{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:42:02Z","timestamp":1782229322788,"version":"3.54.5"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1007\/s12011-007-0043-7","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T13:15:03Z","timestamp":1179148503000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Zinc Supplementation or Regulation of its Homeostasis: Advantages and Threats"],"prefix":"10.1007","volume":"119","author":[{"given":"S\u0142awomir","family":"Tubek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"43_CR1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","volume":"73","author":"BL Vallee","year":"1993","unstructured":"Vallee BL, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79\u201394","journal-title":"Physiol Rev"},{"key":"43_CR2","unstructured":"Kokot F, Tato\u0144 J (1991) Zaburzenia przemiany materii w Chorobach Wewn\u00eatrznych pod red. F. Kokota, PZWL Warszawa 670"},{"key":"43_CR3","unstructured":"Holtmeier HJ, Kuhn M, Rummel K (1976) Zink ein lebenswichtiges Mineral, Wissenschaftliche Verlagsgeselschaft MbH. Stuttgart 13"},{"key":"43_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/0-306-46826-3_25","volume":"477","author":"AJ Turner","year":"2000","unstructured":"Turner AJ, Brown CD, Carson JA, Barens K (2000) The neprilysin family in health and disease. Adv Exp Med Biol 477:229\u2013240","journal-title":"Adv Exp Med Biol"},{"key":"43_CR5","doi-asserted-by":"publisher","first-page":"26423","DOI":"10.1074\/jbc.M000767200","volume":"275","author":"S Lopez-Ongil","year":"2000","unstructured":"Lopez-Ongil S, Senchak V, Saura M, Zaragoza C, Ames M, Ballerman BJ, Rodriguez-Puyol M, Rodroguez-Puyol D, Lowenstein CJ (2000) Superoxide regulation of endothelin converting enzyme. J Biol Chem 275:26423\u201326429","journal-title":"J Biol Chem"},{"key":"43_CR6","first-page":"20","volume":"4","author":"RJ Cousins","year":"1986","unstructured":"Cousins RJ (1986) Toward a molecular understanding of zinc metabolism. Clin Physiol Biochem 4:20\u201330","journal-title":"Clin Physiol Biochem"},{"key":"43_CR7","first-page":"195","volume":"74","author":"P Csermely","year":"1989","unstructured":"Csermely P, Somogyi J (1989) Zinc as a possible mediator of signal transduction in T lymphocytes. Acta Physiol Hung 74:195\u2013197","journal-title":"Acta Physiol Hung"},{"key":"43_CR8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/jn\/122.3.428","volume":"122","author":"RA Avery","year":"1992","unstructured":"Avery RA, Bettger WJ (1992) Zinc deficiency alters the protein composition of the membrane skeleton but not the extractability or oligomeric form of spectrin in rat erythrocyte membranes. J Nutr 122:428\u2013434","journal-title":"J Nutr"},{"key":"43_CR9","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/0024-3205(81)90374-X","volume":"28","author":"WJ Bettger","year":"1981","unstructured":"Bettger WJ, O\u2019Dell BL (1981) A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 28:1425\u20131438","journal-title":"Life Sci"},{"key":"43_CR10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1432-1033.1972.tb01865.x","volume":"27","author":"A Carvalho","year":"1972","unstructured":"Carvalho A (1972) Binding and release of cations by sarcoplasmic reticulum before and after removal of lipids. Eur J Biochem 27:491\u2013502","journal-title":"Eur J Biochem"},{"key":"43_CR11","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1079\/BJN19910050","volume":"66","author":"I Dorup","year":"1991","unstructured":"Dorup I, Clausen T (1991). Effects of magnesium and zinc deficiencies on growth and protein synthesis in skeletal muscle and the heart. Br J Nutr 66:493\u2013504","journal-title":"Br J Nutr"},{"key":"43_CR12","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/BF02535574","volume":"27","author":"ER Driscoll","year":"1992","unstructured":"Driscoll ER, Bettger WJ (1992) Zinc deficiency in the rat alters the lipid composition of the