{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:03:03Z","timestamp":1789786983842,"version":"4.0.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Kastamonu University Scientific Research Projects Coordination Unit","award":["K\u00dcBAP-01\/2023-25"],"award-info":[{"award-number":["K\u00dcBAP-01\/2023-25"]}],"id":[{"id":"https:\/\/ror.org\/015scty35","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"DOI":"10.1007\/s12010-026-05937-x","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:37:41Z","timestamp":1789785461000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiproliferative Effects of Reynoutrin via Modulation of Oxidative Stress, Inflammation, and Apoptosis in Breast Cancer (MCF-7) and Prostate Cancer (PC-3) Cell Lines"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-3030","authenticated-orcid":false,"given":"Sedat","family":"G\u00f6kmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-2556","authenticated-orcid":false,"given":"\u0130rfan","family":"\u00c7inar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"5937_CR1","unstructured":"International Agency for Research on Cancer (2022). Estimated age-standardized incidence and mortality rates (World) in 2020, worldwide, both sexes, all ages. IARC. https:\/\/gco.iarc.fr\/. Accessed 2 April 2023."},{"key":"5937_CR2","doi-asserted-by":"crossref","unstructured":"Valentovic, M. A. (2018). Evaluation of Resveratrol in Cancer Patients and Experimental Models. In K. D. Tew & P. B. Fisher (Eds.), Advances in Cancer Research (Vol. vol 137, p. pp 171-188). Academic Press.","DOI":"10.1016\/bs.acr.2017.11.006"},{"issue":"1","key":"5937_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67643-w","volume":"10","author":"E Amjad","year":"2020","unstructured":"Amjad, E., Asnaashari, S., Sokouti, B., & Dastmalchi, S. (2020). Systems biology comprehensive analysis on breast cancer for identification of key gene modules and genes associated with TNM-based clinical stages. Scientific Reports, 10(1), Article 10816. https:\/\/doi.org\/10.1038\/s41598-020-67643-w","journal-title":"Scientific Reports"},{"issue":"9","key":"5937_CR4","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/ijms21093233","volume":"21","author":"K Bukowski","year":"2020","unstructured":"Bukowski, K., Kciuk, M., & Kontek, R. (2020). Mechanisms of Multidrug Resistance in Cancer Chemotherapy. International Journal Of Molecular Sciences, 21(9), 3233. https:\/\/doi.org\/10.3390\/ijms21093233","journal-title":"International Journal Of Molecular Sciences"},{"issue":"1","key":"5937_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s40199-019-00251-w","volume":"27","author":"Z Moradi","year":"2019","unstructured":"Moradi, Z., Mohammadian, M., Saberi, H., Ebrahimifar, M., Mohammadi, Z., Ebrahimpour, M., & Behrouzkia, Z. (2019). Anti-cancer effects of chemotherapeutic agent; 17-AAG, in combined with gold nanoparticles and irradiation in human colorectal cancer cells. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 27(1), 111\u2013119. https:\/\/doi.org\/10.1007\/s40199-019-00251-w","journal-title":"Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences"},{"issue":"4","key":"5937_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10585-018-9903-0","volume":"35","author":"M Nikolaou","year":"2018","unstructured":"Nikolaou, M., Pavlopoulou, A., Georgakilas, A. G., & Kyrodimos, E. (2018). The challenge of drug resistance in cancer treatment: A current overview. Clinical & Experimental Metastasis, 35(4), 309\u2013318. https:\/\/doi.org\/10.1007\/s10585-018-9903-0","journal-title":"Clinical & Experimental Metastasis"},{"issue":"2","key":"5937_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3892\/ijo.2018.4661","volume":"54","author":"V