{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:32:52Z","timestamp":1787164372983,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360529"],"award-info":[{"award-number":["82360529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Province\u2019s Middle and Young-aged Academic and Technical Leading Talent Project","award":["202205AC160089"],"award-info":[{"award-number":["202205AC160089"]}]},{"name":"Chuxiong Prefecture Science and Technology Leading Talent Project-Zongqiang Hu","award":["2025XCKJLJRC01"],"award-info":[{"award-number":["2025XCKJLJRC01"]}]},{"name":"Self-funded research projects of the Science and Technology Bureau of Chuxiong Prefecture in 2025","award":["Self-funded research projects of the Science and Technology Bureau of Chuxiong Prefecture in 2025"],"award-info":[{"award-number":["Self-funded research projects of the Science and Technology Bureau of Chuxiong Prefecture in 2025"]}]},{"name":"Research Project of Chuxiong Medical College","award":["Research Project of Chuxiong Medical College"],"award-info":[{"award-number":["Research Project of Chuxiong Medical College"]}]},{"name":"Research Start-up Fund - Zongqiang Hu","award":["Research Start-up Fund - Zongqiang Hu (Liver Diseases and Transplantation Research Group)"],"award-info":[{"award-number":["Research Start-up Fund - Zongqiang Hu (Liver Diseases and Transplantation Research Group)"]}]},{"name":"Research Project of Chuxiong Medical Collegein 2025","award":["Research Project of Chuxiong Medical Collegein 2025"],"award-info":[{"award-number":["Research Project of Chuxiong Medical Collegein 2025"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s12010-026-05656-3","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:19:38Z","timestamp":1775467178000},"page":"5045-5066","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paris Saponin VII Inhibits Ferroptosis through USP7\/SLC7A11 to Alleviate Metabolic-associated Fatty Liver Disease in Rats"],"prefix":"10.1007","volume":"198","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"issue":"7","key":"5656_CR1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J (2020). MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease [J]. Gastroenterology, 158(7), 1999\u20132014e1.","journal-title":"Gastroenterology"},{"issue":"5","key":"5656_CR2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/hep.31150","volume":"71","author":"J Zhou","year":"2020","unstructured":"Zhou, J., Zhou, F., Wang, W., et al. (2020). Epidemiological Features of NAFLD From 1999 to 2018 in China [J]. Hepatology, 71(5), 1851\u20131864.","journal-title":"Hepatology"},{"key":"5656_CR3","doi-asserted-by":"publisher","first-page":"761538","DOI":"10.3389\/fmed.2021.761538","volume":"8","author":"W Qu","year":"2021","unstructured":"Qu, W., Ma, T., Cai, J., et al. (2021). Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies [J]. Front Med (Lausanne), 8, 761538.","journal-title":"Front Med (Lausanne)"},{"issue":"Suppl 2","key":"5656_CR4","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1007\/s12072-024-10692-4","volume":"18","author":"ME Argenziano","year":"2024","unstructured":"Argenziano, M. E., Kim, M. N., Montori, M. et al. (2024). Epidemiology, pathophysiology and clinical aspects of Hepatocellular Carcinoma in MAFLD patients [J]. Hepatol Int, 18(Suppl 2), 922\u2013940.","journal-title":"Hepatol Int"},{"issue":"4","key":"5656_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s13105-023-00954-4","volume":"79","author":"P Sangro","year":"2023","unstructured":"Sangro, P., de la Torre Al\u00e1ez, M., Sangro, B., et al. (2023). Metabolic dysfunction-associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment [J]. Journal Of Physiology And Biochemistry, 79(4), 869\u2013879.","journal-title":"Journal Of Physiology And Biochemistry"},{"issue":"10","key":"5656_CR6","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.cmet.2024.09.005","volume":"36","author":"T Shao","year":"2024","unstructured":"Shao, T., & Chung, R. T. (2024). Ironing out MAFLD: Therapeutic targeting of liver ferroptosis. Cell Metab, 36(10), 2167\u20132169.","journal-title":"Cell Metab"},{"issue":"12","key":"5656_CR7","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.1002\/ptr.7986","volume":"37","author":"Y Xiang","year":"2023","unstructured":"Xiang, Y., Wan, F., Ren, Y., et al. (2023). Polyphyllin VII induces autophagy-dependent ferroptosis in human gastric cancer through targeting T-lymphokine-activated killer cell-originated protein kinase [J]. Phytotherapy Research: Ptr, 37(12), 5803\u20135820.","journal-title":"Phytotherapy Research: Ptr"},{"issue":"5","key":"5656_CR8","doi-asserted-by":"publisher","first-page":"101147","DOI":"10.1016\/j.jpha.2024.101147","volume":"15","author":"F Jiang","year":"2025","unstructured":"Jiang, F., Li, X., Li, M., et al. (2025). Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1\/CX3CL1\/GPX4 axis [J]. J Pharm Anal, 15(5), 101147.","journal-title":"J Pharm Anal"},{"issue":"3","key":"5656_CR9","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1142\/S0192415X24500368","volume":"52","author":"SG Du","year":"2024","unstructured":"Du, S. G., Zhang, H. M., Ji, Y. X., et al. (2024). Polyphyllin VII Promotes Apoptosis in Breast Cancer by Inhibiting MAPK\/ERK Signaling Pathway through Downregulation of SOS1 [J]. American Journal Of Chinese Medicine, 52(3), 885\u2013904.","journal-title":"American Journal Of Chinese Medicine"},{"issue":"2","key":"5656_CR10","first-page":"597","volume":"21","author":"H He","year":"2020","unstructured":"He, H., & Xu, C. (2020). Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K\/Akt and NF\u2013\u03baB pathways in A549 human lung cancer cells [J]. Molecular Medicine Reports, 21(2), 597\u2013606.","journal-title":"Molecular Medicine Reports"},{"issue":"23","key":"5656_CR11","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1016\/j.scib.2024.09.019","volume":"69","author":"J Shen","year":"2024","unstructured":"Shen, J., Xie, E., Shen, S., et al. (2024). Essentiality of SLC7A11-mediated nonessential amino acids in MASLD [J]. Sci Bull (Beijing), 69(23), 3700\u20133716.","journal-title":"Sci Bull (Beijing)"},{"key":"5656_CR12","doi-asserted-by":"publisher","first-page":"102963","DOI":"10.1016\/j.redox.2023.102963","volume":"68","author":"T Jiang","year":"2023","unstructured":"Jiang, T., Xiao, Y., Zhou, J., et al. (2023). Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO\/SLC7A11 pathway [J]. Redox Biology, 68, 102963.","journal-title":"Redox Biology"},{"issue":"3","key":"5656_CR13","doi-asserted-by":"publisher","first-page":"e70257","DOI":"10.1002\/ctm2.70257","volume":"15","author":"Y Zhou","year":"2025","unstructured":"Zhou, Y., Zhao, Z., Jiang, C., et al. (2025). LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF\/USP7 axis [J]. Clinical and translational medicine, 15(3), e70257.","journal-title":"Clinical and translational medicine"},{"issue":"46","key":"5656_CR14","doi-asserted-by":"publisher","first-page":"32886","DOI":"10.1074\/jbc.M113.496331","volume":"288","author":"KW Lee","year":"2013","unstructured":"Lee, K. W., Cho, J. G., Kim, C. M., et al. (2013). Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) stability through its deubiquitinating activity [J]. Journal Of Biological Chemistry, 288(46), 32886\u201332896.","journal-title":"Journal Of Biological Chemistry"},{"issue":"1","key":"5656_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12944-023-01798-z","volume":"22","author":"Z Hu","year":"2023","unstructured":"Hu, Z., Zhang, H., Wang, Y., et al. (2023). Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease [J]. Lipids In Health And Disease, 22(1), 33.","journal-title":"Lipids In Health And Disease"},{"issue":"12","key":"5656_CR16","first-page":"1331","volume":"22","author":"XY Huang","year":"2020","unstructured":"Huang, X. Y., Yu-Feng, Q. U. A. N., Long-Li, Y. A. N., et al. (2020). [Expression of ubiquitin-specific protease 7 in lung tissue of preterm rats after hyperoxia exposure] [J]. Zhongguo Dang Dai Er Ke Za Zhi, 22(12), 1331\u20131337.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"4","key":"5656_CR17","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1172\/JCI124049","volume":"130","author":"K Hu","year":"2020","unstructured":"Hu, K., Li, K., Lv, J., et al. (2020). Suppression of the SLC7A11\/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma [J]. J Clin Invest, 130(4), 1752\u20131766.","journal-title":"J Clin Invest"},{"key":"5656_CR18","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.2147\/DDDT.S417378","volume":"17","author":"N Zhang","year":"2023","unstructured":"Zhang, N., Liu, T., Wang, J., et al. (2023). Si-Ni-San Reduces Hepatic Lipid Deposition in Rats with Metabolic Associated Fatty Liver Disease by AMPK\/SIRT1 Pathway [J]. Drug design development and therapy, 17, 3047\u20133060.","journal-title":"Drug design development and therapy"},{"issue":"1","key":"5656_CR19","doi-asserted-by":"publisher","first-page":"16185","DOI":"10.1038\/s41598-019-52837-8","volume":"9","author":"W Qi","year":"2019","unstructured":"Qi, W., Li, Z., Xia, L., et al. (2019). LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells [J]. Scientific Reports, 9(1), 16185.","journal-title":"Scientific Reports"},{"key":"5656_CR20","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.biopha.2018.09.089","volume":"108","author":"Y Liu","year":"2018","unstructured":"Liu, Y., Yu, Q., & Chen, Y. (2018). Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells [J]. Biomedicine & Pharmacotherapy, 108, 716\u2013723.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"5656_CR21","doi-asserted-by":"publisher","first-page":"155437","DOI":"10.1016\/j.phymed.2024.155437","volume":"126","author":"Y Liu","year":"2024","unstructured":"Liu, Y., & Sun, Z. (2024). Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK\/SREBP1 pathway [J]. Phytomedicine, 126, 155437.","journal-title":"Phytomedicine"},{"key":"5656_CR22","doi-asserted-by":"crossref","unstructured":"Sakurai, Y., Kubota, N., Yamauchi, T. (2021). Role of Insulin Resistance in MAFLD. International Journal Of Molecular Sciences, 22(8).","DOI":"10.3390\/ijms22084156"},{"key":"5656_CR23","doi-asserted-by":"crossref","unstructured":"Cui, S., Ye, J. (2025). MAFLD: a ferroptotic disease. Trends in Molecular Medicine..","DOI":"10.1016\/j.molmed.2025.08.006"},{"key":"5656_CR24","doi-asserted-by":"crossref","unstructured":"Li, S., Zhang, Y., Li, P. (2025). IL-22 attenuates MAFLD progression by modulating oxidative stress and ferroptosis. Scientific Reports.","DOI":"10.1038\/s41598-025-28718-8"},{"issue":"1","key":"5656_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41418-022-01051-7","volume":"30","author":"Q Chen","year":"2023","unstructured":"Chen, Q., & Zheng, W. (2023). SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma [J]. Cell Death And Differentiation, 30(1), 137\u2013151.","journal-title":"Cell Death And Differentiation"},{"issue":"1","key":"5656_CR26","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"M Eslam","year":"2020","unstructured":"Eslam, M., Newsome P. N., Sarin, S. K., et al. (2020). A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement [J]. Journal Of Hepatology, 73(1), 202\u2013209.","journal-title":"Journal Of Hepatology"},{"issue":"1","key":"5656_CR27","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s12933-022-01697-0","volume":"21","author":"XD Zhou","year":"2022","unstructured":"Zhou X D, Cai, J., Targher, G., et al. (2022). Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention [J]. Cardiovasc Diabetol, 21(1), 270.","journal-title":"Cardiovasc Diabetol"},{"key":"5656_CR28","doi-asserted-by":"publisher","first-page":"154170","DOI":"10.1016\/j.metabol.2020.154170","volume":"111","author":"A Mantovani","year":"2020","unstructured":"Mantovani, A., & Scorletti, E., Mosca A. (2020). Complications, morbidity and mortality of nonalcoholic fatty liver disease. Metabolism, 111, 154170.","journal-title":"Metabolism"},{"issue":"4","key":"5656_CR29","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1111\/cbdd.13818","volume":"97","author":"B Ahmad","year":"2021","unstructured":"Ahmad, B., Rehman, S. U., Azizullah, A. et al. (2021). Molecular mechanisms of anticancer activities of polyphyllin VII [J]. Chemical Biology & Drug Design, 97(4), 914\u2013929.","journal-title":"Chemical Biology & Drug Design"},{"issue":"Pt 2","key":"5656_CR30","doi-asserted-by":"publisher","first-page":"113423","DOI":"10.1016\/j.intimp.2024.113423","volume":"143","author":"Q Sang","year":"2024","unstructured":"Sang, Q., Kang, C., Liu, D., et al. (2024). Polyphyllin VII ameliorates neuroinflammation and brain injury via modulating Treg\/Th17 balance in a mouse model of cerebral ischemia-reperfusion injury [J]. International Immunopharmacology, 143(Pt 2), 113423.","journal-title":"International Immunopharmacology"},{"key":"5656_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12906-016-1036-x","volume":"16","author":"C Zhang","year":"2016","unstructured":"Zhang, C., Jia, X., Bao, J., et al. (2016). Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways [J]. Bmc Complementary And Alternative Medicine, 16, 58.","journal-title":"Bmc Complementary And Alternative Medicine"},{"key":"5656_CR32","doi-asserted-by":"crossref","unstructured":"Zhang, C., Li, C., Jia, X. (2019). In Vitro and In Vivo Anti-inflammatory effects of polyphyllin VII through downregulating MAPK and NF-\u03baB pathways. Molecules, 24(5).","DOI":"10.3390\/molecules24050875"},{"issue":"7","key":"5656_CR33","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/liv.15163","volume":"42","author":"G Feng","year":"2022","unstructured":"Feng, G., Byrne C. D., Targher, G., et al. (2022). Ferroptosis and metabolic dysfunction-associated fatty liver disease: Is there a link? Liver International : Official Journal Of The International Association For The Study Of The Liver, 42(7), 1496\u20131502.","journal-title":"Liver International : Official Journal Of The International Association For The Study Of The Liver"},{"issue":"1","key":"5656_CR34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s11658-021-00254-z","volume":"26","author":"J Zhao","year":"2021","unstructured":"Zhao, J., & Hu, Y. (2021). Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy [J]. Cellular & Molecular Biology Letters, 26(1), 17.","journal-title":"Cellular & Molecular Biology Letters"},{"issue":"1","key":"5656_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12876-022-02137-9","volume":"22","author":"X Dai","year":"2022","unstructured":"Dai, X., Zhang, R., & Wang, B. (2022). Contribution of classification based on ferroptosis-related genes to the heterogeneity of MAFLD [J]. Bmc Gastroenterology, 22(1), 55.","journal-title":"Bmc Gastroenterology"},{"issue":"5","key":"5656_CR36","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/s41401-022-01010-5","volume":"44","author":"J Tong","year":"2023","unstructured":"Tong, J., Lan X. T., Zhang, Z., et al. (2023). Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis [J]. Acta Pharmacologica Sinica, 44(5), 1014\u20131028.","journal-title":"Acta Pharmacologica Sinica"},{"issue":"4","key":"5656_CR37","doi-asserted-by":"publisher","first-page":"e70186","DOI":"10.1002\/jbt.70186","volume":"39","author":"Y Wu","year":"2025","unstructured":"Wu, Y., Yang, L., Li, Z., et al. (2025). Polyphyllin VII Enhances the Antitumor Activity of Cisplatin in Non-Small Cell Lung Cancer Cells by Inducing Ferroptosis and Enhancing Apoptosis [J]. Journal Of Biochemical And Molecular Toxicology, 39(4), e70186.","journal-title":"Journal Of Biochemical And Molecular Toxicology"},{"issue":"1","key":"5656_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/10815589231204058","volume":"72","author":"G Bu","year":"2024","unstructured":"Bu, G., Chen, G., Li, J., et al. (2024). Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway [J]. Journal Of Investigative Medicine, 72(1), 67\u201379.","journal-title":"Journal Of Investigative Medicine"},{"issue":"11","key":"5656_CR39","doi-asserted-by":"publisher","first-page":"114872","DOI":"10.1016\/j.celrep.2024.114872","volume":"43","author":"S Keshri","year":"2024","unstructured":"Keshri, S., VIcinanza, M., Takla, M., et al. (2024). USP7 protects TFEB from proteasome-mediated degradation [J]. Cell Rep, 43(11), 114872.","journal-title":"Cell Rep"},{"key":"5656_CR40","doi-asserted-by":"crossref","unstructured":"Kitamura, H. (2023). Ubiquitin-Specific Proteases (USPs) and metabolic disorders. International Journal Of Molecular Sciences, 24(4).","DOI":"10.3390\/ijms24043219"},{"key":"5656_CR41","doi-asserted-by":"crossref","unstructured":"Xie, J., Ma, C., Zhao, S. (2025). Deubiquitination by USP7 stabilizes JunD and activates AIFM2 (FSP1) to inhibit ferroptosis in melanoma. The Journal Of Investigative Dermatology.","DOI":"10.1016\/j.jid.2025.03.018"},{"key":"5656_CR42","doi-asserted-by":"publisher","first-page":"105554","DOI":"10.1016\/j.neuint.2023.105554","volume":"168","author":"C Wang","year":"2023","unstructured":"Wang, C., Zhu, Y., Zhu, X., et al. (2023). USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats [J]. Neurochemistry International, 168, 105554.","journal-title":"Neurochemistry International"},{"issue":"1","key":"5656_CR43","doi-asserted-by":"publisher","first-page":"2260646","DOI":"10.1080\/13510002.2023.2260646","volume":"28","author":"Y Liu","year":"2023","unstructured":"Liu, Y., Wu, K., Fu, Y., et al. (2023). Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes [J]. Redox Report, 28(1), 2260646.","journal-title":"Redox Report"},{"issue":"6","key":"5656_CR44","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s41419-024-06836-x","volume":"15","author":"R Yan","year":"2024","unstructured":"Yan, R., Liu, D., Guo, H., et al. (2024). LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer. Cell Death And Disease, 15(6), 436.","journal-title":"Cell Death And Disease"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05656-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05656-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05656-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:30:27Z","timestamp":1782099027000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05656-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["5656"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05656-3","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2 March 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental protocols were approved by the Animal Experiment Ethics Committee of Yunnan Zequn Biotechnology Co., Ltd., and all animal experiments complied with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All the authors agreed to publish this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare that they have no conflicts of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}