{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:54:19Z","timestamp":1783958059136,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s12011-017-0964-8","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T06:12:03Z","timestamp":1487657523000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium"],"prefix":"10.1007","volume":"179","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"964_CR1","unstructured":"P.R.China Ministry of Health (2012) The prevention and control status of Kaschin-Beck disease in 2011. Available at: http:\/\/www.nhfpcgovcn\/htmlfiles\/zwgkzt\/ptjnj\/year2012\/index2012html"},{"issue":"11","key":"964_CR2","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","volume":"22","author":"X Guo","year":"2014","unstructured":"Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ (2014) Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthr Cartil 22(11):1774\u20131783. doi: 10.1016\/j.joca.2014.07.023","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"964_CR3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s002640100248","volume":"25","author":"G Xiong","year":"2001","unstructured":"Xiong G (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop 25(3):147\u2013150","journal-title":"Int Orthop"},{"issue":"5","key":"964_CR4","first-page":"350","volume":"29","author":"Y Kong","year":"2014","unstructured":"Kong Y, Pubu C, Wang J, Jiangcu Q, Zewang G, Duzhu S (2014) To investigate and analyze the condition of Kashin-Beck disease around 7\u201312\u00a0years old children in Bianba county of Tibet in 2013. Chin J Ctrl Endem Dis 29(5):350\u2013351","journal-title":"Chin J Ctrl Endem Dis"},{"issue":"2","key":"964_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/15287399209531597","volume":"35","author":"A Peng","year":"1992","unstructured":"Peng A, Yang C, Rui H, Li H (1992) Study on the pathogenic factors of Kashin-Beck disease. J Toxicol Environ Health 35(2):79\u201390. doi: 10.1080\/15287399209531597","journal-title":"J Toxicol Environ Health"},{"issue":"2","key":"964_CR6","first-page":"99","volume":"4","author":"X Guo","year":"1992","unstructured":"Guo X, Shiyuan Z, Dongxu M (1992) The role of low selenium in occurence of Kashin-Beck Disese. J Xi\u2019 an M ED UN IV (S) 4(2):99\u2013108","journal-title":"J Xi\u2019 an M ED UN IV (S)"},{"key":"964_CR7","unstructured":"Dongxu M (1986) Pathology of selenium deficiency in Kashin-Beck disease. In: Selenium in Biology and Medicine. No strand Reinhold Company, New York"},{"issue":"1","key":"964_CR8","first-page":"18","volume":"12","author":"M Dongxu","year":"1997","unstructured":"Dongxu M, Dexiu D, Zhilun W (1997) Study on relationship between selenium and Kashin-Beck disease in 20\u00a0years. Chinese J Control Endem Dis 12(1):18\u201321","journal-title":"Chinese J Control Endem Dis"},{"issue":"2","key":"964_CR9","first-page":"119","volume":"9","author":"M Dongxu","year":"1990","unstructured":"Dongxu M, Lu S, Chai B (1990) Progress of the relationship between low selenium and Kashin-Beck disease. Chinese J of Endemic 9(2):119\u2013121","journal-title":"Chinese J of Endemic"},{"key":"964_CR10","first-page":"118","volume":"9","author":"X Guo","year":"1999","unstructured":"Guo X, Dexiu D, Wang Z, Lu S, Guo J, Tan X, Dong G, Peipu Y, Ma C, Wenxin C, Wenzhen H (1999) A study on the reparative action of X-ray lesions in metaphyses and distal end of bone in children\u2019s fingers with Kashin-Beck disease treated by Se-fortified wheat. Chinese J of Control of Endemic Diseases 9:118\u2013120","journal-title":"Chinese J of Control of Endemic Diseases"},{"issue":"7","key":"964_CR11","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","volume":"16","author":"T Fukada","year":"2011","unstructured":"Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T (2011) Zinc homeostasis and signaling in health and diseases: zinc signaling. Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry 16(7):1123\u20131134. doi: 10.1007\/s00775-011-0797-4","journal-title":"Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry"},{"issue":"4","key":"964_CR12","first-page":"238","volume":"3","author":"S Zhang","year":"1988","unstructured":"Zhang S, Guo X, Li S, Wang H (1988) The relationship between zinc and Kashin-Beck disease. Chinese Journal of Control of Endemic Disenaces 3(4):238\u2013239","journal-title":"Chinese Journal of Control of Endemic Disenaces"},{"issue":"5","key":"964_CR13","first-page":"281","volume":"13","author":"C Bai","year":"1994","unstructured":"Bai C, Lv S, Wang Z (1994) Determination of hair zinc contents in children from Kashin-Beck endemic area in Shaanxi province. Chinese Journal of Endemiology 13(5):281\u2013282","journal-title":"Chinese Journal of Endemiology"},{"issue":"5","key":"964_CR14","first-page":"285","volume":"7","author":"P Huang","year":"1996","unstructured":"Huang P, Yang G, Cui C, Wang S (1996) Comparative analysis zinc content in children aged 7\u201312 with Kashin Beck disease in ten years. Henan journal of preventive medicine 7(5):285\u2013286","journal-title":"Henan journal of preventive medicine"},{"issue":"2","key":"964_CR15","first-page":"163","volume":"17","author":"Y Lei","year":"1996","unstructured":"Lei Y, Xu G, Yang Y (1996) Comparative detection of hair Cu, Zn, Fe, Mn contents of children from Keshan disease and Kashin-Beck disease co-existing endemic area. Journal of Xi\u2019an Medical University 17(2):163\u2013164","journal-title":"Journal of Xi\u2019an Medical University"},{"key":"964_CR16","first-page":"111","volume":"2","author":"Z Yu","year":"1993","unstructured":"Yu Z (1993) Determination of zinc content in Qinling Mountain KBD endemic areas. Chinese Journal of Endemiology 2:111\u2013113","journal-title":"Chinese Journal of Endemiology"},{"issue":"1","key":"964_CR17","first-page":"35","volume":"8","author":"Z Yu","year":"1993","unstructured":"Yu Z (1993) Determination of Zn concentration in Kashin-Beck disease affected areas. Endemic Diseases Bulletin 8(1):35\u201337","journal-title":"Endemic Diseases Bulletin"},{"issue":"7","key":"964_CR18","first-page":"131","volume":"3","author":"S Wang","year":"1992","unstructured":"Wang S (1992) Analysis of Zn contents in the water, soil and children\u2019s hair in Kashin-Beck disease areas of Shanxi Province. Endemic Diseases Bulletin 3(7):131\u2013132","journal-title":"Endemic Diseases Bulletin"},{"issue":"5","key":"964_CR19","first-page":"57","volume":"23","author":"Z Wang","year":"1989","unstructured":"Wang Z, He F, Gao B, Zhang X, Yang J (1989) A case-control study in Kashin-Beck disease. Journal of Harbin Medical University 23(5):57\u201359","journal-title":"Journal of Harbin Medical University"},{"issue":"1","key":"964_CR20","first-page":"7","volume":"10","author":"C Bai","year":"1995","unstructured":"Bai C, Lv S, Wang Z, Xue L (1995) Studies on zinc nutritional status of children from Kashin-Beck disease affected areas. Chinese Journal of Control of Endemic Disenaces 10(1):7\u20138","journal-title":"Chinese Journal of Control of Endemic Disenaces"},{"key":"964_CR21","unstructured":"Cai Bai, Shemin Lv, Zhilun Wang, Xue L (1995) Analyses of zinc contents in sera and hairs of children from Kashin-Beck disease affected areas in the north region of WeiHe River in Shaanxi Province. Journal of Xi\u2019an Medical University 16 (4)"},{"key":"964_CR22","unstructured":"Liu L, Zhao X, Ming D, Ma W (2014) Analysis of 18 kinds of elements in blood of patients with Kashin-Beck disease in parts of Aba autonomous prefecture, Sichuan. J Environ Health 31(7):587-589"},{"key":"964_CR23","unstructured":"Yang C, Yang Z, Zhuoma BS, Ruodeng XR, Ciwang BM, Shengcheng Z, Zhu ZS (2013) Correlations between diet structure and serum indicators among population in Kashin-Beck disease area in Tibet. Chin J Public Health 29(1):122-125"},{"key":"964_CR24","unstructured":"Lu G, Jin M, Lei S (2004) Relationship between Kashin-Beck disease in children and trace elements and clinical significance. Chin J Endemiol 23(6):596-599"},{"key":"964_CR25","unstructured":"Sun G, Xiong C, Zhang Y, Wang S, Xie Y, Wang H,Shi N, Wang J (2004) Comparative analysis of the inorganic elements in wheats collected from\u00a0Kashin-Beck disease(KBD)area and non-KBD area. Studies of Trace Elements and Health 21(3):23-25"},{"key":"964_CR26","unstructured":"Bai C, Zhang S, Yu Z, Xiong Y, Xue L, Li Y, Fan W (1990) Contrastive analyses on