Schirrmacher","year":"2019","unstructured":"Schirrmacher, V. (2019). From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). International Journal Of Oncology, 54(2), 407\u2013419. https:\/\/doi.org\/10.3892\/ijo.2018.4661","journal-title":"International Journal Of Oncology"},{"key":"5937_CR8","doi-asserted-by":"publisher","first-page":"107099","DOI":"10.1016\/j.phrs.2024.107099","volume":"202","author":"T Chen","year":"2024","unstructured":"Chen, T., Xiao, Z., Liu, X., Wang, T., Wang, Y., Ye, F., Su, J., Yao, X., Xiong, L., & Yang, D. H. (2024). Natural products for combating multidrug resistance in cancer. Pharmacological Research, 202, 107099. https:\/\/doi.org\/10.1016\/j.phrs.2024.107099","journal-title":"Pharmacological Research"},{"key":"5937_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01253","volume":"9","author":"QY Zhang","year":"2018","unstructured":"Zhang, Q. Y., Wang, F. X., Jia, K. K., & Kong, L. D. (2018). Natural product interventions for chemotherapy and radiotherapy-induced side effects. Frontiers in Pharmacology, 9, Article 1253. https:\/\/doi.org\/10.3389\/fphar.2018.01253","journal-title":"Frontiers in Pharmacology"},{"key":"5937_CR10","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.toxrep.2023.02.008","volume":"10","author":"N Poormolaie","year":"2023","unstructured":"Poormolaie, N., Mohammadi, M., Mir, A., Asadi, M., Kararoudi, A. N., Vahedian, V., Rashidi, M., & Maroufi, N. F. (2023). Xanthomicrol: Effective therapy for cancer treatment. Toxicol Rep, 10, 436\u2013440. https:\/\/doi.org\/10.1016\/j.toxrep.2023.02.008","journal-title":"Toxicol Rep"},{"issue":"2","key":"5937_CR11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.2174\/187152511796196498","volume":"9","author":"N Clere","year":"2011","unstructured":"Clere, N., Faure, S., Martinez, M. C., & Andriantsitohaina, R. (2011). Anticancer properties of flavonoids: Roles in various stages of carcinogenesis. Cardiovascular & Hematological Agents in Medicinal Chemistry, 9(2), 62\u201377. https:\/\/doi.org\/10.2174\/187152511796196498","journal-title":"Cardiovascular & Hematological Agents in Medicinal Chemistry"},{"issue":"3","key":"5937_CR12","first-page":"287","volume":"22","author":"J Gonz\u00e1lez-Gallego","year":"2007","unstructured":"Gonz\u00e1lez-Gallego, J., S\u00e1nchez-Campos, S., & Tu\u00f1\u00f3n, M. J. (2007). Anti-inflammatory properties of dietary flavonoids. Nutricion Hospitalaria, 22(3), 287\u2013293.","journal-title":"Nutricion Hospitalaria"},{"issue":"12","key":"5937_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300727","volume":"68","author":"H Li","year":"2024","unstructured":"Li, H., Zeng, Y., Zi, J., Hu, Y., Ma, G., Wang, X., Shan, S., Cheng, G., & Xiong, J. (2024). Dietary flavonoids consumption and health: An umbrella review. Molecular Nutrition & Food Research, 68(12), Article e2300727. https:\/\/doi.org\/10.1002\/mnfr.202300727","journal-title":"Molecular Nutrition & Food Research"},{"issue":"14","key":"5937_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/foods13142253","volume":"13","author":"Y Pyo","year":"2024","unstructured":"Pyo, Y., Kwon, K. H., & Jung, Y. J. (2024). Anticancer potential of flavonoids: Their role in cancer prevention and health benefits. Foods, 13(14), Article 2253. https:\/\/doi.org\/10.3390\/foods13142253","journal-title":"Foods"},{"key":"5937_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111489","volume":"413","author":"K Jomova","year":"2025","unstructured":"Jomova, K., Alomar, S. Y., Valko, R., Liska, J., Nepovimova, E., Kuca, K., & Valko, M. (2025). Flavonoids and their role in