{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T12:13:23Z","timestamp":1772367203952,"version":"3.50.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12011-017-1030-2","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T18:37:24Z","timestamp":1494268644000},"page":"142-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Molecular Mechanisms of Protective Role of Se on the G2\/M Phase Arrest of Jejunum Caused by AFB1"],"prefix":"10.1007","volume":"181","author":[{"given":"Jing","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicai","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengmin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junliang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"issue":"4","key":"1030_CR1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jat.1669","volume":"32","author":"R Liu","year":"2012","unstructured":"Liu R, Jin Q, Huang J, Liu Y, Wang X, Zhou X, Mao W, Wang S (2012) In vitro toxicity of aflatoxin B1 and its photodegradation products in HepG2 cells. J Appl Toxicol 32(4):276\u2013281","journal-title":"J Appl Toxicol"},{"issue":"3","key":"1030_CR2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.rvsc.2010.04.011","volume":"89","author":"S Rawal","year":"2010","unstructured":"Rawal S, Kim JE, Coulombe R (2010) Aflatoxin B1 in poultry: toxicology, metabolism and prevention. Res Vet Sci 89(3):325\u2013331","journal-title":"Res Vet Sci"},{"issue":"1","key":"1030_CR3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tvjl.2007.12.034","volume":"176","author":"J Fink-Gremmels","year":"2008","unstructured":"Fink-Gremmels J (2008) The role of mycotoxins in the health and performance of dairy cows. The Vet J 176(1):84\u201392","journal-title":"The Vet J"},{"issue":"1","key":"1030_CR4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijfoodmicro.2007.07.019","volume":"119","author":"JL Richard","year":"2007","unstructured":"Richard JL (2007) Some major mycotoxins and their mycotoxicoses\u2014an overview. Int J Food Microbiol 119(1):3\u201310","journal-title":"Int J Food Microbiol"},{"issue":"2","key":"1030_CR5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2005.11.018","volume":"241","author":"LL Bedard","year":"2006","unstructured":"Bedard LL, Massey TE (2006) Aflatoxin B1-induced DNA damage and its repair. Cancer Lett 241(2):174\u2013183","journal-title":"Cancer Lett"},{"issue":"5","key":"1030_CR6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/0748233711434956","volume":"29","author":"G Agar","year":"2013","unstructured":"Agar G, Alpsoy L, Bozari S, Erturk FA, Yildirim N (2013) Determination of protective role of selenium against aflatoxin B1-induced DNA damage. Toxicol Ind Health 29(5):396\u2013403","journal-title":"Toxicol Ind Health"},{"key":"1030_CR7","unstructured":"Cancer IAfRo and Organization WH (1993) Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. International Agency for Research on Cancer."},{"issue":"5192","key":"1030_CR8","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1126\/science.7997877","volume":"266","author":"LH Hartwell","year":"1994","unstructured":"Hartwell LH, Kastan MB (1994) Cell cycle control and cancer. Science 266(5192):1821\u20131828","journal-title":"Science"},{"issue":"6","key":"1030_CR9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/030098589803500601","volume":"35","author":"K Schafer","year":"1998","unstructured":"Schafer K (1998) The cell cycle: a review. Vet Pathol 35(6):461\u2013478","journal-title":"Vet Pathol"},{"issue":"4863","key":"1030_CR10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.3291120","volume":"241","author":"T Weinert","year":"1988","unstructured":"Weinert T, Hartwell LH (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241(4863):317\u2013322","journal-title":"Science"},{"key":"1030_CR11","unstructured":"Bbosa GS, Lubega A, Kyegombe DB, Kitya D, Ogwal-Okeng J and Anokbonggo WW (2013) Review of the biological and health effects of aflatoxins on body organs and body systems"},{"issue":"1","key":"1030_CR12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12011-015-0344-1","volume":"168","author":"Z Yu","year":"2015","unstructured":"Yu Z, Wang F, Liang N, Wang C, Peng X, Fang J, Cui H, Mughal MJ, Lai W (2015) Effect of selenium supplementation on apoptosis and cell cycle blockage of renal cells in broilers fed a diet containing aflatoxin B1. Biol Trace Elem Res 168(1):242\u2013251","journal-title":"Biol Trace Elem Res"},{"issue":"24","key":"1030_CR13","doi-asserted-by":"crossref","first-page":"35592","DOI":"10.18632\/oncotarget.9594","volume":"7","author":"H