{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:47:10Z","timestamp":1792079230127,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s12010-026-05887-4","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:28:14Z","timestamp":1787552894000},"page":"9093-9117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical and Molecular Insights Into the Anti-PCOS Potential of Anchusa Strigosa: Targeting Hormones, Biochemical Markers, and WNT Genes"],"prefix":"10.1007","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-6853","authenticated-orcid":false,"given":"Wajid Mohammad","family":"Sheikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeena","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-1231","authenticated-orcid":false,"given":"Atif Khurshid","family":"Wani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Shafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishraq","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrani","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Showkeen Muzamil","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"5887_CR1","doi-asserted-by":"publisher","first-page":"177516","DOI":"10.1016\/j.ejphar.2025.177516","volume":"998","author":"SM Bashir","year":"2025","unstructured":"Bashir, S. M., Ali, S. I., Rather, M. A., Sheikh, W. M., Singh, H., Nabi, S. U., & Hassan, S. (2025). Evaluating spironolactone monotherapy against combined treatment with metformin in rat PCOS model. European Journal of Pharmacology, 998, 177516. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177516","journal-title":"European Journal of Pharmacology"},{"key":"5887_CR2","doi-asserted-by":"crossref","unstructured":"McLuskie, I., & Newth, A. (2017). New diagnosis of polycystic ovary syndrome. BMJ: British Medical Journal, 356 https:\/\/www.jstor.org\/stable\/26942533","DOI":"10.1136\/bmj.i6456"},{"issue":"8","key":"5887_CR3","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.steroids.2013.04.009","volume":"78","author":"A Dokras","year":"2013","unstructured":"Dokras, A. (2013). Cardiovascular disease risk in women with PCOS. Steroids, 78(8), 773\u2013776. https:\/\/doi.org\/10.1016\/j.steroids.2013.04.009","journal-title":"Steroids"},{"issue":"12","key":"5887_CR4","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3390\/metabo11120869","volume":"11","author":"W Chen","year":"2021","unstructured":"Chen, W., & Pang, Y. (2021). Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites. Metabolites, 11(12), 869. https:\/\/doi.org\/10.3390\/metabo11120869","journal-title":"Metabolites"},{"issue":"1","key":"5887_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1515\/bmc-2020-0005","volume":"11","author":"F Ashkar","year":"2019","unstructured":"Ashkar, F., Rezaei, S., Salahshoornezhad, S., Vahid, F., Gholamalizadeh, M., Dahka, S. M., & Doaei, S. (2019). The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. Biomolecular Concepts, 11(1), 57\u201375. https:\/\/doi.org\/10.1515\/bmc-2020-0005","journal-title":"Biomolecular Concepts"},{"issue":"2","key":"5887_CR6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.bpobgyn.2009.09.005","volume":"24","author":"E Diamanti-Kandarakis","year":"2010","unstructured":"Diamanti-Kandarakis, E. (2010). PCOS in adolescents. Best Practice & Research Clinical Obstetrics & Gynaecology, 24(2), 173\u2013183. https:\/\/doi.org\/10.1016\/j.bpobgyn.2009.09.005","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"issue":"5","key":"5887_CR7","doi-asserted-by":"publisher","first-page":"585","DOI":"10.4239\/wjd.v14.i5.585","volume":"14","author":"E Sayedali","year":"2023","unstructured":"Sayedali, E., Yalin, A. E., & Yalin, S. (2023). Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes. World Journal of Diabetes, 14(5), 585\u2013593. https:\/\/doi.org\/10.4239\/wjd.v14.i5.585","journal-title":"World Journal of Diabetes"},{"issue":"4","key":"5887_CR8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.mefs.2018.04.005","volume":"23","author":"Z Abasian","year":"2018","unstructured":"Abasian, Z., Rostamzadeh, A., Mohammadi, M., Hosseini, M., & Rafieian-kopaei, M. (2018). A review on role of medicinal plants in polycystic ovarian syndrome: Pathophysiology, neuroendocrine signaling, therapeutic status and future prospects. Middle East Fertility Society Journal, 23(4), 255\u2013262. https:\/\/doi.org\/10.1016\/j.mefs.2018.04.005","journal-title":"Middle East Fertility Society Journal"},{"key":"5887_CR9","doi-asserted-by":"publisher","unstructured":"Li, Y., Huang, F., Qian, X., Liu, C., Yao, Y., Wang, Z., & Guo, Q. (2025). Exploring