{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:18:19Z","timestamp":1783574299117,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100021725","name":"National Institute of Ocean Technology, Ministry of Earth Sciences","doi-asserted-by":"publisher","award":["MoES\/11\u2010MRDF\/ESTC\u2010 MEB (SU)\/2\/2014 PC\u2010 III"],"award-info":[{"award-number":["MoES\/11\u2010MRDF\/ESTC\u2010 MEB (SU)\/2\/2014 PC\u2010 III"]}],"id":[{"id":"10.13039\/501100021725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022833","name":"Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR41474\/NDB\/39\/760\/2020"],"award-info":[{"award-number":["BT\/PR41474\/NDB\/39\/760\/2020"]}],"id":[{"id":"10.13039\/100022833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006593","name":"Board of Research in Nuclear Sciences","doi-asserted-by":"publisher","award":["56\/14\/03\/2020-BRNS\/36152"],"award-info":[{"award-number":["56\/14\/03\/2020-BRNS\/36152"]}],"id":[{"id":"10.13039\/501100006593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"DOI":"10.1007\/s12010-026-05816-5","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:56:03Z","timestamp":1783572963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiofilm Activity and Chemical Profiling of Marine Bacterial Extracts with Antifouling Potential"],"prefix":"10.1007","author":[{"given":"Anu","family":"C.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbakandan","family":"D.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarita","family":"Clements","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naren Kumar","family":"T.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharani","family":"G.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinithkumar","family":"N. V.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"5816_CR1","doi-asserted-by":"publisher","first-page":"103385","DOI":"10.1016\/j.bcab.2024.103385","volume":"61","author":"S Ghattavi","year":"2024","unstructured":"Ghattavi, S., Homaei, A., & Fernandes, P. (2024). Marine natural products for biofouling elimination in marine environments. Biocatalysis and Agricultural Biotechnology, 61, 103385. https:\/\/doi.org\/10.1016\/j.bcab.2024.103385","journal-title":"Biocatalysis and Agricultural Biotechnology"},{"issue":"3","key":"5816_CR2","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3390\/life13030802","volume":"13","author":"NN Rawi","year":"2023","unstructured":"Rawi, N. N., Ramzi, M. M., Rahman, N. I. A., Ariffin, F., Saidin, J., Bhubalan, K., & Ismail, N. (2023). Antifouling Potential of Ethyl Acetate Extract of Marine Bacteria Pseudomonas aeruginosa Strain RLimb. Life, 13(3), 802. https:\/\/doi.org\/10.3390\/life13030802","journal-title":"Life"},{"issue":"13","key":"5816_CR3","doi-asserted-by":"publisher","first-page":"10518","DOI":"10.3390\/ijms241310518","volume":"24","author":"S Dobretsov","year":"2023","unstructured":"Dobretsov, S., & Rittschof, D. (2023). Omics Techniques Used in Marine Biofouling Studies. International Journal of Molecular Sciences, 24(13), 10518. https:\/\/doi.org\/10.3390\/ijms241310518","journal-title":"International Journal of Molecular Sciences"},{"key":"5816_CR4","doi-asserted-by":"publisher","first-page":"150853","DOI":"10.1016\/j.apsusc.2021.150853","volume":"569","author":"E Manderfeld","year":"2021","unstructured":"Manderfeld, E., Kleinberg, M. N., Thamaraiselvan, C., Koschitzki, F., Gnutt, P., Plumere, N., & Rosenhahn, A. (2021). Electrochemically activated laser-induced graphene coatings against marine biofouling. Applied Surface Science, 569, 150853. https:\/\/doi.org\/10.1016\/j.apsusc.2021.150853","journal-title":"Applied Surface Science"},{"issue":"2","key":"5816_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s42235-021-0017-z","volume":"18","author":"L Tian","year":"2021","unstructured":"Tian, L., Yin, Y., Bing, W., & Jin, E. (2021). Antifouling Technology Trends in Marine Environmental Protection. Journal of Bionic Engineering, 18(2), 