Yin","year":"2016","unstructured":"Yin H, Jiang M, Peng X, Cui H, Zhou Y, He M, Zuo Z, Ouyang P, Fan J, Fang J (2016) The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. Oncotarget 7(24):35592\u201335607","journal-title":"Oncotarget"},{"issue":"4","key":"1030_CR14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0145-305X(91)90030-3","volume":"15","author":"TR Scott","year":"1991","unstructured":"Scott TR, Rowland SM, Rodgers RS, Bodine AB (1991) Genetic selection for aflatoxin B1 resistance influences chicken T-cell and thymocyte proliferation. D Dev Comp Immunol 15(4):383\u2013391","journal-title":"D Dev Comp Immunol"},{"issue":"1","key":"1030_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08923973.2013.850506","volume":"36","author":"A Bahari","year":"2014","unstructured":"Bahari A, Mehrzad J, Mahmoudi M, Bassami MR, Dehghani H (2014) Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes. Immunopharm Immun 36(1):1\u201310","journal-title":"Immunopharm Immun"},{"issue":"6","key":"1030_CR16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.toxicon.2012.02.010","volume":"59","author":"G Bianco","year":"2012","unstructured":"Bianco G, Russo R, Marzocco S, Velotto S, Autore G, Severino L (2012) Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2. Toxicon 59(6):644\u2013650","journal-title":"Toxicon"},{"issue":"5","key":"1030_CR17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1520-6866(1998)18:5<249::AID-TCM5>3.0.CO;2-R","volume":"18","author":"HG Raj","year":"1998","unstructured":"Raj HG, Gupta K, Rohil V, Bose M, Biswas G, Singh SK, Jain SC, Parmar VS, Olsen CE, Wengel J (1998) Aflatoxin B1-induced micronuclei and cell cycle alterations in lung and bone marrow cells and their modulation by Piper argyrophyllum extract. Teratogen Carcin Mut 18(5):249\u2013261","journal-title":"Teratogen Carcin Mut"},{"issue":"2","key":"1030_CR18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2013.04.005","volume":"270","author":"X Yang","year":"2013","unstructured":"Yang X, Zhang Z, Wang X, Wang Y, Zhang X, Lu H, Wang S-L (2013) Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cells to aflatoxin B1-induced DNA damage. Toxicol Appl Pharmacol 270(2):114\u2013121","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"1030_CR19","first-page":"2568","volume":"44","author":"JA Milner","year":"1985","unstructured":"Milner JA (1985) Effect of selenium on virally induced and transplantable tumor models. Fed Proc 44(9):2568\u20132572","journal-title":"Fed Proc"},{"issue":"4","key":"1030_CR20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/jn\/132.4.674","volume":"132","author":"H Zeng","year":"2002","unstructured":"Zeng H (2002) Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr 132(4):674\u2013679","journal-title":"J Nutr"},{"issue":"1","key":"1030_CR21","first-page":"49","volume":"9","author":"C Ip","year":"2000","unstructured":"Ip C, Thompson HJ, Ganther HE (2000) Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Cancer Epidem Biomar 9(1):49\u201354","journal-title":"Cancer Epidem Biomar"},{"issue":"1","key":"1030_CR22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12011-010-8639-8","volume":"139","author":"X Peng","year":"2011","unstructured":"Peng X, Cui Y, Cui W, Deng J, Cui H, Yang F (2011) The cell cycle arrest and apoptosis of bursa of Fabricius induced by low selenium in chickens. Biol Trace Elem Res 139(1):32\u201340","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"1030_CR23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3835(96)04373-X","volume":"107","author":"R Sinha","year":"1996","unstructured":"Sinha R, Said T, Medina D (1996) Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Lett 107(2):277\u2013284","journal-title":"Cancer Lett"},{"issue":"3","key":"1030_CR24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/molecules14031263","volume":"14","author":"H Zeng","year":"2009","unstructured":"Zeng H (2009) Selenium as an essential micronutrient: roles in cell cycle and apoptosis. Molecules 14(3):1263\u20131278","journal-title":"Molecules"},{"issue":"3","key":"1030_CR25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/10623320390233391","volume":"10","author":"J Yeh","year":"2003","unstructured":"Yeh J, Cheng L-c, Liang Y-C, Ou BR (2003) Modulation of the arsenic effects on cytotoxicity, viability, and cell cycle in porcine endothelial cells by selenium. Endothelium 10(3):127\u2013139","journal-title":"Endothelium"},{"issue":"1","key":"1030_CR26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12011-014-0009-5","volume":"160","author":"S Zhang","year":"2014","unstructured":"Zhang