{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:12:34Z","timestamp":1789197154930,"version":"build-2803163510"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s12010-026-05758-y","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:27:32Z","timestamp":1780658852000},"page":"6836-6863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Hyaluronic Acid\u2013Glycyrrhizic Acid Complex Mitigates \u03b3-Radiation\u2013Induced Neurotransmitter Damage in Rats"],"prefix":"10.1007","volume":"198","author":[{"given":"Eman I.","family":"Sobeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar A.","family":"Ahmed-Farid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-211X","authenticated-orcid":false,"given":"Souad A.","family":"Elfeky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"5758_CR1","doi-asserted-by":"publisher","first-page":"100620","DOI":"10.1016\/j.enmm.2021.100620","volume":"vol. 17","author":"EI Sobeh","year":"2022","unstructured":"Sobeh, E. I., Amin, R., Saleh, H. M., Ali, S. E., & ElFeky, S. A. (2022). Evaluation of the radio-protective role of PEG-Fe3O4 NPs on \u03b3-irradiated male Wistar rats. Environmental Nanotechnology, Monitoring & Management, 17, 100620. https:\/\/doi.org\/10.1016\/j.enmm.2021.100620","journal-title":"Environmental Nanotechnology, Monitoring & Management"},{"key":"5758_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107297","volume":"112","author":"EI Sobeh","year":"2025","unstructured":"Sobeh, E. I., Elfeky, S. A., Korany, R. M. S., Saleh, H. M., Ahmed-Farid, O. A., & El-ghannam, G. (2025). Exploring the radioprotective shield of ZnFe2O4\/cysteine-folic acid nanocomposite in \u03b3-irradiated male Wistar rats. Journal of Drug Delivery Science and Technology, Article 107297. https:\/\/doi.org\/10.1016\/j.jddst.2025.107297","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"5758_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110328","volume":"370","author":"EI Sobeh","year":"2023","unstructured":"Sobeh, E. I., El-ghannam, G., Korany, R. M. S., Saleh, H. M., & Elfeky, S. A. (2023). Curcumin-loaded hydroxyapatite nanocomposite as a novel biocompatible shield for male Wistar rats from \u03b3-irradiation hazard. Chemico-Biological Interactions, Article 110328. https:\/\/doi.org\/10.1016\/j.cbi.2022.110328","journal-title":"Chemico-Biological Interactions"},{"key":"5758_CR4","doi-asserted-by":"publisher","unstructured":"El-Missiry, M. A., Shabana, S., Ghazala, S. J., Othman, A. I., & Amer, M. E. (2021). Melatonin exerts a neuroprotective effect against \u03b3-radiation-induced brain injury in the rat through the modulation of neurotransmitters, inflammatory cytokines, oxidative stress, and apoptosis. Environmental Science and Pollution Research(24). https:\/\/doi.org\/10.1007\/s11356-021-12951-5","DOI":"10.1007\/s11356-021-12951-5"},{"key":"5758_CR5","doi-asserted-by":"publisher","unstructured":"Turnquist, C., Harris, B. T., & Harris, C. C. (2020). Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation. Neurooncol Advances, 2(1). https:\/\/doi.org\/10.1093\/noajnl\/vdaa057","DOI":"10.1093\/noajnl\/vdaa057"},{"key":"5758_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00517","author":"K Lumniczky","year":"2017","unstructured":"Lumniczky, K., Szatm\u00e1ri, T., & S\u00e1fr\u00e1ny, G. (2017). Ionizing radiation-induced immune and inflammatory reactions in the brain. Frontiers in Immunology. https:\/\/doi.org\/10.3389\/fimmu.2017.00517","journal-title":"Frontiers in Immunology"},{"key":"5758_CR7","doi-asserted-by":"publisher","unstructured":"Ayano, G. (2016). Dopamine: receptors, functions, synthesis, pathways, locations and mental disorders: review of literatures. Journal of Mental Disorders and Treatment, 2(2). https:\/\/doi.org\/10.4172\/2471-271X.1000120","DOI":"10.4172\/2471-271X.1000120"},{"key":"5758_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00561","author":"C Madeira","year":"2018","unstructured":"Madeira, C., et al. (2018). Elevated glutamate and glutamine levels in the cerebrospinal fluid of patients with probable Alzheimer\u2019s disease and depression. Frontiers in Psychiatry. https:\/\/doi.org\/10.3389\/fpsyt.2018.00561","journal-title":"Frontiers in Psychiatry"},{"key":"5758_CR9","doi-asserted-by":"publisher","unstructured":"Hashimoto, K., Malchow, B., Falkai, P., & Schmitt, A. (2013). Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders. European Archives of Psychiatry and Clinical Neuroscience(5). https:\/\/doi.org\/10.1007\/s00406-013-0399-y","DOI":"10.1007\/s00406-013-0399-y"},{"issue":"12","key":"5758_CR10","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1080\/13607863.2020.1855626","volume":"25","author":"JL Sheffler","year":"2021","unstructured":"Sheffler, J. L., Schmiege, S. J., Sussman, J., & Bekelman, D. B. (2021). A longitudinal analysis of the relationships between depression, fatigue, and pain in patients with heart failure. Aging & Mental Health, 25(12), 2272\u20132278. https:\/\/doi.org\/10.1080\/13607863.2020.1855626","journal-title":"Aging & Mental Health"},{"key":"5758_CR11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neubiorev.2018.12.003","volume":"110","author":"A Abi-Dargham","year":"2020","unstructured":"Abi-Dargham, A. (2020). From \u2018bedside\u2019 to \u2018bench\u2019 and back: A translational approach to studying dopamine dysfunction in schizophrenia. Neuroscience and Biobehavioral Reviews, 110, 174\u2013179. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.12.003","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"5758_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.601519","author":"JA Ross","year":"2021","unstructured":"Ross, J. A., & Van Bockstaele, E. J. (2021). The Locus Coeruleus- norepinephrine system in stress and arousal: Unraveling historical, current, and future perspectives. Frontiers in Psychiatry. https:\/\/doi.org\/10.3389\/fpsyt.2020.601519","journal-title":"Frontiers in Psychiatry"},{"issue":"1","key":"5758_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-020-00134-x","volume":"6","author":"ML Bucher","year":"2020","unstructured":"Bucher, M. L., et al. (2020). Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson\u2019s disease. NPJ Parkinsons Dis., 6(1), Article 34. https:\/\/doi.org\/10.1038\/s41531-020-00134-x","journal-title":"NPJ Parkinsons Dis."},{"issue":"1","key":"5758_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01716-y","volume":"15","author":"J Franco-P\u00e9rez","year":"2020","unstructured":"Franco-P\u00e9rez, J., Montes, S., S\u00e1nchez-Hern\u00e1ndez, J., & Ballesteros-Zebad\u00faa, P. (2020). Whole-brain irradiation differentially modifies neurotransmitters levels and receptors in the hypothalamus and the prefrontal cortex. Radiation Oncology, 15(1), Article 269. https:\/\/doi.org\/10.1186\/s13014-020-01716-y","journal-title":"Radiation Oncology"},{"issue":"10","key":"5758_CR15","doi-asserted-by":"publisher","first-page":"5147","DOI":"10.1021\/cr3000994","volume":"112","author":"IW Hamley","year":"2012","unstructured":"Hamley, I. W. (2012). The Amyloid Beta peptide: A chemist\u2019s perspective. Role in Alzheimer\u2019s and fibrillization. Chemical Reviews, 112(10), 5147\u20135192. https:\/\/doi.org\/10.1021\/cr3000994","journal-title":"Chemical Reviews"},{"issue":"8","key":"5758_CR16","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway, J. M., et al. (2015). Clearance systems in the brain\u2014Implications for Alzheimer disease. Nature Reviews. Neurology, 11(8), 457\u2013470. https:\/\/doi.org\/10.1038\/nrneurol.2015.119","journal-title":"Nature Reviews. Neurology"},{"issue":"4","key":"5758_CR17","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3233\/JAD-161088","volume":"57","author":"E T\u00f6nnies","year":"2017","unstructured":"T\u00f6nnies, E., & Trushina, E. (2017). Oxidative stress, synaptic dysfunction, and Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease, 57(4), 