{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:08:41Z","timestamp":1773212921688,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T00:00:00Z","timestamp":1433808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s12011-015-0381-9","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T02:50:59Z","timestamp":1433731859000},"page":"94-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Protective Effect of Bafilomycin A1 Against Cobalt Nanoparticle-Induced Cytotoxicity and Aseptic Inflammation in Macrophages In Vitro"],"prefix":"10.1007","volume":"169","author":[{"given":"Songhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"381_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1749-799X-9-3","volume":"9","author":"J Smith","year":"2014","unstructured":"Smith J, Lee D, Bali K, Railton P, Kinniburgh D, Faris P, Marshall D, Burkart B, Powell J (2014) Does bearing size influence metal ion levels in large-head metal-on-metal total hip arthroplasty? A comparison of three total hip systems. J Orthop Surg Res 9:3","journal-title":"J Orthop Surg Res"},{"key":"381_CR2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12011-011-9221-8","volume":"146","author":"H Jiang","year":"2012","unstructured":"Jiang H, Liu F, Yang H, Li Y (2012) Effects of cobalt nanoparticles on human T cells in vitro. Biol Trace Elem Res 146:23\u201329","journal-title":"Biol Trace Elem Res"},{"key":"381_CR3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jat.2957","volume":"34","author":"A Avalos","year":"2014","unstructured":"Avalos A, Haza AI, Mateo D, Morales P (2014) Cytotoxicity and ROS production of manufactured silver nanoparticles of different sizes in hepatoma and leukemia cells. J Appl Toxicol 34:413\u2013423","journal-title":"J Appl Toxicol"},{"key":"381_CR4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/(SICI)1097-4636(199810)42:1<103::AID-JBM13>3.0.CO;2-M","volume":"42","author":"PF Doorn","year":"1988","unstructured":"Doorn PF, Campbell PA, Worrall J, Benya PD, McKellop HA, Amstutz HC (1988) Metal wear particle characterization from metal on metal total hip replacements: transmission electron microscopy study of periprosthetic tissues and isolated particles. J Biomed Mater Res 42:103\u2013111","journal-title":"J Biomed Mater Res"},{"key":"381_CR5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jor.20837","volume":"27","author":"JM Queally","year":"2009","unstructured":"Queally JM, Devitt BM, Butler JS, Malizia AP, Murray D, Doran PP, O\u2019Byrne JM (2009) Cobalt ions induce chemokine secretion in primary human osteoblasts. J Orthop Res 27:855\u2013864","journal-title":"J Orthop Res"},{"key":"381_CR6","doi-asserted-by":"crossref","unstructured":"Stryker LS, Odum SM, Fehring TK, Springer BD (2015) Revisions of monoblock metal-on-metal THAs have high early complication rates. Clin Orthop Relat Res 473:469\u2013474","DOI":"10.1007\/s11999-014-3791-7"},{"key":"381_CR7","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.arth.2013.06.022","volume":"28","author":"KT Hwang","year":"2013","unstructured":"Hwang KT, Kim YH, Kim YS, Choi IY (2013) Is second generation metal-on-metal primary total hip arthroplasty with a 28\u00a0mm head a worthy option?: a 12- to 18-year follow-up study. J Arthroplast 28:1828\u20131833","journal-title":"J Arthroplast"},{"key":"381_CR8","doi-asserted-by":"crossref","first-page":"025018","DOI":"10.1088\/1748-6041\/4\/2\/025018","volume":"4","author":"YM Kwon","year":"2009","unstructured":"Kwon YM, Xia Z, Glyn-Jones S, Beard D, Gill HS, Murray DW (2009) Dose-dependent cytotoxicity of clinically relevant cobalt nanoparticles and ions on macrophages in vitro. Biomed Mater 4:025018","journal-title":"Biomed Mater"},{"key":"381_CR9","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1016\/j.actbio.2012.05.003","volume":"8","author":"AJ Hart","year":"2012","unstructured":"Hart AJ, Quinn PD, Lali F, Sampson B, Skinner JA, Powell JJ, Nolan J, Tucker K, Donell S, Flanagan A, Mosselmans JF (2012) Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for periprosthetic tissue reactions. Acta Biomater 8:3865\u20133873","journal-title":"Acta Biomater"},{"key":"381_CR10","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/jbm.a.34122","volume":"100","author":"A Dalal","year":"2012","unstructured":"Dalal A, Pawar V, McAllister K, Weaver C, Hallab NJ (2012) Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages. J