S, Peng X, Fang J, Cui H, Zuo Z, Chen Z (2014) Effects of aflatoxin B1 exposure and sodium selenite supplementation on the histology, cell proliferation, and cell cycle of jejunum in broilers. Biol Trace Elem Res 160(1):32\u201340","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"1030_CR27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/00071660802538632","volume":"50","author":"M Choct","year":"2009","unstructured":"Choct M (2009) Managing gut health through nutrition. Br Poult Sci 50(1):9\u201315","journal-title":"Br Poult Sci"},{"key":"1030_CR28","unstructured":"Kaoud H (2013) Innovative methods for the amelioration of aflatoxin (afb1) effect in broiler chicks. Sjar Net 1"},{"issue":"11","key":"1030_CR29","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.18632\/oncotarget.7731","volume":"7","author":"X Peng","year":"2016","unstructured":"Peng X, Yu Z, Liang N, Chi X, Li X, Jiang M, Fang J, Cui H, Lai W, Zhou Y (2016) The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1. Oncotarget 7(11):12222\u201312234","journal-title":"Oncotarget"},{"issue":"1","key":"1030_CR30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/japr\/3.1.101","volume":"3","author":"N Dale","year":"1994","unstructured":"Dale N (1994) National Research Council Nutrient Requirements of Poultry\u2013Ninth Revised Edition (1994). J Appl Poult Res 3(1):101\u2013101","journal-title":"J Appl Poult Res"},{"issue":"6","key":"1030_CR31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1439-0264.2011.01094.x","volume":"40","author":"J Fang","year":"2011","unstructured":"Fang J, Cui H, Peng X, Chen Z, He M, Tang L (2011) Developmental changes in cell proliferation and apoptosis in the normal duck thymus. Anat Histol Embryol 40(6):457\u2013465","journal-title":"Anat Histol Embryol"},{"key":"1030_CR32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fct.2013.10.033","volume":"63","author":"B Wu","year":"2014","unstructured":"Wu B, Cui H, Peng X, Fang J, Zuo Z, Deng J, Huang J (2014) Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax\/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers. Food Chem Toxicol 63:18\u201329","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"1030_CR33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"6","key":"1030_CR34","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/hep.1840050623","volume":"5","author":"RD Dorado","year":"1985","unstructured":"Dorado RD, Porta EA, Aquino TM (1985) Effects of dietary selenium on hepatic and renal tumorigenesis induced in rats by diethylnitrosamine. Hepatology 5(6):1201\u20131208","journal-title":"Hepatology"},{"issue":"1\u20134","key":"1030_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/biof.5520140120","volume":"14","author":"G Combs","year":"2001","unstructured":"Combs G, Clark L, Turnbull B (2001) An analysis of cancer prevention by selenium. Biofactors 14(1\u20134):153\u2013159","journal-title":"Biofactors"},{"issue":"1","key":"1030_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.19.1.1","volume":"19","author":"CB Allan","year":"1999","unstructured":"Allan CB, Lacourciere GM, Stadtman TC (1999) Responsiveness of selenoproteins to dietary selenium 1, 2. Annu Rev Nutr 19(1):1\u201316","journal-title":"Annu Rev Nutr"},{"issue":"6","key":"1030_CR37","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1021\/acs.jafc.5b05621","volume":"64","author":"S Hao","year":"2016","unstructured":"Hao S, Hu J, Song S, Huang D, Xu H, Qian G, Gan F, Huang K (2016) Selenium alleviates aflatoxin B1-induced immune toxicity through improving glutathione peroxidase 1 and selenoprotein S expression in primary porcine splenocytes. J Agric Food Chem 64(6):1385\u20131393","journal-title":"J Agric Food Chem"},{"key":"1030_CR38","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2013.06.032","volume":"59","author":"K Chen","year":"2013","unstructured":"Chen K, Shu G, Peng X, Fang J, Cui H, Chen J, Wang F, Chen Z, Zuo Z, Deng J (2013) Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B1. Food Chem Toxicol 59:446\u2013454","journal-title":"Food Chem Toxicol"},{"issue":"7","key":"1030_CR39","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.3390\/ijerph10072834","volume":"10","author":"F Wang","year":"2013","unstructured":"Wang F, Shu G, Peng X, Fang J, Chen K, Cui H, Chen Z, Zuo Z, Deng J, Geng Y (2013) Protective effects of sodium selenite against aflatoxin B1-induced oxidative stress and apoptosis in broiler spleen. Inter J Env Res Pub Heal 10(7):2834\u20132844","journal-title":"Inter J Env Res Pub Heal"},{"issue":"1","key":"1030_CR40","first-page":"167","volume":"159","author":"H