erythrocyte membrane Triton shell. Lipids 27:972\u2013977","journal-title":"Lipids"},{"key":"43_CR13","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.3283939","volume":"240","author":"RM Evans","year":"1988","unstructured":"Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889\u2013895","journal-title":"Science"},{"key":"43_CR14","first-page":"482","volume":"43","author":"NL Harrison","year":"1993","unstructured":"Harrison NL, Radke HK, Tamkun MM, Lovinger DM (1993) Modulation of gating of cloned rat and human K+ channels by micromolar Zn+2. Mol Pharmacol 43:482\u2013486","journal-title":"Mol Pharmacol"},{"key":"43_CR15","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.1985.248.1.C3","volume":"248","author":"IG Maccara","year":"1985","unstructured":"Maccara IG (1985) Oncogenesis, ions and phospholipids. Am J Physiol 248:C3\u2013C11","journal-title":"Am J Physiol"},{"key":"43_CR16","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0006-291X(89)80042-7","volume":"165","author":"P Csermely","year":"1989","unstructured":"Csermely P, Sandor P, Radics L, Somogyi J (1989) Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example. Biochem Biophys Res Commun 165:838\u2013844","journal-title":"Biochem Biophys Res Commun"},{"key":"43_CR17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/cs0840113","volume":"84","author":"NM Lowe","year":"1993","unstructured":"Lowe NM, Green A, Rhodes JM, Lombard M, Jalan R, Jackson MJ (1993) Studies of human zinc kinetics using the stable isotope 70Zn. Clin Sci 84:113\u2013117","journal-title":"Clin Sci"},{"issue":"Suppl 32","key":"43_CR18","first-page":"103","volume":"39","author":"R Girchev","year":"1988","unstructured":"Girchev R, Tzachev K (1988) Metabolism and homeostasis of zinc and copper. Acta Physiol Pol 39(Suppl 32):103\u2013118","journal-title":"Acta Physiol Pol"},{"key":"43_CR19","doi-asserted-by":"crossref","first-page":"1360S","DOI":"10.1093\/jn\/130.5.1360S","volume":"130","author":"JC King","year":"2000","unstructured":"King JC, Shames DM, Woodhouse LR (2000) Zinc homeostasis in humans. J Nutr 130:1360S\u20131366S","journal-title":"J Nutr"},{"key":"43_CR20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000153396","volume":"33","author":"P Darlu","year":"1983","unstructured":"Darlu P, Lalouel JM, Henrotte JG, Rao DC (1983) A genetic study of red blood zinc concentration in man. Hum Hered 33:311\u2013318","journal-title":"Hum Hered"},{"key":"43_CR21","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/BF00396108","volume":"25","author":"JG Henrotte","year":"1987","unstructured":"Henrotte JG, Santarromana M, Pia M (1987) Genetic factors regulating zinc concentrations in mics spleen and liver: relationship with the H-2 complex. Immunogenetics 25:408\u2013410","journal-title":"Immunogenetics"},{"key":"43_CR22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/07315724.1990.10720390","volume":"9","author":"JG Henrotte","year":"1990","unstructured":"Henrotte JG, Santarromana M, Franck G, Bourdon R (1990) Blood and tissue zinc levels in spontaneously hypertensive rats. J Am Coll Nutr 9:340\u2013344","journal-title":"J Am Coll Nutr"},{"key":"43_CR23","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1097\/00004872-199206000-00008","volume":"10","author":"JG Henrotte","year":"1992","unstructured":"Henrotte JG, Santarromana M, Franck G, Guicheney P, Boulu R, Bourdon R (1992) High cardiac zinc levels in spontaneously hypertensive rats. J Hypertens 10:553\u2013559","journal-title":"J Hypertens"},{"key":"43_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/BF00278903","volume":"46","author":"P Olholm-Larsen","year":"1979","unstructured":"Olholm-Larsen P (1979) Serum zinc levels in heterozygous carriers of the gene for acrodermatitis enteropathica. Hum Genet 46:65\u201374","journal-title":"Hum Genet"},{"key":"43_CR25","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1126\/science.941021","volume":"193","author":"JC