{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:53:16Z","timestamp":1793962396765,"version":"4.8.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s12011-014-9922-x","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T23:20:15Z","timestamp":1393888815000},"page":"259-267","source":"Crossref","is-referenced-by-count":33,"title":["Zinc Modulates High Glucose-Induced Apoptosis by Suppressing Oxidative Stress in Renal Tubular Epithelial Cells"],"prefix":"10.1007","volume":"158","author":[{"given":"Xiuli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"9922_CR1","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.2337\/dc10-0596","volume":"33","author":"E Lapice","year":"2010","unstructured":"Lapice E, Pinelli M, Riccardi G et al (2010) Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients: comment on the study by Liu et al. Diabetes Care 33:e114, author reply e115","journal-title":"Diabetes Care"},{"key":"9922_CR2","first-page":"1445","volume":"96","author":"OE Ayodele","year":"2004","unstructured":"Ayodele OE, Alebiosu CO, Salako BL (2004) Diabetic nephropathy\u2014a review of the natural history, burden, risk factors and treatment. J Natl Med Assoc 96:1445\u20131454","journal-title":"J Natl Med Assoc"},{"key":"9922_CR3","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/sj.ki.5002531","volume":"72","author":"D Verzola","year":"2007","unstructured":"Verzola D, Gandolfo MT, Ferrario F et al (2007) Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int 72:1262\u20131272","journal-title":"Kidney Int"},{"key":"9922_CR4","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1159\/000076749","volume":"96","author":"D Kumar","year":"2004","unstructured":"Kumar D, Zimpelmann J, Robertson S et al (2004) Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney. Nephron Exp Nephrol 96:e77\u2013e88","journal-title":"Nephron Exp Nephrol"},{"key":"9922_CR5","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.fct.2011.06.012","volume":"49","author":"YJ Kim","year":"2011","unstructured":"Kim YJ, Kim YA, Yokozawa T et al (2011) Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells. Food Chem Toxicol 49:2196\u20132201","journal-title":"Food Chem Toxicol"},{"key":"9922_CR6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1523-1755.2000.00188.x","volume":"58","author":"A Ortiz","year":"2000","unstructured":"Ortiz A (2000) Nephrology forum: apoptotic regulatory proteins in renal injury. Kidney Int 58:467\u2013485","journal-title":"Kidney Int"},{"key":"9922_CR7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1681\/ASN.2005111148","volume":"17","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Wada J, Hashimoto I et al (2006) Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. J Am Soc Nephrol 17:1090\u20131101","journal-title":"J Am Soc Nephrol"},{"key":"9922_CR8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/db11-0141","volume":"61","author":"GJ Lau","year":"2012","unstructured":"Lau GJ, Godin N, Maachi H et al (2012) Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice. Diabetes 61:474\u2013484","journal-title":"Diabetes"},{"key":"9922_CR9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/10799893.2012.672994","volume":"32","author":"M Naziroglu","year":"2012","unstructured":"Naziroglu M (2012) Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system. J Recept Signal Transduct Res 32:134\u2013141","journal-title":"J Recept Signal Transduct Res"},{"key":"9922_CR10","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s11064-012-0850-x","volume":"37","author":"M Naziroglu","year":"2012","unstructured":"Naziroglu M, Dikici DM, Dursun S (2012) Role of oxidative stress and Ca(2)(+) signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels. Neurochem Res 37:2065\u20132075","journal-title":"Neurochem Res"},{"key":"9922_CR11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/sj.cdd.4401234","volume":"10","author":"N Ganju","year":"2003","unstructured":"Ganju N, Eastman A (2003) Zinc inhibits Bax and Bak activation and cytochrome c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways. Cell Death Differ 10:652\u2013661","journal-title":"Cell Death Differ"},{"key":"9922_CR12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s12011-012-9473-y","volume":"150","author":"X Zhang","year":"2012","unstructured":"Zhang X, Liang D, Ma J et al (2012) Zinc inhibits high glucose-induced apoptosis in peritoneal mesothelial cells. Biol Trace Elem Res 150:424\u2013432","journal-title":"Biol Trace Elem Res"},{"key":"9922_CR13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jtemb.2012.07.006","volume":"27","author":"A