239\u2013263. https:\/\/doi.org\/10.1007\/s42235-021-0017-z","journal-title":"Journal of Bionic Engineering"},{"key":"5816_CR6","doi-asserted-by":"publisher","first-page":"153638","DOI":"10.1016\/j.cej.2024.153638","volume":"495","author":"Q Qiu","year":"2024","unstructured":"Qiu, Q., Gu, Y., Ren, Y., Ding, H., Hu, C., Wu, D., & Dai, D. (2024). Research progress on eco-friendly natural antifouling agents and their antifouling mechanisms. Chemical Engineering Journal, 495, 153638. https:\/\/doi.org\/10.1016\/j.cej.2024.153638","journal-title":"Chemical Engineering Journal"},{"issue":"17","key":"5816_CR7","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.3390\/ijms21176068","volume":"21","author":"M Alem\u00e1n-Vega","year":"2020","unstructured":"Alem\u00e1n-Vega, M., S\u00e1nchez-Lozano, I., Hern\u00e1ndez-Guerrero, C. J., Hellio, C., & Quintana, E. T. (2020). Exploring Antifouling Activity of Biosurfactants Producing Marine Bacteria Isolated from Gulf of California. International Journal of Molecular Sciences, 21(17), 6068. https:\/\/doi.org\/10.3390\/ijms21176068","journal-title":"International Journal of Molecular Sciences"},{"key":"5816_CR8","doi-asserted-by":"publisher","unstructured":"Barzkar, N., Sukhikh, S., & Babich, O. (2024). Study of marine microorganism metabolites: new resources for bioactive natural products. Frontiers in Microbiology, 14. https:\/\/doi.org\/10.3389\/fmicb.2023.1285902","DOI":"10.3389\/fmicb.2023.1285902"},{"issue":"10","key":"5816_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3390\/md19100530","volume":"19","author":"R Srinivasan","year":"2021","unstructured":"Srinivasan, R., Kannappan, A., Shi, C., & Lin, X. (2021). Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds. Marine Drugs, 19(10), 530. https:\/\/doi.org\/10.3390\/md19100530","journal-title":"Marine Drugs"},{"key":"5816_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejbt.2016.02.002","volume":"21","author":"S Satheesh","year":"2016","unstructured":"Satheesh, S., Ba-akdah, M. A., & Al-Sofyani, A. A. (2016). Natural antifouling compound production by microbes associated with marine macroorganisms \u2014 A review. Electronic Journal of Biotechnology, 21, 26\u201335. https:\/\/doi.org\/10.1016\/j.ejbt.2016.02.002","journal-title":"Electronic Journal of Biotechnology"},{"key":"5816_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2021.711108","author":"A Muras","year":"2021","unstructured":"Muras, A., Larroze, S., Mayer, C., Teixeira, T., Wengier, R., Benayahu, Y., & Otero, A. (2021). Evaluation of the anti-fouling efficacy of Bacillus licheniformis extracts under environmental and natural conditions. Frontiers in Marine Science. https:\/\/doi.org\/10.3389\/fmars.2021.711108","journal-title":"Frontiers in Marine Science"},{"key":"5816_CR12","doi-asserted-by":"publisher","unstructured":"D\u2019Angelo, C., Casillo, A., Melchiorre, C., Lauro, C., Corsaro, M. M., Carpentieri,A., \u2026 Parrilli, E. (2022). CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020. Marine Drugs, 20(12), 747. https:\/\/doi.org\/10.3390\/md20120747.","DOI":"10.3390\/md20120747."},{"issue":"3","key":"5816_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/08927010600780771","volume":"22","author":"X Li","year":"2006","unstructured":"Li, X., Dobretsov, S., Xu, Y., Xiao, X., Hung, O. S., & Qian, P. (2006). Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus. Biofouling, 22(3), 187\u2013194. https:\/\/doi.org\/10.1080\/08927010600780771","journal-title":"Biofouling"},{"key":"5816_CR14","doi-asserted-by":"publisher","first-page":"102096","DOI":"10.1016\/j.eti.2021.102096","volume":"25","author":"K Stalin","year":"2022","unstructured":"Stalin, K., Ravi, L., & Raghavan, V. (2022). Extraction, purification and structural elucidation of environmentally benign antifouling metabolite from Streptomyces thermolineatus VITKV6A. Environmental Technology & Innovation, 25, 102096. https:\/\/doi.org\/10.1016\/j.eti.2021.102096","journal-title":"Environmental Technology & Innovation"},{"issue":"4","key":"5816_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.26881\/oahs-2022.4.02","volume":"51","author":"RI Tunkal","year":"2022","unstructured":"Tunkal, R. I., Jamal, M. T., Abdulrahman, I., Pugazhendi, A., & Satheesh, S. (2022). Antifouling activity of bacterial extracts associated with soft coral and macroalgae from the Red Sea. Oceanological and Hydrobiological Studies, 51(4), 325\u2013336. https:\/\/doi.org\/10.26881\/oahs-2022.4.02","journal-title":"Oceanological and Hydrobiological Studies"},{"issue":"1","key":"5816_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00253-010-2777-y","volume":"88","author":"C Nithya","year":"2010","unstructured":"Nithya, C., Begum, M. F., & Pandian, S. K. (2010). Marine bacterial isolates inhibit biofilm formation and disrupt mature biofilms of Pseudomonas aeruginosa PAO1. Applied Microbiology and Biotechnology, 88(1), 341\u2013358. https:\/\/doi.org\/10.1007\/s00253-010-2777-y","journal-title":"Applied Microbiology and Biotechnology"},{"key":"5816_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.micpath.2018.08.014","volume":"124","author":"WA Lotfy","year":"2018","unstructured":"Lotfy, W. A., Mostafa, S. W., Adel, A. A., & Ghanem, K. M. (2018). Production of di-(2-ethylhexyl) phthalate by Bacillus subtilis AD35: Isolation, purification, characterization and biological activities. Microbial Pathogenesis, 124, 89\u2013100. https:\/\/doi.org\/10.1016\/j.micpath.2018.08.014","journal-title":"Microbial Pathogenesis"},{"issue":"2","key":"5816_CR18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s12088-011-0138-x","volume":"52","author":"R Vijayakumar","year":"2012","unstructured":"Vijayakumar, R., Panneerselvam, K., Muthukumar, C., Thajuddin, N., Panneerselvam, A., & Saravanamuthu, R. (2012). Optimization of Antimicrobial Production by a Marine Actinomycete Streptomyces afghaniensis VPTS3-1 Isolated from Palk Strait, East Coast of India. Indian Journal of Microbiology, 52(2), 230\u2013239. https:\/\/doi.org\/10.1007\/s12088-011-0138-x","journal-title":"Indian Journal of Microbiology"},{"key":"5816_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1350391","author":"A Shariati","year":"2024","unstructured":"Shariati, A., Noei, M., Askarinia, M., Khoshbayan, A., Farahani, A., & Chegini, Z. (2024). Inhibitory effect of natural compounds on quorum sensing system in Pseudomonas aeruginosa: A helpful promise for managing biofilm community. Frontiers in Pharmacology. https:\/\/doi.org\/10.3389\/fphar.2024.1350391","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"5816_CR20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s10126-007-9036-y","volume":"10","author":"ME Skindersoe","year":"2008","unstructured":"Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, T., de Nys, R., & Givskov, M. (2008). Quorum Sensing Antagonism from Marine Organisms. Marine Biotechnology, 10(1), 56\u201363. https:\/\/doi.org\/10.1007\/s10126-007-9036-y","journal-title":"Marine Biotechnology"},{"issue":"7","key":"5816_CR21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3390\/md17070427","volume":"17","author":"A Borges","year":"2019","unstructured":"Borges, A., & Sim\u00f5es, M. (2019). Quorum Sensing Inhibition by Marine Bacteria. Marine Drugs, 17(7), 427. https:\/\/doi.org\/10.3390\/md17070427","journal-title":"Marine Drugs"},{"issue":"1","key":"5816_CR22","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s13104-023-06580-z","volume":"16","author":"M Wijaya","year":"2023","unstructured":"Wijaya, M., Delicia, D., & Waturangi, D. E. (2023). Control of pathogenic bacteria using marine actinobacterial extract with antiquorum sensing and antibiofilm activity. BMC Research Notes, 16(1), 305. https:\/\/doi.org\/10.1186\/s13104-023-06580-z","journal-title":"BMC Research Notes"},{"issue":"3","key":"5816_CR23","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1021\/ac60111a017","volume":"28","author":"M DuBois","year":"1956","unstructured":"DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956). Colorimetric Method for Determination of Sugars