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This study aimed to evaluate the effects of\n                    <jats:italic>Artemisia haussknechtii<\/jats:italic>\n                    leaves ethanolic lyophilized and nanoparticle extract forms on glycemic regulation, oxidative stress markers, and tissue integrity in an experimental diabetes model. A total of 48 female rats were divided into six groups; diabetes was induced with 45\u00a0mg\/kg STZ (i.p.). DYEE and DYNE were administered orally at doses of 50 and 100\u00a0mg\/kg for 21 days. Weekly fasting glucose and body weight were monitored. At the end of the study, serum biochemistry, erythrocyte and tissue oxidative stress markers (MDA, GSH, CAT, GPx, SOD, GR, TAS, TOS) were analyzed; liver, kidney, and pancreas tissues were evaluated histopathologically. Diabetic rats exhibited persistent hyperglycemia, body weight loss, dyslipidemia, elevated liver and kidney injury biomarkers, increased lipid peroxidation (MDA), and total oxidant status (TOS), accompanied by marked suppression of antioxidant defense systems. Treatment with\n                    <jats:italic>Artemisia haussknechtii<\/jats:italic>\n                    extracts significantly ameliorated these alterations in a dose-dependent manner. Notably, the high-dose nanoparticle formulation (DYNE2) produced the most pronounced improvements, reflected by reduced blood glucose levels, improved lipid profile, normalization of insulin, HbA1c and c-peptide levels, decreased MDA and TOS, and restoration of antioxidant parameters toward control values. Histopathological findings corroborated the biochemical data, demonstrating substantial attenuation of diabetes-induced tissue damage, particularly in the DYNE2 group.\n                    <jats:italic>Artemisia haussknechtii<\/jats:italic>\n                    extract, particularly in its nanoparticle form, has demonstrated antihyperglycemic, antioxidant, and tissue-protective effects in experimental diabetes. The findings suggest that the plant is a promising candidate for complementary treatment against diabetes-related oxidative stress and organ damage.\n                  <\/jats:p>","DOI":"10.1007\/s12010-026-05751-5","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:53:50Z","timestamp":1780563230000},"page":"6807-6835","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Ethanolic Lyophilized and Nanoparticle Extracts of Cilo Wormwood (Artemisia haussknechtii Boiss.) Leaves on Histopathological Findings Antioxidant Defence System and Serum Biomarker Constituents in Diabetic Rats"],"prefix":"10.1007","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5546-380X","authenticated-orcid":false,"given":"Musa","family":"\u0130\u015fnas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-6348","authenticated-orcid":false,"given":"\u0130smail","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-7822","authenticated-orcid":false,"given":"Bedia","family":"Bati\u0307","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-5881","authenticated-orcid":false,"given":"Nevra","family":"Aydemi\u0307r Celep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"5751_CR1","unstructured":"World Health Organization (2016). 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