{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:13:02Z","timestamp":1779333182186,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12010-026-05666-1","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:52:10Z","timestamp":1773474730000},"page":"4229-4248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Anticancer Potential of Leucas Aspera Mediated Magnetic Iron Oxide Nanoparticles"],"prefix":"10.1007","volume":"198","author":[{"given":"Jeyabharathi Veluchamy","family":"Mouna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjani","family":"Soundhararajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karunya Jenin","family":"Ravindranath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-7721","authenticated-orcid":false,"given":"Hemalatha","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"5666_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s11671-024-04163-w","volume":"20","author":"AS Benjamin","year":"2025","unstructured":"Benjamin, A. S., & Nayak, S. (2025). Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment. Discover Nano, 20, 18. https:\/\/doi.org\/10.1186\/s11671-024-04163-w","journal-title":"Discover Nano"},{"key":"5666_CR2","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s12013-024-01256-2","volume":"82","author":"HM Fahmy","year":"2024","unstructured":"Fahmy, H. M., Shekewy, S., Elhusseiny, F. A., et al. (2024). Enhanced Biocompatibility by Evaluating the Cytotoxic and Genotoxic Effects of Magnetic Iron Oxide Nanoparticles and Chitosan on Hepatocellular Carcinoma Cells (HCC). Cell Biochemistry And Biophysics, 82, 1027\u20131042. https:\/\/doi.org\/10.1007\/s12013-024-01256-2","journal-title":"Cell Biochemistry And Biophysics"},{"key":"5666_CR3","doi-asserted-by":"publisher","first-page":"102952","DOI":"10.1016\/j.bcab.2023.102952","volume":"54","author":"MH Noorul Samsoon","year":"2023","unstructured":"Noorul Samsoon, M. H., Karunya, J. R., & Hemalatha, S. (2023). Targeted Cytotoxicity against MDA-MB-231 Triple-Negative Breast Cancer Cells with Borassus Flabellifer Haustorium-Derived Silver Nanoparticles: An Integrated In Silico and Experimental Approach. Biocatalysis and Agricultural Biotechnology, 54, 102952. https:\/\/doi.org\/10.1016\/j.bcab.2023.102952","journal-title":"Biocatalysis and Agricultural Biotechnology"},{"issue":"1","key":"5666_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12951-023-02235-0","volume":"22","author":"YQ Meng","year":"2024","unstructured":"Meng, Y. Q., Shi, Y. N., Zhu, Y. P., et al. (2024). Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal Of Nanbiotechnology, 22(1), 24. https:\/\/doi.org\/10.1186\/s12951-023-02235-0","journal-title":"Journal Of Nanbiotechnology"},{"key":"5666_CR5","doi-asserted-by":"publisher","first-page":"105599","DOI":"10.1016\/j.jddst.2024.105599","volume":"95","author":"N Rashidi","year":"2024","unstructured":"Rashidi, N., Davidson, M., Apostolopoulos, V., & Nurgali, K. (2024). Nanoparticles in cancer diagnosis and treatment: Progress, challenges, and opportunities. Journal Of Drug Delivery Science And Technology, 95, 105599. https:\/\/doi.org\/10.1016\/j.jddst.2024.105599","journal-title":"Journal Of Drug Delivery Science And Technology"},{"key":"5666_CR6","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.2147\/IJN.S361483","volume":"17","author":"H Zhou","year":"2022","unstructured":"Zhou, H., Tian, J., Sun, H., Fu, J., Lin, N., Yuan, D., Zhou, L., Xia, M., & Sun, L. (2022). Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics. Int J Nanomedicine, 17, 2823\u20132841. https:\/\/doi.org\/10.2147\/IJN.S361483","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"5666_CR7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.26689\/itps.v2i1.436","volume":"2","author":"EV Kumar","year":"2019","unstructured":"Kumar, E. V., Avinash, N., Bakshi, V., Kiran, G., & Narender, B. (2019). A Review on Leucas aspera for Phytopharmacological Studies. INNOSC Theranostics Pharmacol Sci, 2(1), 436. https:\/\/doi.org\/10.26689\/itps.v2i1.436","journal-title":"INNOSC Theranostics Pharmacol Sci"},{"issue":"1","key":"5666_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5114\/bta.2024.135642","volume":"105","author":"MBSM Fazeela","year":"2024","unstructured":"Fazeela, M. B. S. M., & Sankarram, M. (2024). Phytochemical characterization by GC-MS and in vitro evaluation of antiproliferative and antimigratory studies of Leucas aspera leaf extracts on MDA-MB-231 cell line. Bio Technologia (Pozn), 105(1), 55\u201368. https:\/\/doi.org\/10.5114\/bta.2024.135642","journal-title":"Bio Technologia (Pozn)"},{"key":"5666_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s43094-021-00208-4","volume":"7","author":"NU Olivia","year":"2021","unstructured":"Olivia, N. U., Goodness, U. C., & Obinna, O. M. (2021). Phytochemical profiling and GC-MS analysis of aqueous methanol fraction of Hibiscus asper leaves. Futur J Pharm Sci, 7, 59. https:\/\/doi.org\/10.1186\/s43094-021-00208-4","journal-title":"Futur J Pharm Sci"},{"issue":"7","key":"5666_CR10","doi-asserted-by":"publisher","first-page":"6246","DOI":"10.1016\/j.arabjc.2020.05.035","volume":"13","author":"SR Kareti","year":"2020","unstructured":"Kareti, S. R., & Subash, P. (2020). In silico exploration of anti-Alzheimer\u2019s compounds present in methanolic extract of Neolamarckia cadamba bark using GC\u2013MS\/MS. Arabian J Chem, 13(7), 6246\u20136255. https:\/\/doi.org\/10.1016\/j.arabjc.2020.05.035","journal-title":"Arabian J Chem"},{"issue":"6","key":"5666_CR11","doi-asserted-by":"publisher","first-page":"707","DOI":"10.6026\/97320630019707","volume":"19","author":"AA Rahman","year":"2023","unstructured":"Rahman, A. A., Azhar, K. M., Hussain, A. A., Abdullah, A. A., Marui, I. S., Hadi, G. M., Mamdouh, A. H., & Qamre, A. (2023). Molecular docking analysis of MCL-1 inhibitors for breast cancer management. Bioinformation, 19(6), 707\u2013712. https:\/\/doi.org\/10.6026\/97320630019707","journal-title":"Bioinformation"},{"key":"5666_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/24701556.2021.2025077","volume":"53:5","author":"S Kamalavarshini","year":"2023","unstructured":"Kamalavarshini, S., & Hemalatha, R. S., S (2023). Gold nanoparticles: A Novel paradigm for targeted Drug delivery. Inorganic and Nano-Metal Chemistry, 53:5, 449\u2013459. https:\/\/doi.org\/10.1080\/24701556.2021.2025077","journal-title":"Inorganic and Nano-Metal Chemistry"},{"issue":"1","key":"5666_CR13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40360-025-00906-2","volume":"26","author":"V Unsal","year":"2025","unstructured":"Unsal, V., Keskin, C., & Oner, E. (2025). Can quercetin reduce arsenic induced toxicity in mouse BALB\/c 3T3 fibroblast cells? A study involving in vitro, molecular docking, and ADME predictions. BMC Pharmacol Toxicol, 26(1), 68. https:\/\/doi.org\/10.1186\/s40360-025-00906-2","journal-title":"BMC Pharmacol Toxicol"},{"issue":"3","key":"5666_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.32768\/abc.2023103291-300","volume":"10","author":"J Vishal","year":"2023","unstructured":"Vishal, J., Ranjani, S., Karunya, J. R., & Hemalatha, S. (2023). Synthesis, Characterization and Evaluation of Antioxidant, Anticancer and Toxicity Properties of Silver Nanoparticles Synthesized from Syzygium Aromaticum: SNP synthesized from Syzygium aromaticum. Arch breast cancer, 10(3), 291\u2013300. https:\/\/doi.org\/10.32768\/abc.2023103291-300","journal-title":"Arch breast cancer"},{"key":"5666_CR15","doi-asserted-by":"publisher","unstructured":"Kumar, V. V. G., & Prem, A. A. (2018). Green Synthesis and Characterization of Iron