172260.","journal-title":"Science of the Total Environment"},{"issue":"13","key":"5486_CR3","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.3390\/ijms25137183","volume":"25","author":"M Muleiro Alvarez","year":"2024","unstructured":"Muleiro Alvarez, M., Cano-Herrera, G., Osorio Mart\u00ednez, M. F., Vega Gonzales-Portillo, J., Monroy, G. R., Murguiondo P\u00e9rez, R., Torres-R\u00edos, J. A., van Tienhoven, X. A., Garibaldi Bernot, E. M., Esparza Salazar, F., & Ibarra, A. (2024). A comprehensive approach to Parkinson\u2019s disease: Addressing its molecular, clinical, and therapeutic aspects. International Journal of Molecular Sciences, 25(13), Article 7183.","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"5486_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.20517\/and.2023.36","volume":"4","author":"J Bendig","year":"2024","unstructured":"Bendig, J., Frank, A., & Reichmann, H. (2024). Aging and Parkinson\u2019s disease: A complex interplay of vulnerable neurons, the immune system, and the blood-brain barrier. Ageing and Neurodegenerative Diseases, 4(1), Article 5.","journal-title":"Ageing and Neurodegenerative Diseases"},{"issue":"11","key":"5486_CR5","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1093\/brain\/awab242","volume":"144","author":"A Tozzi","year":"2021","unstructured":"Tozzi, A., Sciaccaluga, M., Loffredo, V., Megaro, A., Ledonne, A., Cardinale, A., Federici, M., Bellingacci, L., Paciotti, S., Ferrari, E., & Rocca, L., A (2021). Dopamine-dependent early synaptic and motor dysfunctions induced by \u03b1-synuclein in the nigrostriatal circuit. Brain, 144(11), 3477\u20133491.","journal-title":"Brain"},{"key":"5486_CR6","doi-asserted-by":"crossref","unstructured":"Chen, H., Li, J., Huang, Z., Fan, X., Wang, X., Chen, X., Guo, H., Liu, H., Li, S., Yu, S., & Li, H. (n.d.). Dopaminergic system and neurons: Role in multiple neurological diseases. Neuropharmacology, 260, 110133.","DOI":"10.1016\/j.neuropharm.2024.110133"},{"key":"5486_CR7","doi-asserted-by":"publisher","first-page":"719807","DOI":"10.3389\/fimmu.2021.719807","volume":"12","author":"Y Li","year":"2021","unstructured":"Li, Y., Xia, Y., Yin, S., Wan, F., Hu, J., Kou, L., Sun, Y., Wu, J., Zhou, Q., Huang, J., & Xiong, N. (2021). Targeting microglial \u03b1-synuclein\/TLRs\/NF-kappaB\/NLRP3 inflammasome axis in Parkinson\u2019s disease. Frontiers in Immunology, 12, Article 719807.","journal-title":"Frontiers in Immunology"},{"issue":"7","key":"5486_CR8","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3390\/cells12071012","volume":"12","author":"S Isik","year":"2023","unstructured":"Isik, S., Yeman Kiyak, B., Akbayir, R., Seyhali, R., & Arpaci, T. (2023). Microglia mediated neuroinflammation in Parkinson\u2019s disease. Cells, 12(7), Article 1012.","journal-title":"Cells"},{"key":"5486_CR9","doi-asserted-by":"crossref","unstructured":"Chang, B., Jiang, Y., Feng, C., Li, B., Mei, J., & Niu, C. (2025). Effect of purine diet on prognosis of deep brain stimulation for parkinson\u2019s disease. Food Science and Human Wellness, 14(3).","DOI":"10.26599\/FSHW.2024.9250066"},{"issue":"4","key":"5486_CR10","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3390\/antiox12040955","volume":"12","author":"S Chakrabarti","year":"2023","unstructured":"Chakrabarti, S., & Bisaglia, M. (2023). Oxidative stress and neuroinflammation in parkinson\u2019s disease: The role of dopamine oxidation products. Antioxidants, 12(4), 955.","journal-title":"Antioxidants"},{"issue":"3","key":"5486_CR11","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","volume":"14","author":"P Calabresi","year":"2023","unstructured":"Calabresi, P., Mechelli, A., Natale, G., Volpicelli-Daley, L., Di Lazzaro, G., & Ghiglieri, V. (2023). Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction. Cell Death & Disease, 14(3), Article 176.","journal-title":"Cell Death & Disease"},{"issue":"9","key":"5486_CR12","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1080\/1028415X.2025.2469170","volume":"28","author":"R Sharma","year":"2025","unstructured":"Sharma, R., Bhate, L., Agrawal, Y., & Aspatwar, A. (2025). Advanced nutraceutical approaches to Parkinson\u2019s disease: Bridging nutrition and neuroprotection. Nutritional Neuroscience, 28(9), 1134\u20131150.","journal-title":"Nutritional Neuroscience"},{"key":"5486_CR13","doi-asserted-by":"publisher","first-page":"885500","DOI":"10.3389\/fnagi.2022.885500","volume":"14","author":"XY Gao","year":"2022","unstructured":"Gao, X. Y., Yang, T., Gu, Y., & Sun, X. H. (2022). Mitochondrial dysfunction in Parkinson\u2019s disease: From mechanistic insights to therapy. Frontiers in Aging Neuroscience, 14, Article 885500.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"5486_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13024-023-00676-7","volume":"18","author":"MT Henrich","year":"2023","unstructured":"Henrich, M. T., Oertel, W. H., Surmeier, D. J., & Geibl, F. F. (2023). Mitochondrial dysfunction in Parkinson\u2019s disease\u2013a key disease hallmark with therapeutic potential. Molecular Neurodegeneration, 18(1), Article 83.","journal-title":"Molecular Neurodegeneration"},{"key":"5486_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fnagi.2018.00109","volume":"10","author":"XS Zeng","year":"2018","unstructured":"Zeng, X. S., Geng, W. S., Jia, J. J., Chen, L., & Zhang, P. P. (2018). Cellular and molecular basis of neurodegeneration in Parkinson disease. Frontiers in Aging Neuroscience, 10, Article 109.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"19","key":"5486_CR16","doi-asserted-by":"publisher","first-page":"7229","DOI":"10.1039\/D3SC05661A","volume":"15","author":"AJ Dear","year":"2024","unstructured":"Dear, A. J., Teng, X., Ball, S. R., Lewin, J., Horne, R. I., Clow, D., & Meisl, G. (2024). Molecular mechanism of \u03b1-synuclein aggregation on lipid membranes revealed. Chemical Science, 15(19), 7229\u20137242.","journal-title":"Chemical Science"},{"key":"5486_CR17","doi-asserted-by":"publisher","first-page":"736978","DOI":"10.3389\/fmed.2021.736978","volume":"8","author":"E Srinivasan","year":"2021","unstructured":"Srinivasan, E., Chandrasekhar, G., Chandrasekar, P., Anbarasu, K., Vickram, A. S., Karunakaran, R., & Srikumar, P. S. (2021). Alpha-synuclein aggregation in parkinson\u2019s disease. Frontiers in Medicine, 8, 736978.","journal-title":"Frontiers in Medicine"},{"issue":"12","key":"5486_CR18","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/biomedicines8120591","volume":"8","author":"O Buneeva","year":"2020","unstructured":"Buneeva, O., Fedchenko, V., Kopylov, A., & Medvedev, A. (2020). Mitochondrial dysfunction in Parkinson\u2019s disease: Focus on mitochondrial DNA. Biomedicines, 8(12), Article 591.","journal-title":"Biomedicines"},{"key":"5486_CR19","doi-asserted-by":"crossref","unstructured":"Jalouli, M., Rahman, M. A., Biswas, P., Rahman, H., Harrath, A. H., Lee, I. S., \u2026Kim, B. (2025). Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: A comprehensive review. Frontiers in Pharmacology, 16, 1492517.","DOI":"10.3389\/fphar.2025.1492517"},{"key":"5486_CR20","doi-asserted-by":"publisher","first-page":"123088","DOI":"10.1016\/j.lfs.2024.123088","volume":"357","author":"R Qiu","year":"2024","unstructured":"Qiu, R., Sun, W., Su, Y., Sun, Z., Fan, K., Liang, Y., Lin, X., & Zhang, Y. (2024). Irisin\u2019s emerging role in Parkinson\u2019s disease research: A review from molecular mechanisms to therapeutic prospects. Life Sciences, 357, Article 123088.","journal-title":"Life Sciences"},{"issue":"11","key":"5486_CR21","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/WNR.0000000000001922","volume":"34","author":"R Yang","year":"2023","unstructured":"Yang, R., Ye, S., Zhang, S., Huang, H., Zhang, Y., Yang, Y., Xie, S., He, L., Yang, Y., & Shi, J. (2023). Serotonin and dopamine depletion in distinct brain regions may cause