and Related Substances. Analytical Chemistry, 28(3), 350\u2013356. https:\/\/doi.org\/10.1021\/ac60111a017","journal-title":"Analytical Chemistry"},{"issue":"4","key":"5816_CR24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/08927014.2013.776042","volume":"29","author":"S Dobretsov","year":"2013","unstructured":"Dobretsov, S., Abed, R. M. M., & Teplitski, M. (2013). Mini-review: Inhibition of biofouling by marine microorganisms. Biofouling, 29(4), 423\u2013441. https:\/\/doi.org\/10.1080\/08927014.2013.776042","journal-title":"Biofouling"},{"key":"5816_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00337","author":"VK Singh","year":"2017","unstructured":"Singh, V. K., Mishra, A., & Jha, B. (2017). Anti-quorum sensing and anti-biofilm activity of Delftia tsuruhatensis extract by attenuating the quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa. Frontiers in Cellular and Infection Microbiology. https:\/\/doi.org\/10.3389\/fcimb.2017.00337","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"1","key":"5816_CR26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00253-024-13024-6","volume":"108","author":"Y Lin","year":"2024","unstructured":"Lin, Y., Fang, M., Liu, J., Zhang, Y., & Yu, Y. (2024). Transcriptomic analyses of Vibrio parahaemolyticus under the phenyllactic acid stress. Applied Microbiology and Biotechnology, 108(1), 180. https:\/\/doi.org\/10.1007\/s00253-024-13024-6","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"1","key":"5816_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ismej.2007.92","volume":"2","author":"T Defoirdt","year":"2008","unstructured":"Defoirdt, T., Boon, N., Sorgeloos, P., Verstraete, W., & Bossier, P. (2008). Quorum sensing and quorum quenching in Vibrio harveyi: Lessons learned from in vivo work. The ISME Journal, 2(1), 19\u201326. https:\/\/doi.org\/10.1038\/ismej.2007.92","journal-title":"The ISME Journal"},{"issue":"3","key":"5816_CR28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/2049-632X.12033","volume":"67","author":"SL Gellatly","year":"2013","unstructured":"Gellatly, S. L., & Hancock, R. E. W. (2013). Pseudomonas aeruginosa: New insights into pathogenesis and host defenses. Pathogens and Disease, 67(3), 159\u2013173. https:\/\/doi.org\/10.1111\/2049-632X.12033","journal-title":"Pathogens and Disease"},{"issue":"4","key":"5816_CR29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.4155\/fmc.15.6","volume":"7","author":"N Rabin","year":"2015","unstructured":"Rabin, N., Zheng, Y., Opoku-Temeng, C., Du, Y., Bonsu, E., & Sintim, H. O. (2015). Biofilm Formation Mechanisms and Targets for Developing Antibiofilm Agents. Future Medicinal Chemistry, 7(4), 493\u2013512. https:\/\/doi.org\/10.4155\/fmc.15.6","journal-title":"Future Medicinal Chemistry"},{"key":"5816_CR30","doi-asserted-by":"publisher","unstructured":"Behzadnia, A., Moosavi-Nasab, M., & Oliyaei, N. (2024). Anti-biofilm activity of marine algae-derived bioactive compounds. Frontiers in Microbiology, 15. https:\/\/doi.org\/10.3389\/fmicb.2024.1270174","DOI":"10.3389\/fmicb.2024.1270174"},{"key":"5816_CR31","doi-asserted-by":"publisher","unstructured":"Deng, Y., Liu, Y., Li, J., Wang, X., He, S., Yan, X., \u2026 Ding, L. (2022). Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development. European Journal of Medicinal Chemistry, 239, 114513. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114513.","DOI":"10.1016\/j.ejmech.2022.114513."},{"key":"5816_CR32","doi-asserted-by":"publisher","unstructured":"Rashiya, N., Padmini, N., Ajilda, A. A. K., Prabakaran, P., Durgadevi, R., Veera Ravi, A., \u2026 Selvakumar, G. (2021). Inhibition of biofilm formation and quorum sensing mediated virulence in Pseudomonas aeruginosa by marine sponge symbiont Brevibacterium casei strain Alu 1. Microbial Pathogenesis, 150, 104693. https:\/\/doi.org\/10.1016\/j.micpath.2020.104693.","DOI":"10.1016\/j.micpath.2020.104693."