{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:29:01Z","timestamp":1786487341942,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1-3","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s12011-013-9686-8","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T02:35:26Z","timestamp":1367807726000},"page":"1-4","source":"Crossref","is-referenced-by-count":38,"title":["Selenium: A Protective Factor for Kaschin\u2013Beck Disease in Qing-Tibet Plateau"],"prefix":"10.1007","volume":"153","author":[{"given":"Zhi-Jun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-chuan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"issue":"6","key":"9686_CR1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.joca.2007.09.002","volume":"16","author":"J Cao","year":"2008","unstructured":"Cao J, Li S, Shi Z et al (2008) Articular cartilage metabolism in patients with Kaschin\u2013Beck disease: an endemic osteoarthropathy in China. Osteoarthr Cartil 16(6):680\u2013688","journal-title":"Osteoarthr Cartil"},{"key":"9686_CR2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s002640050139","volume":"21","author":"F Mathieu","year":"1997","unstructured":"Mathieu F, Begaux F, Lan ZY, Suetens C, Hinsenkamp M (1997) Clinical manifestations of Kaschin\u2013Beck disease in Nyemo Valley, Tibet. Int Orthop 21:151\u2013156","journal-title":"Int Orthop"},{"issue":"1","key":"9686_CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1148\/radiology.201.1.8816556","volume":"201","author":"Y Wang","year":"1996","unstructured":"Wang Y, Yang Z, Gilula LA, Zhu C et al (1996) Kaschin\u2013Beck disease: radiographic appearance in the hands and wrist. Radiology 201(1):265\u2013270","journal-title":"Radiology"},{"key":"9686_CR4","first-page":"201","volume":"14","author":"JB Yang","year":"1995","unstructured":"Yang JB (1995) Etiology of Kaschin\u2013Beck disease. Chin J Endemiol 14:201\u2013204","journal-title":"Chin J Endemiol"},{"issue":"4","key":"9686_CR5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1289\/ehp.99107293","volume":"107","author":"A Peng","year":"1999","unstructured":"Peng A, Wang WH, Wang CX et al (1999) The role of humic substances in drinking water in Kaschin\u2013Beck disease in China. Environ Heal Perspect 107(4):293\u2013296","journal-title":"Environ Heal Perspect"},{"key":"9686_CR6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s002640100247","volume":"25","author":"C Suetens","year":"2001","unstructured":"Suetens C, Moreno-Reyes R, Chasseur C et al (2001) Epidemiological support for a multifactorial etiology of Kaschin\u2013Beck disease in Tibet. Int Orthop 25:180\u2013187","journal-title":"Int Orthop"},{"issue":"1\u20133","key":"9686_CR7","first-page":"68","volume":"138","author":"BJ Zhang","year":"2010","unstructured":"Zhang BJ, Yang LS, Wang WY et al (2010) Quantification and comparison of soil elements in the Tibetan Plateau Kaschin\u2013Beck disease area. Biol Trace Elem Res 138(1\u20133):68\u201378","journal-title":"Biol Trace Elem Res"},{"issue":"12","key":"9686_CR8","first-page":"2167","volume":"27","author":"SJ Li","year":"2008","unstructured":"Li SJ, Li W, Hu X et al (2008) Distribution of Kaschin-Beck Disease (KBD) and its relation to selenium content in soil-plant-animal (human being) ecosystem in Tibet. Chin J Ecol 27(12):2167\u20132170","journal-title":"Chin J Ecol"},{"issue":"5","key":"9686_CR9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10653-010-9366-y","volume":"33","author":"B Zhang","year":"2011","unstructured":"Zhang B, Yang L, Wang W et al (2011) Environmental selenium in the Kaschin\u2013Beck disease area, Tibetan Plateau, China. Environ Geochem Health 33(5):495\u2013501","journal-title":"Environ Geochem Health"},{"issue":"2","key":"9686_CR10","first-page":"151","volume":"9","author":"H Wen","year":"1990","unstructured":"Wen H, Wang ZH, Deng SR et al (1990) Investigation report of Kaschin\u2013Beck disease in Xinghai County, Qinghai Province. Chin J Endemiol 9(2):151\u2013154","journal-title":"Chin J Endemiol"},{"issue":"4","key":"9686_CR11","first-page":"428","volume":"25","author":"SJ Li","year":"2006","unstructured":"Li SJ, Yang LS, Wang WY et al (2006) Study on the relationship between selenium concentrations in drinking water and Kaschin\u2013Beck disease in Tibet. Chin J Endemiol 25(4):428\u2013429","journal-title":"Chin