1105\u20131121. https:\/\/doi.org\/10.3233\/JAD-161088","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"7","key":"5758_CR18","doi-asserted-by":"publisher","first-page":"e359","DOI":"10.1038\/emm.2017.85","volume":"49","author":"J Kim","year":"2017","unstructured":"Kim, J., & Jung, Y. (2017). Radiation-induced liver disease: Current understanding and future perspectives. Experimental and Molecular Medicine, 49(7), e359\u2013e359. https:\/\/doi.org\/10.1038\/emm.2017.85","journal-title":"Experimental and Molecular Medicine"},{"issue":"5","key":"5758_CR19","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.hpb.2017.11.007","volume":"20","author":"A Sultana","year":"2018","unstructured":"Sultana, A., et al. (2018). Prospective evaluation of the International Study Group for Liver Surgery definition of post hepatectomy liver failure after liver resection: An international multicentre study. HPB, 20(5), 462\u2013469. https:\/\/doi.org\/10.1016\/j.hpb.2017.11.007","journal-title":"HPB"},{"key":"5758_CR20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/978-981-95-4126-3_7","volume-title":"Multifunctional Marine Polysaccharides","author":"SA Elfeky","year":"2026","unstructured":"Elfeky, S. A., El-ghannam, G., Zedan, M., & Qenawi, N. (2026). Marine Algae Polysaccharides in Anticancer Drug Delivery. Multifunctional Marine Polysaccharides (pp. 173\u2013205). Springer Nature Singapore. https:\/\/doi.org\/10.1007\/978-981-95-4126-3_7"},{"issue":"0","key":"5758_CR21","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/ejchem.2025.380546.11677","volume":"0","author":"SM Hussein","year":"2025","unstructured":"Hussein, S. M., et al. (2025). Aloe vera embedded with silver\/hydroxyapatite nanocomposite for enhanced wound healing (in vitro), supported by molecular docking studies. Egyptian Journal of Chemistry, 0(0), 0\u20130. https:\/\/doi.org\/10.21608\/ejchem.2025.380546.11677","journal-title":"Egyptian Journal of Chemistry"},{"key":"5758_CR22","doi-asserted-by":"publisher","unstructured":"Elfeky, S. A., & Qenawi, N. (2025). Biocompatible nanocomposites for cancer therapy, pp. 185\u2013246. https:\/\/doi.org\/10.1007\/978-981-96-7450-3_7","DOI":"10.1007\/978-981-96-7450-3_7"},{"issue":"7","key":"5758_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070852","volume":"17","author":"AOE Eltahir","year":"2024","unstructured":"Eltahir, A. O. E., Omoruyi, S. I., Augustine, T. N., Luckay, R. C., & Hussein, A. A. (2024). Neuroprotective effects of Glycyrrhiza glabra total extract and isolated compounds. Pharmaceuticals, 17(7), Article 852. https:\/\/doi.org\/10.3390\/ph17070852","journal-title":"Pharmaceuticals"},{"key":"5758_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.cbi.2019.05.045","volume":"308","author":"OA Ahmed-Farid","year":"2019","unstructured":"Ahmed-Farid, O. A., Haredy, S. A., Niazy, R. M., Linhardt, R. J., & Warda, M. (2019). Dose-dependent neuroprotective effect of oriental phyto-derived glycyrrhizin on experimental neuroterminal norepinephrine depletion in a rat brain model. Chemico-biological Interactions, 308, 279\u2013287. https:\/\/doi.org\/10.1016\/j.cbi.2019.05.045","journal-title":"Chemico-biological Interactions"},{"issue":"15","key":"5758_CR25","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1002\/elps.201700469","volume":"39","author":"YF Wong","year":"2018","unstructured":"Wong, Y. F., et al. (2018). Untargeted profiling of Glycyrrhiza glabra extract with comprehensive two-dimensional liquid chromatography\u2010mass spectrometry using multi\u2010segmented shift gradients in the second dimension: Expanding the metabolic coverage. Electrophoresis, 39(15), 1993\u20132000. https:\/\/doi.org\/10.1002\/elps.201700469","journal-title":"Electrophoresis"},{"issue":"1","key":"5758_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0014-5793(95)00627-L","volume":"368","author":"HA Norman","year":"1995","unstructured":"Norman, H. A., Pillai, P., & Baker, M. E. (1995). Licorice-derived