},{"issue":"36","key":"5816_CR33","doi-asserted-by":"publisher","first-page":"11353","DOI":"10.1073\/pnas.1503058112","volume":"112","author":"LK Jennings","year":"2015","unstructured":"Jennings, L. K., Storek, K. M., Ledvina, H. E., Coulon, C., Marmont, L. S., Sadovskaya, I., & Parsek, M. R. (2015). Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix. Proceedings of the National Academy of Sciences, 112(36), 11353\u201311358. https:\/\/doi.org\/10.1073\/pnas.1503058112","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"5","key":"5816_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrmicro.2016.190","volume":"15","author":"U Jenal","year":"2017","unstructured":"Jenal, U., Reinders, A., & Lori, C. (2017). Cyclic di-GMP: Second messenger extraordinaire. Nature Reviews Microbiology, 15(5), 271\u2013284. https:\/\/doi.org\/10.1038\/nrmicro.2016.190","journal-title":"Nature Reviews Microbiology"},{"issue":"4","key":"5816_CR35","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.bpj.2011.07.013","volume":"101","author":"HI Ing\u00f3lfsson","year":"2011","unstructured":"Ing\u00f3lfsson, H. I., & Andersen, O. S. (2011). Alcohol\u2019s Effects on Lipid Bilayer Properties. Biophysical Journal, 101(4), 847\u2013855. https:\/\/doi.org\/10.1016\/j.bpj.2011.07.013","journal-title":"Biophysical Journal"},{"issue":"2","key":"5816_CR36","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1529\/biophysj.103.034280","volume":"87","author":"HV Ly","year":"2004","unstructured":"Ly, H. V., & Longo, M. L. (2004). The Influence of Short-Chain Alcohols on Interfacial Tension, Mechanical Properties, Area\/Molecule, and Permeability of Fluid Lipid Bilayers. Biophysical Journal, 87(2), 1013\u20131033. https:\/\/doi.org\/10.1529\/biophysj.103.034280","journal-title":"Biophysical Journal"},{"key":"5816_CR37","doi-asserted-by":"publisher","unstructured":"Tan, W. S., Law, J. W. F., Law, L. N. S., Letchumanan, V., & Chan, K. G. (2020). Insights into quorum sensing (QS): QS-regulated biofilm and inhibitors. Progress In Microbes & Molecular Biology, 3(1). https:\/\/doi.org\/10.36877\/pmmb.a0000141","DOI":"10.36877\/pmmb.a0000141"},{"issue":"1","key":"5816_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11418-023-01754-2","volume":"78","author":"L Sukmarini","year":"2024","unstructured":"Sukmarini, L., Atikana, A., & Hertiani, T. (2024). Antibiofilm activity of marine microbial natural products: Potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens. Journal of Natural Medicines, 78(1), 1\u201320. https:\/\/doi.org\/10.1007\/s11418-023-01754-2","journal-title":"Journal of Natural Medicines"},{"issue":"1","key":"5816_CR39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/md21010050","volume":"21","author":"JT Wibowo","year":"2023","unstructured":"Wibowo, J. T., Bayu, A., Aryati, W. D., Fernandes, C., Yanuar, A., Kijjoa, A., & Putra, M. Y. (2023). Secondary Metabolites from Marine-Derived Bacteria with Antibiotic and Antibiofilm Activities against Drug-Resistant Pathogens. Marine Drugs, 21(1), 50. https:\/\/doi.org\/10.3390\/md21010050","journal-title":"Marine Drugs"},{"issue":"11","key":"5816_CR40","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1007\/s00253-019-09808-w","volume":"103","author":"J Liu","year":"2019","unstructured":"Liu, J., Li, W., Zhu, X., Zhao, H., Lu, Y., Zhang, C., & Lu, Z. (2019). Surfactin effectively inhibits Staphylococcus aureus adhesion and biofilm formation on surfaces. Applied Microbiology and Biotechnology, 103(11), 4565\u20134574. https:\/\/doi.org\/10.1007\/s00253-019-09808-w","journal-title":"Applied Microbiology and Biotechnology"},{"key":"5816_CR41","doi-asserted-by":"publisher","first-page":"127363","DOI":"10.1016\/j.micres.2023.127363","volume":"271","author":"SM Sreedharan","year":"2023","unstructured":"Sreedharan, S. M., Rishi, N., & Singh, R. (2023). Microbial lipopeptides: Properties, mechanics and engineering for novel lipopeptides. Microbiological Research, 271, 127363. https:\/\/doi.org\/10.1016\/j.micres.2023.127363","journal-title":"Microbiological Research"},{"issue":"3","key":"5816_CR42","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/08927010290013026","volume":"18","author":"SV