Biomed Mater Res A 100:2147\u20132158","journal-title":"J Biomed Mater Res A"},{"key":"381_CR11","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/1748-6041\/1\/1\/R01","volume":"1","author":"Z Xia","year":"2006","unstructured":"Xia Z, Triffitt JT (2006) A review on macrophage responses to biomaterials. Biomed Mater 1:R1\u2013R9","journal-title":"Biomed Mater"},{"key":"381_CR12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.nano.2011.08.002","volume":"7","author":"Z Xia","year":"2011","unstructured":"Xia Z, Kwon YM, Mehmood S, Downing C, Jurkschat K, Murray DW (2011) Characterization of metal-wear nanoparticles in pseudotumor following metal-on-metal hip resurfacing. Nanomedicine 7:674\u2013681","journal-title":"Nanomedicine"},{"key":"381_CR13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-8977-11-14","volume":"11","author":"R Ortega","year":"2014","unstructured":"Ortega R, Bresson C, Darolles C, Gautier C, Roudeau S, Perrin L, Janin M, Floriani M, Aloin V, Carmona A, Malard V (2014) Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells. Part Fibre Toxicol 11:14","journal-title":"Part Fibre Toxicol"},{"key":"381_CR14","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1016\/j.biomaterials.2013.01.085","volume":"34","author":"VK Raghunathan","year":"2013","unstructured":"Raghunathan VK, Devey M, Hawkins S, Hails L, Davis SA, Mann S, Chang IT, Ingham E, Malhas A, Vaux DJ, Lane JD, Case CP (2013) Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity. Biomaterials 34:3559\u20133570","journal-title":"Biomaterials"},{"key":"381_CR15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.biomaterials.2004.05.017","volume":"26","author":"T Masui","year":"2005","unstructured":"Masui T, Sakano S, Hasegawa Y, Warashina H, Ishiguro N (2005) Expression of inflammatory cytokines, RANKL and OPG induced by titanium, cobalt-chromium and polyethylene particles. Biomaterials 26:1695\u20131702","journal-title":"Biomaterials"},{"key":"381_CR16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1302\/0301-620X.80B3.8158","volume":"80","author":"SB Goodman","year":"1998","unstructured":"Goodman SB, Huie P, Song Y, Schurman D, Maloney W, Woolson S, Sibley R (1998) Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. J Bone Joint Surg Br 80:531\u2013539","journal-title":"J Bone Joint Surg Br"},{"key":"381_CR17","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/jbm.a.32627","volume":"93","author":"MS Caicedo","year":"2010","unstructured":"Caicedo MS, Pennekamp PH, McAllister K, Jacobs JJ, Hallab NJ (2010) Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res A 93:1312\u20131321","journal-title":"J Biomed Mater Res A"},{"key":"381_CR18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00003086-199602000-00045","volume":"323","author":"DR Haynes","year":"1996","unstructured":"Haynes DR, Rogers SD, Howie DW, Pearcy MJ, Vernon-Roberts B (1996) Drug inhibition of the macrophage response to metal wear particles in vitro. Clin Orthop Relat Res 323:316\u2013326","journal-title":"Clin Orthop Relat Res"},{"key":"381_CR19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1243\/095441103765212659","volume":"217","author":"S Williams","year":"2003","unstructured":"Williams S, Tipper JL, Ingham E, Stone MH, Fisher J (2003) In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacements. Proc Inst Mech Eng H J Eng Med 217:155\u2013163","journal-title":"Proc Inst Mech Eng H J Eng Med"},{"key":"381_CR20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.taap.2008.08.022","volume":"233","author":"R Wan","year":"2008","unstructured":"Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q (2008) Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation. Toxicol Appl Pharmacol 233:276\u2013285","journal-title":"Toxicol Appl Pharmacol"},{"key":"381_CR21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12012-009-9040-8","volume":"9","author":"IT Mak","year":"2009","unstructured":"Mak IT, Chmielinska JJ, Kramer JH, Weglicki WB (2009) AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation. Cardiovasc Toxicol 9:78\u201385","journal-title":"Cardiovasc Toxicol"},{"key":"381_CR22","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1139\/y2012-104","volume":"90","author":"IT Mak","year":"2012","unstructured":"Mak IT, Landgraf KM, Chmielinska JJ, Weglicki WB (2012) Angiotensin II promotes iron accumulation