anxiety in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as a model of early parkinson\u2019s disease. Neuroreport, 34(11), 551\u2013559.","journal-title":"Neuroreport"},{"issue":"4","key":"5486_CR22","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1177\/09731296241251916","volume":"20","author":"W Ban","year":"2024","unstructured":"Ban, W., Lu, L., Teng, X., Zhang, Y., & Qi, H. (2024). Aridanin attenuates behavior deficits and neuroinflammatory response in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinson\u2019s disease in mice. Pharmacognosy Magazine, 20(4), 1248\u20131257.","journal-title":"Pharmacognosy Magazine"},{"key":"5486_CR23","doi-asserted-by":"publisher","first-page":"9829176","DOI":"10.1155\/2020\/9829176","volume":"2020","author":"S Di Meo","year":"2020","unstructured":"Di Meo, S., & Venditti, P. (2020). Evolution of the knowledge of free radicals and other oxidants. Oxidative Medicine and Cellular Longevity, 2020, Article 9829176.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"8","key":"5486_CR24","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1007\/s12035-023-03358-z","volume":"60","author":"L Rani","year":"2023","unstructured":"Rani, L., Ghosh, B., Ahmad, M. H., & Mondal, A. C. (2023). Evaluation of potential neuroprotective effects of Vanillin against MPP\u207a\/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and a mouse model of parkinson\u2019s disease. Molecular Neurobiology, 60(8), 4693\u20134715.","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"5486_CR25","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3390\/antiox12020517","volume":"12","author":"EO Olufunmilayo","year":"2023","unstructured":"Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. D. (2023). Oxidative stress and antioxidants in neurodegenerative disorders. Antioxidants, 12(2), Article 517.","journal-title":"Antioxidants"},{"issue":"1","key":"5486_CR26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ipha.2023.09.006","volume":"2","author":"M Mursal","year":"2024","unstructured":"Mursal, M., Kumar, A., Hasan, S. M., Hussain, S., Singh, K., Kushwaha, S. P., Arif, M., Singh, R. K., Singh, D., Mohammad, A., & Fatima, S. K. (2024). Role of natural bioactive compounds in the management of neurodegenerative disorders. Intelligent Pharmacy, 2(1), 102\u2013113.","journal-title":"Intelligent Pharmacy"},{"issue":"2","key":"5486_CR27","doi-asserted-by":"publisher","first-page":"e155","DOI":"10.1016\/S2542-5196(22)00317-5","volume":"7","author":"S Theodoridis","year":"2023","unstructured":"Theodoridis, S., Drakou, E. G., Hickler, T., Thines, M., & Nogu\u00e9s-Bravo, D. (2023). Evaluating natural medicinal resources and their exposure to global change. The Lancet Planetary Health, 7(2), e155\u2013e163.","journal-title":"The Lancet Planetary Health"},{"key":"5486_CR28","doi-asserted-by":"publisher","first-page":"100113","DOI":"10.1016\/j.arres.2024.100113","volume":"2024","author":"JK Paul","year":"2024","unstructured":"Paul, J. K., Azmal, M., Haque, A. S., Talukder, O. F., Meem, M., & Ghosh, A. (2024). Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery. Advances in Redox Research, 2024, 100113.","journal-title":"Advances in Redox Research"},{"issue":"8","key":"5486_CR29","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3390\/md22080372","volume":"22","author":"Y Yu","year":"2024","unstructured":"Yu, Y., Wang, Z., Xiong, D., Zhou, L., Kong, F., & Wang, Q. (2024). New secondary metabolites of mangrove-associated strains. Marine Drugs, 22(8), Article 372.","journal-title":"Marine Drugs"},{"issue":"9","key":"5486_CR30","doi-asserted-by":"publisher","first-page":"6174","DOI":"10.1002\/fsn3.4318","volume":"12","author":"R Chowdhury","year":"2024","unstructured":"Chowdhury, R., Bhuia, M. S., Al Hasan, M. S., Hossain Snigdha, S., Afrin, S., B\u00fcsselberg, D., Habtemariam, S., S\u00f6nmez G\u00fcrer, E., Sharifi-Rad, J., Ahmed Aldahish, A., & Akhtayeva, N. (2024). Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights. Food Science & Nutrition, 12(9), 6174\u20136205.","journal-title":"Food Science & Nutrition"},{"issue":"62B","key":"5486_CR31","doi-asserted-by":"publisher","first-page":"321","DOI":"10.9734\/jpri\/2021\/v33i62B35586","volume":"33","author":"PT Lakshme","year":"2021","unstructured":"Lakshme, P. T., Roy, A., Sivaperumal, P., & Lakshmi, T. (2021). Exploration of antioxidant effects of crude extract of mangrove plant Avicennia marina. Journal of Pharmaceutical Research International, 33(62B), 321\u2013329.","journal-title":"Journal of Pharmaceutical Research International"},{"issue":"5","key":"5486_CR32","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3390\/molecules29051180","volume":"29","author":"Y Liang","year":"2024","unstructured":"Liang, Y., Ban, Y., Liu, L., & Li, Y. (2024). Inhibitory effects of the polyphenols from the root of Rhizophora apiculata Blume on fatty acid synthase activity and human colon cancer cells. Molecules (Basel, Switzerland), 29(5), Article 1180.","journal-title":"Molecules (Basel, Switzerland)"},{"key":"5486_CR33","doi-asserted-by":"crossref","unstructured":"Acharya, S., Jali, P., Pradhan, M., Pradhan, C., & Mohapatra, P. K. (2023). Antimicrobial and antioxidant property of a true Mangrove rhizophora apiculata Bl. Chemistry & Biodiversity, 20(9), e202201144.","DOI":"10.1002\/cbdv.202201144"},{"key":"5486_CR34","doi-asserted-by":"crossref","unstructured":"Govindhan, P. (2024). Phytochemical analysis of the methanolic extract from the Mangrove species Avicennia Marina plant species inhabited in coastal water. Natural Product Research, 1\u201311.","DOI":"10.1080\/14786419.2024.2402474"},{"key":"5486_CR35","first-page":"7095","volume":"30","author":"MK Mollah","year":"2024","unstructured":"Mollah, M. K., & Das, S. (2024). The evaluation of pharmacological activity of potential mangrove Avicennia officinalis & Heritiera fomes: A review. Educational Administration: Theory and Practice, 30, 7095\u20137109.","journal-title":"Educational Administration: Theory and Practice"},{"issue":"47","key":"5486_CR36","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.17485\/IJST\/v15i47.1633","volume":"15","author":"S Khadeeja","year":"2022","unstructured":"Khadeeja, S., Ragunathan, R., Johney, J., & Muthusamy, K. (2022). Phytochemical analysis, antimicrobial and antioxidant activity of mangrove plants Bruguiera gymnorrhiza (L.) Lam. and Excoecaria agallocha L. Indian Journal of Science and Technology, 15(47), 2594\u20132604.","journal-title":"Indian Journal of Science and Technology"},{"key":"5486_CR37","doi-asserted-by":"crossref","unstructured":"Sarkar, P., Ahnaf, T. R., Rouf, R., Shilpi, J. A., & Uddin, S. J. (2024). A review on bioactive phytochemical constituents and pharmacological activities of Aegiceras corniculatum: A pharmaceutically important mangrove plant. Journal of Chemistry, 2024, 9992568.","DOI":"10.1155\/2024\/9992568"},{"issue":"1","key":"5486_CR38","first-page":"1046","volume":"17","author":"AP Nugraha","year":"2023","unstructured":"Nugraha, A. P., Sibero, M. T., Nugraha, A. P., Puspitaningrum, M. S., Rizqianti, Y., Rahmadhani, D., Kharisma, V. D., Ramadhani, N. F., Ridwan, R. D., & Ernawati, D. S. (2023). Anti-periodontopathogenic ability of mangrove leaves (Aegiceras corniculatum) ethanol extract: In silico and in vitro study. European Journal of Dentistry, 17(1), 1046\u20131056.","journal-title":"European Journal of Dentistry"},{"key":"5486_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1201\/9780429318429-2","volume-title":"Phytomedicine and Alzheimer\u2019s Disease","author":"GK Pratap","year":"2020","unstructured":"Pratap, G. K., & Shantaram, M. (2020). An alternative approach for anti-Alzheimer\u2019s compounds from plant extracts. Phytomedicine and Alzheimer\u2019s Disease (pp. 15\u201340). CRC Press."},{"issue":"19","key":"5486_CR40","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.3390\/molecules28196890","volume":"28","author":"T Maliar","year":"2023","unstructured":"Maliar, T., Maliarov\u00e1, M., Blazkova, M., Kunstek, M., Uvackova, L., Viskupicova, J., Purdesova, A., & Benovic, P. (2023). Simultaneously determined antioxidant and pro-oxidant activity of randomly selected plant secondary metabolites and plant extracts. Molecules, 28(19), Article 6890.","journal-title":"Molecules"},{"issue":"5","key":"5486_CR41","doi-asserted-by":"publisher","first-page":"103979","DOI":"10.1016\/j.sjbs.2024.103979","volume":"31","author":"SA Jaber","year":"2024","unstructured":"Jaber, S. A. (2024). The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts. Saudi Journal of Biological Sciences, 31(5), Article 103979.","journal-title":"Saudi Journal of Biological Sciences"},{"issue":"1","key":"5486_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/abio.1996.0292","volume":"239","author":"IF Benzie","year":"1996","unstructured":"Benzie, I. F., & Strain, J. J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: The FRAP assay. Analytical Biochemistry, 239(1), 70\u201376.","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"5486_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0308-8146(99)00269-1","volume":"70","author":"M Wettasinghe","year":"2000","unstructured":"Wettasinghe, M., & Shahidi, F. (2000). Scavenging of reactive-oxygen species and DPPH free radicals by extracts of borage and evening primrose meals. Food Chemistry, 70(1), 17\u201326.","journal-title":"Food Chemistry"},{"key":"5486_CR44","doi-asserted-by":"crossref","unstructured":"Pang, Y., Wu, Q., Zhang, M., Lai, J., Chen, D., Su, J., \u2026 Li, Y. (2023). Hesperidin Induced HePG-2 Cell Apoptosis through ROS\u2010Mediated p53\/Bcl\u20102\/Bax and p\u2010mTOR Signaling Pathways. Journal of Food Biochemistry, 2023(1), 3788655.","DOI":"10.1155\/2023\/3788655"},{"issue":"1","key":"5486_CR45","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s42269-024-01250-x","volume":"48","author":"AA Sattar","year":"2024","unstructured":"Sattar, A. A., Matin, A. A., Hadwan, M. H., Hadwan, A. M., & Mohammed, R. M. (2024). Rapid and effective protocol to measure glutathione peroxidase activity. Bulletin of the National Research Centre, 48(1), Article 100.","journal-title":"Bulletin of the National Research Centre"},{"issue":"1","key":"5486_CR46","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/pharmaceutics15010212","volume":"15","author":"S Andrade","year":"2023","unstructured":"Andrade, S., Nunes, D., Dabur, M., Ramalho, M. J., Pereira, M. C., & Loureiro, J. A. (2023). Therapeutic potential of natural compounds in neurodegenerative diseases: Insights from clinical trials. Pharmaceutics, 15(1), Article 212.","journal-title":"Pharmaceutics"},{"issue":"12","key":"5486_CR47","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.7150\/thno.98457","volume":"14","author":"J Meng","year":"2024","unstructured":"Meng, J., Fang, J., Bao, Y., Chen, H., Hu, X., Wang, Z., Li, M., Cheng, Q., Dong, Y., Yang, X., & Zou, Y. (2024). The biphasic role of Hspb1 on ferroptotic cell death in Parkinson\u2019s disease. Theranostics, 14(12), 4643.","journal-title":"Theranostics"},{"issue":"1","key":"5486_CR48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s40001-024-01779-7","volume":"29","author":"B Alharbi","year":"2024","unstructured":"Alharbi, B., Al-Kuraishy, H. M., Al-Gareeb, A. I., Elekhnawy, E., Alharbi, H., Alexiou, A., Papadakis, M., & Batiha, G. E. (2024). Role of GABA pathway in motor and non-motor symptoms in Parkinson\u2019s disease: A bidirectional circuit. European Journal of Medical Research, 29(1), Article 205.","journal-title":"European Journal of Medical Research"},{"issue":"7","key":"5486_CR49","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41386-025-02080-9","volume":"50","author":"Y