Dobretsov","year":"2002","unstructured":"Dobretsov, S. V., & Qian, P. Y. (2002). Effect of Bacteria Associated with the Green Alga Ulva reticulata on Marine Micro- and Macrofouling. Biofouling, 18(3), 217\u2013228. https:\/\/doi.org\/10.1080\/08927010290013026","journal-title":"Biofouling"},{"issue":"2","key":"5816_CR43","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1039\/C0NP00034E","volume":"28","author":"N Fusetani","year":"2011","unstructured":"Fusetani, N. (2011). Antifouling marine natural products. Natural Products Reports, 28(2), 400\u2013410. https:\/\/doi.org\/10.1039\/C0NP00034E","journal-title":"Natural Products Reports"},{"issue":"4","key":"5816_CR44","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1128\/AEM.71.4.1729-1736.2005","volume":"71","author":"D Rao","year":"2005","unstructured":"Rao, D., Webb, J. S., & Kjelleberg, S. (2005). Competitive Interactions in Mixed-Species Biofilms Containing the Marine Bacterium Pseudoalteromonas tunicata. Applied and Environmental Microbiology, 71(4), 1729\u20131736. https:\/\/doi.org\/10.1128\/AEM.71.4.1729-1736.2005","journal-title":"Applied and Environmental Microbiology"},{"issue":"05","key":"5816_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1055\/s-2007-971236","volume":"45","author":"B Meyer","year":"1982","unstructured":"Meyer, B., Ferrigni, N., Putnam, J., Jacobsen, L., Nichols, D., & McLaughlin, J. (1982). Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents. Planta Medica, 45(05), 31\u201334. https:\/\/doi.org\/10.1055\/s-2007-971236","journal-title":"Planta Medica"},{"issue":"1","key":"5816_CR46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1472-6750-2-17","volume":"2","author":"JL Carballo","year":"2002","unstructured":"Carballo, J. L., Hern\u00e1ndez-Inda, Z. L., P\u00e9rez, P., & Garc\u00eda-Gr\u00e1valos, M. D. (2002). A comparison between two brine shrimp assays to detect in vitrocytotoxicity in marine natural products. BMC Biotechnology, 2(1), 17. https:\/\/doi.org\/10.1186\/1472-6750-2-17","journal-title":"BMC Biotechnology"},{"key":"5816_CR47","doi-asserted-by":"publisher","unstructured":"Palaniappan, S., Panchanathan, M., Packiyaraj, V., Kannan, S., Shanmugam, S., Subramaniam,P., \u2026 Balasubramanian, T. (2013). Antibacterial and brine shrimp lethality effect of marine actinobacterium Streptomyces sp. CAS72 against human pathogenic bacteria.Asian Pacific Journal of Tropical Disease, 3(4), 286\u2013293. https:\/\/doi.org\/10.1016\/S2222-1808(13)60071-7.","DOI":"10.1016\/S2222-1808(13)60071-7."},{"issue":"1","key":"5816_CR48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.22370\/rbmo.2024.59.1.4456","volume":"59","author":"EG Rico-Virgen","year":"2024","unstructured":"Rico-Virgen, E. G., Ortiz-Aguirre, I., Hellio, C., Rangel-D\u00e1valos, C., Escobedo-Fregoso, A., L\u00f3pez-Fuerte, F. O., & Aguila-Ram\u00edrez, R. N. (2024). Antifouling activity of marine bacterial extracts: A non-toxic alternative as biocide. Revista de Biolog\u00eda Marina y Oceanograf\u00eda, 59(1), 39\u201350. https:\/\/doi.org\/10.22370\/rbmo.2024.59.1.4456","journal-title":"Revista de Biolog\u00eda Marina y Oceanograf\u00eda"},{"key":"5816_CR49","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.toxrep.2022.01.007","volume":"9","author":"M Tapia-Salazar","year":"2022","unstructured":"Tapia-Salazar, M., Diaz-Sosa, V. R., & C\u00e1rdenas-Ch\u00e1vez, D. L. (2022). Toxicological effect and enzymatic disorder of non-studied emerging contaminants in Artemia salina model. Toxicology Reports, 9, 210\u2013218. https:\/\/doi.org\/10.1016\/j.toxrep.2022.01.007","journal-title":"Toxicology Reports"},{"issue":"03","key":"5816_CR50","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1055\/s-2006-959661","volume":"59","author":"P Solis","year":"1993","unstructured":"Solis, P., Wright, C., Anderson, M., Gupta, M., & Phillipson, J. (1993). A Microwell Cytotoxicity Assay using Artemia salina (Brine Shrimp). Planta Medica, 59(03), 