and depresses PGI2 and NO synthesis in endothelial cells: effects of losartan and propranolol analogs. Can J Physiol Pharmacol 90:1413\u20131418","journal-title":"Can J Physiol Pharmacol"},{"key":"381_CR23","doi-asserted-by":"crossref","unstructured":"Zhang JQ, Shen M, Zhu CC, Yu FX, Liu ZQ, Ally N, Sun SC, Li K, Liu HL (2014) 3-Nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse. PLoS ONE 9: e86589.","DOI":"10.1371\/journal.pone.0086589"},{"key":"381_CR24","doi-asserted-by":"crossref","unstructured":"Li HX, Xiao Y, Cao LL, Yan X, Li C, Shi HY, Wang JW, Ye YH (2013) Cerebroside C increases tolerance to chilling injury and alters lipid composition in wheat roots. PLoS ONE 8:e73380.","DOI":"10.1371\/journal.pone.0073380"},{"key":"381_CR25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588\u2013590","journal-title":"Science"},{"key":"381_CR26","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/C2CP42968C","volume":"15","author":"Y Liao","year":"2013","unstructured":"Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L (2013) CoCrMo metal-on-metal hip replacements. Phys Chem Chem Phys 15:746\u2013756","journal-title":"Phys Chem Chem Phys"},{"key":"381_CR27","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.tiv.2013.04.008","volume":"27","author":"C Darolles","year":"2013","unstructured":"Darolles C, Sage N, Armengaud J, Malard V (2013) In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference. Toxicol In Vitro 27:1699\u20131710","journal-title":"Toxicol In Vitro"},{"key":"381_CR28","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1021\/tx800179f","volume":"21","author":"CY Jin","year":"2008","unstructured":"Jin CY, Zhu BS, Wang XF, Lu QH (2008) Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells. Chem Res Toxicol 21:1871\u20131877","journal-title":"Chem Res Toxicol"},{"key":"381_CR29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/mutage\/gep027","volume":"24","author":"J Ponti","year":"2009","unstructured":"Ponti J, Sabbioni E, Munaro B, Broggi F, Marmorato P, Franchini F, Colognato R, Rossi F (2009) Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb\/3T3 mouse fibroblasts. Mutagenesis 24:439\u2013445","journal-title":"Mutagenesis"},{"key":"381_CR30","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1021\/es062629t","volume":"41","author":"LK Limbach","year":"2007","unstructured":"Limbach LK, Wick P, Manser P, Grass RN, Bruinink A, Stark WJ (2007) Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. Environ Sci Technol 41:4158\u20134163","journal-title":"Environ Sci Technol"},{"key":"381_CR31","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.tiv.2009.12.001","volume":"24","author":"EJ Park","year":"2010","unstructured":"Park EJ, Yi J, Kim Y, Choi K, Park K (2010) Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol in Vitro 24:872\u2013878","journal-title":"Toxicol in Vitro"},{"key":"381_CR32","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/smll.201201069","volume":"9","author":"P Cronholm","year":"2013","unstructured":"Cronholm P, Karlsson HL, Hedberg J, Lowe TA, Winnberg L, Elihn K, Wallinder IO, M\u00f6ller L (2013) Intracellular uptake and toxicity of Ag and CuO nanoparticles: a comparison between nanoparticles and their corresponding metal ions. Small 9:970\u2013982","journal-title":"Small"},{"key":"381_CR33","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/nn800511k","volume":"2","author":"T Xia","year":"2008","unstructured":"Xia T, Kovochich M, Liong M, M\u00e4dler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2:2121\u20132134","journal-title":"ACS Nano"},{"key":"381_CR34","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1016\/j.biomaterials.2010.02.074","volume":"31","author":"Y Su","year":"2010","unstructured":"Su Y, Hu M, Fan C, He Y, Li Q, Li W, Wang LH, Shen P, Huang Q (2010) The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials 31:4829\u20134834","journal-title":"Biomaterials"},{"key":"381_CR35","first-page":"182","volume":"67","author":"NJ Hallab","year":"2009","unstructured":"Hallab NJ, Jacobs JJ (2009) Biologic effects of implant debris. Bull NYU Hosp Jt Dis 67:182\u2013188","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"381_CR36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jbm.a.10352","volume":"64","author":"JB Lewis","year":"2003","unstructured":"Lewis JB, Randol TM, Lockwood PE, Wataha JC (2003) Effect