compounds inhibit linoleic acid (C: 18: 2\u03c96) desaturation in soybean chloroplasts. FEBS Letters, 368(1), 135\u2013138. https:\/\/doi.org\/10.1016\/0014-5793(95)00627-L","journal-title":"FEBS Letters"},{"issue":"9","key":"5758_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092113","volume":"9","author":"G Jensen","year":"2020","unstructured":"Jensen, G., Holloway, J. L., & Stabenfeldt, S. E. (2020). Hyaluronic acid biomaterials for central nervous system regenerative medicine. Cells, 9(9), Article 2113. https:\/\/doi.org\/10.3390\/cells9092113","journal-title":"Cells"},{"issue":"1654","key":"5758_CR28","doi-asserted-by":"publisher","first-page":"20130606","DOI":"10.1098\/rstb.2013.0606","volume":"369","author":"JC Valenzuela","year":"2014","unstructured":"Valenzuela, J. C., et al. (2014). Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1654), 20130606. https:\/\/doi.org\/10.1098\/rstb.2013.0606","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"5758_CR29","doi-asserted-by":"publisher","unstructured":"Sharifi-Rad, J. (2021). Glycyrrhiza Genus: enlightening phytochemical components for pharmacological and health-promoting abilities, Oxidative Medicine and Cellular Longevity,\u00a01. https:\/\/doi.org\/10.1155\/2021\/7571132","DOI":"10.1155\/2021\/7571132"},{"issue":"1\u20132","key":"5758_CR30","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ijpharm.2012.10.030","volume":"441","author":"L Zhang","year":"2013","unstructured":"Zhang, L., Yao, J., Zhou, J., Wang, T., & Zhang, Q. (2013). Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs. International Journal of Pharmaceutics, 441(1\u20132), 654\u2013664. https:\/\/doi.org\/10.1016\/j.ijpharm.2012.10.030","journal-title":"International Journal of Pharmaceutics"},{"issue":"5","key":"5758_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.4103\/1995-7645.233182","volume":"11","author":"O-H Ahmed-Farid","year":"2018","unstructured":"Ahmed-Farid, O.-H., Abd El-Motelp, B., Essa, E.-M., & Warda, M. (2018). Synergistic renoprotective effect of a compiled branched-chain amino acids and Cymbopogon schoenanthus extract against experimentally induced oxido-nitrosative renal insult. Asian Pacific Journal of Tropical Medicine, 11(5), 342. https:\/\/doi.org\/10.4103\/1995-7645.233182","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"issue":"12","key":"5758_CR32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.15419\/bmrat.v3i12.143","volume":"3","author":"AM Algohary","year":"2016","unstructured":"Algohary, A. M., Ahmad-Farid, O.-H., Abd-Elrazek, A. M., & Al-Baradie, R. S. (2016). Neuroprotective effects of herbal cocktail on cerebrovascular dysfunction in rats with induced hyperhomocysteinaemia. Biomedical Research and Therapy, 3(12), 1045. https:\/\/doi.org\/10.15419\/bmrat.v3i12.143","journal-title":"Biomedical Research and Therapy"},{"issue":"3","key":"5758_CR33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for Superoxide Dismutase. European Journal of Biochemistry, 47(3), 469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"European Journal of Biochemistry"},{"issue":"1","key":"5758_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56306-9","volume":"14","author":"R Garc\u00eda-Carrillo","year":"2024","unstructured":"Garc\u00eda-Carrillo, R., et al. (2024). An adenosine derivative promotes mitochondrial supercomplexes reorganization and restoration of mitochondria structure and bioenergetics in a diethylnitrosamine-induced hepatocellular carcinoma model. Scientific Reports, 14(1), Article 6348. https:\/\/doi.org\/10.1038\/s41598-024-56306-9","journal-title":"Scientific Reports"},{"key":"5758_CR35","volume-title":"theory and practice of Histological Techniques","author":"j Bancroft","year":"2008","unstructured":"Bancroft, j, & Gamble, M. (2008). theory and practice of Histological Techniques (6th edition). Elsivier.","edition":"6th edition"},{"key":"5758_CR36","unstructured":"El-Genaidy, M., A, E. A., badawy