Karatug","year":"2013","unstructured":"Karatug A, Kaptan E, Bolkent S et al (2013) Alterations in kidney tissue following zinc supplementation to STZ-induced diabetic rats. J Trace Elem Med Biol 27:52\u201357","journal-title":"J Trace Elem Med Biol"},{"key":"9922_CR14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jnutbio.2009.01.009","volume":"20","author":"J Jansen","year":"2009","unstructured":"Jansen J, Karges W, Rink L (2009) Zinc and diabetes\u2014clinical links and molecular mechanisms. J Nutr Biochem 20:399\u2013417","journal-title":"J Nutr Biochem"},{"key":"9922_CR15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","volume":"138","author":"D Wessel","year":"1984","unstructured":"Wessel D, Flugge UI (1984) A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138:141\u2013143","journal-title":"Anal Biochem"},{"key":"9922_CR16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cellsig.2012.12.013","volume":"25","author":"X Zhang","year":"2013","unstructured":"Zhang X, Liang D, Chi ZH et al (2013) Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. Cell Signal 25:999\u20131010","journal-title":"Cell Signal"},{"key":"9922_CR17","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1590\/S0100-879X2011007500078","volume":"44","author":"LY Zhang","year":"2011","unstructured":"Zhang LY, Zhou YY, Deng YW et al (2011) Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter\/ERK signaling pathway. Braz J Med Biol Res 44:618\u2013623","journal-title":"Braz J Med Biol Res"},{"key":"9922_CR18","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ars.2010.3211","volume":"13","author":"NF Villeneuve","year":"2010","unstructured":"Villeneuve NF, Lau A, Zhang DD (2010) Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal 13:1699\u20131712","journal-title":"Antioxid Redox Signal"},{"key":"9922_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","volume":"192","author":"JL Martindale","year":"2002","unstructured":"Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1\u201315","journal-title":"J Cell Physiol"},{"key":"9922_CR20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.archoralbio.2007.01.005","volume":"52","author":"T Nishiura","year":"2007","unstructured":"Nishiura T, Abe K (2007) Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells. Arch Oral Biol 52:778\u2013785","journal-title":"Arch Oral Biol"},{"key":"9922_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-013-8417-7","volume":"48","author":"N Singla","year":"2013","unstructured":"Singla N, Dhawan DK (2013) Zinc, a neuroprotective agent against aluminum-induced oxidative DNA injury. Mol Neurobiol 48:1\u201312","journal-title":"Mol Neurobiol"},{"key":"9922_CR22","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.2337\/diabetes.50.9.2040","volume":"50","author":"H Chen","year":"2001","unstructured":"Chen H, Carlson EC, Epstein PN et al (2001) Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes 50:2040\u20132046","journal-title":"Diabetes"},{"key":"9922_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:112:1:1","volume":"112","author":"MN Batista","year":"2006","unstructured":"Batista MN, Cuppari L, de Medeiros AC et al (2006) Effect of end-stage renal disease and diabetes on zinc and copper status. Biol Trace Elem Res 112:1\u201312","journal-title":"Biol Trace Elem Res"},{"key":"9922_CR24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2337\/dc06-1682","volume":"30","author":"M Soinio","year":"2007","unstructured":"Soinio M, Marniemi J, Lehto S, Ronnemaa T (2007) Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care 30:523\u2013528","journal-title":"Diabetes Care"},{"key":"9922_CR25","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.freeradbiomed.2012.07.008","volume":"53","author":"SD Kumar","year":"2012","unstructured":"Kumar SD, Vijaya M, Watt F et al (2012) Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice. Free Radic Biol Med 53:1595\u20131606","journal-title":"Free Radic Biol Med"},{"key":"9922_CR26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/cdd.2013.25","volume":"20","author":"P Tripathi","year":"2013","unstructured":"Tripathi P, Koss B, Opferman JT et al (2013) Mcl-1 antagonizes Bax\/Bak to promote effector CD4(+) and CD8(+) T-cell responses. Cell Death Differ 20:998\u20131007","journal-title":"Cell Death Differ"},{"key":"9922_CR27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s12011-012-9387-8","volume":"148","author":"D Liang","year":"2012","unstructured":"Liang D, Yang M, Guo B et al (2012) Zinc inhibits H(2)O(2)-induced MC3T3-E1 cells