Yang","year":"2014","unstructured":"Yang H, Jing F, Xi P, Cui H, Zuo Z (2014) Effects of sodium selenite on aflatoxin B1-induced decrease of ileac T cell and the mRNA contents of IL-2, IL-6, and TNF-\u03b1 in broilers. Biol Trace Elem Res 159(1):167\u2013173","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"1030_CR41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12011-011-9201-z","volume":"145","author":"D Shi","year":"2012","unstructured":"Shi D, Guo S, Liao S, Su R, Pan J, Lin Y, Tang Z (2012) Influence of selenium on hepatic mitochondrial antioxidant capacity in ducklings intoxicated with aflatoxin B1. Biol Trace Elem Res 145(3):325\u2013329","journal-title":"Biol Trace Elem Res"},{"issue":"74","key":"1030_CR42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.fct.2014.09.003","volume":"74","author":"K Chen","year":"2014","unstructured":"Chen K, Jing F, Xi P, Cui H, Jin C, Wang F, Chen Z, Zuo Z, Deng J, Lai W (2014) Effect of selenium supplementation on aflatoxin B1-induced histopathological lesions and apoptosis in bursa of Fabricius in broilers. Food Chem Toxicol 74(74):91\u201397","journal-title":"Food Chem Toxicol"},{"key":"1030_CR43","doi-asserted-by":"crossref","unstructured":"Verma RJ (2003) Aflatoxin cause DNA damage. Inter J of Hum Genet 4(4)","DOI":"10.1080\/09723757.2004.11885899"},{"issue":"5383","key":"1030_CR44","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.281.5383.1674","volume":"281","author":"S Banin","year":"1998","unstructured":"Banin S, Moyal L, Shieh S-Y, Taya Y, Anderson C, Chessa L, Smorodinsky N, Prives C, Reiss Y, Shiloh Y (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281(5383):1674\u20131677","journal-title":"Science"},{"issue":"22","key":"1030_CR45","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.4161\/cc.7.22.7102","volume":"7","author":"KA Wilson","year":"2008","unstructured":"Wilson KA, Stern DF (2008) NFBD1\/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. Cell Cycle 7(22):3584\u20133594","journal-title":"Cell Cycle"},{"issue":"5459","key":"1030_CR46","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","volume":"287","author":"A Hirao","year":"2000","unstructured":"Hirao A, Kong Y-Y, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287(5459):1824\u20131827","journal-title":"Science"},{"issue":"20","key":"1030_CR47","first-page":"5743","volume":"62","author":"Q Yu","year":"2002","unstructured":"Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y (2002) UCN-01 inhibits p53 up-regulation and abrogates \u03b3-radiation-induced G2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res 62(20):5743\u20135748","journal-title":"Cancer Res"},{"issue":"9","key":"1030_CR48","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/sj.onc.1201432","volume":"15","author":"J Piette","year":"1997","unstructured":"Piette J, Neel H, Marechal V (1997) Mdm2: keeping p53 under control. Oncogene 15(9):1001\u20131010","journal-title":"Oncogene"},{"issue":"18","key":"1030_CR49","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1073\/pnas.92.18.8493","volume":"92","author":"ML Agarwal","year":"1995","unstructured":"Agarwal ML, Agarwal A, Taylor WR, Stark GR (1995) p53 controls both the G2\/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. P Natl Acad Sci 92(18):8493\u20138497","journal-title":"P Natl Acad Sci"},{"issue":"8","key":"1030_CR50","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/MCB.25.8.3364-3387.2005","volume":"25","author":"BC Dash","year":"2005","unstructured":"Dash BC, Eldeiry WS (2005) Phosphorylation of p21 in G2\/M promotes cyclin B-Cdc2 kinase activity. Mol Cell Biol 25(8):3364\u20133387","journal-title":"Mol Cell Biol"},{"issue":"4","key":"1030_CR51","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","volume":"75","author":"WS Eldeiry","year":"1993","unstructured":"Eldeiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75(4):817\u2013825","journal-title":"Cell"},{"issue":"46","key":"1030_CR52","doi-asserted-by":"crossref","first-page":"42971","DOI":"10.1074\/jbc.M106460200","volume":"276","author":"T Ando","year":"2001","unstructured":"Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M, Okamoto T (2001) Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2\/M arrest after DNA damage. J Biol Chem 276(46):42971\u201342977","journal-title":"J Biol Chem"},{"issue":"9","key":"1030_CR53","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1091\/mbc.4.9.897","volume":"4","author":"H Zhang","year":"1993","unstructured":"Zhang H, Xiong Y, Beach D (1993) Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 