S, E. S., S, S. M., & Genaidy, E. M. A, Chemical composition and insecticidal activity of Glycyrrhiza glabra L., root extract against Bactrocera zonata (Saunders, 1841) (Diptera: Tephritidae) International Journal of Agriculture and Plant Science www.agriculturejournal.in Online Chemical composition and insecticidal activity of Glycyrrhiza glabra L., root extract against Bactrocera zonata (Saunders, 1841) (Diptera: Tephritidae), [Online]. Available: https:\/\/www.researchgate.net\/publication\/384895255"},{"key":"5758_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phytochem.2011.12.010","volume":"76","author":"MA Farag","year":"2012","unstructured":"Farag, M. A., Porzel, A., & Wessjohann, L. A. (2012). Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC\u2013MS, LC\u2013MS and 1D NMR techniques. Phytochemistry, 76, 60\u201372. https:\/\/doi.org\/10.1016\/j.phytochem.2011.12.010","journal-title":"Phytochemistry"},{"issue":"18","key":"5758_CR38","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1021\/jp710432d","volume":"112","author":"A Kov\u00e1cs","year":"2008","unstructured":"Kov\u00e1cs, A., Nyerges, B., & Izvekov, V. (2008). Vibrational analysis of N-Acetyl-\u03b1-d-glucosamine and \u03b2-d-Glucuronic Acid. Journal of Physical Chemistry B, 112(18), 5728\u20135735. https:\/\/doi.org\/10.1021\/jp710432d","journal-title":"Journal of Physical Chemistry B"},{"key":"5758_CR39","doi-asserted-by":"publisher","unstructured":"Khalik, Z. A., Saleh, Z., & Ali, M. (2022). Solvent Effect in Glycyrrhizic Acid Spectra (Absorption and Fluorescence). 12. https:\/\/doi.org\/10.21203\/rs.3.rs-1056129\/v1","DOI":"10.21203\/rs.3.rs-1056129\/v1"},{"issue":"1","key":"5758_CR40","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12010-016-2326-y","volume":"182","author":"NC Pan","year":"2017","unstructured":"Pan, N. C., Pereira, H. C. B., da Silva, M., Vasconcelos, A. F. D., & Celligoi, M. A. P. C. (2017). Improvement production of Hyaluronic Acid by Streptococcus zooepidemicus in sugarcane molasses. Applied Biochemistry and Biotechnology, 182(1), 276\u2013293. https:\/\/doi.org\/10.1007\/s12010-016-2326-y","journal-title":"Applied Biochemistry and Biotechnology"},{"key":"5758_CR41","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","volume":"235","author":"S Bhattacharjee","year":"2016","unstructured":"Bhattacharjee, S. (2016). DLS and zeta potential \u2013 What they are and what they are not? Journal of Controlled Release, 235, 337\u2013351. https:\/\/doi.org\/10.1016\/j.jconrel.2016.06.017","journal-title":"Journal of Controlled Release"},{"issue":"2","key":"5758_CR42","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v12i2.20","volume":"12","author":"S Honary","year":"2013","unstructured":"Honary, S., & Zahir, F. (2013). Effect of zeta potential on the properties of nano-drug delivery systems - A review (Part 2). Tropical Journal of Pharmaceutical Research, 12(2), Article 20. https:\/\/doi.org\/10.4314\/tjpr.v12i2.20","journal-title":"Tropical Journal of Pharmaceutical Research"},{"issue":"sup1","key":"5758_CR43","doi-asserted-by":"publisher","first-page":"S132","DOI":"10.1080\/09553002.2020.1820598","volume":"97","author":"E Pariset","year":"2021","unstructured":"Pariset, E., Malkani, S., Cekanaviciute, E., & Costes, S. V. (2021). Ionizing radiation-induced risks to the central nervous system and countermeasures in cellular and rodent models. International Journal of Radiation Biology, 97(sup1), S132\u2013S150. https:\/\/doi.org\/10.1080\/09553002.2020.1820598","journal-title":"International Journal of Radiation Biology"},{"issue":"7","key":"5758_CR44","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1007\/s10571-023-01381-1","volume":"43","author":"IA Kolesnikova","year":"2023","unstructured":"Kolesnikova, I. A., et al. (2023). The effects of whole body gamma irradiation on mice, age-related behavioral, and pathophysiological changes. Cellular and Molecular Neurobiology, 43(7), 3723\u20133741. https:\/\/doi.org\/10.1007\/s10571-023-01381-1","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"1","key":"5758_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.nbd.2011.12.056","volume":"46","author":"S-W Kim","year":"2012","unstructured":"Kim, S.