{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:04:57Z","timestamp":1789628697335,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"DOI":"10.1007\/s12010-026-05924-2","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:33:35Z","timestamp":1789626815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RBM15 Contributes to Bladder Carcinoma Progression via m6A-dependent Stabilization of IFI6 mRNA"],"prefix":"10.1007","author":[{"given":"Hanchao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"1","key":"5924_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","volume":"9","author":"L Dyrskj\u00f8t","year":"2023","unstructured":"Dyrskj\u00f8t, L., et al. (2023). Bladder cancer. Nat Rev Dis Primers, 9(1), 58.","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"5924_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/01.NURSE.0001007608.96581.fa","volume":"54","author":"RL Pullen Jr","year":"2024","unstructured":"Pullen, R. L., Jr. (2024). Bladder cancer: An update. Nursing, 54(4), 27\u201339.","journal-title":"Nursing"},{"issue":"4","key":"5924_CR3","doi-asserted-by":"publisher","first-page":"216","DOI":"10.6004\/jnccn.2024.0024","volume":"22","author":"TW Flaig","year":"2024","unstructured":"Flaig, T. W., et al. (2024). NCCN Guidelines\u00ae Insights: Bladder Cancer, Version 3.2024. Journal Of The National Comprehensive Cancer Network, 22(4), 216\u2013225.","journal-title":"Journal Of The National Comprehensive Cancer Network"},{"issue":"1","key":"5924_CR4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13046-020-01646-3","volume":"39","author":"Z Liu","year":"2020","unstructured":"Liu, Z., et al. (2020). IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress. Journal Of Experimental & Clinical Cancer Research : Cr, 39(1), 144.","journal-title":"Journal Of Experimental & Clinical Cancer Research : Cr"},{"issue":"4","key":"5924_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcac035","volume":"4","author":"R Dutta","year":"2022","unstructured":"Dutta, R., et al. (2022). UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress. NAR Cancer, 4(4), Article zcac035.","journal-title":"NAR Cancer"},{"issue":"2","key":"5924_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009283","volume":"17","author":"L Xu","year":"2021","unstructured":"Xu, L., et al. (2021). ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. PLoS Genetics, 17(2), Article e1009283.","journal-title":"PLoS Genetics"},{"issue":"8","key":"5924_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00262-004-0645-2","volume":"54","author":"E Tahara Jr","year":"2005","unstructured":"Tahara, E., Jr., et al. (2005). G1P3, an interferon inducible gene 6\u201316, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. Cancer Immunology, Immunotherapy, 54(8), 729\u201340.","journal-title":"Cancer Immunology, Immunotherapy"},{"issue":"1","key":"5924_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang, X., et al. (2021). The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther, 6(1), 74.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"5924_CR9","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1042\/BST20230574","volume":"52","author":"G Wei","year":"2024","unstructured":"Wei, G. (2024). RNA m6A modification, signals for degradation or stabilisation? Biochemical Society Transactions, 52(2), 707\u2013717.","journal-title":"Biochemical Society Transactions"},{"issue":"44","key":"5924_CR10","doi-asserted-by":"publisher","first-page":"36935","DOI":"10.1074\/jbc.M501725200","volume":"280","author":"E Hiriart","year":"2005","unstructured":"Hiriart, E., et al. (2005). Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. Journal of Biological Chemistry, 280(44), 36935\u201345.","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"5924_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41388-024-03220-z","volume":"44","author":"H Li","year":"2025","unstructured":"Li, H., et al. (2025). RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1. Oncogene, 44(5), 307\u2013321.","journal-title":"Oncogene"},{"issue":"2","key":"5924_CR12","doi-asserted-by":"publisher","first-page":"159580","DOI":"10.1016\/j.bbalip.2024.159580","volume":"1870","author":"X Cai","year":"2025","unstructured":"Cai, X., et al. (2025). RBM15 promotes lipogenesis and malignancy in gastric cancer by regulating N6-Methyladenosine modification of ACLY mRNA in an IGF2BP2-dependent manner. Biochim Biophys Acta Mol Cell Biol Lipids, 1870(2), 159580.