J Endemiol"},{"issue":"3","key":"9686_CR12","first-page":"325","volume":"29","author":"Y Fu","year":"2010","unstructured":"Fu Y, Meng FG, Deng JY et al (2010) Investigation on the selenium and T-2 toxin level in Kaschin\u2013Beck disease relative active regions in Aba State of Sichuan Province in (2008). Chin J Endemiol 29(3):325\u2013329","journal-title":"Chin J Endemiol"},{"key":"9686_CR13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12011-012-9469-7","volume":"1\u20133","author":"LY Sun","year":"2012","unstructured":"Sun LY, Li Q, Meng FG et al (2012) T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin\u2013Beck disease endemic areas of Qinghai Province. Biol Trace Elem Res 1\u20133:371\u2013375","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"9686_CR14","first-page":"426","volume":"31","author":"FG Meng","year":"2012","unstructured":"Meng FG, Li Q, Yin F et al (2012) Investigation of state and influence factors of children\u2019s Kaschin\u2013Beck disease in Xinghai County of Qinghai Province in 2009. Chin J Endemiol 31(4):426\u2013429","journal-title":"Chin J Endemiol"},{"issue":"6","key":"9686_CR15","first-page":"673","volume":"25","author":"SJ Li","year":"2006","unstructured":"Li SJ, Yang LS, Li YH et al (2006) Relationship between the content of selenium in grains and the Kaschin\u2013Beck disease in Tibet, China. Chin J Endemiol 25(6):673\u2013674","journal-title":"Chin J Endemiol"},{"issue":"6","key":"9686_CR16","first-page":"886","volume":"28","author":"B Zhang","year":"2009","unstructured":"Zhang B, Yang L, Wang W et al (2009) Selenium in environment and its relationship with Kaschin\u2013Beck disease in Rangtang County, Sichuan Province. Prog Geogr 28(6):886\u2013891","journal-title":"Prog Geogr"},{"issue":"16","key":"9686_CR17","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199810153391604","volume":"339","author":"R Moreno-Reyes","year":"1998","unstructured":"Moreno-Reyes R, Suetens C, Mathieu F et al (1998) Kaschin\u2013Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339(16):1112\u20131120","journal-title":"N Engl J Med"},{"issue":"6","key":"9686_CR18","first-page":"694","volume":"25","author":"LL Kang","year":"2006","unstructured":"Kang LL, Xu P, Zhaxi SZ et al (2006) The changes of hyalurona, nitric oxide and selenium contents in serum for patients with Kaschin\u2013Beck disease in Tibet. Chin J Endemiol 25(6):694\u2013696","journal-title":"Chin J Endemiol"},{"issue":"6","key":"9686_CR19","first-page":"531","volume":"23","author":"LL Kang","year":"2007","unstructured":"Kang LL, Zhao FC, Yang FY et al (2007) Changes of the content of Se and the levels of several cytokines in the serum of patients with Kaschin\u2013Beck disease. Chin J Cell Mol Immunol 23(6):531\u2013532","journal-title":"Chin J Cell Mol Immunol"},{"issue":"3","key":"9686_CR20","first-page":"78","volume":"33","author":"X Xiao-yan","year":"2012","unstructured":"Xiao-yan X, Gao Q, Chen Y et al (2012) The selenium nutritional states of the children in Kaschin\u2013Beck disease area in Gangmuda Village, Rangtang County, Sichuan. J China West Normal Univ (Nat Sci) 33(3):78\u201390","journal-title":"J China West Normal Univ (Nat Sci)"},{"issue":"7","key":"9686_CR21","first-page":"655","volume":"11","author":"BJ Zhang","year":"2010","unstructured":"Zhang BJ, Yang LS, Wang WY et al (2010) Study on the selenium nutrition of children in Kaschin\u2013Beck disease endemic areas in Rangtang County, Sichuan Province. Ch J Prev Med 11(7):655\u2013658","journal-title":"Ch J Prev Med"},{"issue":"4","key":"9686_CR22","first-page":"56","volume":"2","author":"Q Liu","year":"1995","unstructured":"Liu Q, Su Q, Xie SH et al (1995) Condition and effect of selenium deficiency in Qinghai Plateau. Guangdong Trace Elem Sci 2(4):56\u201362","journal-title":"Guangdong Trace Elem Sci"},{"issue":"6","key":"9686_CR23","first-page":"214","volume":"12","author":"HZ Yan","year":"1995","unstructured":"Yan HZ, Gou YF, Su SG et al (1995) Studies on investigation selenium content distribution in blood of crowds in Qinghai-Tibet Plateau. J Environ Health 12(6):214\u2013242","journal-title":"J Environ Health"},{"issue":"2","key":"9686_CR24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12011-011-9232-5","volume":"146","author":"YF Yao","year":"2012","unstructured":"Yao YF, Pei FX, Li XB