-W., et al. (2012). Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiology of Disease, 46(1), 147\u2013156. https:\/\/doi.org\/10.1016\/j.nbd.2011.12.056","journal-title":"Neurobiology of Disease"},{"issue":"6","key":"5758_CR46","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1021\/acs.biomac.5b00168","volume":"16","author":"ILM Isa","year":"2015","unstructured":"Isa, I. L. M., et al. (2015). Hyaluronic Acid based hydrogels attenuate inflammatory receptors and neurotrophins in Interleukin-1\u03b2 induced inflammation model of nucleus pulposus cells. Biomacromolecules, 16(6), 1714\u20131725. https:\/\/doi.org\/10.1021\/acs.biomac.5b00168","journal-title":"Biomacromolecules"},{"issue":"4","key":"5758_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040824","volume":"12","author":"A Berdiaki","year":"2023","unstructured":"Berdiaki, A., Neagu, M., Spyridaki, I., Kuskov, A., Perez, S., & Nikitovic, D. (2023). Hyaluronan and Reactive Oxygen Species Signaling\u2014Novel cues from the matrix?,. Antioxidants, 12(4), Article 824. https:\/\/doi.org\/10.3390\/antiox12040824","journal-title":"Antioxidants"},{"key":"5758_CR48","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1016\/j.wneu.2009.09.004","volume":"72","author":"C-M Lin","year":"2009","unstructured":"Lin, C.-M., et al. (2009). Hyaluronic acid inhibits the glial scar formation after brain damage with tissue loss in rats,. Surgical Neurology, 72, S50\u2013S54. https:\/\/doi.org\/10.1016\/j.wneu.2009.09.004","journal-title":"Surgical Neurology"},{"issue":"1","key":"5758_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-41099-w","volume":"16","author":"G El-ghannam","year":"2026","unstructured":"El-ghannam, G., Elfeky, S. A., Abo-Elfadl, M. T., Zedan, M., & Moawad, M. (2026). The cytotoxic effects of glycyrrhizic acid-modified chitosan\/selenium nanocomposite on osteosarcoma cancer cell line,. Scientific Reports, 16(1), Article 9677. https:\/\/doi.org\/10.1038\/s41598-026-41099-w","journal-title":"Scientific Reports"},{"issue":"Suppl 1","key":"5758_CR50","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.5213\/inj.2040154.077","volume":"24","author":"JY Ban","year":"2020","unstructured":"Ban, J. Y., Park, H. K., & Kim, S. K. (2020). Effect of glycyrrhizic acid on Scopolamine-induced cognitive impairment in mice,. International Neurourology Journal, 24(Suppl 1), S48-55. https:\/\/doi.org\/10.5213\/inj.2040154.077","journal-title":"International Neurourology Journal"},{"issue":"3","key":"5758_CR51","doi-asserted-by":"publisher","first-page":"657","DOI":"10.2307\/3574255","volume":"64","author":"GNA Nayar","year":"1975","unstructured":"Nayar, G. N. A., & Srinivasan, S. (1975). The effects of gamma radiation on solutions of acetylcholinesterase,. Radiation Research, 64(3), 657. https:\/\/doi.org\/10.2307\/3574255","journal-title":"Radiation Research"},{"issue":"11","key":"5758_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ph17111493","volume":"17","author":"Y Li","year":"2024","unstructured":"Li, Y., et al. (2024). Neuroprotective potential of glycyrrhizic acid in ischemic stroke: Mechanisms and therapeutic prospects. Pharmaceuticals, 17(11), Article 1493. https:\/\/doi.org\/10.3390\/ph17111493","journal-title":"Pharmaceuticals"},{"key":"5758_CR53","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbrc.2022.10.017","volume":"635","author":"X Ma","year":"2022","unstructured":"Ma, X., et al. (2022). 