oxidative stress, inflammation, and human diseases. Chemico-Biological Interactions, 413, Article 111489. https:\/\/doi.org\/10.1016\/j.cbi.2025.111489","journal-title":"Chemico-Biological Interactions"},{"key":"5937_CR16","doi-asserted-by":"publisher","first-page":"151739","DOI":"10.1016\/j.ijbiomac.2026","volume":"358","author":"M Lakshmikanthan","year":"2026","unstructured":"Lakshmikanthan, M., Abdulla, M., Krishnan, K., Moovendhan, M., & Muthu, S. (2026). Anthocyanin-loaded chitosan-alginate nanoparticles from red dragon fruit pulp for targeted therapy against HCT116 colon cancer cells. International Journal Of Biological Macromolecules, 358, 151739. https:\/\/doi.org\/10.1016\/j.ijbiomac.2026","journal-title":"International Journal Of Biological Macromolecules"},{"issue":"7","key":"5937_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26072029","volume":"26","author":"LGS Ponte","year":"2021","unstructured":"Ponte, L. G. S., Pavan, I. C. B., Mancini, M. C. S., da Silva, L. G. S., Morelli, A. P., Severino, M. B., Bezerra, R. M. N., & Simabuco, F. M. (2021). The hallmarks of flavonoids in cancer. Molecules, 26(7), Article 2029. https:\/\/doi.org\/10.3390\/molecules26072029","journal-title":"Molecules"},{"issue":"2","key":"5937_CR18","doi-asserted-by":"publisher","first-page":"569","DOI":"10.30621\/jbachs.1056769","volume":"6","author":"TN Y\u00fcksel","year":"2022","unstructured":"Y\u00fcksel, T. N., Bozgeyik, E., & Yayla, M. (2022). The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration. JBACHS, 6(2), 569\u2013578. https:\/\/doi.org\/10.30621\/jbachs.1056769","journal-title":"JBACHS"},{"issue":"3","key":"5937_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1080\/14786419.2011.585610","volume":"26","author":"R Ho","year":"2012","unstructured":"Ho, R., Violette, A., Cressend, D., Raharivelomanana, P., Carrupt, P. A., & Hostettmann, K. (2012). Antioxidant potential and radical-scavenging effects of flavonoids from the leaves of Psidium cattleianum grown in French Polynesia. Natural Product Research, 26(3), 274\u20137. https:\/\/doi.org\/10.1080\/14786419.2011.585610","journal-title":"Natural Product Research"},{"key":"5937_CR20","doi-asserted-by":"publisher","unstructured":"Eldin Elhawary, S. S., Elmotyam, A. K. E., Alsayed, D. K., Zahran, E. M., Fouad, M. A., Sleem, A. A., Elimam, H., Rashed, M. H., Hayallah, A. M., Mohammed, A. F., & Abdelmohsen, U. R. (2020). Cytotoxic and anti-diabetic potential, metabolic profiling and insilico studies of Syzygium cumini (L.) Skeels belonging to family Myrtaceae. Nat Prod Res. 2022 36(4):1026\u20131030. https:\/\/doi.org\/10.1080\/14786419.2020.1843032","DOI":"10.1080\/14786419.2020.1843032"},{"key":"5937_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.703962","volume":"12","author":"W Yang","year":"2021","unstructured":"Yang, W., Tu, H., Tang, K., Huang, H., Ou, S., & Wu, J. (2021). Reynoutrin improves ischemic heart failure in rats via targeting S100A1. Frontiers in Pharmacology, 12, Article 703962. https:\/\/doi.org\/10.3389\/fphar.2021.703962","journal-title":"Frontiers in Pharmacology"},{"key":"5937_CR22","doi-asserted-by":"publisher","first-page":"100236","DOI":"10.1016\/j.fhfh.2025.100236","volume":"8","author":"M Lakshmikanthan","year":"2025","unstructured":"Lakshmikanthan, M., Muthu, S., Mohamed, P. M. D., Krishnan, K., Karuppiah, N., Karuppan, R., Ramalingam, S., Subramanian, A., Venkatachalam, B., & Abdi, G. (2025). Structural characterization and bioactivity of sulfated Galactan GSSG-2 from Gracilaria salicornia: Antioxidant and anticancer potential. Food Hydrocoll Health, 8, 100236. https:\/\/doi.org\/10.1016\/j.fhfh.2025.100236","journal-title":"Food