apoptosis via MAPK and PI3K\/AKT pathways. Biol Trace Elem Res 148:420\u2013429","journal-title":"Biol Trace Elem Res"},{"key":"9922_CR28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ajcn\/71.1.81","volume":"71","author":"P Meerarani","year":"2000","unstructured":"Meerarani P, Ramadass P, Toborek M et al (2000) Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am J Clin Nutr 71:81\u201387","journal-title":"Am J Clin Nutr"},{"key":"9922_CR29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1534-5807(02)00151-X","volume":"2","author":"JJ Bruinsma","year":"2002","unstructured":"Bruinsma JJ, Jirakulaporn T, Muslin AJ et al (2002) Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev Cell 2:567\u2013578","journal-title":"Dev Cell"},{"key":"9922_CR30","doi-asserted-by":"crossref","first-page":"28258","DOI":"10.1074\/jbc.M303318200","volume":"278","author":"W Wu","year":"2003","unstructured":"Wu W, Wang X, Samet JM et al (2003) Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J Biol Chem 278:28258\u201328263","journal-title":"J Biol Chem"},{"key":"9922_CR31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.trsl.2008.06.001","volume":"152","author":"B Bao","year":"2008","unstructured":"Bao B, Prasad AS, Beck FW et al (2008) Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl Res 152:67\u201380","journal-title":"Transl Res"},{"key":"9922_CR32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00232-012-9512-9","volume":"246","author":"M Naziroglu","year":"2013","unstructured":"Naziroglu M, Yoldas N, Uzgur EN et al (2013) Role of contrast media on oxidative stress, Ca(2+) signaling and apoptosis in kidney. J Membr Biol 246:91\u2013100","journal-title":"J Membr Biol"},{"key":"9922_CR33","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","volume":"25","author":"AY Shih","year":"2005","unstructured":"Shih AY, Li P, Murphy TH (2005) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 25:10321\u201310335","journal-title":"J Neurosci"},{"key":"9922_CR34","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1096\/fj.03-1127fje","volume":"18","author":"HY Cho","year":"2004","unstructured":"Cho HY, Reddy SP, Yamamoto M et al (2004) The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 18:1258\u20131260","journal-title":"FASEB J"},{"key":"9922_CR35","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1096\/fj.06-5097fje","volume":"20","author":"MO Leonard","year":"2006","unstructured":"Leonard MO, Kieran NE, Howell K et al (2006) Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J 20:2624\u20132626","journal-title":"FASEB J"},{"key":"9922_CR36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ki.2009.157","volume":"76","author":"M Liu","year":"2009","unstructured":"Liu M, Grigoryev DN, Crow MT et al (2009) Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int 76:277\u2013285","journal-title":"Kidney Int"},{"key":"9922_CR37","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1365-2443.2008.01234.x","volume":"13","author":"K Yoh","year":"2008","unstructured":"Yoh K, Hirayama A, Ishizaki K et al (2008) Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells 13:1159\u20131170","journal-title":"Genes Cells"},{"key":"9922_CR38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1016-8478(23)07386-7","volume":"23","author":"Y Fan","year":"2007","unstructured":"Fan Y, Chen H, Qiao B et al (2007) Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione. Mol Cells 23:30\u201338","journal-title":"Mol Cells"},{"key":"9922_CR39","doi-asserted-by":"crossref","first-page":"42769","DOI":"10.1074\/jbc.M206911200","volume":"277","author":"HC Huang","year":"2002","unstructured":"Huang HC, Nguyen T, Pickett CB (2002) Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277:42769\u201342774","journal-title":"J Biol Chem"},{"key":"9922_CR40","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/bbrc.2000.3830","volume":"278","author":"LM Zipper","year":"2000","unstructured":"Zipper LM, Mulcahy RT (2000) Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochem Biophys Res Commun 278:484\u2013492","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-014-9922-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-014-9922-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-014-9922-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T19:12:06Z","timestamp":1716577926000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-014-9922-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["9922"],"URL":"https:\/\/doi.org\/10.1007\/s12011-014-9922-x","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,4]]}}}