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"2","key":"5924_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.clbc.2024.09.006","volume":"25","author":"H Wang","year":"2025","unstructured":"Wang, H., et al. (2025). RBM15 Drives Breast Cancer Cell Progression and Immune Escape via m6A-Dependent Stabilization of KPNA2 mRNA. Clinical Breast Cancer, 25(2), 96\u2013107.","journal-title":"Clinical Breast Cancer"},{"issue":"24","key":"5924_CR14","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.21037\/atm-22-5993","volume":"10","author":"J Wu","year":"2022","unstructured":"Wu, J., et al. (2022). Bioinformatics analysis of the correlation between m6A RNA methylation regulators and the immune infiltration and prognosis of bladder cancer. Ann Transl Med, 10(24), 1386.","journal-title":"Ann Transl Med"},{"key":"5924_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217002","volume":"595","author":"C Shen","year":"2024","unstructured":"Shen, C., et al. (2024). N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination. Cancer Letters, 595, Article 217002.","journal-title":"Cancer Letters"},{"key":"5924_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080749","author":"J Dobruch","year":"2021","unstructured":"Dobruch, J., & Oszczud\u0142owski, M. (2021). Bladder cancer: Current challenges and future directions. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina57080749","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"5924_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1248\/bpb.b22-00439","volume":"46","author":"C Huang","year":"2023","unstructured":"Huang, C., et al. (2023). IFI6 downregulation reverses oxaliplatin resistance of colorectal cancer cells by activating the ROS-induced p38MAPK signaling pathway. Biological & Pharmaceutical Bulletin, 46(1), 26\u201334.","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"5924_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.677697","volume":"9","author":"H Zhao","year":"2021","unstructured":"Zhao, H., et al. (2021). Single-cell RNA-sequencing portraying functional diversity and clinical implications of IFI6 in ovarian cancer. Frontiers in Cell and Developmental Biology, 9, Article 677697.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"5924_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052691","author":"NK Viet-Nhi","year":"2024","unstructured":"Viet-Nhi, N. K., et al. (2024). Multi-omics analysis reveals the IFI6 gene as a prognostic indicator and therapeutic target in esophageal cancer. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms25052691","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"5924_CR20","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00262-022-03288-0","volume":"72","author":"J Liu","year":"2023","unstructured":"Liu, J., et al. (2023). PLEK2 and IFI6, representing mesenchymal and immune-suppressive microenvironment, predicts resistance to neoadjuvant immunotherapy in esophageal squamous cell carcinoma. Cancer Immunology, Immunotherapy, 72(4), 881\u2013893.","journal-title":"Cancer Immunology, Immunotherapy"},{"key":"5924_CR21","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2023.3.04","author":"Y Gao","year":"2023","unstructured":"Gao, Y., et al. (2023). Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells. Journal of Physiology and Pharmacology. https:\/\/doi.org\/10.26402\/jpp.2023.3.04","journal-title":"Journal of Physiology and Pharmacology"},{"key":"5924_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123146","volume":"358","author":"S Shi","year":"2024","unstructured":"Shi, S., et al. (2024). RBM15 drives the progression of lung adenocarcinoma by regulating N6-methyladenosine-mediated LDHA mRNA stability. Life Sciences, 358, Article 123146.","journal-title":"Life Sciences"},{"key":"5924_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05149-z","author":"Z Huang","year":"2024","unstructured":"Huang, Z., Chen, P., & Liu, Y. (2024). RBM15-mediated the m6A modification of MAT2A promotes osteosarcoma cell proliferation, metastasis and suppresses ferroptosis. Molecular and Cellular Biochemistry. https:\/\/doi.org\/10.1007\/s11010-024-05149-z","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"7","key":"5924_CR24","doi-asserted-by":"publisher","first-page":"e28165","DOI":"10.1016\/j.heliyon.2024.e28165","volume":"10","author":"Y Huang","year":"2024","unstructured":"Huang, Y., et al. (2024). Enhancing m(6)A modification of lncRNA through METTL3 and RBM15 to promote malignant progression in bladder cancer. Heliyon, 10(7), e28165.","journal-title":"Heliyon"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05924-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05924-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05924-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:33:36Z","timestamp":1789626816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05924-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":24,"alternative-id":["5924"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05924-2","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"7 September 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was carried out in strict accordance with the relevant regulations and requirements of the Declaration of Helsinki. Written informed consents were obtained from all participants and this study was permitted by the Ethics Committee of the Affiliated Hospital of Zunyi Medical University.All animal procedures were approved by the Affiliated Hospital of Zunyi Medical University and were conducted in accordance with the [National\/International Animal Welfare Guidelines, e.g., ARRIVE 2.0]. Animals received humane care throughout the study, and efforts were made to minimize suffering.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}