Yao","year":"2025","unstructured":"Yao, Y., Cui, C., Shi, Y., Lei, J., Li, T., Li, M., Peng, X., Yang, X., Ren, K., Yang, J., & Luo, G. (2025). DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson\u2019s disease vulnerability. Neuropsychopharmacology\u202f: Official Publication of the American College of Neuropsychopharmacology, 50(7), 1051\u20131062.","journal-title":"Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology"},{"issue":"4","key":"5486_CR50","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s00044-024-03203-5","volume":"33","author":"N Saini","year":"2024","unstructured":"Saini, N., Singh, N., Kaur, N., Garg, S., Kaur, M., Kumar, A., Verma, M., Singh, K., & Sohal, H. S. (2024). Motor and non-motor symptoms, drugs, and their mode of action in Parkinson\u2019s disease (PD): A review. Medicinal Chemistry Research, 33(4), 580\u2013599.","journal-title":"Medicinal Chemistry Research"},{"issue":"6","key":"5486_CR51","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s40263-025-01179-3","volume":"39","author":"HA Blair","year":"2025","unstructured":"Blair, H. A. (2025). Foslevodopa\/foscarbidopa: A review in advanced Parkinson\u2019s disease. CNS Drugs, 39(6), 621\u2013632.","journal-title":"CNS Drugs"},{"issue":"1","key":"5486_CR52","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s12013-024-01553-w","volume":"83","author":"S Noshin","year":"2025","unstructured":"Noshin, S., Bairagi, R. D., Airin, S., Debnath, D., Rahaman, M. S., Acharzo, A. K., Aktar, M., Bourhia, M., Salamatullah, A. M., & Islam, M. A. (2025). Synergistic bioactivity of Aegiceras corniculatum (L.) Blanco and its endophytic fungus Aspergillus: Antioxidant, antimicrobial, and cytotoxic effects. Cell Biochemistry and Biophysics, 83(1), 1197\u20131206.","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"3","key":"5486_CR53","first-page":"250","volume":"5","author":"ARK Reddy","year":"2016","unstructured":"Reddy, A. R. K., & Grace, J. R. (2016). In vitro evaluation of antioxidant activity of methanolic extracts of selected Mangrove plants. Medicinal and Aromatic Plants, 5(3), 250.","journal-title":"Medicinal and Aromatic Plants"},{"key":"5486_CR54","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.sajb.2017.09.019","volume":"113","author":"H Janmanchi","year":"2017","unstructured":"Janmanchi, H., Raju, A., Degani, M. S., Ray, M. K., & Rajan, M. G. R. (2017). Antituberculosis, antibacterial and antioxidant activities of Aegiceras corniculatum, a mangrove plant and effect of various extraction processes on its phytoconstituents and bioactivity. South African Journal of Botany, 113, 421\u2013427.","journal-title":"South African Journal of Botany"},{"issue":"9","key":"5486_CR55","doi-asserted-by":"publisher","first-page":"516","DOI":"10.26538\/tjnpr\/v4i9","volume":"4","author":"SL Debnath","year":"2020","unstructured":"Debnath, S. L., Kundu, P., Golder, M., Biswas, B., & Sadhu, S. K. (2020). Phytochemical characterization and evaluation of Pharmacological activities of leaves of a Mangrove plant Species-Aegiceras corniculatum (L). Tropical Journal of Natural Product Research (TJNPR), 4(9), 516\u2013522. https:\/\/doi.org\/10.26538\/tjnpr\/v4i9. 4.","journal-title":"Tropical Journal of Natural Product Research (TJNPR)"},{"issue":"3","key":"5486_CR56","doi-asserted-by":"publisher","first-page":"793","DOI":"10.5530\/ijper.55.3.152","volume":"55","author":"M Mohapatra","year":"2021","unstructured":"Mohapatra, M., & Basak, U. C. (2021). Assessment of antioxidant activity of crude and purified Bio-active Compound, Embelin in Aegiceras corniculatum (L.) blanco: A Less-explored Mangrove plant. Indian Journal of Pharmaceutical Education & Research, 55(3), 793\u2013800.","journal-title":"Indian Journal of Pharmaceutical Education & Research"},{"issue":"2","key":"5486_CR57","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s12031-025-02342-7","volume":"75","author":"EM Elmorsy","year":"2025","unstructured":"Elmorsy, E. M., Al-Ghafari, A. B., Al Doghaither, H. A., Elghareeb, M. M., & Alsaqati, M. (2025). Fucoxanthinol