4(9):897\u2013906","journal-title":"Mol Biol Cell"},{"key":"1030_CR54","doi-asserted-by":"crossref","unstructured":"Kelman Z (1997) PCNA: structure, functions and interactions. Oncogene 14(6)","DOI":"10.1038\/sj.onc.1200886"},{"issue":"15","key":"1030_CR55","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1242\/jcs.00653","volume":"116","author":"G Maga","year":"2003","unstructured":"Maga G, H\u00fcbscher U (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116(15):3051\u20133060","journal-title":"J Cell Sci"},{"key":"1030_CR56","doi-asserted-by":"crossref","unstructured":"Bravo R, Frank R, Blundell PA and Macdonald-Bravo H (1987) Cyclin\/PCNA is the auxiliary protein of DNA polymerase-\u03b4","DOI":"10.1038\/326515a0"},{"issue":"24","key":"1030_CR57","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.4161\/cc.22917","volume":"11","author":"M Quaas","year":"2012","unstructured":"Quaas M, M\u00fcller GA, Engeland K (2012) p53 can repress transcription of cell cycle genes through a p21WAF1\/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements. Cell Cycle 11(24):4661\u20134672","journal-title":"Cell Cycle"},{"issue":"4","key":"1030_CR58","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/MCB.16.4.1335","volume":"16","author":"W Poluha","year":"1996","unstructured":"Poluha W, Poluha DK, Chang B, Crosbie NE, Schonhoff CM, Kilpatrick DL, Ross AH (1996) The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16(4):1335\u20131341","journal-title":"Mol Cell Biol"},{"issue":"8","key":"1030_CR59","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jnutbio.2006.11.003","volume":"18","author":"N Kaushal","year":"2007","unstructured":"Kaushal N, Bansal MP (2007) Dietary selenium variation-induced oxidative stress modulates CDC2\/cyclin B1 expression and apoptosis of germ cells in mice testis. J Nutr Biochem 18(8):553\u2013564","journal-title":"J Nutr Biochem"},{"issue":"1\u20132","key":"1030_CR60","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-006-9360-y","volume":"298","author":"N Kaushal","year":"2007","unstructured":"Kaushal N, Bansal MP (2007) Inhibition of CDC2\/cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21. Mol Cell Biochem 298(1\u20132):139\u2013150","journal-title":"Mol Cell Biochem"},{"key":"1030_CR61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4615-4253-7_10","volume":"4","author":"I Nilsson","year":"2000","unstructured":"Nilsson I, Hoffmann I (2000) Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res 4:107\u2013114","journal-title":"Prog Cell Cycle Res"},{"issue":"6","key":"1030_CR62","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0955-0674(96)80080-9","volume":"8","author":"DJ Lew","year":"1996","unstructured":"Lew DJ, Kornbluth S (1996) Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol 8(6):795\u2013804","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"1030_CR63","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0955-0674(94)90060-4","volume":"6","author":"TR Coleman","year":"1995","unstructured":"Coleman TR, Dunphy WG (1995) Cdc2 regulatory factors. Curr Opin Cell Biol 6(6):877\u2013882","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"1030_CR64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35048096","volume":"2","author":"EA Nigg","year":"2001","unstructured":"Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Bio 2(1):21\u201332","journal-title":"Nat Rev Mol Cell Bio"},{"issue":"5","key":"1030_CR65","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1535-6108(03)00110-7","volume":"3","author":"J Bartek","year":"2003","unstructured":"Bartek J, Lukas J (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3(5):421\u2013429","journal-title":"Cancer Cell"},{"issue":"12","key":"1030_CR66","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.bbamcr.2012.09.001","volume":"1823","author":"HP Yong","year":"2012","unstructured":"Yong HP, Jeon YH, Kim IY (2012) Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B. Biochim Biophys Acta 1823(12):2217\u20132226","journal-title":"Biochim Biophys Acta"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-017-1030-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-1030-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-1030-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T18:31:31Z","timestamp":1569263491000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-017-1030-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,9]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1030"],"URL":"https:\/\/doi.org\/10.1007\/s12011-017-1030-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,9]]}}}