content of some inorganic elements in wheat flour, maize flour and soybean in Kashin-Beck disease areas. Chin J\u00a0Endemiol 9(2):83-86"},{"issue":"1","key":"964_CR27","first-page":"1","volume":"5","author":"J Yang","year":"1985","unstructured":"Yang J (1985) Study on the ecological environment of Kaschin Beck disease in Yongshou County in Shaanxi province. Acta Sci Circumst 5(1):1\u201319","journal-title":"Acta Sci Circumst"},{"issue":"5","key":"964_CR28","first-page":"279","volume":"7","author":"C Li","year":"1988","unstructured":"Li C, Zhang S (1988) A study of the relationship between zinc and Kashin-Beck disease. Chinese Journal of endemic diseases 7(5):279\u2013280","journal-title":"Chinese Journal of endemic diseases"},{"key":"964_CR29","first-page":"45","volume":"2","author":"B Jia","year":"1992","unstructured":"Jia B, Zhang Q, Jiang Z, Wei L, Yang S (1992) The relationship between zinc and Kashin-Beck disease. Chinese Community Doctors 2:45\u201346","journal-title":"Chinese Community Doctors"},{"issue":"1","key":"964_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.joca.2008.05.008","volume":"17","author":"WZ Wang","year":"2009","unstructured":"Wang WZ, Guo X, Duan C, Ma WJ, Zhang YG, Xu P, Gao ZQ, Wang ZF, Yan H, Zhang YF, Yu YX, Chen JC, Lammi MJ (2009) Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis. Osteoarthr Cartil 17(1):83\u201390. doi: 10.1016\/j.joca.2008.05.008","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"964_CR31","doi-asserted-by":"publisher","first-page":"e28439","DOI":"10.1371\/journal.pone.0028439","volume":"7","author":"S Wang","year":"2012","unstructured":"Wang S, Guo X, Wu XM, Lammi MJ (2012) Genome-wide gene expression analysis suggests an important role of suppressed immunity in pathogenesis of Kashin-Beck disease. PLoS One 7(1):e28439. doi: 10.1371\/journal.pone.0028439","journal-title":"PLoS One"},{"issue":"4872","key":"964_CR32","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1126\/science.3047872","volume":"241","author":"G Parraga","year":"1988","unstructured":"Parraga G, Horvath SJ, Eisen A, Taylor WE, Hood L, Young ET, Klevit RE (1988) Zinc-dependent structure of a single-finger domain of yeast ADR1. Science 241(4872):1489\u20131492","journal-title":"Science"},{"issue":"3","key":"964_CR33","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/jn\/129.3.620","volume":"129","author":"LM Lepage","year":"1999","unstructured":"Lepage LM, Giesbrecht JA, Taylor CG (1999) Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice. J Nutr 129(3):620\u2013627","journal-title":"J Nutr"},{"issue":"1","key":"964_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/jor.22708","volume":"33","author":"J Chen","year":"2015","unstructured":"Chen J, Luo M, Wang W, Zhang Z, He Y, Duance VC, Hughes CE, Caterson B, Cao J (2015) Altered proteolytic activity and expression of MMPs and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of orthopaedic research: official publication of the Orthopaedic Research Society 33(1):47\u201355. doi: 10.1002\/jor.22708","journal-title":"Journal of orthopaedic research: official publication of the Orthopaedic Research Society"},{"issue":"3","key":"964_CR35","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrm2125","volume":"8","author":"A Page-McCaw","year":"2007","unstructured":"Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8(3):221\u2013233. doi: 10.1038\/nrm2125","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"964_CR36","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.cell.2014.01.007","volume":"156","author":"JH Kim","year":"2014","unstructured":"Kim JH, Jeon J, Shin M, Won Y, Lee M, Kwak JS, Lee G, Rhee J, Ryu JH, Chun CH, Chun JS (2014) Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell 156(4):730\u2013743. doi: 10.1016\/j.cell.2014.01.007","journal-title":"Cell"},{"issue":"3","key":"964_CR37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3109\/03009742.2015.1058416","volume":"45","author":"X Wang","year":"2016","unstructured":"Wang X, Ning Y, Tan W, Yu H, Li Z, Guo X (2016) Population-based comparative analysis of differentially expressed genes between Kashin-Beck disease grades I and II. Scand J Rheumatol 