the anti-aging potential of phytoestrogens: focus on molecular mechanisms and menopausal symptom modulation. Frontiers in Nutrition, 12. https:\/\/doi.org\/10.3389\/fnut.2025.1651367","DOI":"10.3389\/fnut.2025.1651367"},{"issue":"6","key":"5887_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1068-607X(00)00055-X","volume":"7","author":"D Carusi","year":"2000","unstructured":"Carusi, D. (2000). Phytoestrogens as hormone replacement therapy: an evidence-based approach. Primary Care Update for OB\/GYNS, 7(6), 253\u2013259. https:\/\/doi.org\/10.1016\/S1068-607X(00)00055-X","journal-title":"Primary Care Update for OB\/GYNS"},{"issue":"2","key":"5887_CR11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3390\/biom13020194","volume":"13","author":"AK Wani","year":"2023","unstructured":"Wani, A. K., Akhtar, N., Mir, T. G., Singh, R., Jha, P. K., Mallik, S. K., & Prakash, A. (2023). Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials. Biomolecules, 13(2), 194. https:\/\/doi.org\/10.3390\/biom13020194","journal-title":"Biomolecules"},{"key":"5887_CR12","doi-asserted-by":"publisher","first-page":"100136","DOI":"10.1016\/j.prmcm.2022.100136","volume":"4","author":"TG Mir","year":"2022","unstructured":"Mir, T. G., Wani, A. K., Singh, J., & Shukla, S. (2022). Therapeutic application and toxicity associated with Crocus sativus (saffron) and its phytochemicals. Pharmacological Research - Modern Chinese Medicine, 4, 100136. https:\/\/doi.org\/10.1016\/j.prmcm.2022.100136","journal-title":"Pharmacological Research - Modern Chinese Medicine"},{"issue":"1","key":"5887_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/biotech12010004","volume":"12","author":"JN Lakshmi","year":"2023","unstructured":"Lakshmi, J. N., Babu, A. N., Kiran, S. S. M., Nori, L. P., Hassan, N., Ashames, A., & Shaik, A. B. (2023). Herbs as a Source for the Treatment of Polycystic Ovarian Syndrome:A Systematic Review. BioTech, 12(1), 4. https:\/\/doi.org\/10.3390\/biotech12010004","journal-title":"BioTech"},{"key":"5887_CR14","doi-asserted-by":"publisher","first-page":"1301154","DOI":"10.3389\/fphar.2023.1301154","volume":"14","author":"Z Chebaro","year":"2023","unstructured":"Chebaro, Z., Badran, A., Maresca, M., Baydoun, E., & Mesmar, J. E. (2023). Ethnopharmacology and therapeutic potential of Anchusa strigosa: a comprehensive review. Frontiers in Pharmacology, 14, 1301154. https:\/\/doi.org\/10.3389\/fphar.2023.1301154","journal-title":"Frontiers in Pharmacology"},{"key":"5887_CR15","doi-asserted-by":"publisher","unstructured":"Chebaro, Z., Abdallah, R., Badran, A., Hamade, K., Hijazi, A., Maresca, M., & Baydoun, E. (2023). Study of the antioxidant and anti-pancreatic cancer activities of Anchusa strigosa aqueous extracts obtained by maceration and ultrasonic extraction techniques. Frontiers in Pharmacology, 14. https:\/\/doi.org\/10.3389\/fphar.2023.1201969","DOI":"10.3389\/fphar.2023.1201969"},{"issue":"23","key":"5887_CR16","doi-asserted-by":"publisher","first-page":"8239","DOI":"10.3390\/molecules27238239","volume":"27","author":"L Yarmolinsky","year":"2022","unstructured":"Yarmolinsky, L., Budovsky, A., Khalfin, B., Yarmolinsky, L., & Ben-Shabat, S. (2022). Medicinal Properties of Anchusa strigosa and Its Active Compounds. Molecules, 27(23), 8239. https:\/\/doi.org\/10.3390\/molecules27238239","journal-title":"Molecules"},{"key":"5887_CR17","doi-asserted-by":"publisher","first-page":"108051","DOI":"10.1016\/j.toxicon.2024.108051","volume":"249","author":"WM Sheikh","year":"2024","unstructured":"Sheikh, W. M., Jadhav, I., Shafi, M., Muzamil Bashir, S., Jan, J., Kalam, M. A., & Yousuf, S. (2024). Acute and sub-acute Toxicity Profiles of Anchusa strigosa and Zataria Multiflora: Insights from wistar albino rats. Toxicon, 249, 108051. https:\/\/doi.org\/10.1016\/j.toxicon.2024.108051","journal-title":"Toxicon"},{"issue":"37","key":"5887_CR18","doi-asserted-by":"publisher","first-page":"33067","DOI":"10.1021\/acsomega.2c03117","volume":"7","author":"PK Singh","year":"2022","unstructured":"Singh, P. K., Singh, J., Medhi, T., & Kumar, A. (2022). Phytochemical Screening, Quantification, FT-IR Analysis, and In Silico Characterization of Potential Bio-active Compounds Identified in HR-LC\/MS Analysis of the Polyherbal Formulation from Northeast India. ACS Omega, 7(37), 33067\u201333078. https:\/\/doi.org\/10.1021\/acsomega.2c03117","journal-title":"ACS Omega"},{"issue":"2","key":"5887_CR19","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.nimb.2008.10.021","volume":"267","author":"A Iordache","year":"2009","unstructured":"Iordache, A., Culea, M., Gherman, C., & Cozar, O. (2009). Characterization of some plant extracts by GC\u2013MS. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 267(2), 338\u2013342. https:\/\/doi.org\/10.1016\/j.nimb.2008.10.021","journal-title":"Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms"},{"issue":"2","key":"5887_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.arcmed.2003.10.005","volume":"35","author":"H Kafali","year":"2004","unstructured":"Kafali, H., Iriadam, M., Ozardal\u0131, I., & Demir, N. (2004). Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease. Archives of Medical Research, 35(2), 103\u2013108. https:\/\/doi.org\/10.1016\/j.arcmed.2003.10.005","journal-title":"Archives of Medical Research"},{"issue":"2","key":"5887_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.apjr.2016.01.006","volume":"5","author":"PS Reddy","year":"2016","unstructured":"Reddy, P. S., Begum, N., Mutha, S., & Bakshi, V. (2016). Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pacific Journal of Reproduction, 5(2), 116\u2013122. https:\/\/doi.org\/10.1016\/j.apjr.2016.01.006","journal-title":"Asian Pacific Journal of Reproduction"},{"issue":"2","key":"5887_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair, A. B., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27\u201331. https:\/\/doi.org\/10.4103\/0976-0105.177703","journal-title":"Journal of Basic and Clinical Pharmacy"},{"key":"5887_CR23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak, J., & Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Analytical biochemistry, 25, 192\u2013205.","journal-title":"Analytical biochemistry"},{"issue":"4","key":"5887_CR24","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.3390\/jcm12041454","volume":"12","author":"S Singh","year":"2023","unstructured":"Singh, S., Pal, N., Shubham, S., Sarma, D. K., Verma, V., Marotta, F., & Kumar, M. (2023). Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. Journal of Clinical Medicine, 12(4), 1454. https:\/\/doi.org\/10.3390\/jcm12041454","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"5887_CR25","doi-asserted-by":"publisher","first-page":"2357737","DOI":"10.1080\/07853890.2024.2357737","volume":"56","author":"NA Sta\u0144czak","year":"2024","unstructured":"Sta\u0144czak, N. A., Grywalska, E., & Dudzi\u0144ska, E. (2024). The latest reports and treatment methods on polycystic ovary syndrome. Annals of Medicine, 56(1), 2357737. https:\/\/doi.org\/10.1080\/07853890.2024.2357737","journal-title":"Annals of Medicine"},{"issue":"1","key":"5887_CR26","doi-asserted-by":"publisher","first-page":"525340","DOI":"10.1155\/2014\/525340","volume":"2014","author":"SY Pan","year":"2014","unstructured":"Pan, S. Y., Litscher, G., Gao, S. H., Zhou, S. F., Yu, Z. L., Chen, H. Q., & Ko, K. M. (2014). Historical Perspective of Traditional Indigenous Medical Practices:The Current Renaissance and Conservation of Herbal Resources. Evidence-Based Complementary and Alternative Medicine, 2014(1), 525340. https:\/\/doi.org\/10.1155\/2014\/525340","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"4","key":"5887_CR27","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3390\/biomedicines10040753","volume":"10","author":"J Gambini","year":"2022","unstructured":"Gambini, J., & Stromsnes, K. (2022). Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches. Biomedicines, 10(4), 753. https:\/\/doi.org\/10.3390\/biomedicines10040753","journal-title":"Biomedicines"},{"key":"5887_CR28","doi-asserted-by":"publisher","unstructured":"Katsoulis, D. E., Schmidt, R. G., & Zank, G. A. (2017). Chapter 7 - Siloxanes and Silicones (Advances in Silicone Technologies 2000\u201315). In V. Ya. Lee (Ed.), Organosilicon Compounds (pp. 301\u2013322). Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-814213-4.00007-1","DOI":"10.1016\/B978-0-12-814213-4.00007-1"},{"issue":"1","key":"5887_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40738-020-00074-3","volume":"6","author":"AF Ajayi","year":"2020","unstructured":"Ajayi, A. F., & Akhigbe, R. E. (2020). Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fertility Research and Practice, 6(1), 5. https:\/\/doi.org\/10.1186\/s40738-020-00074-3","journal-title":"Fertility Research and Practice"},{"key":"5887_CR30","doi-asserted-by":"publisher","first-page":"114860","DOI":"10.1016\/j.bbr.2024.114860","volume":"461","author":"GM Raimondi","year":"2024","unstructured":"Raimondi, G. M., Eng, A. K., Kenny, M. P., Britting, M. A., & Ostroff, L. E. (2024). Track-by-Day: A standardized approach to estrous cycle monitoring in biobehavioral research. Behavioural Brain Research, 461, 114860. https:\/\/doi.org\/10.1016\/j.bbr.2024.114860","journal-title":"Behavioural Brain Research"},{"issue":"1","key":"5887_CR31","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1038\/s41598-020-73669-x","volume":"10","author":"T Ohara","year":"2020","unstructured":"Ohara, T., Nakamura, T. J., Nakamura, W., & Tokuda, I. T. (2020). Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity. Scientific Reports, 10(1), 16767. https:\/\/doi.org\/10.1038\/s41598-020-73669-x","journal-title":"Scientific Reports"},{"issue":"1","key":"5887_CR32","doi-asserted-by":"publisher","first-page":"11247","DOI":"10.1038\/s41598-018-29423-5","volume":"8","author":"S Li","year":"2018","unstructured":"Li, S., Herrera, G. G., Tam, K. K., Lizarraga, J. S., Beedle, M. T., & Winuthayanon, W. (2018). Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity. Scientific Reports, 8(1), 11247. https:\/\/doi.org\/10.1038\/s41598-018-29423-5","journal-title":"Scientific Reports"},{"key":"5887_CR33","doi-asserted-by":"publisher","first-page":"e923073","DOI":"10.12659\/MSM.923073","volume":"26","author":"J Xu","year":"2020","unstructured":"Xu, J., Dun, J., Yang, J., Zhang, J., Lin, Q., Huang, M., & Lin, Y. (2020). Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e923073\u2013e923071. https:\/\/doi.org\/10.12659\/MSM.923073","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"5887_CR34","unstructured":"Review (2025). Role of metformin in the management of polycystic ovary syndrome - Hany Lashen, 2010. (n.d.). Retrieved August 20, from https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/2042018810380215"},{"key":"5887_CR35","doi-asserted-by":"publisher","unstructured":"Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies -, Thomas, M., Barber, P., Hanson, M. O., & Weickert (2019). Stephen Franks, (n.d.). Retrieved August 20, 2025, from https:\/\/journals.sagepub.com\/doi\/full\/https:\/\/doi.org\/10.1177\/1179558119874042","DOI":"10.1177\/1179558119874042"},{"issue":"7","key":"5887_CR36","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.numecd.2008.05.004","volume":"18","author":"A Galluzzo","year":"2008","unstructured":"Galluzzo, A., Amato, M. C., & Giordano, C. (2008). Insulin resistance and polycystic ovary syndrome. Nutrition Metabolism and Cardiovascular Diseases, 18(7), 511\u2013518. https:\/\/doi.org\/10.1016\/j.numecd.2008.05.004","journal-title":"Nutrition Metabolism and Cardiovascular Diseases"},{"key":"5887_CR37","doi-asserted-by":"publisher","first-page":"121672","DOI":"10.1016\/j.lfs.2023.121672","volume":"322","author":"G Sudhakaran","year":"2023","unstructured":"Sudhakaran, G., Babu, S. R., Mahendra, H., & Arockiaraj, J. (2023). Updated experimental cellular models to study polycystic ovarian syndrome. Life Sciences, 322, 121672. https:\/\/doi.org\/10.1016\/j.lfs.2023.121672","journal-title":"Life Sciences"},{"issue":"8","key":"5887_CR38","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41574-023-00833-4","volume":"19","author":"M Foretz","year":"2023","unstructured":"Foretz, M., Guigas, B., & Viollet, B. (2023). Metformin: update on mechanisms of action and repurposing potential. Nature Reviews Endocrinology, 19(8), 460\u2013476. https:\/\/doi.org\/10.1038\/s41574-023-00833-4","journal-title":"Nature Reviews Endocrinology"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05887-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05887-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05887-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:15:55Z","timestamp":1792077355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05887-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["5887"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05887-4","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"19 August 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Institutional Animal Ethics Committee (IAEC) of Faculty of Veterinary Sciences & Animal Husbandry, SKUAST-Kashmir approved the investigation (Reg. No-1809\/GO\/ReBi-S\/Re-L\/15\/CPCSEA and No. FVSc\/VCC-9\/19\/286\u2009\u2212\u200987 dated:02-05-2019) under the Committee for Control and Supervision of Experiments on Animals (CCSEA).","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":3,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":4,"name":"Ethics","label":"<b>Consent for Publication<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}]}}