Smith","year":"1976","unstructured":"Smith JC, Zeller JA, Brown ED, Ong SC (1976) Elevated Plasma zinc: a heritable anomaly. Science 193:496\u2013498","journal-title":"Science"},{"key":"43_CR26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ajcn\/56.2.440","volume":"56","author":"D McMaster","year":"1992","unstructured":"McMaster D, McCrum E, Patterson CC, Kerr MM, O\u2019Reilly D, Evans AE, Love AH (1992) Serum copper and zinc in random samples of the population of Northen Ireland. Am J Clin Nutr 56:440\u2013446","journal-title":"Am J Clin Nutr"},{"key":"43_CR27","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF01993964","volume":"123","author":"TJB Simons","year":"1991","unstructured":"Simons TJB (1991) Intracellular free zinc and zinc buffering in human red blood cells. J Membr Biol 123:63\u201371","journal-title":"J Membr Biol"},{"key":"43_CR28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/BF01993965","volume":"123","author":"TJB Simson","year":"1991","unstructured":"Simson TJB (1991) Calcium-dependent zinc efflux in human red blood cells. J Membr Biol 123:73\u201380","journal-title":"J Membr Biol"},{"key":"43_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcp.1041510102","volume":"151","author":"DJ Bobilya","year":"1992","unstructured":"Bobilya DJ, Briske-Anderson M, Reeves PG (1992) Zinc transport into endothelial cell is a facilitated process. J Cell Physiol 151:1\u20137","journal-title":"J Cell Physiol"},{"key":"43_CR30","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/jcp.1041520217","volume":"152","author":"RD Raffaniello","year":"1992","unstructured":"Raffaniello RD, Shih-Yu L, Teichberg S, Wapnir RA (1992) Distinct mechanisms of zinc uptake at the apical and basolateral membranes of caco-2 cells. J Cell Physiol 152:356\u2013361","journal-title":"J Cell Physiol"},{"key":"43_CR31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1113\/jphysiol.1993.sp019666","volume":"465","author":"F Tacnet","year":"1993","unstructured":"Tacnet F, Lauthier F, Ripoche P (1993) Mechanisms of zinc transport into pig small intestine brush-border membrane vesicles. J Physiol 465:57\u201372","journal-title":"J Physiol"},{"key":"43_CR32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.HYP.26.6.863","volume":"26","author":"CE Gracia","year":"1995","unstructured":"Gracia CE, Kdcoyne CM, Cardillo C, Cannon RO 3, Quyyumi AA, Panza JA (1995) Effect of copper-zinc superoxide dismutase on endothelium-dependent vasodilation in patients with essential hypertension. Hypertension 26:863\u2013868","journal-title":"Hypertension"},{"key":"43_CR33","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1081\/CEH-120004797","volume":"24","author":"M Sato","year":"2002","unstructured":"Sato M, Yanagisawa H, Nojima Y, Tamura J, Wada O (2002) Zn deficiency aggravates hypertension in spontaneously hypertensive rats: possible role of Cu\/Zn-superoxide dismutase. Clin Exp Hypertens 24:355\u2013370","journal-title":"Clin Exp Hypertens"},{"key":"43_CR34","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1385\/BTER:90:1-3:239","volume":"90","author":"SA Cebeci","year":"2002","unstructured":"Cebeci SA, Kocaturk PA, Kavas GO (2002) Hypertension: does impaired endothelium-dependent relaxation affect superoxide scavenging? Biol Trace Elem Res 90:239\u2013249","journal-title":"Biol Trace Elem Res"},{"key":"43_CR35","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1385\/BTER:91:2:157","volume":"91","author":"M Sato","year":"2003","unstructured":"Sato M, Kurihara N, Moridaira K, Sakamoto H, Tamura J, Wada O, Yanagisawa H (2003) Dietary Zn deficiency does not influence systemic blood pressure and vascular nitric oxide signaling in normotensive rats. Biol Trace Elem Res 91:157\u2013172","journal-title":"Biol Trace Elem Res"},{"key":"43_CR36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00004872-200403000-00017","volume":"22","author":"H Yanagisawa","year":"2004","unstructured":"Yanagisawa