mitigates the cytotoxic effect of chlorpyrifos and MPTP on the dopaminergic differentiation of SH-SY5Y human neuroblastoma cells. Journal of Molecular Neuroscience, 75(2), Article 46.","journal-title":"Journal of Molecular Neuroscience"},{"issue":"7","key":"5486_CR58","doi-asserted-by":"publisher","first-page":"8899","DOI":"10.1007\/s00210-025-03815-7","volume":"398","author":"X Ding","year":"2025","unstructured":"Ding, X., Tan, D., Wang, Z., & Yin, H. (2025). Ginkgolide B regulates apoptosis, oxidative stress, and mitochondrial dysfunction in MPP\u207a-induced SK-N-SH cells by targeting HDAC4\/JNK pathway. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology, 398(7), 8899\u20138908.","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"5486_CR59","doi-asserted-by":"publisher","first-page":"105798","DOI":"10.1016\/j.neuint.2024.105798","volume":"178","author":"RM Gahtani","year":"2024","unstructured":"Gahtani, R. M., Shoaib, S., Hani, U., Jayachithra, R., Alomary, M. N., Chauhan, W., Jahan, R., Tufail, S., & Ansari, M. A. (2024). Combating Parkinson\u2019s disease with plant-derived polyphenols: Targeting oxidative stress and neuroinflammation. Neurochemistry International, 178, Article 105798.","journal-title":"Neurochemistry International"},{"issue":"16","key":"5486_CR60","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1080\/10408398.2022.2155106","volume":"64","author":"R Shi","year":"2024","unstructured":"Shi, R., Gao, D., Stoika, R., Liu, K., Sik, A., & Jin, M. (2024). Potential implications of polyphenolic compounds in neurodegenerative diseases. Critical Reviews in Food Science and Nutrition, 64(16), 5491\u20135514.","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"9","key":"5486_CR61","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1080\/1028415X.2025.2472773","volume":"28","author":"P Panda","year":"2025","unstructured":"Panda, P., Mohanty, S., Gouda, S. R., Baral, T. C., Mohanty, A., Nayak, J., & Mohapatra, R. (2025). Advanced strategies for enhancing the neuroprotective potential of curcumin: Delivery systems and mechanistic insights in neurodegenerative disorders. Nutritional Neuroscience, 28(9), 1151\u20131176.","journal-title":"Nutritional Neuroscience"},{"issue":"1","key":"5486_CR62","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11011-024-01452-2","volume":"40","author":"V Sharma","year":"2024","unstructured":"Sharma, V., Sharma, P., & Singh, T. G. (2024). Emerging role of Nrf2 in parkinson\u2019s disease therapy: A critical reassessment. Metabolic Brain Disease, 40(1), 70.","journal-title":"Metabolic Brain Disease"},{"key":"5486_CR63","doi-asserted-by":"publisher","first-page":"154887","DOI":"10.1016\/j.phymed.2023.154887","volume":"126","author":"X Cheng","year":"2024","unstructured":"Cheng, X., Huang, J., Li, H., Zhao, D., Liu, Z., Zhu, L., & Peng, W. (2024). Quercetin: A promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis. Phytomedicine, 126, Article 154887.","journal-title":"Phytomedicine"},{"key":"5486_CR64","doi-asserted-by":"crossref","unstructured":"Abolaji, A. O., Adedara, A. O., Madu, J. C., Owalude, O. T., Ogunyemi, O. M., Omoboyowa,D. A., \u2026 Aschner, M. (2025). Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila \u03b1-synuclein model of Parkinson\u2019s disease. Scientific Reports, 15(1), 17769.","DOI":"10.1038\/s41598-025-00698-9"},{"key":"5486_CR65","doi-asserted-by":"publisher","first-page":"112433","DOI":"10.1016\/j.fct.2021.112433","volume":"155","author":"A Singh","year":"2021","unstructured":"Singh, A., Yadawa, A. K., Chaturvedi, S., Wahajuddin, M., Mishra, A., & Singh, S. (2021). Mechanism for antiParkinsonian effect of resveratrol: Involvement of transporters, synaptic proteins, dendrite arborization, biochemical alterations, ER stress and apoptosis. Food and Chemical Toxicology, 155, Article 112433.","journal-title":"Food and Chemical Toxicology"},{"key":"5486_CR66","doi-asserted-by":"publisher","first-page":"117397","DOI":"10.1016\/j.biopha.2024.117397","volume":"179","author":"Q Zhou","year":"2024","unstructured":"Zhou, Q., Guo, X., Chen, T., Liu, Y., Ji, H., Sun, Y., Yang, X., Ouyang, C., Liu, X., & Lei, M. (2024). The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, A\u03b2 reduction and synaptic plasticity alternation. Biomedicine & Pharmacotherapy, 179, Article 117397.