Hydrocoll Health"},{"issue":"2","key":"5937_CR23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/nu12020457","volume":"12","author":"DM Kopustinskiene","year":"2020","unstructured":"Kopustinskiene, D. M., Jakstas, V., Savickas, A., & Bernatoniene, J. (2020). Flavonoids as Anticancer Agents. Nutrients, 12(2), 457. https:\/\/doi.org\/10.3390\/nu12020457","journal-title":"Nutrients"},{"issue":"5","key":"5937_CR24","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/jcb.25729","volume":"118","author":"W Lim","year":"2017","unstructured":"Lim, W., Park, S., Bazer, F. W., & Song, G. (2017). Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K\/AKT and MAPK Signaling Pathways. Journal Of Cellular Biochemistry, 118(5), 1118\u20131131. https:\/\/doi.org\/10.1002\/jcb.25729","journal-title":"Journal Of Cellular Biochemistry"},{"key":"5937_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02160","volume":"9","author":"SC Gupta","year":"2018","unstructured":"Gupta, S. C., Kunnumakkara, A. B., Aggarwal, S., & Aggarwal, B. B. (2018). Inflammation, a double-edge sword for cancer and other age-related diseases. Frontiers in Immunology, 9, Article 2160. https:\/\/doi.org\/10.3389\/fimmu.2018.02160","journal-title":"Frontiers in Immunology"},{"key":"5937_CR26","doi-asserted-by":"publisher","first-page":"100209","DOI":"10.1016\/j.fhfh.2025.100209","volume":"7","author":"S Muthu","year":"2025","unstructured":"Muthu, S., Altemimi, A. B., Lakshmikanthan, M., Krishnan, K., Alkaisy, Q. H., Awlqadr, F. H., & Hesarinejad, M. A. (2025). Phycocolloids from Sargassum microcystum: Immunomodulatory and antioxidant activities of alginic acid and fucoidan. Food Hydrocoll Health, 7, 100209. https:\/\/doi.org\/10.1016\/j.fhfh.2025.100209","journal-title":"Food Hydrocoll Health"},{"key":"5937_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110278","volume":"128","author":"S Chukiatsiri","year":"2020","unstructured":"Chukiatsiri, S., Siriwong, S., & Thumanu, K. (2020). Pupae protein extracts exert anticancer effects by downregulating the expression of IL-6, IL-1\u03b2 and TNF-\u03b1 through biomolecular changes in human breast cancer cells. Biomedicine & Pharmacotherapy, 128, Article 110278. https:\/\/doi.org\/10.1016\/j.biopha.2020.110278","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"5937_CR28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.lfs.2004.10.072","volume":"77","author":"O Golovko","year":"2005","unstructured":"Golovko, O., Nazarova, N., & Tuohimaa, P. (2005). Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. Life Sciences, 77(5), 562\u2013577. https:\/\/doi.org\/10.1016\/j.lfs.2004.10.072","journal-title":"Life Sciences"},{"issue":"12","key":"5937_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124449","volume":"21","author":"TO Adekoya","year":"2020","unstructured":"Adekoya, T. O., & Richardson, R. M. (2020). Cytokines and chemokines as mediators of prostate cancer metastasis. International Journal of Molecular Sciences, 21(12), Article 4449. https:\/\/doi.org\/10.3390\/ijms21124449","journal-title":"International Journal of Molecular Sciences"},{"issue":"12","key":"5937_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60122110","volume":"60","author":"A Aslan","year":"2024","unstructured":"Aslan, A., & Se\u00e7me, M. (2024). Effects of Pelargonium sidoides extract on apoptosis and oxidative stress in human neuroblastoma cells. Medicina (Kaunas), 60(12), Article 2110. https:\/\/doi.org\/10.3390\/medicina60122110","journal-title":"Medicina (Kaunas)"},{"issue":"6","key":"5937_CR31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/j.1476-4431.2008.00363.x","volume":"18","author":"MA