H, Sato M, Nodera M, Wada O (2004). Excessive zinc intake elevates systemic blood pressure levels in normotensive rats\u2014potential role of superoxide-induced oxidative stress. J Hypertens 22:543\u2013550","journal-title":"J Hypertens"},{"key":"43_CR37","first-page":"17","volume":"6","author":"NV Davydenko","year":"1995","unstructured":"Davydenko NV, Smirnova IP, Kvasha EA, Gorbas EAIM, Koblianskaia AV (1995) Interrelatioship between dietary intake of minerals and prevalence of hypertension. Vopr Pitan 6:17\u201319","journal-title":"Vopr Pitan"},{"key":"43_CR38","first-page":"73","volume":"5-6","author":"NV Davydenko","year":"1995","unstructured":"Davydenko NV, Smirnova IP, Kvasha EA, Gorbas EAIM (1995) The relationship between the copper and zinc intake with food and the prevalence of ischaemic heart disease and its risk factors. Lik Sprava 5-6:73\u201377","journal-title":"Lik Sprava"},{"key":"43_CR39","first-page":"141","volume":"43","author":"Anonymous","year":"1985","unstructured":"Anonymous (1985) Megadose zinc intakes impairs immune responses. Nutr Rev 43:141\u2013143","journal-title":"Nutr Rev"},{"key":"43_CR40","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1001\/jama.252.11.1443","volume":"252","author":"RK Chandra","year":"1984","unstructured":"Chandra RK (1984) Excessive intake of zinc impairs immune response. JAMA 252:1443\u20131445","journal-title":"JAMA"},{"key":"43_CR41","first-page":"647","volume":"85","author":"S Ripa","year":"1994","unstructured":"Ripa S, Ripa R (1994) Zinc and atherosclerosis. Minerva Med 85:647\u2013654","journal-title":"Minerva Med"},{"key":"43_CR42","first-page":"455","volume":"85","author":"S Ripa","year":"1994","unstructured":"Ripa S, Ripa R (1994) Zinc and arterial pressure. Minerva Med 85:455\u2013459","journal-title":"Minerva Med"},{"key":"43_CR43","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/07315724.1998.10718804","volume":"17","author":"RB Singh","year":"1998","unstructured":"Singh RB, Niaz MA, Rastogi SS, Bajaj S, Gaoli Z, Shoumin Z (1998) Current zinc intake and diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India. J Am Coll Nutr 17:564\u2013570","journal-title":"J Am Coll Nutr"},{"key":"43_CR44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/07315724.2004.10719367","volume":"23","author":"SA Chiplonkar","year":"2004","unstructured":"Chiplonkar SA, Agte VV, Tarwadi KV, Paknikar KM, Diwate UP (2004) Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll Nutr 23:239\u2013247","journal-title":"J Am Coll Nutr"},{"key":"43_CR45","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/sj.jhh.1001508","volume":"17","author":"AE Schutte","year":"2003","unstructured":"Schutte AE, Van Rooyen JM, Huisman HW, Kruger HS, Malan NT, De Didder JH (2003) Dietary risk markers that contribute to the aetiology of hypertension in black South African children: the THUSA BANA study. J Hum Hypertens 17:29\u201335","journal-title":"J Hum Hypertens"},{"key":"43_CR46","first-page":"586","volume":"10","author":"JG Fodor","year":"1987","unstructured":"Fodor JG, Rusted IE (1987) Electrolyte profiles in a hypertensive population: The Newfoundland Study. Clin Invest Med 10:586\u2013591","journal-title":"Clin Invest Med"},{"key":"43_CR47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/jn\/133.1.211","volume":"133","author":"I Hajjar","year":"2003","unstructured":"Hajjar I, Kotchen T (2003) Regional variations of blood pressure in the United States are associated with regional variation in dietary intakes: the NHANES-II data. J Nutr 133:211\u2013214","journal-title":"J Nutr"},{"key":"43_CR48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/geronj\/26.3.358","volume":"26","author":"RD Lindeman","year":"1971","unstructured":"Lindeman RD, Clark ML, Colmore JP (1971) Influence of age and sex on plasma and red-cell zinc concentration. J Gerontol 26:358\u2013363","journal-title":"J Gerontol"},{"issue":"5 Pt 