{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:58:10Z","timestamp":1762459090135},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,7,28]],"date-time":"2013-07-28T00:00:00Z","timestamp":1374969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s12011-013-9752-2","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T08:16:49Z","timestamp":1374913009000},"page":"448-456","source":"Crossref","is-referenced-by-count":17,"title":["Role of Endoplasmic Reticulum Stress in Aberrant Activation of Fluoride-Treated Osteoblasts"],"prefix":"10.1007","volume":"154","author":[{"given":"Yu-lai","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,28]]},"reference":[{"key":"9752_CR1","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1002\/jbmr.5650051382","volume":"1","author":"G Boivin","year":"1990","unstructured":"Boivin G, Chavassieux P, Chapuy MC et al (1990) Skeletal fluorosis: histomorphometric findings. J Bone Miner Res Suppl 1:S185\u2013S189","journal-title":"J Bone Miner Res Suppl"},{"key":"9752_CR2","first-page":"277","volume":"26","author":"G Li","year":"1997","unstructured":"Li G, Ren L (1997) Effects of excess fluoride on bone turnover under conditions of diet with different calcium contents. Zhonghua Bing Li Xue Za Zhi 26:277\u2013280","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"9752_CR3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1139\/o11-034","volume":"89","author":"M Nair","year":"2011","unstructured":"Nair M, Belak ZR, Ovsenek N (2011) Effects of fluoride on expression of bone-specific genes in developing Xenopus laevis larvae. Biochem Cell Biol 89:377\u2013386","journal-title":"Biochem Cell Biol"},{"key":"9752_CR4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0022034510384626","volume":"90","author":"ET Everett","year":"2011","unstructured":"Everett ET (2011) Fluoride\u2019s effects on the formation of teeth and bones, and the influence of genetics. J Dent Res 90:552\u2013560","journal-title":"J Dent Res"},{"key":"9752_CR5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","volume":"569","author":"M Schroder","year":"2005","unstructured":"Schroder M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569:29\u201363","journal-title":"Mutat Res"},{"key":"9752_CR6","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/bit.23282","volume":"108","author":"A Chakrabarti","year":"2011","unstructured":"Chakrabarti A, Chen AW, Varner JD (2011) A review of the mammalian unfolded protein response. Biotechnol Bioeng 108:2777\u20132793","journal-title":"Biotechnol Bioeng"},{"key":"9752_CR7","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1074\/jbc.M110.152900","volume":"286","author":"A Saito","year":"2011","unstructured":"Saito A, Ochiai K, Kondo S et al (2011) Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem 286:4809\u20134818","journal-title":"J Biol Chem"},{"key":"9752_CR8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1074\/jbc.M111.253187","volume":"287","author":"WG Jang","year":"2012","unstructured":"Jang WG, Kim EJ, Kim DK et al (2012) BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription. J Biol Chem 287:905\u2013915","journal-title":"J Biol Chem"},{"key":"9752_CR9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/embor.2011.34","volume":"12","author":"T Tohmonda","year":"2011","unstructured":"Tohmonda T, Miyauchi Y, Ghosh R et al (2011) The IRE1\u03b1-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of osterix. EMBO Rep 12:451\u2013457","journal-title":"EMBO Rep"},{"key":"9752_CR10","first-page":"2228","volume":"123","author":"J Dequeker","year":"1993","unstructured":"Dequeker J, Declerck K, Schweiz MW (1993) Fluor in the treatment of osteoporosis. An overview of thirty years clinical research. Schweiz Med Wochenschr 123:2228\u20132234","journal-title":"Schweiz Med Wochenschr"},{"issue":"1\u20133","key":"9752_CR11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12011-007-8086-3","volume":"123","author":"H Xu","year":"2008","unstructured":"Xu H, Jing L, Li GS (2008) Proteomic analysis of osteoblasts exposed to fluoride in vitro. Biol Trace Elem Res 123(1\u20133):91\u20137","journal-title":"Biol Trace Elem Res"},{"key":"9752_CR12","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s12011-010-8881-0","volume":"143","author":"H Liu","year":"2011","unstructured":"Liu H, Sun JC, Zhao ZT (2011) Fluoride-induced oxidative stress in three-dimensional culture of OS732 cells and rats. Biol Trace Elem Res 143:446\u2013456","journal-title":"Biol Trace