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"5486_CR67","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13020-023-00745-5","volume":"18","author":"E Hu","year":"2023","unstructured":"Hu, E., Li, Z., Li, T., Yang, X., Ding, R., Jiang, H., Su, H., Cheng, M., Yu, Z., Li, H., Tang, T., & Wang, Y. (2023). A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: The effects of Astragaloside IV on intracerebral hemorrhage as an example. Chinese Medicine, 18(1), Article 40.","journal-title":"Chinese Medicine"},{"issue":"3","key":"5486_CR68","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4103\/pr.pr_48_19","volume":"11","author":"BD Kulkarni","year":"2019","unstructured":"Kulkarni, B. D., Hoskeri, J. H., & Vedamurthy, A. B. (2019). Neuroprotective and anti-inflammatory activities of Aegiceras corniculatum (L.) Blanco. Pharmacognosy Research, 11(3), 260\u2013266.","journal-title":"Pharmacognosy Research"},{"key":"5486_CR69","doi-asserted-by":"publisher","first-page":"1468850","DOI":"10.3389\/fphar.2024.1468850","volume":"15","author":"K Yang","year":"2024","unstructured":"Yang, K., Lv, Z., Zhao, W., Lai, G., Zheng, C., Qi, F., Zhao, C., Hu, K., Chen, X., Fu, F., Li, J., Xie, G., Wang, H., Wu, X., & Zheng, W. (2024). The potential of natural products to inhibit abnormal aggregation of \u03b1-Synuclein in the treatment of Parkinson\u2019s disease. Frontiers in Pharmacology, 15, Article 1468850.","journal-title":"Frontiers in Pharmacology"},{"key":"5486_CR70","doi-asserted-by":"publisher","first-page":"0355","DOI":"10.34133\/research.0355","volume":"7","author":"H Feng","year":"2024","unstructured":"Feng, H., Qiao, Q. C., Luo, Q. F., Zhou, J. Y., Lei, F., Chen, Y., Wen, S. Y., Chen, W. H., Pang, Y. J., Hu, Z. A., Jiang, Y. B., Zhang, X. Y., Zhou, T. Y., Yang, N., Zhang, J., & Hu, R. (2024). Orexin neurons to sublaterodorsal tegmental nucleus pathway prevents sleep onset REM sleep-like behavior by relieving the REM sleep pressure. Research, 7, Article 0355.","journal-title":"Research"},{"issue":"4","key":"5486_CR71","first-page":"422","volume":"21","author":"M Mustapha","year":"2021","unstructured":"Mustapha, M., & Taib, C. N. M. (2021). MPTP-induced mouse model of Parkinson\u2019s disease: A promising direction for therapeutic strategies. Bosnian Journal of Basic Medical Sciences, 21(4), 422.","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"issue":"1","key":"5486_CR72","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1038\/s41598-020-59310-x","volume":"10","author":"JM Chemmarappally","year":"2020","unstructured":"Chemmarappally, J. M., Pegram, H. C., Abeywickrama, N., Fornari, E., Hargreaves, A. J., De Girolamo, L. A., & Stevens, B. (2020). A co-culture nanofibre scaffold model of neural cell degeneration relevant to Parkinson\u2019s disease. Scientific Reports, 10(1), Article 2767.","journal-title":"Scientific Reports"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-025-05486-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-025-05486-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-025-05486-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:03:20Z","timestamp":1774692200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-025-05486-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["5486"],"URL":"https:\/\/doi.org\/10.1007\/s12010-025-05486-9","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"10 December 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no conflict of interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}