2","key":"43_CR49","first-page":"R1162","volume":"263","author":"ME Wastney","year":"1992","unstructured":"Wastney ME, Ahmed S, Henkin RI (1992) Changes in regulation of human zinc metabolism with age. Am J Physiol 263(5 Pt 2):R1162\u2013R1168","journal-title":"Am J Physiol"},{"key":"43_CR50","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mad.2005.09.003","volume":"127","author":"AN Donahue","year":"2006","unstructured":"Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag WE (2006) Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mech Ageing Dev 127:57\u201363","journal-title":"Mech Ageing Dev"},{"issue":"Suppl 2","key":"43_CR51","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1038\/sj.ejcn.1602301","volume":"59","author":"CF Hodkinson","year":"2005","unstructured":"Hodkinson CF, Kelly M, Coudray C, Gilmore WS, Hannigan BM, O\u2019Connor JM, Strain JJ, Wallace JM (2005) Zinc status and age-related changes in peripheral blood leucocyte subpopupations in healthy men and women aged 55\u201370 y: the ZENITH study. Eur J Clin Nutr 59(Suppl 2):S63\u2013S67","journal-title":"Eur J Clin Nutr"},{"key":"43_CR52","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ajcn\/71.2.590","volume":"71","author":"G Ravaglia","year":"2000","unstructured":"Ravaglia G, Forti P, Maioli F, Bastagli L, Facchini A, Mariani E, Savarino L, Sassi S, Cucinotta D, Lenaz G (2000) Effect of micronutrient on natural killer cell immune function in healthy free-living subjects aged \u226590 y. Am J Clin Nutr 71:590\u2013598","journal-title":"Am J Clin Nutr"},{"key":"43_CR53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1742-4933-3-6","volume":"3","author":"E Mocchegiani","year":"2006","unstructured":"Mocchegiani E, Malavolta M, Marcellini F, Pawelec G (2006) Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing. Immunity and Ageing 3:6","journal-title":"Immunity and Ageing"},{"key":"43_CR54","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1089\/rej.2006.9.351","volume":"9","author":"E Mocchegiani","year":"2006","unstructured":"Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Rink L, Malavolta M (2006) Zinc homeostasis in aging: two elusive faces of the same metal. Rejuvenation Res 9:351\u2013354","journal-title":"Rejuvenation Res"},{"key":"43_CR55","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1385\/BTER:107:2:089","volume":"107","author":"S Tubek","year":"2005","unstructured":"Tubek S (2005) The zinc content in lymphocytes and the activity of zinc ions efflux from lymphocytes in primary arterial hypertension. Biol Trace Elem Res 107:89\u201399","journal-title":"Biol Trace Elem Res"},{"key":"43_CR56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1054\/mehy.1999.0867","volume":"53","author":"JE Sprietsma","year":"1999","unstructured":"Sprietsma JE (1999) Modern diets and diseases: NO-zinc balance. Under Th1, zinc and nitrogen monoxide (NO) collectively protect against viruses, AIDS, autoimmunity, diabetes, allergies, asthma, infectious diseases, atherosclerosis and cancer. Med Hypotheses 53:6\u201316","journal-title":"Med Hypotheses"},{"key":"43_CR57","first-page":"3795","volume":"41","author":"RK Chandra","year":"1981","unstructured":"Chandra RK (1981) Immune response in overnutrition. Cancer Res 41:3795\u20133796","journal-title":"Cancer Res"},{"key":"43_CR58","first-page":"571","volume":"73","author":"M Takakura","year":"1998","unstructured":"Takakura M (1998) Analysis of zinc concentrations in leucocytes and its application to patients with non-insulin-dependent diabetes mellitus. Hokkaido Igaku Zasshi 73:571\u2013580","journal-title":"Hokkaido Igaku Zasshi"},{"key":"43_CR59","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1006\/excr.1994.1096","volume":"211","author":"S Treves","year":"1994","unstructured":"Treves S, Trentini PL, Ascanelli M, Bucci G, Di Vrigilio F (1994) Apoptosis is dependent on intracellular zinc and independent of intracellular calcium in lymphocytes. Exp Cell Res 