Elem Res"},{"key":"9752_CR13","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.yexcr.2010.05.011","volume":"316","author":"D Hong","year":"2010","unstructured":"Hong D, Chen HX, Yu HQ et al (2010) Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells. Exp Cell Res 316:2291\u20132300","journal-title":"Exp Cell Res"},{"key":"9752_CR14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12199-010-0181-y","volume":"16","author":"YE Song","year":"2011","unstructured":"Song YE, Tan H, Liu KJ et al (2011) Effect of fluoride exposure on bone metabolism indicators ALP, BALP, and BGP. Environ Health Prev Med 16:158\u2013163","journal-title":"Environ Health Prev Med"},{"key":"9752_CR15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11250-007-9069-2","volume":"40","author":"VK Bharti","year":"2008","unstructured":"Bharti VK, Gupta M, Lall D (2008) Ameliorative effects of boron on serum profile in buffalo (Bubalus bubalis) fed high fluoride ration. Trop Anim Health Prod 40:111\u2013116","journal-title":"Trop Anim Health Prod"},{"key":"9752_CR16","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","volume":"89","author":"T Komori","year":"1997","unstructured":"Komori T, Yagi H, Nomura S et al (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755\u2013764","journal-title":"Cell"},{"key":"9752_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","volume":"108","author":"K Nakashima","year":"2002","unstructured":"Nakashima K, Zhou X, Kunkel G et al (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17\u201329","journal-title":"Cell"},{"key":"9752_CR18","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1289\/ehp.11375","volume":"116","author":"R Sharma","year":"2008","unstructured":"Sharma R, Tsuchiya M, Bartlett JD (2008) Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion. Environ Health Perspect 116:1142\u20131146","journal-title":"Environ Health Perspect"},{"key":"9752_CR19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00204-008-0341-7","volume":"83","author":"M Ito","year":"2009","unstructured":"Ito M, Nakagawa H, Okada T et al (2009) ER-stress caused by accumulated intracistanal granules activates autophagy through a different signal pathway from unfolded protein response in exocrine pancreas cells of rats exposed to fluoride. Arch Toxicol 83:151\u2013159","journal-title":"Arch Toxicol"},{"key":"9752_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2010.08.006","volume":"277","author":"H Xu","year":"2010","unstructured":"Xu H, Zhou YL, Zhang XY et al (2010) Activation of PERK signaling through fluoride-mediated endoplasmic reticulum stress in OS732 cells. Toxicology 277:1\u20135","journal-title":"Toxicology"},{"key":"9752_CR21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00774-009-0117-z","volume":"28","author":"S Hino","year":"2010","unstructured":"Hino S, Kondo S, Yoshinaga K et al (2010) Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. J Bone Miner Metab 28:131\u2013138","journal-title":"J Bone Miner Metab"},{"key":"9752_CR22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jcp.21543","volume":"217","author":"J Wei","year":"2008","unstructured":"Wei J, Sheng X, Feng D et al (2008) PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol 217:693\u2013707","journal-title":"J Cell Physiol"},{"key":"9752_CR23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biocel.2005.09.018","volume":"38","author":"SB Cullinan","year":"2006","unstructured":"Cullinan SB, Diehl JA (2006) Coordination of ER and oxidative stress signaling: the PERK\/Nrf2 signaling pathway. Int J Biochem Cell Biol 38:317\u201332","journal-title":"Int J Biochem Cell Biol"},{"key":"9752_CR24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00204-011-0674-5","volume":"85","author":"L Baird","year":"2011","unstructured":"Baird L, Dinkova-Kostova AT (2011) The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol 85:241\u2013272","journal-title":"Arch Toxicol"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-013-9752-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-013-9752-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-013-9752-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T13:50:31Z","timestamp":1715781031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-013-9752-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,28]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["9752"],"URL":"https:\/\/doi.org\/10.1007\/s12011-013-9752-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,28]]}}}