Oxide Nanoparticles Using Phyllanthus Niruri Extract. Oriental Journal Of Chemistry, 34(5). https:\/\/doi.org\/10.13005\/ojc\/340547","DOI":"10.13005\/ojc\/340547"},{"issue":"2","key":"5666_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.22271\/chemi.2020.v8.i2i.8834","volume":"8","author":"JR Shaikh","year":"2020","unstructured":"Shaikh, J. R., & Patil, M. K. (2020). Qualitative tests for preliminary phytochemical screening: An overview. Int J Chem Stud, 8(2), 603\u2013608. https:\/\/doi.org\/10.22271\/chemi.2020.v8.i2i.8834","journal-title":"Int J Chem Stud"},{"issue":"2","key":"5666_CR17","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.matpr.2020.03.167","volume":"36","author":"SO Aisida","year":"2021","unstructured":"Aisida, S. O., Ugwu, K., Akpa, P. A., Nwanya, A. C., et al. (2021). Synthesis and characterization of iron oxide nanoparticles capped with Moringa Oleifera: The mechanisms of formation effects on the optical, structural, magnetic and morphological properties. Mater Today Proc, 36(2), 214\u2013218. https:\/\/doi.org\/10.1016\/j.matpr.2020.03.167","journal-title":"Mater Today Proc"},{"issue":"3","key":"5666_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.32768\/abc.2023103222-231","volume":"10","author":"H Madhumitha","year":"2023","unstructured":"Madhumitha, H., Ranjani, S., Karunya, J. R., & Hemalatha, S. (2023). Clitoria Ternatea Floral Mediated Synthesis, Characterization, Antioxidant, and Cytotoxicity Evaluation of Silver Nanoparticles: Clitoria ternatea floral mediated SNP to control BC. Arch Breast Cancer, 10(3), 222\u2013231. https:\/\/www.archbreastcancer.com\/index.php\/abc\/article\/view\/655","journal-title":"Arch Breast Cancer"},{"key":"5666_CR19","doi-asserted-by":"publisher","unstructured":"Ranjani, S., Karunya, J. R., & Ali, S. S. L. and Hemalatha.S (2024). Synthesis, characterization and anti-cancerous evaluation of single clove garlic nanoparticles on Triple-Negative Breast Cancer Cell Lines. Materials letters, 359135913. https:\/\/doi.org\/10.1016\/j.matlet.2024.135913","DOI":"10.1016\/j.matlet.2024.135913"},{"issue":"7","key":"5666_CR20","doi-asserted-by":"publisher","first-page":"e65354","DOI":"10.7759\/cureus.65354","volume":"16","author":"N Nedumaran","year":"2024","unstructured":"Nedumaran, N., Rajasekar, A., Venkatakrishnan, S., et al. (2024). An In Vitro Study of Antioxidant, Anti-inflammatory, and Cytotoxic Effects of Echinacea-Mediated Zinc Oxide Nanoparticles. Cureus, 16(7), e65354. https:\/\/doi.org\/10.7759\/cureus.65354","journal-title":"Cureus"},{"key":"5666_CR21","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1186\/s12885-025-13796-8","volume":"25","author":"KJ Ravindranath","year":"2025","unstructured":"Ravindranath, K. J., & Srinivasan, H. (2025). Deciphering the anti-neoplastic potential of Allium ascalonicum in averting the proliferation and epithelial-mesenchymal transition of triple-negative breast cancer through virtual docking and In Vitro approaches. Bmc Cancer, 25, 414. https:\/\/doi.org\/10.1186\/s12885-025-13796-8","journal-title":"Bmc Cancer"},{"key":"5666_CR22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s42452-025-06469-5","volume":"7","author":"SBA Basha","year":"2025","unstructured":"Basha, S. B. A., Soundhararajan, R., & Srinivasan, H. (2025). Solanum virginianum mediated green nanoparticles to control dental pathogens. Discov Appl Sci, 7, 67. https:\/\/doi.org\/10.1007\/s42452-025-06469-5","journal-title":"Discov Appl Sci"},{"issue":"16","key":"5666_CR23","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1080\/08927022.2024.2402498","volume":"50","author":"S Deepak","year":"2024","unstructured":"Deepak, S., Hemalatha, A. V. S. A., & Monisha, S., M (2024). Expression analysis, molecular docking and molecular dynamics simulations to