O'Brien","year":"2008","unstructured":"O\u2019Brien, M. A., & Kirby, R. (2008). Apoptosis: A review of pro-apoptotic and anti\u2010apoptotic pathways and dysregulation in disease. Journal of Veterinary Emergency and Critical Care, 18(6), 572\u2013585. https:\/\/doi.org\/10.1111\/j.1476-4431.2008.00363.x","journal-title":"Journal of Veterinary Emergency and Critical Care"},{"issue":"10","key":"5937_CR32","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","volume":"60","author":"G Sahoo","year":"2023","unstructured":"Sahoo, G., Samal, D., Khandayataray, P., & Murthy, M. K. (2023). A Review on Caspases: Key Regulators of Biological Activities and Apoptosis. Molecular Neurobiology, 60(10), 5805\u20135837. https:\/\/doi.org\/10.1007\/s12035-023-03433-5","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"5937_CR33","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3390\/ijms24021680","volume":"24","author":"A Chimento","year":"2023","unstructured":"Chimento, A., De Luca, A., D\u2019Amico, M., De Amicis, F., & Pezzi, V. (2023). The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy. International Journal Of Molecular Sciences, 24(2), 1680. https:\/\/doi.org\/10.3390\/ijms24021680","journal-title":"International Journal Of Molecular Sciences"},{"issue":"6","key":"5937_CR34","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s10534-017-0060-8","volume":"30","author":"Y T\u00fcl\u00fcce","year":"2017","unstructured":"T\u00fcl\u00fcce, Y., Lak, P. T. A., Koyuncu, \u0130, K\u0131l\u0131\u00e7, A., Durgun, M., & \u00d6zkol, H. (2017). The apoptotic, cytotoxic and genotoxic effect of novel binuclear boron-fluoride complex on endometrial cancer. Biometals, 30(6), 933\u2013944. https:\/\/doi.org\/10.1007\/s10534-017-0060-8","journal-title":"Biometals"},{"issue":"1","key":"5937_CR35","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s11033-024-09453-1","volume":"51","author":"\u0130 \u00c7\u0131nar","year":"2024","unstructured":"\u00c7\u0131nar, \u0130., G\u0131d\u0131k, B., & Dirican, E. (2024). Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells. Molecular Biology Reports, 51(1), 491. https:\/\/doi.org\/10.1007\/s11033-024-09453-1","journal-title":"Molecular Biology Reports"},{"issue":"6","key":"5937_CR36","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00449-024-03023-2","volume":"47","author":"K Marathe","year":"2024","unstructured":"Marathe, K., Naik, J., & Maheshwari, V. (2024). Synthesis, characterisation and in vitro anticancer activity of conjugated protease inhibitor-silver nanoparticles (AgNPs-PI) against human breast MCF-7 and prostate PC-3 cancer cell lines. Bioprocess and Biosystems Engineering, 47(6), 931\u2013942. https:\/\/doi.org\/10.1007\/s00449-024-03023-2","journal-title":"Bioprocess and Biosystems Engineering"},{"key":"5937_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177536","volume":"998","author":"X Wang","year":"2025","unstructured":"Wang, X., Gong, M., Zhu, Z., Zhang, B., Han, L., Li, W., Wu, Z., Ma, Q., Wang, Z., & Qian, W. (2025). Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia. European Journal of Pharmacology, 998, Article 177536. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177536","journal-title":"European Journal of Pharmacology"},{"issue":"9","key":"5937_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ph16091229","volume":"16","author":"FCF de Luna","year":"2023","unstructured":"de Luna, F. C. F., Ferreira, W. A. S., Casseb, S. M. M., & de Oliveira, E. H. C. (2023). Anticancer potential of flavonoids: An overview with an emphasis on tangeretin. Pharmaceuticals (Basel), 16(9), Article 1229. https:\/\/doi.org\/10.3390\/ph16091229","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"5937_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/annonc\/mdp499","volume":"21","author":"S Jin","year":"2010","unstructured":"Jin, S., Zhang, Q. Y., Kang, X. M., Wang, J. X., & Zhao, W. H. (2010). Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Annals Of Oncology, 21(2), 263\u2013268. https:\/\/doi.org\/10.1093\/annonc\/mdp499","journal-title":"Annals Of Oncology"},{"issue":"8","key":"5937_CR40","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/jcp.24818","volume":"230","author":"S Palit","year":"2015","unstructured":"Palit, S., Kar, S., Sharma, G., & Das, P. K. (2015). Hesperetin induces apoptosis in breast carcinoma by triggering accumulation of ROS and activation of ASK1\/JNK pathway. Journal of Cellular Physiology, 230(8), 1729\u201339. https:\/\/doi.org\/10.1002\/jcp.24818","journal-title":"Journal of Cellular Physiology"},{"issue":"2","key":"5937_CR41","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.taap.2007.09.013","volume":"226","author":"WJ Lee","year":"2008","unstructured":"Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L., & Tseng, T. H. (2008). Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K\/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol, 226(2), 178\u2013191. https:\/\/doi.org\/10.1016\/j.taap.2007.09.013","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"5937_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040858","volume":"11","author":"A Ghi\u021bu","year":"2019","unstructured":"Ghi\u021bu, A., Schwiebs, A., Radeke, H. H., Avram, S., Zupko, I., Bor, A., Pavel, I. Z., Dehelean, C. A., Oprean, C., Bojin, F., Farcas, C., Soica, C., Duicu, O., & Danciu, C. (2019). A comprehensive assessment of apigenin as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. Nutrients, 11(4), Article 858. https:\/\/doi.org\/10.3390\/nu11040858","journal-title":"Nutrients"},{"issue":"1","key":"5937_CR43","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/pharmaceutics14010116","volume":"14","author":"RP do Nascimento","year":"2022","unstructured":"do Nascimento, R. P., Dos Santos, B. L., Amparo, J. A. O., Soares, J. R. P., da Silva, K. C., Santana, M. R., Almeida, \u00c1. M. A. N., da Silva, V. D. A., Costa, M. F. D., Ulrich, H., Moura-Neto, V., Lopes, G. P. F., & Costa, S. L. (2022). Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma. Pharmaceutics, 14(1), 116. https:\/\/doi.org\/10.3390\/pharmaceutics14010116","journal-title":"Pharmaceutics"},{"issue":"78","key":"5937_CR44","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4103\/pm.pm_284_21","volume":"18","author":"Q Yao","year":"2022","unstructured":"Yao, Q., Luo, Y., Sun, L., Wang, H., & Li, W. (2022). Luteolin suppressed growth of colon tumor via inflammation, oxidative stress, and NLRP3\/IL-1\u03b2 signal axis. Pharmacognosy Magazine, 18(78), 494\u2013501. https:\/\/doi.org\/10.4103\/pm.pm_284_21","journal-title":"Pharmacognosy Magazine"},{"issue":"3","key":"5937_CR45","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1007\/s10753-016-0311-9","volume":"39","author":"H Ren","year":"2016","unstructured":"Ren, H., Hao, J., Liu, T., Zhang, D., Lv, H., Song, E., & Zhu, C. (2016). Hesperetin Suppresses Inflammatory Responses in Lipopolysaccharide-Induced RAW 264.7 Cells via the Inhibition of NF-\u03baB and Activation of Nrf2\/HO-1 Pathways. Inflammation, 39(3), 964\u2013973. https:\/\/doi.org\/10.1007\/s10753-016-0311-9","journal-title":"Inflammation"},{"issue":"1","key":"5937_CR46","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/cbdd.14152","volume":"101","author":"B Song","year":"2023","unstructured":"Song, B., Shen, X., Tong, C., Zhang, S., Chen, Q., Li, Y., & Li, S. (2023). Gossypin: A flavonoid with diverse pharmacological effects. Chemical Biology & Drug Design, 101(1), 131\u2013137. https:\/\/doi.org\/10.1111\/cbdd.14152","journal-title":"Chemical Biology & Drug Design"},{"issue":"5","key":"5937_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052159","volume":"28","author":"B Horta","year":"2023","unstructured":"Horta, B., Freitas-Silva, J., Silva, J., Dias, F., Teixeira, A. L., Medeiros, R., Cidade, H., Pinto, M., & Cerqueira, F. (2023). Antitumor effect of chalcone derivatives against human prostate (LNCaP and PC-3), cervix HPV-positive (HeLa) and lymphocyte (Jurkat) cell lines and their effect on macrophage functions. Molecules, 28(5), Article 2159. https:\/\/doi.org\/10.3390\/molecules28052159","journal-title":"Molecules"},{"issue":"7","key":"5937_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11072023","volume":"11","author":"M Pellegrino","year":"2023","unstructured":"Pellegrino, M., Bevacqua, E., Frattaruolo, L., Cappello, A. R., Aquaro, S., & Tucci, P. (2023). Enhancing the anticancer and anti-inflammatory properties of curcumin in combination with quercetin, for the prevention and treatment of prostate cancer. Biomedicines, 11(7), Article 2023. https:\/\/doi.org\/10.3390\/biomedicines11072023","journal-title":"Biomedicines"},{"issue":"3","key":"5937_CR49","first-page":"178","volume":"5","author":"G Shafiee","year":"2016","unstructured":"Shafiee, G., Saidijam, M., Tavilani, H., Ghasemkhani, N., & Khodadadi, I. (2016). Genistein Induces Apoptosis and Inhibits Proliferation of HT29 Colon Cancer Cells. Int J Mol Cell Med, 5(3), 178\u2013191.","journal-title":"Int J Mol Cell Med"},{"issue":"4","key":"5937_CR50","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.3892\/ol.2019.10052","volume":"17","author":"L Huang","year":"2019","unstructured":"Huang, L., Jin, K., & Lan, H. (2019). Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase. Oncol Lett, 17(4), 3842\u20133850. https:\/\/doi.org\/10.3892\/ol.2019.10052","journal-title":"Oncol Lett"},{"issue":"4","key":"5937_CR51","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s12253-013-9641-1","volume":"19","author":"D Arul","year":"2013","unstructured":"Arul, D., & Subramanian, P. (2013). Naringenin (citrus flavonone) induces growth inhibition, cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Pathology Oncology Research, 19(4), 763\u201370. https:\/\/doi.org\/10.1007\/s12253-013-9641-1","journal-title":"Pathology Oncology Research"},{"issue":"4","key":"5937_CR52","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.21037\/tau-20-1094","volume":"9","author":"Y Li","year":"2020","unstructured":"Li, Y., Sun, Q., Li, H., Yang, B., & Wang, M. (2020). Vitexin suppresses renal cell carcinoma by regulating mTOR pathways. Translational Andrology and Urology, 9(4), 1700\u20131711. https:\/\/doi.org\/10.21037\/tau-20-1094","journal-title":"Translational Andrology and Urology"},{"issue":"4","key":"5937_CR53","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.3892\/mmr.2018.8604","volume":"17","author":"W Zheng","year":"2018","unstructured":"Zheng, W., Liu, T., Sun, R., Yang, L., An, R., & Xue, Y. (2018). Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway. Molecular Medicine Reports, 17(4), 6093\u20136099. https:\/\/doi.org\/10.3892\/mmr.2018.8604","journal-title":"Molecular Medicine Reports"},{"issue":"5","key":"5937_CR54","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s10495-014-0971-6","volume":"19","author":"S Shukla","year":"2014","unstructured":"Shukla, S., Fu, P., & Gupta, S. (2014). Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. Apoptosis, 19(5), 883\u2013894. https:\/\/doi.org\/10.1007\/s10495-014-0971-6","journal-title":"Apoptosis"},{"issue":"2","key":"5937_CR55","first-page":"701","volume":"34","author":"ME Kim","year":"2014","unstructured":"Kim, M. E., Ha, T. K., Yoon, J. H., & Lee, J. S. (2014). Myricetin induces cell death of human colon cancer cells via BAX\/BCL2-dependent pathway. Anticancer Research, 34(2), 701\u2013706.","journal-title":"Anticancer Research"},{"issue":"4","key":"5937_CR56","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/tox.22698","volume":"34","author":"YC Hsiao","year":"2019","unstructured":"Hsiao, Y. C., Peng, S. F., Lai, K. C., Liao, C. L., Huang, Y. P., Lin, C. C., Lin, M. L., Liu, K. C., Tsai, C. C., Ma, Y. S., & Chung, J. G. (2019). Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo. Environmental Toxicology, 34(4), 443\u2013456. https:\/\/doi.org\/10.1002\/tox.22698","journal-title":"Environmental Toxicology"},{"issue":"1","key":"5937_CR57","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12013-014-0428-0","volume":"72","author":"R Wei","year":"2015","unstructured":"Wei, R., Zhu, G., Jia, N., & Yang, W. (2015). Epigallocatechin-3-gallate Sensitizes Human 786-O Renal Cell Carcinoma Cells to TRAIL-Induced Apoptosis. Cell Biochemistry And Biophysics, 72(1), 157\u2013164. https:\/\/doi.org\/10.1007\/s12013-014-0428-0","journal-title":"Cell Biochemistry And Biophysics"},{"issue":"3","key":"5937_CR58","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.3892\/or.2015.4133","volume":"34","author":"BJ Han","year":"2015","unstructured":"Han, B. J., Li, W., Jiang, G. B., Lai, S. H., Zhang, C., Zeng, C. C., & Liu, Y. J. (2015). Effects of daidzein in regards to cytotoxicity in vitro, apoptosis, reactive oxygen species level, cell cycle arrest and the expression of caspase and Bcl-2 family proteins. Oncology Reports, 34(3), 1115\u201320. https:\/\/doi.org\/10.3892\/or.2015.4133","journal-title":"Oncology Reports"},{"issue":"3","key":"5937_CR59","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3390\/cancers16030487","volume":"16","author":"K Jakimiuk","year":"2024","unstructured":"Jakimiuk, K., Szoka, \u0141., Sura\u017cy\u0144ski, A., & Tomczyk, M. (2024). Using Flavonoid Substitution Status to Predict Anticancer Effects in Human Melanoma Cancers: An In Vitro Study. Cancers (Basel), 16(3), 487. https:\/\/doi.org\/10.3390\/cancers16030487","journal-title":"Cancers (Basel)"},{"issue":"4","key":"5937_CR60","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2174\/1871520620666200721103422","volume":"21","author":"I Cinar","year":"2021","unstructured":"Cinar, I. (2021). Apoptosis-Inducing Activity and Antiproliferative Effect of Gossypin on PC-3 Prostate Cancer Cells. Anticancer Agents Med Chem, 21(4), 445\u2013450. https:\/\/doi.org\/10.2174\/1871520620666200721103422","journal-title":"Anticancer Agents Med Chem"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05937-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12010-026-05937-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-026-05937-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:37:44Z","timestamp":1789785464000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12010-026-05937-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":60,"alternative-id":["5937"],"URL":"https:\/\/doi.org\/10.1007\/s12010-026-05937-x","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"assertion":[{"value":"9 September 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"was not required because it was a cell culture study.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agreed to the publication of this paper.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}