of subtoxic concentrations of metal ions on NFkappaB activation in THP-1 human monocytes. J Biomed Mater Res A 64:217\u2013224","journal-title":"J Biomed Mater Res A"},{"key":"381_CR37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jbm.a.31467","volume":"84","author":"AM Kaufman","year":"2008","unstructured":"Kaufman AM, Alabre CI, Rubash HE, Shanbhag AS (2008) Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: analysis of multiple cytokines using protein arrays. J Biomed Mater Res A 84:464\u2013474","journal-title":"J Biomed Mater Res A"},{"key":"381_CR38","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/000164702321022767","volume":"73","author":"PA Campbell","year":"2002","unstructured":"Campbell PA, Wang M, Amstutz HC, Goodman SB (2002) Positive cytokine production in failed metal-on-metal total hip replacements. Acta Orthop Scand 73:506\u2013512","journal-title":"Acta Orthop Scand"},{"key":"381_CR39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0142-9612(02)00351-4","volume":"24","author":"I Catelas","year":"2003","unstructured":"Catelas I, Petit A, Zukor DJ, Antoniou J, Huk OL (2003) TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro-qualitative analysis of apoptosis. Biomaterials 24:383\u2013391","journal-title":"Biomaterials"},{"key":"381_CR40","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.actbio.2012.01.033","volume":"8","author":"V Thomas","year":"2012","unstructured":"Thomas V, Halloran BA, Ambalavanan N, Catledge SA, Vohra YK (2012) In vitro studies on the effect of particle size on macrophage responses to nanodiamond wear debris. Acta Biomater 8:1939\u20131947","journal-title":"Acta Biomater"},{"key":"381_CR41","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.biomaterials.2004.04.035","volume":"26","author":"E Ingham","year":"2005","unstructured":"Ingham E, Fisher J (2005) The role of macrophages in osteolysis of total joint replacement. Biomaterials 26:1271\u20131286","journal-title":"Biomaterials"},{"key":"381_CR42","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jor.1100180321","volume":"18","author":"EM Schwarz","year":"2000","unstructured":"Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O\u2019Keefe RJ (2000) Tumor necrosis factor-alpha\/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res 18:472\u2013480","journal-title":"J Orthop Res"},{"key":"381_CR43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jor.1100140107","volume":"14","author":"SM Algan","year":"1996","unstructured":"Algan SM, Purdon M, Horowitz SM (1996) Role of tumor necrosis factor alpha in particulate-induced bone resorption. J Orthop Res 14:30\u201335","journal-title":"J Orthop Res"},{"key":"381_CR44","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1016\/j.biomaterials.2010.03.046","volume":"31","author":"SB Goodman","year":"2010","unstructured":"Goodman SB, Ma T (2010) Cellular chemotaxis induced by wear particles from joint replacements. Biomaterials 31:5045\u20135050","journal-title":"Biomaterials"},{"key":"381_CR45","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/17453670510041321","volume":"76","author":"NJ Epstein","year":"2005","unstructured":"Epstein NJ, Bragg WE, Ma T, Spanogle J, Smith RL, Goodman SB (2005) UHMWPE wear debris upregulates mononuclear cell proinflammatory gene expression in a novel murine model of intramedullary particle disease. Acta Orthop 76:412\u2013420","journal-title":"Acta Orthop"},{"key":"381_CR46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/01.bor.0000198004.88568.96","volume":"18","author":"RJ Looney","year":"2006","unstructured":"Looney RJ, Schwarz EM, Boyd A, O\u2019Keefe RJ (2006) Periprosthetic osteolysis: an immunologist\u2019s update. Curr Opin Rheumatol 18:80\u201387","journal-title":"Curr Opin Rheumatol"},{"key":"381_CR47","doi-asserted-by":"crossref","unstructured":"Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ (2008) Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res 3:\u20136","DOI":"10.1186\/1749-799X-3-6"},{"key":"381_CR48","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","volume":"28","author":"SB Goodman","year":"2007","unstructured":"Goodman SB (2007) Wear particles, periprosthetic osteolysis and the immune system. Biomaterials 28:5044\u20135048","journal-title":"Biomaterials"},{"key":"381_CR49","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2106\/JBJS.F.00453","volume":"88","author":"JJ Jacobs","year":"2006","unstructured":"Jacobs JJ, Hallab NJ (2006) Loosening and osteolysis associated with metal-on-metal bearings: a local effect of metal hypersensitivity? J Bone Joint Surg Am 88:1171\u20131172","journal-title":"J Bone Joint Surg Am"},{"key":"381_CR50","first-page":"69","volume":"30","author":"Heung Mook Shin","year":"2009","unstructured":"Shin HM (2009) Mixture of wild panax ginseng and red-mold rice extracts activates macrophages through protection of cell regression and cytokine expression in methotrexate-treated RAW264.7 cells. J Korean Orient Med 30:69\u201379","journal-title":"J Korean Orient Med"},{"key":"381_CR51","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tox.2005.05.007","volume":"213","author":"JR Gurr","year":"2005","unstructured":"Gurr JR, Wang AS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66\u201373","journal-title":"Toxicology"},{"key":"381_CR52","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","volume":"311","author":"A Nel","year":"2006","unstructured":"Nel A, Xia T, M\u00e4dler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622\u2013627","journal-title":"Science"},{"key":"381_CR53","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jhazmat.2013.01.046","volume":"248-249","author":"H Liu","year":"2013","unstructured":"Liu H, Yang D, Yang H, Zhang H, Zhang W, Fang Y, Lin Z, Tian L, Lin B, Yan J, Xi Z (2013) Comparative study of respiratory tract immune toxicity induced by three sterilisation nanoparticles: silver, zinc oxide and titanium dioxide. J Hazard Mater 248-249:478\u2013486","journal-title":"J Hazard Mater"},{"key":"381_CR54","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.nano.2011.04.005","volume":"7","author":"YF Zhang","year":"2011","unstructured":"Zhang YF, Zheng YF, Qin L (2011) A comprehensive biological evaluation of ceramic nanoparticles as wear debris. Nanomedicine 7:975\u2013982","journal-title":"Nanomedicine"},{"key":"381_CR55","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.biomaterials.2009.11.107","volume":"31","author":"O Roualdes","year":"2010","unstructured":"Roualdes O, Duclos ME, Gutknecht D, Frappart L, Chevalier J, Hartmann DJ (2010) In vitro and in vivo evaluation of an alumina-zirconia composite for arthroplasty applications. Biomaterials 31:2043\u20132054","journal-title":"Biomaterials"},{"key":"381_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2010.01.012","volume":"697","author":"A Tsaousi","year":"2010","unstructured":"Tsaousi A, Jones E, Case CP (2010) The in vitro genotoxicity of orthopaedic ceramic (Al2O3) and metal (CoCr alloy) particles. Mutat Res 697:1\u20139","journal-title":"Mutat Res"},{"key":"381_CR57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.tiv.2015.02.004","volume":"29","author":"K Niska","year":"2015","unstructured":"Niska K, Santos-Martinez MJ, Radomski MW, Inkielewicz-Stepniak I (2015) CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin. Toxicol in Vitro 29:663\u2013671","journal-title":"Toxicol in Vitro"},{"key":"381_CR58","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1023\/A:1012800813662","volume":"12","author":"I Catelas","year":"2001","unstructured":"Catelas I, Petit A, Zukor DJ, Huk OL (2001) Cytotoxic and apoptotic effects of cobalt and chromium ions on J774 macrophages-implication of caspase-3 in the apoptotic pathway. J Mater Sci Mater Med 12:949\u2013953","journal-title":"J Mater Sci Mater Med"},{"key":"381_CR59","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/jbm.b.32704","volume":"100","author":"SF Rose","year":"2012","unstructured":"Rose SF, Weaver CL, Fenwick SA, Horner A, Pawar VD (2012) The effect of diffusion hardened oxidized zirconium wear debris on cell viability and inflammation\u2014an in vitro study. J Biomed Mater Res B Appl Biomater 100:1359\u20131368","journal-title":"J Biomed Mater Res B Appl Biomater"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-015-0381-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-015-0381-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-015-0381-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T11:34:25Z","timestamp":1717932865000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-015-0381-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["381"],"URL":"https:\/\/doi.org\/10.1007\/s12011-015-0381-9","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}