211:339\u2013343","journal-title":"Exp Cell Res"},{"key":"43_CR60","doi-asserted-by":"publisher","first-page":"9507","DOI":"10.1523\/JNEUROSCI.0868-05.2005","volume":"25","author":"LM Malaiyandi","year":"2005","unstructured":"Malaiyandi LM, Honick AS, Rintoul GL, Wang QJ, Reynolds IJ (2005) Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. J Neurosci 25:9507\u20139514","journal-title":"J Neurosci"},{"key":"43_CR61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-2005-8202","volume":"8","author":"M Capasso","year":"2005","unstructured":"Capasso M, Jeng JM, Malavolta M, Mocchegiani E, Sensi SL (2005) Zinc dyshomeostasis: a key modulator of neuronal injury. J Alzheimers Dis 8:93\u2013108","journal-title":"J Alzheimers Dis"},{"key":"43_CR62","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/oxfordjournals.aje.a114118","volume":"122","author":"D Kromhout","year":"1985","unstructured":"Kromhout D, Wibowo AA, Herber i wsp RF (1985) Trace metals and coronary heart disease risk indicators in 152 elderly men (The Zutphen Study). Am J Epidemiol 122:378\u2013385","journal-title":"Am J Epidemiol"},{"key":"43_CR63","first-page":"315","volume":"86","author":"S Ripa","year":"1995","unstructured":"Ripa S, Ripa R (1995) Zinc and immune function. Minerva Med 86:315\u2013318","journal-title":"Minerva Med"},{"key":"43_CR64","unstructured":"Przybylski J (1991) The role of arterial chemoreceptors and tissue oxygen supply in primary arterial hypertension pathogenesis, based upon investigations carried out on animal model (SAH). Qualifying thesis. Medical University of Warsaw, Warsaw, pp 24\u201342, 85\u2013167 (in Polish)."},{"key":"43_CR65","unstructured":"Ishikawa Y, Kudo H, Kagawa Y, Sakamoto S (2005) Increased plasma of zinc in obese adult females on a weight-loss program based on a hypocaloric balanced diet in vivo 19:1035\u20131037"},{"key":"43_CR66","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/153537020122600107","volume":"226","author":"SF Simon","year":"2001","unstructured":"Simon SF, Taylor CG (2001) Dietary zinc supplementation attenuates hyperglycemia in db\/db mice. Exp Biol Med (Maywood) 226:43\u201351","journal-title":"Exp Biol Med (Maywood)"},{"key":"43_CR67","first-page":"73","volume":"11","author":"I Raz","year":"1989","unstructured":"Raz I, Karsai D, Katz M (1989) The influence of zinc supplementation on glucose homeostasis in NIDDM. Diabetes Res 11:73\u201379","journal-title":"Diabetes Res"},{"key":"43_CR68","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.semnephrol.2005.03.010","volume":"25","author":"W Schoner","year":"2005","unstructured":"Schoner W, Scheiner-Bobis G (2005) Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer. Semin Nephrol 25:343\u2013351","journal-title":"Semin Nephrol"},{"key":"43_CR69","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1749-6632.2003.tb07282.x","volume":"986","author":"W Schoner","year":"2003","unstructured":"Schoner W, Bauer N, Muller-Ehmsen J, Kramer U, Hambarchian N, Schwinger R, Moeller H, Kost H, Weitkamp C, Schweitzer T, Kirch U, Neu H, Grunbaum EG (2003) Ouabain as a mammalian hormone. Ann NY Acad Sci 986:678\u2013684","journal-title":"Ann NY Acad Sci"},{"key":"43_CR70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1385\/BTER:83:1:31","volume":"83","author":"S Tubek","year":"2001","unstructured":"Tubek S (2001) Increased absorption of zinc from alimentary tract in the primary arterial hypertension. Biol Trace Elem Res 83:31\u201338","journal-title":"Biol Trace Elem Res"},{"key":"43_CR71","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/07315724.1996.10718568","volume":"15","author":"LM Henderson","year":"1996","unstructured":"Henderson LM, Brewer GJ, Dressman JB, Swidan SZ, DuRoss DJ, Adair CH, Barnett JL, Berardi RR (1996) Use of zinc tolerance test and 24-hour urinary zinc content to assess oral zinc absorption. J Am Coll Nutr 15:79\u201383","journal-title":"J Am Coll