{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:47Z","timestamp":1790189987542,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12010-026-05771-1","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:07:24Z","timestamp":1782461244000},"page":"7757-7772","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MAFB Overexpression in Macrophages Promotes Wound Healing in Diabetic Foot Ulcer by Transcriptionally Activating WDR74 to Drive a Tissue-Repair Phenotype and Suppress Inflammation and Oxidative Stress"],"prefix":"10.1007","volume":"198","author":[{"given":"Hai","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinwei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"5771_CR1","doi-asserted-by":"publisher","first-page":"1221705","DOI":"10.3389\/fendo.2023.1221705","volume":"14","author":"P Jiang","year":"2023","unstructured":"Jiang, P., Li, Q., Luo, Y., et al. (2023). Current status and progress in research on dressing management for diabetic foot ulcer. Frontiers in endocrinology, 14, 1221705.","journal-title":"Frontiers in endocrinology"},{"issue":"1","key":"5771_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2337\/dci22-0043","volume":"46","author":"K McDermott","year":"2023","unstructured":"McDermott, K., Fang, M., Boulton, A. J. M., Selvin, E., & Hicks, C. W. (2023). Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers. Diabetes care, 46(1), 209\u2013221.","journal-title":"Diabetes care"},{"issue":"8","key":"5771_CR3","first-page":"929","volume":"45","author":"J Guo","year":"2020","unstructured":"Guo, J., Zhang, J., Huang, Z., & Qi, M. (2020). Role of CD147 in regulating the RSK2\/Slug\/EMT pathway in diabetic foot ulcer healing. Zhong nan da xue xue bao Yi xue ban\u2009=\u2009Journal of Central South University Medical sciences, 45(8), 929\u2013934.","journal-title":"Zhong nan da xue xue bao Yi xue ban\u2009=\u2009Journal of Central South University Medical sciences"},{"issue":"9","key":"5771_CR4","doi-asserted-by":"publisher","first-page":"e70047","DOI":"10.1002\/kjm2.70047","volume":"41","author":"CM Li","year":"2025","unstructured":"Li, C. M., Zheng, X. J., Xie, S. S., Lin, D. Y., & Liu, Z. T. (2025). Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction. The Kaohsiung journal of medical sciences, 41(9), e70047.","journal-title":"The Kaohsiung journal of medical sciences"},{"key":"5771_CR5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/978-3-319-54090-0_14","volume":"62","author":"GJ Kotwal","year":"2017","unstructured":"Kotwal, G. J., & Chien, S. (2017). Macrophage Differentiation in Normal and Accelerated Wound Healing. Results and problems in cell differentiation, 62, 353\u2013364.","journal-title":"Results and problems in cell differentiation"},{"issue":"10","key":"5771_CR6","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.3390\/pharmaceutics14102065","volume":"14","author":"CW Lin","year":"2022","unstructured":"Lin, C. W., Hung, C. M., & Chen, W. J. (2022). New horizons of macrophage immunomodulation in the healing of diabetic foot ulcers. Pharmaceutics. 14(10), 2065.","journal-title":"Pharmaceutics"},{"issue":"21","key":"5771_CR7","doi-asserted-by":"publisher","first-page":"4111","DOI":"10.1007\/s00018-015-1995-y","volume":"72","author":"A Sica","year":"2015","unstructured":"Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015). Macrophage polarization in pathology. Cellular and molecular life sciences: CMLS, 72(21), 4111\u20134126.","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"1","key":"5771_CR8","doi-asserted-by":"publisher","first-page":"4863","DOI":"10.1038\/s41467-018-07358-9","volume":"9","author":"T Kubota","year":"2018","unstructured":"Kubota, T., Inoue, M., Kubota, N., et al. (2018). Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nature communications, 9(1), 4863.","journal-title":"Nature communications"},{"issue":"1","key":"5771_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1538\/expanim.19-0076","volume":"69","author":"M Hamada","year":"2020","unstructured":"Hamada, M., Tsunakawa, Y., Jeon, H., Yadav, M. K., & Takahashi, S. (2020). Role of MafB in macrophages. Experimental animals, 69(1), 1\u201310.","journal-title":"Experimental animals"},{"key":"5771_CR10","doi-asserted-by":"crossref","unstructured":"Fujino, M., Ojima, M., Takahashi, S., & Exploring Large, M. A. F. (2023). Transcription Factors: Functions, Pathology, and Mouse Models with Point Mutations. Genes. 14(10).","DOI":"10.3390\/genes14101883"},{"issue":"11","key":"5771_CR11","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ni.2419","volume":"13","author":"EL Gautier","year":"2012","unstructured":"Gautier, E. L., Shay, T., Miller, J., et al. (2012). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature immunology, 13(11), 1118\u20131128.","journal-title":"Nature immunology"},{"issue":"5","key":"5771_CR12","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.4049\/jimmunol.1601667","volume":"198","author":"VD Cuevas","year":"2017","unstructured":"Cuevas, V. D., Anta, L., Samaniego, R., et al. (2017). MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis. Journal of immunology (Baltimore Md: 1950), 198(5), 2070\u20132081.","journal-title":"Journal of immunology (Baltimore Md: 1950)"},{"issue":"8","key":"5771_CR13","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.4049\/jimmunol.2300844","volume":"213","author":"M Kanai","year":"2024","unstructured":"Kanai, M., Nishino, T., Daassi, D., et al. (2024). MAFB in Macrophages Regulates Prostaglandin E2-Mediated Lipid Mediator Class Switch through ALOX15 in Ischemic Acute Kidney Injury. Journal of immunology (Baltimore Md: 1950), 213(8), 1212\u20131224.","journal-title":"Journal of immunology (Baltimore Md: 1950)"},{"issue":"4","key":"5771_CR14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s00018-023-04745-4","volume":"80","author":"AG de la Aleja","year":"2023","unstructured":"de la Aleja, A. G., Herrero, C., Torres-Torresano, M., et al. (2023). Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. Cellular and molecular life sciences: CMLS, 80(4), 96.","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"11","key":"5771_CR15","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1681\/ASN.2013090993","volume":"25","author":"N Morito","year":"2014","unstructured":"Morito, N., Yoh, K., Ojima, M., et al. (2014). Overexpression of Mafb in podocytes protects against diabetic nephropathy. Journal of the American Society of Nephrology: JASN, 25(11), 2546\u20132557.","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"1","key":"5771_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bbrc.2017.10.148","volume":"495","author":"N Hiraishi","year":"2018","unstructured":"Hiraishi, N., Ishida, Y. I., Sudo, H., & Nagahama, M. (2018). WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2. Biochemical and biophysical research communications, 495(1), 116\u2013123.","journal-title":"Biochemical and biophysical research communications"},{"issue":"5","key":"5771_CR17","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.str.2017.03.008","volume":"25","author":"YH Lo","year":"2017","unstructured":"Lo, Y. H., Romes, E. M., Pillon, M. C., Sobhany, M., & Stanley, R. E. (2017). Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1\/WDR74 Important for Localization and Interaction with Rix7\/NVL2. Structure (London England: 1993), 25(5), 762\u2013772e764.","journal-title":"Structure (London England: 1993)"},{"key":"5771_CR18","doi-asserted-by":"publisher","first-page":"860940","DOI":"10.3389\/fgene.2022.860940","volume":"13","author":"X Wu","year":"2022","unstructured":"Wu, X., Song, P., Wang, S., et al. (2022). A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors. Frontiers in genetics, 13, 860940.","journal-title":"Frontiers in genetics"},{"issue":"4","key":"5771_CR19","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s10565-022-09748-8","volume":"39","author":"K Geng","year":"2023","unstructured":"Geng, K., Ma, X., Jiang, Z., et al. (2023). WDR74 facilitates TGF-\u03b2\/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice. Cell biology and toxicology, 39(4), 1577\u20131591.","journal-title":"Cell biology and toxicology"},{"issue":"3","key":"5771_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2174\/0115701646309538240805093732","volume":"21","author":"Y Yue","year":"2024","unstructured":"Yue, Y., Yiying, T., Jiaxin, W., et al. (2024). Circulating Exosomes Studied by Label-free Proteomics Analysis Reveal Transition Signatures from Diabetes Mellitus to Diabetic Kidney Disease. Current Proteomics, 21(3), 187\u2013203.","journal-title":"Current Proteomics"},{"issue":"3","key":"5771_CR21","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.dsx.2015.04.007","volume":"9","author":"S Noor","year":"2015","unstructured":"Noor, S., Zubair, M., & Ahmad, J. (2015). Diabetic foot ulcer\u2013A review on pathophysiology, classification and microbial etiology. Diabetes & metabolic syndrome, 9(3), 192\u2013199.","journal-title":"Diabetes & metabolic syndrome"},{"issue":"6","key":"5771_CR22","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.12968\/bjon.2019.28.6.S38","volume":"28","author":"SA Subrata","year":"2019","unstructured":"Subrata, S. A., & Phuphaibul, R. (2019). A nursing metaparadigm perspective of diabetic foot ulcer care. British journal of nursing (Mark Allen Publishing), 28(6), S38\u2013s50.","journal-title":"British journal of nursing (Mark Allen Publishing)"},{"issue":"1","key":"5771_CR23","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/s42003-023-05426-5","volume":"6","author":"H Cui","year":"2023","unstructured":"Cui, H., Banerjee, S., Xie, N., et al. (2023). MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages. Communications biology, 6(1), 1047.","journal-title":"Communications biology"},{"issue":"1","key":"5771_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.kint.2021.10.020","volume":"101","author":"DP Basile","year":"2022","unstructured":"Basile, D. P. (2022). Macrophage dynamics in kidney repair: elucidation of a COX-2-dependent MafB pathway to affect macrophage differentiation. Kidney international, 101(1), 15\u201318.","journal-title":"Kidney international"},{"issue":"4","key":"5771_CR25","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela, R., McPherson, C. A., & Harry, G. J. (2016). Microglial M1\/M2 polarization and metabolic states. British journal of pharmacology, 173(4), 649\u2013665.","journal-title":"British journal of pharmacology"},{"key":"5771_CR26","doi-asserted-by":"publisher","first-page":"8852759","DOI":"10.1155\/2021\/8852759","volume":"2021","author":"L Deng","year":"2021","unstructured":"Deng, L., Du, C., Song, P., et al. (2021). The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing. Oxidative medicine and cellular longevity, 2021, 8852759.","journal-title":"Oxidative medicine and cellular longevity"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05771-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05771-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05771-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:03:12Z","timestamp":1790186592000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05771-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["5771"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05771-1","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"29 May 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal studies were performed in compliance with the ARRIVE guidelines and the Basel Declaration. All animals received humane care according to the National Institutes of Health (USA) guidelines. The study was approved by the Animal Care and Use Committee of Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine [Approval Number: 20231109S].","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}