identify potential BTK inhibitors: Strategy for targeting pan cancer. Molecular Simulation, 50(16), 1343\u20131353. https:\/\/doi.org\/10.1080\/08927022.2024.2402498","journal-title":"Molecular Simulation"},{"key":"5666_CR24","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s43094-021-00335-y","volume":"7","author":"MM Abdelshaheed","year":"2021","unstructured":"Abdelshaheed, M. M., Fawzy, I. M., El-Subbagh, H. I., et al. (2021). Piperidine nucleus in the field of drug discovery. Futur J Pharm Sci, 7, 188. https:\/\/doi.org\/10.1186\/s43094-021-00335-y","journal-title":"Futur J Pharm Sci"},{"key":"5666_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12906-022-03642-w","volume":"22","author":"M Amirzadeh","year":"2022","unstructured":"Amirzadeh, M., Soltanian, S., & Mohamadi, N. (2022). Chemical composition, anticancer and antibacterial activity of Nepeta mahanensis essential oil. BMC Complement Med Ther, 22, 173. https:\/\/doi.org\/10.1186\/s12906-022-03642-w","journal-title":"BMC Complement Med Ther"},{"key":"5666_CR26","doi-asserted-by":"publisher","first-page":"9228","DOI":"10.1038\/s41598-025-94111-0","volume":"15","author":"JR Karunya","year":"2025","unstructured":"Karunya, J. R., and Hemalatha.S (2025). Regulating the expression of matrix metalloproteinases to inhibit ovarian carcinoma using isoquinoline alkaloid from Allium ascalonicum. Scientific Reports, 15, 9228. https:\/\/doi.org\/10.1038\/s41598-025-94111-0","journal-title":"Scientific Reports"},{"issue":"24","key":"5666_CR27","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.3390\/ma17246064","volume":"17","author":"K K\u0131z\u0131lbey","year":"2024","unstructured":"K\u0131z\u0131lbey, K., K\u00f6pr\u00fcl\u00fc, E. N., Tem\u00fcr, H., Can\u0131m Ate\u015f, S., & \u00d6zer, S. (2024). Magnetic and Biomedical Properties of Iron Nanoparticles Synthesized Using Vitex agnus-castus Extract. Materials, 17(24), 6064. https:\/\/doi.org\/10.3390\/ma17246064","journal-title":"Materials"},{"issue":"2","key":"5666_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ipha.2024.09.009","volume":"3","author":"J Joselin","year":"2025","unstructured":"Joselin, J., Benila, B. S., Brintha, S., & Jeeva, T. S., S (2025). Phytochemical profiling, FT-IR spectroscopy, and antioxidant evaluation of select Lamiaceae species. Intelligent Pharmacy, 3(2), 111\u2013117. https:\/\/doi.org\/10.1016\/j.ipha.2024.09.009","journal-title":"Intelligent Pharmacy"},{"issue":"4","key":"5666_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/ayu.AYU_27_18","volume":"39","author":"D Sharmila","year":"2019","unstructured":"Sharmila, D., Lahiru, G., Prasadinie, C., & Nishantha, K. (2019). In vitro anti-inflammatory activity of Ficus racemosa L. bark using albumin denaturation method. AYU, 39(4), 239. https:\/\/doi.org\/10.4103\/ayu.AYU_27_18","journal-title":"AYU"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05666-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:35:43Z","timestamp":1779330943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05666-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5666"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05666-1","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,14]]},"assertion":[{"value":"5 March 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors read and approved the manuscript for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The toxicity study in the embryos of\n                      Danio rerio\n                      was approved by institutional ethics committee of Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry (NO.IEC\/C-P\/11\/2023) in accordance with the institute guidelines and regulations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not Applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}]}}