et al (2012) Preventive effects of supplemental selenium and selenium plus iodine on bone and cartilage development in rats fed with diet from Kaschin\u2013Beck disease endemic area. Biol Trace Elem Res 146(2):199\u2013206","journal-title":"Biol Trace Elem Res"},{"issue":"5","key":"9686_CR25","first-page":"480","volume":"29","author":"D Chen","year":"2010","unstructured":"Chen D, Xiong G, Xiao-dong Z et al (2010) Effect of selenium on proliferation and apoptosis of Kaschin\u2013Beck disease chondrocyte cultured in vitro. Chin J Endemiol 29(5):480\u2013484","journal-title":"Chin J Endemiol"},{"key":"9686_CR26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/ajcn\/78.1.137","volume":"78","author":"R Moreno-Reyes","year":"2003","unstructured":"Moreno-Reyes R, Mathieu F, Boelaert M et al (2003) Selenium and iodine supplementation of rural Tibetan children affected by Kaschin\u2013Beck osteoarthropathy. Am J Clin Nutr 78:137\u2013144","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"9686_CR27","first-page":"130","volume":"22","author":"S Zhaxi","year":"2007","unstructured":"Zhaxi S, Baima C, Xirao R et al (2007) Effect observation on Kaschin\u2013Beck disease control pilots in Tibet Autonomous Region. Chin J Ctrl Endem Dis 22(2):130\u2013131","journal-title":"Chin J Ctrl Endem Dis"},{"issue":"6","key":"9686_CR28","first-page":"710","volume":"26","author":"C Baima","year":"2007","unstructured":"Baima C, Zhaxi S, Xirao R et al (2007) Effect investigation on supplement selenium of Kaschin\u2013Beck disease in Lingzhou, Xiemengtong Counties, Tibet Autonomous Region. Chin J Endemiol 26(6):710","journal-title":"Chin J Endemiol"},{"issue":"1","key":"9686_CR29","first-page":"61","volume":"19","author":"HQ Gong","year":"2004","unstructured":"Gong HQ, Zhaxi S, Xirao R et al (2004) Effect observation on selenium\u2013iodine salt for Kaschin\u2013Beck disease control in Xiemengtong County, Tibet Autonomous Region. Endem Dis Bull 19(1):61\u201362","journal-title":"Endem Dis Bull"},{"issue":"1","key":"9686_CR30","first-page":"94","volume":"21","author":"YG Wang","year":"2005","unstructured":"Wang YG, Deng JY, Li DY (2005) Dynamic monitoring on Kaschin\u2013Beck disease in Aba County after 22 years. J Prev Medinf 21(1):94\u201396","journal-title":"J Prev Medinf"},{"key":"9686_CR31","unstructured":"Fan XH, Wang XL, Huang Y et al (2012) Prevalence state and analysis on children\u2019s Kaschin-Beck disease in Aba Area, Sichuan Province. Yi Yao Qian Yan 377\u2013378"},{"issue":"20","key":"9686_CR32","first-page":"4056","volume":"35","author":"FZ Li","year":"2008","unstructured":"Li FZ, Deng JY, Huang H et al (2008) Survey of Kaschin\u2013Beck disease activity and related influence factor in Sichuan Province in 2007. Mod Prev Med 35(20):4056\u20134062","journal-title":"Mod Prev Med"},{"key":"9686_CR33","first-page":"62","volume":"19","author":"Q Li","year":"2004","unstructured":"Li Q, Zhao ZHJ, Wen H (2004) Effective observation on children KBD: control with three different methods of selenium supplement in guide endemic area, Qinghai. Endem Dis Bull 19:62\u201364","journal-title":"Endem Dis Bull"},{"issue":"5","key":"9686_CR34","first-page":"522","volume":"29","author":"Q Li","year":"2010","unstructured":"Li Q, Zhao ZJ, Zhou LW et al (2010) Effect of changing grain and selenium supplementation on control of children\u2019s Kaschin\u2013Beck disease in Qinghai Province. Chin J Endemiol 29(5):522\u2013524","journal-title":"Chin J Endemiol"},{"issue":"5","key":"9686_CR35","first-page":"492","volume":"29","author":"Y Hui-zhen","year":"2010","unstructured":"Hui-zhen Y, Hai-kun W, Zhang Q et al (2010) Level investigation on children after supplement selenium of Kaschin\u2013Beck disease area in Xinghai County, Qinghai Province in 2008. Chin J Endemiol 29(5):492","journal-title":"Chin J Endemiol"},{"issue":"1","key":"9686_CR36","first-page":"118","volume":"31","author":"ZJ Zhao","year":"2012","unstructured":"Zhao ZJ, Li Q (2012) Result analysis on children\u2019s hair selenium supplied of Kaschin\u2013Beck disease area in guide county, Qinghai Province. Chin J Endemiol 31(1):118","journal-title":"Chin J Endemiol"},{"issue":"2","key":"9686_CR37","first-page":"130","volume":"26","author":"JH Chen","year":"2005","unstructured":"Chen JH, Chu YL, Yang ZT et al (2005) Effect of T-2 toxin on