Nutr"},{"key":"43_CR72","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/BF03189977","volume":"16","author":"J Neve","year":"1991","unstructured":"Neve J, Hanocq M, Peretz A, Abi Khalil F, Pelen F, Famaey JP, Fontaine J (1991) Pharmacokinetic study of orally administered zinc in humans: evidence for an enteral recirculation. Eur J Drug Metab Pharmacokinet 16:315\u2013323","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"43_CR73","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1042\/BJ20050627","volume":"394","author":"S Balesaria","year":"2006","unstructured":"Balesaria S, Hogstrand Ch (2006) Identification, cloning and characterization of a plasma membrane zinc efflux transporter, TrZnT-1, from fugu pufferfish (Takifugu rubripes). Biochem J 394:485\u2013493","journal-title":"Biochem J"},{"key":"43_CR74","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/07315724.2005.10719482","volume":"24","author":"VV Agte","year":"2005","unstructured":"Agte VV, Chiplonkar SA, Tarwadi KV (2005) Factors influencing zinc status of apparently healthy Indians. J Am Coll Nutr 24:334\u2013341","journal-title":"J Am Coll Nutr"},{"key":"43_CR75","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF02788959","volume":"49","author":"G Vivoli","year":"1995","unstructured":"Vivoli G, Bergomi M, Rovesti S et al (1995) Zinc, copper and zinc- or copper-dependent enzymes in human hypertension. Biol Trace Elem Res 49:97\u2013106","journal-title":"Biol Trace Elem Res"},{"key":"43_CR76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02783978","volume":"38","author":"J Kok","year":"1993","unstructured":"Kok J, Van der Schoot C, Veldhuizen M, Wolterbeek HT (1993) The uptake of zinc by erythrocytes under near-physiological conditions. Biol Trace Elem Res 38:13\u201326","journal-title":"Biol Trace Elem Res"},{"key":"43_CR77","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1385\/BTER:114:1:65","volume":"114","author":"S Tubek","year":"2006","unstructured":"Tubek S (2006) Selected zinc metabolism parameters in relation to insulin, renin\u2013angiotensin\u2013aldosterone system and blood pressure in healthy subjects\u2014gender differences. Biol Trace Elem Res 114:65\u201372","journal-title":"Biol Trace Elem Res"},{"key":"43_CR78","first-page":"1569","volume":"7","author":"ML Tetef","year":"2001","unstructured":"Tetef ML, Synold TW, Chow W, Leong L, Margolin K, Morgan R, Raschko J, Shibata S, Somlo G, Yen Y, Groshen S, Johnson K, Lenz HJ, Gandara D, Doroshow JH (2001) Phase I trial of 96-hour continuous infusion of dexrazoxane in patients with advanced malignancies. Clin Cancer Res 7:1569\u20131576","journal-title":"Clin Cancer Res"},{"key":"43_CR79","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1006\/nbdi.1997.0163","volume":"4","author":"MP Cuajungco","year":"1997","unstructured":"Cuajungco MP, Lees GJ (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4:137\u2013169","journal-title":"Neurobiol Dis"},{"key":"43_CR80","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1167\/iovs.03-1315","volume":"45","author":"MH Yoo","year":"2004","unstructured":"Yoo MH, Lee JY, Lee SE, Koh JY, Yoon YH (2004) Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo. Invest Ophthalmol Vis Sci 45:1523\u20131530","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-007-0043-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-007-0043-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-007-0043-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-007-0043-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T08:53:27Z","timestamp":1652604807000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-007-0043-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,8]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["43"],"URL":"https:\/\/doi.org\/10.1007\/s12011-007-0043-7","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,8]]},"assertion":[{"value":"25 January 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}