18\u03b2-glycyrrhetinic acid protects neuronal cells from ferroptosis through inhibiting labile iron accumulation and preventing coenzyme Q10 reduction. Biochemical and Biophysical Research Communications, 635, 57\u201364. https:\/\/doi.org\/10.1016\/j.bbrc.2022.10.017","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"5758_CR54","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.asjsur.2024.08.100","volume":"48","author":"H Ye","year":"2025","unstructured":"Ye, H., Zhang, R., Zhang, C., Xia, Y., & Jin, L. (2025). Advances in hyaluronic acid: Bioactivity, complexed biomaterials and biological application: A review. Asian Journal of Surgery, 48(1), 49\u201361. https:\/\/doi.org\/10.1016\/j.asjsur.2024.08.100","journal-title":"Asian Journal of Surgery"},{"key":"5758_CR55","doi-asserted-by":"publisher","unstructured":"Aquilano, K., Baldelli, S., & Ciriolo, M. R. (2014). Glutathione: new roles in redox signaling for an old antioxidant. Frontiers In Pharmacology, 5. https:\/\/doi.org\/10.3389\/fphar.2014.00196","DOI":"10.3389\/fphar.2014.00196"},{"key":"5758_CR56","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.2147\/DDDT.S165225","volume":"12","author":"C Xu","year":"2018","unstructured":"Xu, C., Liang, C., Sun, W., Chen, J., & Chen, X. (2018). Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state. Drug Design, Development and Therapy, 12, 1311\u20131319. https:\/\/doi.org\/10.2147\/DDDT.S165225","journal-title":"Drug Design, Development and Therapy"},{"issue":"6","key":"5758_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061751","volume":"15","author":"S Serini","year":"2023","unstructured":"Serini, S., Trombino, S., Curcio, F., Sole, R., Cassano, R., & Calviello, G. (2023). Hyaluronic acid-mediated phenolic compound nanodelivery for cancer therapy. Pharmaceutics, 15(6), Article 1751. https:\/\/doi.org\/10.3390\/pharmaceutics15061751","journal-title":"Pharmaceutics"},{"issue":"1","key":"5758_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02375-9","volume":"10","author":"Y Shang","year":"2025","unstructured":"Shang, Y., et al. (2025). Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs. Signal Transduction and Targeted Therapy, 10(1), Article 286. https:\/\/doi.org\/10.1038\/s41392-025-02375-9","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"5758_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02596-7","volume":"19","author":"Z Zhang","year":"2022","unstructured":"Zhang, Z., et al. (2022). Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury. Journal of Neuroinflammation, 19(1), Article 231. https:\/\/doi.org\/10.1186\/s12974-022-02596-7","journal-title":"Journal of Neuroinflammation"},{"issue":"16","key":"5758_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165804","volume":"21","author":"J Nuszkiewicz","year":"2020","unstructured":"Nuszkiewicz, J., Wo\u017aniak, A., & Szewczyk-Golec, K. (2020). Ionizing radiation as a source of oxidative stress\u2014The protective role of melatonin and vitamin D. International Journal of Molecular Sciences, 21(16), Article 5804. https:\/\/doi.org\/10.3390\/ijms21165804","journal-title":"International Journal of Molecular Sciences"},{"issue":"9","key":"5758_CR61","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1039\/C8MD00288F","volume":"9","author":"W Liu","year":"2018","unstructured":"Liu, W., et al. (2018). Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K\/Akt-dependent NF-\u03baB signalling pathways in TPA-induced skin inflammation. MedChemComm, 9(9), 1502\u20131510. https:\/\/doi.org\/10.1039\/C8MD00288F","journal-title":"MedChemComm"},{"issue":"2","key":"5758_CR62","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.12932","volume":"27","author":"Z Luo","year":"2023","unstructured":"Luo, Z., Xu, M., Zhang, L., Zhang, H., Xu, Z., & Xu, Z. (2023). Glycyrrhizin regulates the HMGB1\/P38MAPK signalling pathway in status epilepticus. Molecular Medicine Reports, 27(2), Article 45. https:\/\/doi.org\/10.3892\/mmr.2023.12932","journal-title":"Molecular Medicine Reports"},{"issue":"1","key":"5758_CR63","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.fob.2015.05.007","volume":"5","author":"Y Onodera","year":"2015","unstructured":"Onodera, Y., Teramura, T., Takehara, T., & Fukuda, K. (2015). Hyaluronic acid regulates a key redox control factor Nrf2 via phosphorylation of Akt in bovine articular chondrocytes. FEBS Open Bio, 5(1), 476\u2013484. https:\/\/doi.org\/10.1016\/j.fob.2015.05.007","journal-title":"FEBS Open Bio"},{"key":"5758_CR64","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.biopha.2018.06.150","volume":"106","author":"KN Mishra","year":"2018","unstructured":"Mishra, K. N., Moftah, B. A., & Alsbeih, G. A. (2018). Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures. Biomedicine & Pharmacotherapy, 106, 610\u2013617. https:\/\/doi.org\/10.1016\/j.biopha.2018.06.150","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"5758_CR65","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1021\/jf405352g","volume":"62","author":"H-J Chen","year":"2014","unstructured":"Chen, H.-J., Kang, S.-P., Lee, I.-J., & Lin, Y.-L. (2014). Glycyrrhetinic acid suppressed NF-\u03baB activation in TNF-\u03b1-induced hepatocytes. Journal of Agricultural and Food Chemistry, 62(3), 618\u2013625. https:\/\/doi.org\/10.1021\/jf405352g","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"5758_CR66","doi-asserted-by":"publisher","unstructured":"Kim, J., & Seki, E. (2023). Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets. Hepatol Commun, 7(4). https:\/\/doi.org\/10.1097\/HC9.0000000000000083","DOI":"10.1097\/HC9.0000000000000083"},{"issue":"1","key":"5758_CR67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1300\/J044v08n01_02","volume":"8","author":"AA Al-Qarawi","year":"2001","unstructured":"Al-Qarawi, A. A., Abdel-Rahman, H. A., & El-Mougy, S. A. (2001). Hepatoprotective activity of licorice in rat liver injury models. Journal of Herbs, Spices & Medicinal Plants, 8(1), 7\u201314. https:\/\/doi.org\/10.1300\/J044v08n01_02","journal-title":"Journal of Herbs, Spices & Medicinal Plants"},{"issue":"0","key":"5758_CR68","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/fsrt.2021.103363.1051","volume":"0","author":"M Elshehabi","year":"2021","unstructured":"Elshehabi, M., Barakat, N., Zahran, F., Hafez, H. S., & Serag, W. (2021). Therapeutic role of stem cells pretreated with hyaluronic acid against chronic kidney disease in rat model. Frontiers in Scientific Research and Technology, 0(0), 0\u20130. https:\/\/doi.org\/10.21608\/fsrt.2021.103363.1051","journal-title":"Frontiers in Scientific Research and Technology"},{"key":"5758_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117100","volume":"319","author":"L Zhou","year":"2024","unstructured":"Zhou, L., et al. (2024). The protective effect and molecular mechanism of glycyrrhizic acid glycosides against Tripterygium glycosides induced nephrotoxicity based on the RhoA\/ROCK1 signalling pathway. Journal of Ethnopharmacology, 319, Article 117100. https:\/\/doi.org\/10.1016\/j.jep.2023.117100","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"5758_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64270-9","volume":"16","author":"X Yin","year":"2025","unstructured":"Yin, X., et al. (2025). Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice. Nature Communications, 16(1), Article 9229. https:\/\/doi.org\/10.1038\/s41467-025-64270-9","journal-title":"Nature Communications"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05758-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:50:35Z","timestamp":1789195835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05758-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5758"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05758-y","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"assertion":[{"value":"21 May 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This research did not involve any human participants.","order":1,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing interests or personal relationships that could have appeared to influence the work reported in this manuscript.","order":3,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}