chondrocyte apoptosis and Bcl-2, Bex Expression. J Xian Jiaotong Univ (Med Sci) 26(2):130\u2013134","journal-title":"J Xian Jiaotong Univ (Med Sci)"},{"issue":"2","key":"9686_CR38","first-page":"84","volume":"20","author":"TF Yang","year":"2001","unstructured":"Yang TF, Jia ZQ, Shen B (2001) Effect of T-2 toxin on apoptosis of fetus chondrocyte. Chin J Endemiol 20(2):84\u201386","journal-title":"Chin J Endemiol"},{"issue":"3","key":"9686_CR39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1631\/jzus.B0900074","volume":"11","author":"A Zhang","year":"2010","unstructured":"Zhang A, Cao JL, Yang B et al (2010) Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kaschin\u2013Beck disease. J Zhejiang Univ-Sci B (Biomed Biotechnol) 11(3):200\u2013208","journal-title":"J Zhejiang Univ-Sci B (Biomed Biotechnol)"},{"key":"9686_CR40","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tiv.2010.12.001","volume":"25","author":"JH Chen","year":"2011","unstructured":"Chen JH, Chu YL, Cao JL et al (2011) Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), a2-macroglobulin (a2M) and TIMPs. Toxicol Vitr 25:492\u2013499","journal-title":"Toxicol Vitr"},{"issue":"1","key":"9686_CR41","first-page":"46","volume":"31","author":"Y Bo-quan","year":"2012","unstructured":"Bo-quan Y, Cao JL, Chen JH et al (2012) Effects of T-2 toxin and selenium expression of aggrecanase in human chondrocyte. Chin J Endemiol 31(1):46\u201350","journal-title":"Chin J Endemiol"},{"issue":"4","key":"9686_CR42","first-page":"381","volume":"26","author":"JH Chen","year":"2006","unstructured":"Chen JH, Chu YL, Yang ZT et al (2006) Protective effect of selenium against T-2 Toxin-induced inhibition of chondrocyte aggrecan and collagen II synthesis. J South Med Univ 26(4):381\u2013385","journal-title":"J South Med Univ"},{"issue":"1","key":"9686_CR43","first-page":"70","volume":"25","author":"SJ Li","year":"2006","unstructured":"Li SJ, Yang LS, Wang WY et al (2006) Relationship between selenium concentrations in child hair and the distribution of Kaschin\u2013Beck disease in Tibet, China. Chin J Endemiol 25(1):70\u201373","journal-title":"Chin J Endemiol"},{"issue":"1","key":"9686_CR44","first-page":"37","volume":"14","author":"DY Li","year":"1999","unstructured":"Li DY, Deng JY, Zhu L et al (1999) Survey analysis on Kaschin\u2013Beck disease prevalence and hair selenium content of children in endemic areas about 8 years. Chin J Ctrl Endem Dis 14(1):37\u201338","journal-title":"Chin J Ctrl Endem Dis"},{"issue":"4","key":"9686_CR45","first-page":"249","volume":"14","author":"JY Deng","year":"1999","unstructured":"Deng JY, Li DY, Liang DH et al (1999) The influence on selenium seen from the relationship between Kaschin\u2013Beck disease and selenium in Sichuan Province. Chin J Ctrl Endem Dis 14(4):249\u2013251","journal-title":"Chin J Ctrl Endem Dis"},{"issue":"1","key":"9686_CR46","first-page":"53","volume":"22","author":"Q Li","year":"2003","unstructured":"Li Q, Wen H, Ding SR et al (2003) Surveillance and analysis of Kaschin\u2013Beck diseases in guide county during 10 years (1992\u20132001). Chin J Endemiol 22(1):53\u201354","journal-title":"Chin J Endemiol"},{"issue":"6","key":"9686_CR47","first-page":"675","volume":"25","author":"Q Li","year":"2006","unstructured":"Li Q, Zhao ZJ (2006) Prevalence state of Kaschin\u2013Beck disease in Qinghai Province: a retrospective analysis. Chin J Endemiol 25(6):675\u2013677","journal-title":"Chin J Endemiol"},{"issue":"1","key":"9686_CR48","first-page":"1363","volume":"19","author":"QW Li","year":"2003","unstructured":"Li QW, Li J, Zhaxi ZD et al (2003) The strategies and measures of Kaschin\u2013Beck disease control in Qing-Tibet Plateau. Chin J Public Health 19(1):1363","journal-title":"Chin J Public Health"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-013-9686-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-013-9686-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-013-9686-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T08:16:22Z","timestamp":1563005782000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-013-9686-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":48,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["9686"],"URL":"https:\/\/doi.org\/10.1007\/s12011-013-9686-8","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}