45(3):230\u2013235. doi: 10.3109\/03009742.2015.1058416","journal-title":"Scand J Rheumatol"},{"issue":"1 Suppl","key":"964_CR38","first-page":"93","volume":"11","author":"AS Prasad","year":"1995","unstructured":"Prasad AS (1995) Zinc: an overview. Nutrition 11(1 Suppl):93\u201399","journal-title":"Nutrition"},{"issue":"34","key":"964_CR39","doi-asserted-by":"publisher","first-page":"24085","DOI":"10.1074\/jbc.R600011200","volume":"281","author":"RJ Cousins","year":"2006","unstructured":"Cousins RJ, Liuzzi JP, Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281(34):24085\u201324089. doi: 10.1074\/jbc.R600011200","journal-title":"J Biol Chem"},{"key":"964_CR40","doi-asserted-by":"publisher","unstructured":"Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proceedings of the National Academy of Sciences of the United States of America 102 (19):6843\u20136848. doi: 10.1073\/pnas.0502257102","DOI":"10.1073\/pnas.0502257102"},{"issue":"9","key":"964_CR41","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/ni1373","volume":"7","author":"H Kitamura","year":"2006","unstructured":"Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, Hirano T (2006) Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol 7(9):971\u2013977. doi: 10.1038\/ni1373","journal-title":"Nat Immunol"},{"issue":"3","key":"964_CR42","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/ng913","volume":"31","author":"S Kury","year":"2002","unstructured":"Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP (2002) Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet 31(3):239\u2013240. doi: 10.1038\/ng913","journal-title":"Nat Genet"},{"issue":"1","key":"964_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2008.12.001","volume":"23","author":"J Ovesen","year":"2009","unstructured":"Ovesen J, Moller-Madsen B, Nielsen PT, Christensen PH, Simonsen O, Hoeck HC, Laursen MB, Thomsen JS (2009) Differences in zinc status between patients with osteoarthritis and osteoporosis. J Trace Elem Med Biol 23(1):1\u20138. doi: 10.1016\/j.jtemb.2008.12.001","journal-title":"J Trace Elem Med Biol"},{"issue":"11","key":"964_CR44","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.joca.2013.06.029","volume":"21","author":"A Roschger","year":"2013","unstructured":"Roschger A, Hofstaetter JG, Pemmer B, Zoeger N, Wobrauschek P, Falkenberg G, Simon R, Berzlanovich A, Thaler HW, Roschger P, Klaushofer K, Streli C (2013) Differential accumulation of lead and zinc in double-tidemarks of articular cartilage. Osteoarthr Cartil 21(11):1707\u20131715. doi: 10.1016\/j.joca.2013.06.029","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"964_CR45","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.joca.2015.07.016","volume":"24","author":"M Lee","year":"2016","unstructured":"Lee M, Won Y, Shin Y, Kim JH, Chun JS (2016) Reciprocal activation of hypoxia-inducible factor (HIF)-2alpha and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis. Osteoarthr Cartil 24(1):134\u2013145. doi: 10.1016\/j.joca.2015.07.016","journal-title":"Osteoarthr Cartil"},{"key":"964_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.07.008","author":"HE Kim","year":"2016","unstructured":"Kim HE, Rhee J, Park S, Yang J, Chun JS (2016) Upregulation of Atrogin-1\/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis. Osteoarthr Cartil. doi: 10.1016\/j.joca.2016.07.008","journal-title":"Osteoarthr Cartil"},{"key":"964_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.07.009","author":"WS Choi","year":"2016","unstructured":"Choi WS, Chun JS (2016) Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice. Osteoarthr Cartil. doi: 10.1016\/j.joca.2016.07.009","journal-title":"Osteoarthr Cartil"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-017-0964-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-0964-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-0964-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T22:26:30Z","timestamp":1568845590000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-017-0964-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["964"],"URL":"https:\/\/doi.org\/10.1007\/s12011-017-0964-8","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}