250\u2013252. https:\/\/doi.org\/10.1055\/s-2006-959661","journal-title":"Planta Medica"},{"issue":"5","key":"5816_CR51","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1078\/0944-7113-00044","volume":"8","author":"A LAGARTOPARRA","year":"2001","unstructured":"LAGARTOPARRA, A. (2001). Comparative study of the assay of and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine, 8(5), 395\u2013400. https:\/\/doi.org\/10.1078\/0944-7113-00044","journal-title":"Phytomedicine"},{"issue":"9","key":"5816_CR52","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrmicro2415","volume":"8","author":"HC Flemming","year":"2010","unstructured":"Flemming, H. C., & Wingender, J. (2010). The biofilm matrix. Nature Reviews Microbiology, 8(9), 623\u2013633. https:\/\/doi.org\/10.1038\/nrmicro2415","journal-title":"Nature Reviews Microbiology"},{"issue":"1","key":"5816_CR53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/08927010500504784","volume":"22","author":"S Dobretsov","year":"2006","unstructured":"Dobretsov, S., Dahms, H. U., & Qian, P. Y. (2006). Inhibition of biofouling by marine microorganisms and their metabolites. Biofouling, 22(1), 43\u201354. https:\/\/doi.org\/10.1080\/08927010500504784","journal-title":"Biofouling"},{"key":"5816_CR54","unstructured":"Jeganathan, P., Rajasekaran, K. M., Asha Devi, N. K., & Karrupusamy, S. (2013). Indian journal of pharmaceutical and biological research."},{"key":"5816_CR55","doi-asserted-by":"publisher","first-page":"104693","DOI":"10.1016\/j.micpath.2020.104693","volume":"150","author":"N Rashiya","year":"2021","unstructured":"Rashiya, N., Padmini, N., Ajilda, A., K, A., Prabakaran, P., Durgadevi, R., Veera Ravi, A., & Selvakumar, G. (2021). Inhibition of biofilm formation and quorum sensing mediated virulence in Pseudomonas aeruginosa by marine sponge symbiont Brevibacterium casei strain Alu 1. Microbial Pathogenesis, 150, 104693. https:\/\/doi.org\/10.1016\/j.micpath.2020.104693","journal-title":"Microbial Pathogenesis"},{"issue":"7","key":"5816_CR56","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3390\/toxins13070495","volume":"13","author":"L Huang","year":"2021","unstructured":"Huang, L., Zhu, X., Zhou, S., Cheng, Z., Shi, K., Zhang, C., & Shao, H. (2021). Phthalic Acid Esters: Natural Sources and Biological Activities. Toxins, 13(7), 495. https:\/\/doi.org\/10.3390\/toxins13070495","journal-title":"Toxins"},{"issue":"3","key":"5816_CR57","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.bbalip.2013.09.001","volume":"1841","author":"WB Rizzo","year":"2014","unstructured":"Rizzo, W. B. (2014). Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1841(3), 377\u2013389. https:\/\/doi.org\/10.1016\/j.bbalip.2013.09.001","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"5816_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.610936","author":"A Krishnan","year":"2020","unstructured":"Krishnan, A., McNeil, B. A., & Stuart, D. T. (2020). Biosynthesis of fatty alcohols in engineered microbial cell factories: Advances and limitations. Frontiers in Bioengineering and Biotechnology. https:\/\/doi.org\/10.3389\/fbioe.2020.610936","journal-title":"Frontiers in Bioengineering and Biotechnology"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05816-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05816-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05816-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:56:05Z","timestamp":1783572965000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05816-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":58,"alternative-id":["5816"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05816-5","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"24 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve human participants or vertebrate animals. Therefore, ethical approval was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have read and approved the final manuscript and consent to its publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}